The keratinocyte growth factor (KGF), also known as FGF7, is a growth factor present in the epithelialization-phase of wound healing. In this phase, keratinocytes are covering the wound, forming the epithelium.
KGF is a small signaling molecule that binds to fibroblast growth factor receptor 2b (FGFR2b).[1] For signalling to occur, a dimer is required between two FGF:FGFR complexes that is linked together by a molecule of heparin.
There are 23 known FGFs, and 4 FGF receptors. FGF:FGFR binding is complex and regulated by a variety of mechanisms in a tissue specific manner.
See also
editReferences
edit- ^ Rotolo S, Ceccarelli S, Romano F, Frati L, Marchese C, Angeloni A (2008). Maas S (ed.). "Silencing of Keratinocyte Growth Factor Receptor Restores 5-Fluorouracil and Tamoxifen Efficacy on Responsive Cancer Cells". PLOS ONE. 3 (6): e2528. Bibcode:2008PLoSO...3.2528R. doi:10.1371/journal.pone.0002528. PMC 2424182. PMID 18575591.
- ^ "iHOP - Information Hyperlinked over Proteins [ FGF10 ]". Archived from the original on 2012-02-14.
External links
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