OncLive Peer Exchange®

Leading experts discuss the evolving treatment landscape in diffuse large B-cell lymphoma (DLBCL), focusing on front-line therapies, second-line immunotherapies, and strategies for managing relapsed/refractory cases."

Andre Goy, MD, discusses how progress in immunotherapy and precision medicine at ASH 2024 is offering transformative insights, with JTCC highlighting the latest tumor-targeted therapies and biomarker-driven treatments that are shaping the future of personalized cancer care and improving patient outcomes.

Panelists discuss how the BRAF-KIAA-1549 fusion impacts treatment decisions in cancers like such as low-grade gliomas, emphasizing the role of targeted therapies and the importance of molecular testing for optimal patient disease management.

Panelists discuss how recent advances in chronic GVHD treatment, including emerging therapies like ruxolitinib, ibrutinib, and belumosudil, are reshaping management strategies by emphasizing early intervention, treatment sequencing, and the potential of combination therapies to improve patient outcomes.

Panelists discuss how recent advancements in CAR T-cell therapies, including the FDA approval of obe-cel and updates from the ZUMA-3 and FELIX trials, are reshaping the treatment landscape for relapsed/refractory ALL, with a focus on patient selection, bridging therapies, toxicity management, and health care resource utilization.

Panelists discuss how recent advancements in the treatment of polycythemia vera and myelofibrosis, including the role of JAK inhibitors, cytoreductive therapy, and emerging therapies, are shaping current clinical practice and guiding personalized treatment strategies.

Panelists discuss how recent advancements in targeted therapies, particularly the FDA-approved menin inhibitor revumenib, are reshaping the treatment landscape for relapsed/refractory acute monocytic leukemia (R/R AML), offering new options for high-risk patients while emphasizing the importance of genetic testing and minimal residual disease monitoring in guiding therapy.

Matthew S. Davids, MD, MMSc; Alvaro Alencar, MD; Marc S. Hoffmann, MD; Brad S. Kahl, MD, and Nicole Lamanna, MD,engage in a comprehensive discussion of frontline CLL treatment strategies, examining factors influencing the choice between fixed-duration venetoclax-based therapy and continuous BTK inhibitors, analyzing long-term SEQUOIA trial data, evaluating real-world outcomes and adverse events with covalent BTK inhibitors, and assessing emerging combination approaches including zanubrutinib plus venetoclax.

Panelists discuss how recent advancements in treatment strategies for ALK-positive and BRAF-positive V600E NSCLC, including efficacy updates and the management of brain metastases, can enhance personalized care and optimize patient outcomes.

Panelists discuss how recent advancements in the treatment of newly diagnosed multiple myeloma (MM) and early relapse, particularly the role of chimeric antigen receptor T-cell therapy, are reshaping therapeutic strategies and improving patient outcomes.

This series delves into recent advancements in the treatment of advanced or metastatic EGFR-mutated non-small cell lung cancer (NSCLC), focusing on clinical trial findings from FLAURA2, ADAURA, TROPION-Lung01, and HERTHENA-Lung01 and their implications for optimizing patient management and survival outcomes.

Panelists discuss how recent advancements in frontline and second-line therapies for unrespectable hepatocellular carcinoma (uHCC) are reshaping treatment strategies and improving patient outcomes.

In this OncLive Peer Exchange series, a panel of experts discusses the latest advancements in the management of gynecological cancers, highlighting updates from ESMO 2024, including treatment paradigms for advanced ovarian, cervical, and endometrial cancers, biomarker testing strategies, and emerging therapies such as antibody-drug conjugates.

Panelists discuss how recent clinical trials and innovative therapies are reshaping the treatment landscape for small cell lung cancer, emphasizing the importance of personalized approaches and multidisciplinary strategies to improve patient outcomes.

Elias Jabbour, MD; Evandro D. Bezerra, MD; Lori Muffly, MD; Jae H. Park, MD, and Gregory W. Roloff, MD,review the role of CAR T-cell therapy\ for relapsed/refractory acute lymphoblastic leukemia, address adverse event management and supportive care, and highlight significant updates presented at the American Society of Clinical Oncology and European Hematology Association 2024 conferences.

Catherine C. Coombs, MD, Matthew S. Davids, MD, MMSc; Richardo D. Parrondo, MD; Nicole Lamanna, MD, and Alexey Danilov, MD, PhD, examine treatment approaches for newly diagnosed chronic lymphocytic leukemia (CLL), including BTK inhibitor therapy, management of adverse events, and strategies for relapsed/refractory CLL.

Five medical provide insights around breakthrough treatment strategies in relapsed/recurrent DLBCL.

John Marshall, MD; Al B. Benson III, MD, FACP, FACCC, FASCO; Kristen Ciombor, MD, MSCI; Stacey Cohen, MD, and Marwan Fakih, MD, examine the landscape of second-line and third-line treatments for metastatic colorectal cancer, along with recent advancements in managing the disease.

Vijayakrishna Gadi, MD, PhD, sets the stage for a discussion around HER2-directed ADCs in the solid tumor space.

Led by Sandip P. Patel, MD, key opinion leaders address key updates in treatment strategies and management of stage III NSCLC.

Guillermo Garcia-Manero, MD; Rami Komrokji, MD; Esther Natalie Oliva, MD; Amer Zeidan, MBBS, MHS, and Dr Thomas Cluzeauprovide expert insights on the latest developments in Lower-Risk Myelodysplastic Syndromes (LR-MDS) as presented at the European Hematology Association (EHA) 2024 conference.

Medical experts in small cell lung cancer convene to examine first-line treatments, ongoing clinical trials, and emerging therapies shaping the evolving treatment landscape.

A panel of medical experts reviews the latest advances in managing and treating renal cell carcinoma (RCC) and non-clear cell renal cell carcinoma (nccRCC), discussing recent trial data and sharing insights from their clinical practices.

Mark Socinski, MD; Helena A. Yu, MD; Zosia Piotrowska, MD, MHS; Julia Rotow, MD, and Benjamin Levy, MD,discuss the current standard of care, emerging data on novel therapies such as antibody-drug conjugates (ADCs) and clinical trials, patient selection considerations, and practical guidance foroptimizing patient care.

Kelly McCann, MD, PhD, drives a discussion surrounding key topics and highlights in HR+ breast cancer treatment as presented at ASCO 2024.

A panel of experts on HER2+ breast cancer has a comprehensive discussion on recent data updates and how they might impact clinical practice.