DLG4

DLG4
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1KEF, 3I4W, 3K82, 3ZRT
Dynodwyr
Cyfenwau	DLG4, PSD95, SAP-90, SAP90, Dlgh4, PSD-95, SAP90A, discs large homolog 4, discs large MAGUK scaffold protein 4, MRD62
Dynodwyr allanol	OMIM: 602887 HomoloGene: 1047 GeneCards: DLG4
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• beta-1 adrenergic receptor binding; • PDZ domain binding; • GO:0032403 protein-containing complex binding; • scaffold protein binding; • guanylate kinase activity; • P2Y1 nucleotide receptor binding; • acetylcholine receptor binding; • kinase binding; • protein C-terminus binding; • GO:0001948, GO:0016582 protein binding; • ionotropic glutamate receptor binding; • D1 dopamine receptor binding; • protein phosphatase binding; • neuroligin family protein binding; • ligand-gated ion channel activity;
Cydrannau o'r gell	• cytoplasm; • juxtaparanode region of axon; • endocytic vesicle membrane; • synaptic membrane; • postsynaptic membrane; • cell projection; • bilen; • GO:0097483, GO:0097481 postsynaptic density; • synaptic vesicle; • extrinsic component of cytoplasmic side of plasma membrane; • voltage-gated potassium channel complex; • cortical cytoskeleton; • Cellbilen; • dendritic spine; • synapse; • excitatory synapse; • cerebellar mossy fiber; • axon; • cell junction; • dendrite; • basolateral plasma membrane; • Reticwlwm endoplasmig; • neuron spine; • AMPA glutamate receptor complex; • dendrite cytoplasm; • ionotropic glutamate receptor complex; • neuron projection terminus; • cyrion cell; • cytosol; • postsynaptic density membrane; • postsynapse; • neuromuscular junction; • neuron projection; • glutamatergic synapse;
Prosesau biolegol	• receptor localization to synapse; • regulation of grooming behavior; • regulation of long-term neuronal synaptic plasticity; • neuromuscular process controlling balance; • negative regulation of receptor internalization; • establishment of protein localization; • positive regulation of cytosolic calcium ion concentration; • learning; • nervous system development; • MAPK cascade; • locomotory exploration behavior; • regulation of NMDA receptor activity; • AMPA glutamate receptor clustering; • dendritic spine morphogenesis; • vocalization behavior; • positive regulation of synaptic transmission; • establishment or maintenance of epithelial cell apical/basal polarity; • positive regulation of excitatory postsynaptic potential; • social behavior; • synaptic vesicle maturation; • protein localization to synapse; • GO:0072468 signal transduction; • GMP metabolic process; • GDP metabolic process; • chemical synaptic transmission; • transmembrane transport; • cellular response to potassium ion; • receptor clustering; • positive regulation of protein tyrosine kinase activity; • GO:0034622 protein-containing complex assembly; • cell-cell adhesion; • postsynaptic neurotransmitter receptor diffusion trapping; • positive regulation of neuron projection arborization; • neurotransmitter receptor localization to postsynaptic specialization membrane;
	Sources:Amigo / QuickGO
Orthologau
	1742
	n/a
	ENSG00000132535
	n/a
	P78352; O14909
	n/a
NM_001128827; NM_001365; NM_001321074; NM_001321075; NM_001321076;
	NM_001321077; NM_001369566
	n/a
NP_001122299; NP_001308003; NP_001308004; NP_001308005; NP_001308006;
	NP_001356
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn DLG4 yw DLG4 a elwir hefyd yn Discs, large homolog 4 (Drosophila), isoform CRA_d (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 17, band 17p13.1.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn DLG4.

PSD95
SAP90
SAP-90

Llyfryddiaeth

"Site-Specific Phosphorylation of PSD-95 PDZ Domains Reveals Fine-Tuned Regulation of Protein-Protein Interactions. ". ACS Chem Biol. 2017. PMID 28692247.
"Association analysis of genetic variant of rs13331 in PSD95 gene with autism spectrum disorders: A case-control study in a Chinese population. ". J Huazhong Univ Sci Technolog Med Sci. 2016. PMID 27072977.
"Postsynaptic nanodomains generated by local palmitoylation cycles. ". Biochem Soc Trans. 2015. PMID 25849917.
"Targeting protein-protein interactions with trimeric ligands: high affinity inhibitors of the MAGUK protein family. ". PLoS One. 2015. PMID 25658767.
"Population-specific haplotype association of the postsynaptic density gene DLG4 with schizophrenia, in family-based association studies.". PLoS One. 2013. PMID 23936182.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] DLG4 - Cronfa NCBI

[1]

[2]