CCL27
| Hemokinski (C-C motivni) ligand 27 | |||||||
|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||
| Simbol | CCL27 | ||||||
| Alt. simboli | SCYA27, ALP, ILC, CTACK, skinkine, ESkine, PESKY, CTAK | ||||||
| NCBI gen | 10850 | ||||||
| HGNC | 10626 | ||||||
| OMIM | 604833 | ||||||
| RefSeq | NM_006664 | ||||||
| UniProt | Q9Y4X3 | ||||||
| Ostali podaci | |||||||
| Lokus | Hrom. 9 q13 | ||||||
| |||||||
C-C motivni hemokinski ligand 27 jest protein koji je kod ljudi kodiran genom CCL27.[5]
Aminokiselinska sekvenca
[uredi | uredi izvor]Dužina polipeptidnog lanca je 112 aminokiselina, а molekulska težina 12.618 Da.[6]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MKGPPTFCSL | LLLSLLLSPD | PTAAFLLPPS | TACCTQLYRK | PLSDKLLRKV | ||||
| IQVELQEADG | DCHLQAFVLH | LAQRSICIHP | QNPSLSQWFE | HQERKLHGTL | ||||
| PKLNFGMLRK | MG |
Funkcija
[uredi | uredi izvor]Ovaj gen je jedan od nekoliko gena CC citokina grupiranih na p-kraku hromosoma 9. Citokini su porodica izlučenih proteina uključenih u imunoregulacijske i upalne procese. CC citokini su proteini koje karakteriziraju dva susjedna cisteina. Protein kodiran ovim genom je hemotaksijski za kožne povezane memorijske T-limfocite. CCL27 je povezan sa preusmjeravanjem memorije T-limfocita na kožu i ima ulogu u upalama kože posredovanim T-ćelijama.[7][8]
CCL27 se eksprimira u brojnim tkivima, uključujući gonade, timus, placentu i kožu. Izaziva svoje hemotaksijske efekte vezanjem za receptor za hemokine CCR10.[9] Gen za CCL27 kod ljudi nalazi se na hromosomu 9.[10] Studije sličnog mišjeg proteina ukazuju da ove interakcije protein-receptor imaju ključnu ulogu u T-ćelijama posredovanoj upali kože (prema RefSeq, Sep 2014).
Reference
[uredi | uredi izvor]- ^ a b c GRCh38: Ensembl release 89: ENSG00000213927 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000096826 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: C-C motif chemokine ligand 27". Pristupljeno 23. 3. 2018.
- ^ "UniProt, Q9Y4X3". Pristupljeno 7. 9. 2021.
- ^ Morales et al. CTACK, a skin-associated chemokine that preferentially attracts skin-homing memory T cells. Proc. Natl. Acad. Sci. U.S.A. 96:14470-14475, 1999.
- ^ Homey B, Alenius H, Müller A, Soto H, Bowman EP, Yuan W, et al. (februar 2002). "CCL27-CCR10 interactions regulate T cell-mediated skin inflammation". Nature Medicine. 8 (2): 157–65. doi:10.1038/nm0202-157. PMID 11821900. S2CID 35433583.
- ^ Homey B, Wang W, Soto H, Buchanan ME, Wiesenborn A, Catron D, et al. (april 2000). "Cutting edge: the orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC)". Journal of Immunology. 164 (7): 3465–70. doi:10.4049/jimmunol.164.7.3465. PMID 10725697.
- ^ Ishikawa-Mochizuki I, Kitaura M, Baba M, Nakayama T, Izawa D, Imai T, et al. (novembar 1999). "Molecular cloning of a novel CC chemokine, interleukin-11 receptor alpha-locus chemokine (ILC), which is located on chromosome 9p13 and a potential homologue of a CC chemokine encoded by molluscum contagiosum virus". FEBS Letters. 460 (3): 544–8. doi:10.1016/s0014-5793(99)01406-4. PMID 10556532. S2CID 39019419.
Dopunska literatura
[uredi | uredi izvor]- Mackay CR (februar 2002). "New avenues for anti-inflammatory therapy". Nature Medicine. 8 (2): 117–8. doi:10.1038/nm0202-117. PMID 11821893. S2CID 26588760.
- Kakinuma T, Saeki H, Tsunemi Y, Fujita H, Asano N, Mitsui H, et al. (mart 2003). "Increased serum cutaneous T cell-attracting chemokine (CCL27) levels in patients with atopic dermatitis and psoriasis vulgaris". The Journal of Allergy and Clinical Immunology. 111 (3): 592–7. doi:10.1067/mai.2003.114. PMID 12642842.
- Hijnen D, De Bruin-Weller M, Oosting B, Lebre C, De Jong E, Bruijnzeel-Koomen C, Knol E (februar 2004). "Serum thymus and activation-regulated chemokine (TARC) and cutaneous T cell- attracting chemokine (CTACK) levels in allergic diseases: TARC and CTACK are disease-specific markers for atopic dermatitis". The Journal of Allergy and Clinical Immunology. 113 (2): 334–40. doi:10.1016/j.jaci.2003.12.007. PMID 14767451.
- Vestergaard C, Johansen C, Christensen U, Just H, Hohwy T, Deleuran M (septembar 2004). "TARC augments TNF-alpha-induced CTACK production in keratinocytes". Experimental Dermatology. 13 (9): 551–7. doi:10.1111/j.0906-6705.2004.00202.x. PMID 15335355. S2CID 84940084.
- Hirata T, Furukawa Y, Yang BG, Hieshima K, Fukuda M, Kannagi R, et al. (decembar 2004). "Human P-selectin glycoprotein ligand-1 (PSGL-1) interacts with the skin-associated chemokine CCL27 via sulfated tyrosines at the PSGL-1 amino terminus". The Journal of Biological Chemistry. 279 (50): 51775–82. doi:10.1074/jbc.M409868200. PMID 15466853.
- Vestergaard C, Johansen C, Otkjaer K, Deleuran M, Iversen L (januar 2005). "Tumor necrosis factor-alpha-induced CTACK/CCL27 (cutaneous T-cell-attracting chemokine) production in keratinocytes is controlled by nuclear factor kappaB". Cytokine. 29 (2): 49–55. doi:10.1016/j.cyto.2004.09.008. PMID 15598438.
- Spiekstra SW, Toebak MJ, Sampat-Sardjoepersad S, van Beek PJ, Boorsma DM, Stoof TJ, et al. (februar 2005). "Induction of cytokine (interleukin-1alpha and tumor necrosis factor-alpha) and chemokine (CCL20, CCL27, and CXCL8) alarm signals after allergen and irritant exposure". Experimental Dermatology. 14 (2): 109–16. doi:10.1111/j.0906-6705.2005.00226.x. PMID 15679580. S2CID 8770112.
- Kagami S, Saeki H, Komine M, Kakinuma T, Nakamura K, Tsunemi Y, et al. (februar 2006). "CCL28 production in HaCaT cells was mediated by different signal pathways from CCL27". Experimental Dermatology. 15 (2): 95–100. doi:10.1111/j.1600-0625.2005.00390.x. PMID 16433680. S2CID 31590665.