Ergocornine

Ergocornine
Identifiers
	IUPAC name 12′-Hydroxy-2′,5′-α-bis(1-methyl-ethyl)ergotaman-3′,6′,18-trione;
CAS Number	564-36-3 ;
PubChem CID	73453;
ChemSpider	66155 ;
UNII	7W36B25464;
CompTox Dashboard (EPA)	DTXSID40971841 ;
ECHA InfoCard	100.008.430
Chemical and physical data
Formula	C31H39N5O5
Molar mass	561.683 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C3N1CCC[C@H]1[C@]2(O)O[C@](C(=O)N2[C@H]3C(C)C)(NC(=O)[C@@H]7/C=C6/c4cccc5c4c(c[nH]5)C[C@H]6N(C)C7)C(C)C;
	InChI InChI=1S/C31H39N5O5/c1-16(2)26-28(38)35-11-7-10-24(35)31(40)36(26)29(39)30(41-31,17(3)4)33-27(37)19-12-21-20-8-6-9-22-25(20)18(14-32-22)13-23(21)34(5)15-19/h6,8-9,12,14,16-17,19,23-24,26,32,40H,7,10-11,13,15H2,1-5H3,(H,33,37)/t19-,23-,24+,26+,30-,31+/m1/s1 ; Key:UJYGDMFEEDNVBF-OGGGUQDZSA-N ;
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Ergocornine is a crystalline ergopeptine and one of the ergot alkaloids separated from ergotoxine. It is also a dopamine receptor agonist.^[1] It was discovered by Albert Hofmann, the Swiss chemist who created LSD.^[2]

References

^ Fuxe K, Corrodi H, Hökfelt T, Lidbrink P, Ungerstedt U (April 1974). "Ergocornine and 2-Br-alpha-ergocryptine. Evidence for prolonged dopamine receptor stimulation". Medical Biology. 52 (2): 121–32. PMID 4837435.
^ Stoll A, Hoffmann A (1965). "Chapter 21: The Ergot Alkaloids". In Manske RH (ed.). Indole alkaloids. The alkaloids: chemistry and physiology. Vol. 8. New York: Academic Press. p. 759. ISBN 978-0-08-086532-4.

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[pmid4837435-1] Fuxe K, Corrodi H, Hökfelt T, Lidbrink P, Ungerstedt U (April 1974). "Ergocornine and 2-Br-alpha-ergocryptine. Evidence for prolonged dopamine receptor stimulation". Medical Biology. 52 (2): 121–32. PMID 4837435.

[2] Stoll A, Hoffmann A (1965). "Chapter 21: The Ergot Alkaloids". In Manske RH (ed.). Indole alkaloids. The alkaloids: chemistry and physiology. Vol. 8. New York: Academic Press. p. 759. ISBN 978-0-08-086532-4.

[1]

[2]

v t e Ergolines
Lysergic acid derivatives	2-Bromo-LSD (BOL-148) Amesergide Bromerguride (2-bromolisuride) Bromocriptine Cabergoline Dihydroergocornine Dihydroergocristine Dihydroergocryptine Dihydroergometrine (Dihydroergonovine, Dihydroergobasine) Dihydroergosine Dihydroergotamine Epicriptine Ergine (LSA; LA-111; Lysergamide) Ergocornine Ergocristine Ergocryptine Ergoloid (Dihydroergotoxine) Ergometrine (Ergonovine, Ergobasine) Ergometrinine Ergostine Ergotamine Ergotoxine Ergovaline Fludihydroergotamine Lisuride LY-215,840 LSH Lysergic acid Lysergic acid methyl ester Lysergine Lysergol Mergocriptine Mesulergine Metergoline Metergotamine MIPLA Methysergide Propisergide Sergolexole
Psychedelic lysergamides	1B-LSD 1cP-LSD 1P-ETH-LAD 1P-LSD AL-LAD ALD-52 BU-LAD CYP-LAD Diallyllysergamide (DAL) Dimethyllysergamide (DAM-57) ECPLA Ergonovine ETFELA ETH-LAD IP-LAD LAMPA LAE-32 LSD (lysergide) LPD-824 LSM-775 LSH LSD-Pip Lysergic Acid 2-Butylamide Lysergic Acid 2,4-Dimethylazetidide Lysergic Acid 3-Pentylamide Lysergic acid cyclobutylamide Lysergic acid cyclopentylamide Methylergometrine (Methylergonovine, Methylergobasine) MIPLA MLD-41 PARGY-LAD PRO-LAD
Clavines	9-Deacetoxyfumigaclavine C Agroclavine Chanoclavine Chanoclavine II Costaclavin Cycloclavine Elymoclavine Epoxyagroclavine Festuclavine Fumigaclavine A Fumigaclavine B Fumigaclavine C Paliclavine Penniclavine Setoclavine
Other ergolines	Acetergamine Brazergoline Cianergoline CY-208,243 Delergotrile Disulergine Dosergoside Ergoline Etisulergine Lergotrile Nicergoline Pergolide Proterguride Romergoline Terguride Tiomergine Voxergolide
Related compounds	Adrogolide Naxagolide Quinagolide
Natural sources	Achnatherum robustum (Sleepy Grass) Claviceps spp. (Ergot) Morning glory: Argyreia nervosa (Hawaiian Baby Woodrose), Ipomoea spp.(Morning Glory, Tlitliltzin, Badoh Negro), Rivea corymbosa (Coaxihuitl, Ololiúqui)