The following is a list of players and who appeared in at least one game for the Cleveland Spiders franchise of Major League Baseball from 1887 through 1899. This includes both the Cleveland Blues of the American Association and the Cleveland Spiders of the National League. Players in bold are in the Baseball Hall of Fame.
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edit- Jimmy Say
- Frank Scheibeck
- Jack Scheible
- Crazy Schmit
- Ossee Schreckengost
- Ed Seward
- John Shearon
- Hank Simon
- Will Smalley
- Edgar Smith
- Pop Snyder
- Louis Sockalexis
- Joe Sommer
- Andy Sommers
- Charlie Sprague
- John Stafford
- Bill Stemmyer
- Jack Stivetts
- Len Stockwell
- Cub Stricker
- Willie Sudhoff
- Joe Sugden
- Marty Sullivan
- Mike Sullivan
- Suter Sullivan
- Sy Sutcliffe
- Charlie Sweeney