Explore 3D Molecular Structures with iCn3D

Do you want to analyze three-dimensional structures and highlight important features like active site residues, point mutations, and binding partners? Check out NCBI’s “I see in 3D” (iCn3D) – a free, web-based tool that allows you to explore the structure of a biomolecule at an atomistic level.

Features & Benefits

Interactively view 3D structure and corresponding sequence data
Align a protein sequence with unknown structure to a sequence-similar 3D structure
Interactively view 3D alignments of similar structures
View the interaction interfaces in a structure
Save your custom display as a short URL or PNG image
Share a link to your customized display of a structure
Incorporate iCn3D into your own pages

Continue reading “Explore 3D Molecular Structures with iCn3D” →

Try Out a Development Version of NCBI’s Publicly Available Annotation Tool, EGAPx

Latest release now available

Are you generating genomes for vertebrates, arthropods, or plants, and looking for a way to generate high-quality genome annotation? NCBI is working on a public version of the NCBI Eukaryotic Genome Annotation Pipeline (EGAPx), and the latest developmental release is now available for testing and feedback. Continue reading “Try Out a Development Version of NCBI’s Publicly Available Annotation Tool, EGAPx” →

RefSeq Release 227 is Available!

Check out RefSeq release 227, now available online and from the FTP site. You can access RefSeq data through NCBI Datasets. The release is provided in several directories as a complete dataset and also as divided by logical groupings.

What’s included in this release?

As of November 4, 2024, this full release incorporates genomic, transcript, and protein data containing:

497,549,107 records, including
377,783,847 proteins
66,987,567 RNAs
Sequences from 159,324 organisms

Continue reading “RefSeq Release 227 is Available!” →

Update! Improving the Representation of Functional Data in ClinVar

We want your feedback!

As previously announced, NCBI is improving the way that functional data are submitted to ClinVar and how they are represented in the XML format and on the website. We have started enhancing support for functional data and would like your feedback!

What’s new?

We have updated the GitHub repository with:

Continue reading “Update! Improving the Representation of Functional Data in ClinVar” →

Expansion of Ortholog Data for RefSeq Arthropods

250K+ new Hymenoptera orthologs added

NCBI is excited to announce the expansion of ortholog data for RefSeq arthropods. This update expands the breadth of arthropod orthology information, offering new insights into evolutionary biology, gene function, and shared pathways. Whether you’re studying insect genetics, developmental biology, or comparative genomics, the expanded ortholog data opens up new possibilities for research. Check out our previous blog to learn how to access the orthologs using NCBI Datasets. Continue reading “Expansion of Ortholog Data for RefSeq Arthropods” →

MANE v1.4 with MANE Select for Non-Coding Genes

The next release (v1.4) of Matched Annotation from NCBI and EMBL-EBI (MANE) is here! MANE is a collaborative dataset produced jointly by NCBI and EMBL-EBI that provides a representative transcript (MANE Select) for human protein-coding genes, to be used as universal standards for variant reporting and browser display. A second transcript, MANE Plus Clinical, is provided for genes where MANE Select alone is not sufficient to report all known variants. The new MANE release adds another important component to this high-value dataset – non-coding genes, some of which are known to be associated with human disease. Continue reading “MANE v1.4 with MANE Select for Non-Coding Genes” →

GenBank Release 263.0 Now Available!

GenBank release 263.0 (10/19/2024) is now available on the NCBI FTP site. This release has 36.50 trillion bases and 5.13 billion records.

The current release has:

251,998,350 traditional records containing 4,250,942,573,681 base pairs of sequence data
3,745,772,758 WGS records containing 31,362,454,467,668 base pairs of sequence data
948,733,596 bulk-oriented TSA records containing 812,661,461,811 base pairs of sequence data
187,349,395 bulk-oriented TLS records containing 77,037,504,468 base pairs of sequence data

Continue reading “GenBank Release 263.0 Now Available!” →

Upcoming Changes to NCBI’s BioSample Database

Improving Metadata Quality

Do you rely on high-quality metadata from NCBI’s BioSample database? BioSample is home to metadata associated with the biological source materials used to generate raw reads, sequences, and other data submitted to NCBI. We are improving our submission process to ensure we provide you with more complete and robust information.

Attention submitters!

To improve metadata quality, we are introducing new submission validation steps and providing improved help documentation. Continue reading “Upcoming Changes to NCBI’s BioSample Database” →

Explore NLM’s NCBI Bookshelf With New Learning Tools at Your Fingertips

New tutorials, queries, and discovery guides now available

NLM’s NCBI Bookshelf provides free access to more than 13,000 peer-reviewed books and documents in life science and health care using over a dozen formats including monographs, reviews, reference works, government publications, standards and guidelines, technical reports, and textbooks. In acknowledgement of Open Access Week, we are excited to introduce new learning tools to better access and discover subject- and format-based collections within Bookshelf.

Bookshelf strives to advance open and equitable science and scholarship. To achieve this goal, Bookshelf collaborates with over 150 content providers, more than half of which are nontraditional publishers like government agencies and non-governmental organizations, to make their content publicly accessible. This diverse body of content is organized into user-relevant subcollections, such as “health disparities,” to better facilitate access and discovery. Over half of this content is also available for programmatic reuse through Bookshelf’s Open Access Subset. Continue reading “Explore NLM’s NCBI Bookshelf With New Learning Tools at Your Fingertips” →

PubMed Central (PMC) Transitions to Updated Website

The next step in the modernization of PMC

As previously announced, NLM’s NCBI transitioned to an updated PubMed Central (PMC) website, representing the next step in ongoing efforts to modernize NLM’s products and services. As part of this update, the primary URL for the PMC website has changed from ncbi.nlm.nih.gov/pmc to pmc.ncbi.nlm.nih.gov. In addition, you’ll notice a new look, feel, and organization of PMC article pages and the PMC Journal List.

The updated website runs on cloud services to ensure the website’s long-term sustainability and reliability. It also incorporates U.S. Web Design System (USWDS) components and design principles to improve PMC’s readability and accessibility, whether you are visiting on a desktop computer, mobile device, or accessing its content using assistive technology. Continue reading “PubMed Central (PMC) Transitions to Updated Website” →