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EZH2 Identifikatori Aliasi EZH2 Vanjski ID-jevi OMIM : 601573 MGI : 107940 HomoloGene : 37926 GeneCards : EZH2 Ontologija gena Molekularna funkcija • GO:0102674, GO:0102675 methyltransferase activity • sequence-specific DNA binding • aktivnost sa transferazom • promoter-specific chromatin binding • chromatin binding • histone-lysine N-methyltransferase activity • protein-lysine N-methyltransferase activity • GO:0001948, GO:0016582 vezivanje za proteine • vezivanje sa RNK • ribonucleoprotein complex binding • chromatin DNA binding • RNA polymerase II core promoter sequence-specific DNA binding • primary miRNA binding • vezivanje sa DNK • histone methyltransferase activity • histone methyltransferase activity (H3-K27 specific) • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • GO:0001106 transcription corepressor activity Ćelijska komponenta • ESC/E(Z) complex • pronucleus • jedro • nukleoplazma • citoplazma • Telomera Biološki proces • regulation of protein phosphorylation • regulation of gliogenesis • response to estradiol • GO:0009373 regulation of transcription, DNA-templated • positive regulation of MAP kinase activity • rhythmic process • negative regulation of retinoic acid receptor signaling pathway • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • negative regulation of striated muscle cell differentiation • G1 to G0 transition • GO:1901227 negative regulation of transcription by RNA polymerase II • positive regulation of dendrite development • positive regulation of epithelial to mesenchymal transition • negative regulation of transcription elongation from RNA polymerase II promoter • transcription, DNA-templated • negative regulation of DNA-binding transcription factor activity • positive regulation of protein serine/threonine kinase activity • negative regulation of gene expression • GO:1990376 negative regulation of G1/S transition of mitotic cell cycle • histone H3-K27 methylation • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • Metilacija DNK • negative regulation of epidermal cell differentiation • Metilacija • negative regulation of gene expression, epigenetic • regulation of cell population proliferation • regulation of circadian rhythm • skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration • cerebellar cortex development • Regulacija ekspresije gena • GO:0045996 negative regulation of transcription, DNA-templated • protein localization to chromatin • hippocampus development • regulation of neurogenesis • cellular response to hydrogen peroxide • response to tetrachloromethane • cellular response to trichostatin A • histone H3-K27 trimethylation • cardiac muscle hypertrophy in response to stress • hepatocyte homeostasis • liver regeneration • Metilacija histona • negative regulation of G0 to G1 transition • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization • positive regulation of cell population proliferation • positive regulation of cell cycle G1/S phase transition Izvori:Amigo / QuickGO
Ortolozi Vrste Čovjek Miš Entrez Ensembl UniProt RefSeq (mRNK) RefSeq (bjelančevina) Lokacija (UCSC) Chr 7: 148.81 – 148.88 Mb Chr 6: 47.53 – 47.6 Mb PubMed pretraga[ 3] [ 4] Wikipodaci
EGFR-antisens RNK 1 je protein koji je kod ljudi kodiran genom EGFR-AS1 .[ 5]
Dužina polipeptidnog lanca je 746 aminokiselina , а molekulska težina 85.363 Da .[ 6]
10 20 30 40 50
MGQTGKKSEK GPVCWRKRVK SEYMRLRQLK RFRRADEVKS MFSSNRQKIL
ERTEILNQEW KQRRIQPVHI LTSVSSLRGT RECSVTSDLD FPTQVIPLKT
LNAVASVPIM YSWSPLQQNF MVEDETVLHN IPYMGDEVLD QDGTFIEELI
KNYDGKVHGD RECGFINDEI FVELVNALGQ YNDDDDDDDG DDPEEREEKQ
KDLEDHRDDK ESRPPRKFPS DKIFEAISSM FPDKGTAEEL KEKYKELTEQ
QLPGALPPEC TPNIDGPNAK SVQREQSLHS FHTLFCRRCF KYDCFLHPFH
ATPNTYKRKN TETALDNKPC GPQCYQHLEG AKEFAAALTA ERIKTPPKRP
GGRRRGRLPN NSSRPSTPTI NVLESKDTDS DREAGTETGG ENNDKEEEEK
KDETSSSSEA NSRCQTPIKM KPNIEPPENV EWSGAEASMF RVLIGTYYDN
FCAIARLIGT KTCRQVYEFR VKESSIIAPA PAEDVDTPPR KKKRKHRLWA
AHCRKIQLKK DGSSNHVYNY QPCDHPRQPC DSSCPCVIAQ NFCEKFCQCS
SECQNRFPGC RCKAQCNTKQ CPCYLAVREC DPDLCLTCGA ADHWDSKNVS
CKNCSIQRGS KKHLLLAPSD VAGWGIFIKD PVQKNEFISE YCGEIISQDE
ADRRGKVYDK YMCSFLFNLN NDFVVDATRK GNKIRFANHS VNPNCYAKVM
MVNGDHRIGI FAKRAIQTGE ELFFDYRYSQ ADALKYVGIE REMEIP
U jednoj od nedavnih studuja, konstatira se da dugolančane nekodirajuće RNK imaju bitnu ulogu u progresiji raka mokraćnog mjehura i ukazuje da je potrebno je dodatno proučiti ulogu duge nekodirajuće RNK EGFR-AS1 u karcinomu mjehura. Koristili su kliničke uzorke za analizu odnosa između EGFR-AS1 i karakteristika pacijenata s rakom mjehura. Funkcionalni eksperimenti i studije mehanizama izvedeni su pomoću qRT-PCR , transwell testa, analize preživljavanja i korelacijske analize. Otkrili su da je visoka ekspresija EGFR-AS1 gotovo povezana s agresivnim karcinomom mjehura i ukazuje na lošu prognozu za pacijente. Funkcionalni eksperimenti in vivo i in vitro sugerirali su da EGFR-AS1 podstiče proliferaciju i invaziju ćelija raka mjehura. Mehanički, EGFR-AS1 je promovirao ekspresiju EGFR-a inhibiranjem razgradnje EGFR-ove iRNK , čime se podstiče metastaziranje raka mjehura. Osim toga, EGFR-AS1/EGFR može biti uključen u imunološke puteve raka mjehura. Ove studije ukazuju da put EGFR-AS1/EGFR može biti potencijalni dijagnostički marker i terapeutska meta za rak mokraćnog mjehura.[ 7]
^ a b c GRCh38: Ensembl release 89: ENSG00000106462 - Ensembl , maj 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029687 - Ensembl , maj 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Entrez Gene: EGFR antisense RNA 1" . Pristupljeno 6. 9. 2016 .
^ "UniProt, Q15910" (jezik: engleski). Pristupljeno 23. 9. 2021 .
^ Anbang Wang , Aimin Jiang , Xinxin Gan, Zheng Wang , Jinming Huang, Kai Dong, Bing Liu, Linhui Wang, Ming Chen (2020):
Affiliations expand EGFR-AS1 Promotes Bladder Cancer Progression by Upregulating EGFR. Biomed Res Int 6665974; pmid: 33426060; pmcid: pmc7781701; doi: 10.1155/2020/6665974