Modeling of published clinical Voriconazole-Tacrolimus-DDGI studies for model evaluation

Within this repository, we distribute a PK-Sim snapshot containing simulations of all published clinical studies used to evaluate the predictive performance of the tacrolimus model regarding voriconazole-tacrolimus-DDGIs, including the respective observed data digitized from literature reports. The applied voriconazole model has been published previously [1]. For further details and documentation please refer to [2].

PK-Sim Version 10.

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The model is distributed under the GPLv2 Lincense.

[1] Li X, Frechen S, Moj D, Lehr T, Taubert M, Hsin C, Mikus G, Neuvonen PJ, Olkkola KT, Saari TI, Fuhr U. A physiologically based pharmacokinetic model of voriconazole integrating time-dependent inhibition of CYP3A4, genetic polymorphisms of CYP2C19 and predictions of drug-drug interactions. Clin Pharmacokinet 2020;59(6):781-808.

[2] Loer HLH, Feick D, Rüdesheim S, Selzer D, Schwab M, Teutonico D, Frechen S, van der Lee M, Moes DJAR, Swen JJ, Lehr T. Physiologically based pharmacokinetic modeling of tacrolimus for food-drug and CYP3A drug-drug-gene interaction predictions. CPT Pharmacometrics Syst Pharmacol 2023;00:1-15.