ING3

ING3
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	1X4I
Identifikatori
Aliasi	ING3
Vanjski ID-jevi	OMIM: 607493 MGI: 1919027 HomoloGene: 6804 GeneCards: ING3
Lokacija gena (čovjek)
Hrom.	Hromosom 7 (čovjek)
Kraj	120,977,216 bp
Lokacija gena (miš)
Hrom.	Hromosom 6 (miš)
Kraj	21,976,037 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• histone acetyltransferase activity; • methylated histone binding; • vezivanje iona metala;
Ćelijska komponenta	• Piccolo NuA4 histone acetyltransferase complex; • jedro; • nukleoplazma; • Swr1 complex; • NuA4 histone acetyltransferase complex;
Biološki proces	• histone H4 acetylation; • histone H2A acetylation; • regulation of growth; • GO:0009373 regulation of transcription, DNA-templated; • transcription, DNA-templated; • positive regulation of apoptotic process; • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization;
	Izvori:Amigo / QuickGO
Ortolozi
	54556
	71777
	ENSG00000071243
	ENSMUSG00000029670
	Q9NXR8
	Q8VEK6
	NM_198267; NM_019071; NM_198266
	NM_023626; NM_001311061
	NP_061944; NP_938008
	NP_001297990; NP_076115
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Inhibitorni protein rasta 3 je protein koji je kod ljudi kodiran genom ING3.^[5]^[6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 418 aminokiselina, а molekulska težina 46.743 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MLYLEDYLEM	IEQLPMDLRD	RFTEMREMDL	QVQNAMDQLE	QRVSEFFMNA
KKNKPEWREE	QMASIKKDYY	KALEDADEKV	QLANQIYDLV	DRHLRKLDQE
LAKFKMELEA	DNAGITEILE	RRSLELDTPS	QPVNNHHAHS	HTPVEKRKYN
PTSHHTTTDH	IPEKKFKSEA	LLSTLTSDAS	KENTLGCRNN	NSTASSNNAY
NVNSSQPLGS	YNIGSLSSGT	GAGAITMAAA	QAVQATAQMK	EGRRTSSLKA
SYEAFKNNDF	QLGKEFSMAR	ETVGYSSSSA	LMTTLTQNAS	SSAADSRSGR
KSKNNNKSSS	QQSSSSSSSS	SLSSCSSSST	VVQEISQQTT	VVPESDSNSQ
VDWTYDPNEP	RYCICNQVSY	GEMVGCDNQD	CPIEWFHYGC	VGLTEAPKGK
WYCPQCTAAM	KRRGSRHK

Funkcija

Protein kodiran ovim genom sličan je ING1, proteinu supresoru tumora, koji može stupiti u interakciju s TP53, inhibirati rast ćelija i inducirati apoptozu. Ovaj protein sadrži PHD-prst, koji je čest motiv kod proteina uključenih u remodeliranje hromatina. Ovaj gen može aktivirati p53 transaktivirane promotore, uključujući promotore p21/waf1 i bax. Pokazalo se da prekomjerna ekspresija ovog gena inhibira rast ćelija i izaziva apoptozu. Gubitak alela i smanjena ekspresija ovog gena otkriveni su u karcinomu glave i vrata. Uočene su dvije alternativno prerađene varijante transkripta, koje kodiraju različite izoforme.^[6]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000071243 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029670 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Gunduz M, Ouchida M, Fukushima K, Ito S, Jitsumori Y, Nakashima T, Nagai N, Nishizaki K, Shimizu K (Jun 2002). "Allelic loss and reduced expression of the ING3, a candidate tumor suppressor gene at 7q31, in human head and neck cancers". Oncogene. 21 (28): 4462–70. doi:10.1038/sj.onc.1205540. PMID 12080476.
^ ^a ^b "Entrez Gene: ING3 inhibitor of growth family, member 3".
^ "UniProt, Q9NXR8" (jezik: engleski). Pristupljeno 25. 9. 2021.

Dopunska literatura

Doyon Y, Côté J (2004). "The highly conserved and multifunctional NuA4 HAT complex". Curr. Opin. Genet. Dev. 14 (2): 147–54. doi:10.1016/j.gde.2004.02.009. PMID 15196461.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Nagashima M, Shiseki M, Pedeux RM, et al. (2003). "A novel PHD-finger motif protein, p47ING3, modulates p53-mediated transcription, cell cycle control, and apoptosis". Oncogene. 22 (3): 343–50. doi:10.1038/sj.onc.1206115. PMID 12545155.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.
Cai Y, Jin J, Tomomori-Sato C, et al. (2003). "Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex". J. Biol. Chem. 278 (44): 42733–6. doi:10.1074/jbc.C300389200. PMID 12963728.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Doyon Y, Selleck W, Lane WS, et al. (2004). "Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans". Mol. Cell. Biol. 24 (5): 1884–96. doi:10.1128/MCB.24.5.1884-1896.2004. PMC 350560. PMID 14966270.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Cai Y, Jin J, Florens L, et al. (2005). "The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes". J. Biol. Chem. 280 (14): 13665–70. doi:10.1074/jbc.M500001200. PMID 15647280.
Wang Y, Dai DL, Martinka M, Li G (2007). "Prognostic significance of nuclear ING3 expression in human cutaneous melanoma". Clin. Cancer Res. 13 (14): 4111–6. doi:10.1158/1078-0432.CCR-07-0408. PMID 17634537.

Vanjski linkovi

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000071243 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029670 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12080476-5] Gunduz M, Ouchida M, Fukushima K, Ito S, Jitsumori Y, Nakashima T, Nagai N, Nishizaki K, Shimizu K (Jun 2002). "Allelic loss and reduced expression of the ING3, a candidate tumor suppressor gene at 7q31, in human head and neck cancers". Oncogene. 21 (28): 4462–70. doi:10.1038/sj.onc.1205540. PMID 12080476.

[entrez-6] "Entrez Gene: ING3 inhibitor of growth family, member 3".

[UniProt-7] "UniProt, Q9NXR8" (jezik: engleski). Pristupljeno 25. 9. 2021.

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