BCL2L2

BCL2L2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1MK3, 1O0L, 1ZY3, 2Y6W, 4CIM
Dynodwyr
Cyfenwau	BCL2L2, BCL-W, BCL2-L-2, BCLW, PPP1R51, BCL2 like 2
Dynodwyr allanol	OMIM: 601931 HomoloGene: 2989 GeneCards: BCL2L2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001948, GO:0016582 protein binding • protein homodimerization activity • disordered domain specific binding • identical protein binding • protein heterodimerization activity • BH domain binding Cydrannau o'r gell • cytoplasm • cytosol • mitochondrial membranes • mitocondria • bilen • mitochondrial outer membrane • Bcl-2 family protein complex • cnewyllyn cell • nuclear inclusion body Prosesau biolegol • spermatogenesis • regulation of apoptotic process • negative regulation of apoptotic process • Sertoli cell proliferation • GO:0097285 apoptotic process • intrinsic apoptotic signaling pathway in response to DNA damage • extrinsic apoptotic signaling pathway in absence of ligand • negative regulation of intrinsic apoptotic signaling pathway • cellular response to estradiol stimulus • cellular response to amyloid-beta Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	599	n/a
Ensembl	ENSG00000129473	n/a
UniProt	Q92843	n/a
RefSeq (mRNA)	NM_004050 NM_001199839	n/a
RefSeq (protein)	NP_001186768 NP_004041	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn BCL2L2 yw BCL2L2 a elwir hefyd yn BCL2 like 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 14, band 14q11.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn BCL2L2.

• BCLW
• BCL-W
• PPP1R51
• BCL2-L-2

Llyfryddiaeth

• "Down-Regulation of MicroRNA-133b Suppresses Apoptosis of Lens Epithelial Cell by Up-Regulating BCL2L2 in Age-Related Cataracts. ". Med Sci Monit. 2016. PMID 27802259.
• "3-Hydroxy-3',4'-dimethoxyflavone suppresses Bcl-w-induced invasive potentials and stemness in glioblastoma multiforme. ". Biochem Biophys Res Commun. 2014. PMID 24946210.
• "Co-crystallization with conformation-specific designed ankyrin repeat proteins explains the conformational flexibility of BCL-W. ". J Mol Biol. 2014. PMID 24747052.
• "Bcl-w Enhances Mesenchymal Changes and Invasiveness of Glioblastoma Cells by Inducing Nuclear Accumulation of β-Catenin. ". PLoS One. 2013. PMID 23826359.
• "[Expression of Bcl-w protein in human small intestinal adenocarcinoma and effect of Bcl-w siRNA on apoptosis in intestinal adenocarcinoma HuTu-80 cells].". Zhonghua Zhong Liu Za Zhi. 2012. PMID 22780970.