Welcome to the Mac-In-Fac!

Biomolecular Interactions, light scattering, SPR, biosensor, SPR-based biosensor, Biacore 8K, analytical ultracentrifugation, Auto-ITC200, PEAQ ITC-automated, ITC, DSC, microcalorimeters, fluorescence plate reader, circular dichroism, fluorimeter, molecular weight determination, DAWN Heleos, DLS, DynaPro plate reader, Nanotemper, MST, nanoDSF

The Macromolecular Interactions Facility (UNC folks fondly call it the Mac-In-Fac) is a core facility of the University of North Carolina at Chapel Hill. It provides instrumentation and resources for biophysical characterization of biological macromolecules and their interactions with cognate ligands. Core instrumentation include: surface plasmon resonance (SPR)-based and bio-layer interferometry (BLI)-based biosensors; analytical ultracentrifuges; a spectrofluorometer; differential scanning and isothermal titration calorimeters, including two fully-automated ITCs ( Auto-ITC200 and PEAQ ITC-automated); a circular dichroism spectropolarimeter; static and dynamic light scattering instruments; a fluorescence microplate reader; a nano-DSF (nano-differential scanning fluorimeter), and a microscale thermophoresis (MST) instrument.

We welcome researchers from other academic institutions and biotech companies. Researchers from Triangle-based academic institutions and companies can contact the Director directly for using our equipment. Others are requested to contact us through SCIENCEEXCHANGE.COM.

We obtain on-going support from the UNC Lineberger Comprehensive Cancer Center through the University Cancer Research Fund and the Cancer Center Support Grant. Consequently, publications supported by the UNC Center for Structural Biology must acknowledge NIH grant P30CA016086 and be submitted to PubMed Central in compliance with the NIH Public Access Policy.

Suggested acknowledgment: “This work was supported by the National Cancer Institute of the National Institutes of Health under award number P30CA016086. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.”