S Wikipedije, slobodne enciklopedije
Protein 2B sličan metiltransferazi je enzim koji je kod ljudi kodiran genom METTL2B .[ 5] [ 6]
Dužina polipeptidnog lanca je 378 aminokiselina , а molekulska težina 43.426 Da .[ 7]
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MAGSYPEGAP AILADKRQQF GSRFLSDPAR VFHHNAWDNV EWSEEQAAAA
ERKVQENSIQ RVCQEKQVDY EINAHKYWND FYKIHENGFF KDRHWLFTEF
PELAPSQNQN HLKDWFLENK SEVCECRNNE DGPGLIMEEQ HKCSSKSLEH
KTQTPPVEEN VTQKISDLEI CADEFPGSSA TYRILEVGCG VGNTVFPILQ
TNNDPGLFVY CCDFSSTAIE LVQTNSEYDP SRCFAFVHDL CDEEKSYPVP
KGSLDIIILI FVLSAVVPDK MQKAINRLSR LLKPGGMVLL RDYGRYDMAQ
LRFKKGQCLS GNFYVRGDGT RVYFFTQEEL DTLFTTAGLE KVQNLVDRRL
QVNRGKQLTM YRVWIQCKYC KPLLSSTS
Ovaj gen član je porodice metiltransferaza , koje imaju homologe , ali udaljene oblike, porosice UbiE metiltransferaza. Opisane su alternativno prerađene varijante transkripta , koje kodiraju razlićite proteinske izoforme ; međutim ni jedna od njih nije potpuno okarakterizirana.[ 6]
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Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 . PMID 14702039 .
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Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 . PMC 139241 . PMID 12477932 .
Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells" . Genome Res . 10 (10): 1546–60. doi :10.1101/gr.140200 . PMC 310934 . PMID 11042152 .