Potassium voltage-gated channel subfamily H member 2 (Q905000)

PAS domain superfamily

1 reference

RmlC-like jelly roll fold

1 reference

Potassium channel, voltage-dependent, ERG

1 reference

Voltage-dependent channel domain superfamily

1 reference

Potassium channel, voltage-dependent, EAG

1 reference

Transporter Classification Database ID

1.A.1.20.1

2 October 2019

hierarchical database ID heuristic

Ion transport domain, protein family

1 reference

Cyclic nucleotide-binding domain, protein family

1 reference

PAS-associated, C-terminal domain, protein family

1 reference

PAC motif domain, protein family

1 reference

PAS domain, protein family

1 reference

potassium channel activity

1 reference

13 November 2019

1 reference

13 November 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12809

1 reference

8 April 2019

protein homodimerization activity

1 reference

8 April 2019

The human delta1261 mutation of the HERG potassium channel results in a truncated protein that contains a subunit interaction domain and decreases the channel expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12809

scaffold protein binding

1 reference

8 April 2019

The regulation of the cardiac potassium channel (HERG) by caveolin-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12809

voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization

IC

1 reference

8 April 2019

RING finger protein RNF207, a novel regulator of cardiac excitation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12809

C3HC4-type RING finger domain binding

IC

1 reference

8 April 2019

RING finger protein RNF207, a novel regulator of cardiac excitation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12809

voltage-gated ion channel activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12809

1 reference

8 April 2019

ion channel activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12809

1 reference

8 April 2019

protein binding

3 references

8 April 2019

Mechanisms of pharmacological rescue of trafficking-defective hERG mutant channels in human long QT syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12809

8 April 2019

The regulation of the cardiac potassium channel (HERG) by caveolin-1

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12809

8 April 2019

14-3-3 amplifies and prolongs adrenergic stimulation of HERG K+ channel activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12809

identical protein binding

2 references

8 April 2019

Insight into the molecular interaction between the cyclic nucleotide-binding homology domain and the eag domain of the hERG channel

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12809

8 April 2019

The human delta1261 mutation of the HERG potassium channel results in a truncated protein that contains a subunit interaction domain and decreases the channel expression

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12809

voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization

1 reference

8 April 2019

Rescue of Aberrant Gating by a Genetically Encoded PAS (Per-Arnt-Sim) Domain in Several Long QT Syndrome Mutant Human Ether-á-go-go-related Gene Potassium Channels

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12809

voltage-gated potassium channel activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12809&geneProductId=UniProtKB:Q12809

4 references

24 April 2018

24 April 2018

The S1 helix critically regulates the finely tuned gating of Kv11.1 channels

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12809&geneProductId=UniProtKB:Q12809

24 April 2018

14-3-3 amplifies and prolongs adrenergic stimulation of HERG K+ channel activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12809&geneProductId=UniProtKB:Q12809

24 April 2018

Modulation of human ether a gogo related channels by CASQ2 contributes to etiology of catecholaminergic polymorphic ventricular tachycardia (CPVT)

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12809&geneProductId=UniProtKB:Q12809

phosphorelay sensor kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12809&geneProductId=UniProtKB:Q12809

1 reference

10 September 2018

ubiquitin protein ligase binding

1 reference

8 April 2019

Nedd4-2-dependent ubiquitylation and regulation of the cardiac potassium channel hERG1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12809

delayed rectifier potassium channel activity

IGI

inward rectifier potassium channel activity

I Kr drug response is modulated by KCR1 in transfected cardiac and noncardiac cell lines

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12809

8 April 2019

The inward rectification mechanism of the HERG cardiac potassium channel

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12809

8 April 2019

HERG, a Human Inward Rectifier in the Voltage-Gated Potassium Channel Family

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12809

voltage-gated potassium channel activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12809

5 references

8 April 2019

8 April 2019

The S1 helix critically regulates the finely tuned gating of Kv11.1 channels

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12809

8 April 2019

14-3-3 amplifies and prolongs adrenergic stimulation of HERG K+ channel activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12809

8 April 2019

Modulation of human ether a gogo related channels by CASQ2 contributes to etiology of catecholaminergic polymorphic ventricular tachycardia (CPVT)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12809

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12809

integral component of membrane

cell component

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12809

1 reference

8 April 2019

voltage-gated potassium channel complex

RING finger protein RNF207, a novel regulator of cardiac excitation

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12809

8 April 2019

The inward rectification mechanism of the HERG cardiac potassium channel

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12809

8 April 2019

HERG, a Human Inward Rectifier in the Voltage-Gated Potassium Channel Family

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12809

8 April 2019

A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12809

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12809

4 references

8 April 2019

8 April 2019

RING finger protein RNF207, a novel regulator of cardiac excitation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12809

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12809

8 April 2019

8 April 2019

Nedd4-2-dependent ubiquitylation and regulation of the cardiac potassium channel hERG1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12809

cell surface

1 reference

8 April 2019

Rescue of Aberrant Gating by a Genetically Encoded PAS (Per-Arnt-Sim) Domain in Several Long QT Syndrome Mutant Human Ether-á-go-go-related Gene Potassium Channels

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12809

perinuclear region of cytoplasm

1 reference

8 April 2019

RING finger protein RNF207, a novel regulator of cardiac excitation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12809

inward rectifier potassium channel complex

1 reference

8 April 2019

I Kr drug response is modulated by KCR1 in transfected cardiac and noncardiac cell lines

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12809

integral component of plasma membrane

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12809

membrane depolarization during action potential

biological process

1 reference

8 April 2019

HERG, a Human Inward Rectifier in the Voltage-Gated Potassium Channel Family

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12809

cardiac muscle contraction

1 reference

8 April 2019

Rescue of Aberrant Gating by a Genetically Encoded PAS (Per-Arnt-Sim) Domain in Several Long QT Syndrome Mutant Human Ether-á-go-go-related Gene Potassium Channels

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12809

signal transduction

1 reference

10 September 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12809&geneProductId=UniProtKB:Q12809

regulation of ion transmembrane transport

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12809

1 reference

8 April 2019

ventricular cardiac muscle cell action potential

1 reference

8 April 2019

Rescue of Aberrant Gating by a Genetically Encoded PAS (Per-Arnt-Sim) Domain in Several Long QT Syndrome Mutant Human Ether-á-go-go-related Gene Potassium Channels

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12809

potassium ion export across plasma membrane

IGI

1 reference

10 September 2018

RING finger protein RNF207, a novel regulator of cardiac excitation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12809&geneProductId=UniProtKB:Q12809

membrane repolarization during action potential

IGI

3 references

8 April 2019

14-3-3 amplifies and prolongs adrenergic stimulation of HERG K+ channel activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12809

8 April 2019

Nedd4-2-dependent ubiquitylation and regulation of the cardiac potassium channel hERG1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12809

8 April 2019

A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12809

regulation of heart rate by hormone

1 reference

8 April 2019

14-3-3 amplifies and prolongs adrenergic stimulation of HERG K+ channel activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12809

transmembrane transport

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12809

1 reference

8 April 2019

potassium ion transmembrane transport

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12809&geneProductId=UniProtKB:Q12809

6 references

24 April 2018

24 April 2018

14-3-3 amplifies and prolongs adrenergic stimulation of HERG K+ channel activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12809&geneProductId=UniProtKB:Q12809

24 April 2018

A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12809&geneProductId=UniProtKB:Q12809

24 April 2018

The inward rectification mechanism of the HERG cardiac potassium channel

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12809&geneProductId=UniProtKB:Q12809

24 April 2018

Modulation of human ether a gogo related channels by CASQ2 contributes to etiology of catecholaminergic polymorphic ventricular tachycardia (CPVT)

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12809&geneProductId=UniProtKB:Q12809

24 April 2018

HERG, a Human Inward Rectifier in the Voltage-Gated Potassium Channel Family

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12809&geneProductId=UniProtKB:Q12809

positive regulation of potassium ion transmembrane transport

1 reference

8 April 2019

A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12809

phosphorelay signal transduction system

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12809&geneProductId=UniProtKB:Q12809

1 reference

10 September 2018

regulation of membrane repolarization

membrane repolarization during cardiac muscle cell action potential

1 reference

8 April 2019

Rescue of Aberrant Gating by a Genetically Encoded PAS (Per-Arnt-Sim) Domain in Several Long QT Syndrome Mutant Human Ether-á-go-go-related Gene Potassium Channels

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12809

regulation of heart rate by cardiac conduction

regulation of potassium ion transmembrane transport

1 reference

8 April 2019

14-3-3 amplifies and prolongs adrenergic stimulation of HERG K+ channel activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12809

regulation of ventricular cardiac muscle cell membrane repolarization

1 reference

8 April 2019

Rescue of Aberrant Gating by a Genetically Encoded PAS (Per-Arnt-Sim) Domain in Several Long QT Syndrome Mutant Human Ether-á-go-go-related Gene Potassium Channels

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12809

membrane repolarization during ventricular cardiac muscle cell action potential

1 reference

8 April 2019

Rescue of Aberrant Gating by a Genetically Encoded PAS (Per-Arnt-Sim) Domain in Several Long QT Syndrome Mutant Human Ether-á-go-go-related Gene Potassium Channels

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12809

membrane repolarization

1 reference

8 April 2019

I Kr drug response is modulated by KCR1 in transfected cardiac and noncardiac cell lines

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12809

regulation of membrane potential

The inward rectification mechanism of the HERG cardiac potassium channel

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12809

8 April 2019

Nedd4-2-dependent ubiquitylation and regulation of the cardiac potassium channel hERG1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12809

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12809

potassium ion transmembrane transport

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12809

7 references

8 April 2019

8 April 2019

A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12809

8 April 2019

14-3-3 amplifies and prolongs adrenergic stimulation of HERG K+ channel activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12809

8 April 2019

The inward rectification mechanism of the HERG cardiac potassium channel

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12809

8 April 2019

Modulation of human ether a gogo related channels by CASQ2 contributes to etiology of catecholaminergic polymorphic ventricular tachycardia (CPVT)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12809

8 April 2019

HERG, a Human Inward Rectifier in the Voltage-Gated Potassium Channel Family

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12809

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12809

potassium ion import across plasma membrane

1 reference

8 April 2019

HERG, a Human Inward Rectifier in the Voltage-Gated Potassium Channel Family

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12809

cardiac conduction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12809

1 reference

8 April 2019

physically interacts with

rottlerin

1 reference

2611

17 August 2016

1 reference

7167

17 August 2016

1 reference

2604

17 August 2016

1 reference

2603

17 August 2016

1 reference

2605

17 August 2016

1 reference

7200

17 August 2016

1 reference

2608

English

object of statement has role

17 August 2016

guanidine

channel blocker

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL821

sotalol hydrochloride

object of statement has role

channel blocker

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1700

Gene Atlas image

PBB GE KCNH2 205262 at fs.png
732 × 530; 11 KB

0 references

has part(s)

Cyclic nucleotide-binding domain

1 reference

Ion transport domain

1 reference

PAS-associated, C-terminal

1 reference

PAC motif

1 reference

PAS domain

1 reference

D12.776.157.530.400.600.900.249.500

Identifiers

MeSH descriptor ID

D000072237

subject named as

ERG1 Potassium Channel

0 references

MeSH tree code

0 references

D12.776.543.550.450.750.900.249.500

0 references

D12.776.543.585.400.750.900.249.500

0 references

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

28 October 2013

Microsoft Academic ID

0 references

0 references

1 reference

26 January 2022

https://docs.openalex.org/download-snapshot/snapshot-data-format

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

Transporter Classification Database ID

English

1.A.1.20.1

2 references

Transporter Classification database

13 March 2020

Transporter Classification database

29 April 2020

1 reference

inferred by common MeSH mappings on source and on Wikidata

UMLS 2023