Newest Articles
Diversification of dentate gyrus granule cell subtypes is regulated by Nrg1 nuclear back-signalingThe study shows that Nrg1 nuclear signaling maintains granule cell identity and that its disruption drives acquisition of semilunar granule cell fate in the dentate gyrus.
Human iPS cell–derived respiratory organoids as a model for respiratory syncytial virus infectionHuman iPS cell–derived respiratory organoids can be infected with RSV, exhibiting viral replication, epithelial damage, and immune responses, providing a physiologically relevant model for RSV research.
Message from the new Executive EditorTim Fessenden introduces himself as Executive Editor of LSA, shares his view of what editors actually do, and remarks on the current systemic challenges to research funding.
Single-molecule tracking reveals the dynamic turnover of Ipl1 at the kinetochores in Saccharomyces cerevisiaeUnlike ensemble averaging methods, this study visualizes the single molecules of Ipl1 in live yeast cells to quantify its recruitment dynamics and assembly as a part of the CPC at the kinetochores.
Lipid flippases ATP9A and ATP9B form a complex and contribute to the exocytic pathway from the GolgiLipid flippases ATP9A and ATP9B form homomeric or heteromeric complexes and contribute to the exocytic pathway from the Golgi by facilitating changes in Golgi membrane curvature.
STAT5B leukemic mutations, altering SH2 tyrosine 665, have opposing impacts on immune gene programsGermline activating and deactivating mutations of STAT5b, part of the JAK-STAT signaling pathway, push the immune system and hematopoiesis in opposing directions, tuning systems either up or down.
Optogenetic control of pheromone gradients and mating behavior in budding yeastThe authors combined theory and experiment to develop light-induced yeast pheromone gradients that spatially control growth, mating and morphology in hydrogel-embedded cells.
Adenosine-generating CD39+ plasmablasts predispose to successful infliximab therapy in pediatric IBDIFX responders showed increased CD39 expression on plasmablasts and higher levels of CD39/CD73 co-expression on naïve and memory B cells, along with enhanced ATP degradation and adenosine production before treatment. Response was associated with increased IL10-producing plasmablasts and α4β7hi plasmablasts.
DAF-18/PTEN protects LIN-35/Rb from CLP-1/CAPN-mediated cleavage to promote starvation resistanceDAF-18/PTEN acts independently of insulin/IGF signaling to promote starvation resistance via LIN-35/Rb and the DREAM complex in C. elegans L1 arrest.
Shared requirement for MYC upstream super-enhancer region in tissue regeneration and cancerA region located upstream of the MYC oncogene that carries more risk for inherited cancer than any other human genomic region is required for intestinal regeneration.
