solute carrier family 6 member 3 (Q2271947)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q01959

Sodium:neurotransmitter symporter superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q01959

Sodium:neurotransmitter symporter

1 reference

Transporter Classification Database ID

2.A.22.1.3

hierarchical database ID heuristic

2 October 2019

based on heuristic

1 reference

13 November 2019

1 reference

13 November 2019

protein N-terminus binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01959

dopamine:sodium symporter activity

metal ion binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01959

1 reference

8 April 2019

neurotransmitter:sodium symporter activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01959

1 reference

8 April 2019

dopamine binding

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01959&geneProductId=UniProtKB:Q01959

protein binding

9 references

8 April 2019

Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01959

8 April 2019

Effect of torsinA on membrane proteins reveals a loss of function and a dominant-negative phenotype of the dystonia-associated DeltaE-torsinA mutant

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01959

8 April 2019

Modulation of dopamine transporter function by alpha-synuclein is altered by impairment of cell adhesion and by induction of oxidative stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01959

8 April 2019

The Plasma Membrane-Associated GTPase Rin Interacts with the Dopamine Transporter and Is Required for Protein Kinase C-Regulated Dopamine Transporter Trafficking

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01959

8 April 2019

Redistribution of DAT/α-synuclein complexes visualized by "in situ" proximity ligation assay in transgenic mice modelling early Parkinson's disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01959

8 April 2019

The Plasma Membrane-Associated GTPase Rin Interacts with the Dopamine Transporter and Is Required for Protein Kinase C-Regulated Dopamine Transporter Trafficking

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01959

8 April 2019

GPR37 associates with the dopamine transporter to modulate dopamine uptake and behavioral responses to dopaminergic drugs.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01959

8 April 2019

Identification of a small-molecule inhibitor of the PICK1 PDZ domain that inhibits hippocampal LTP and LTD.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01959

8 April 2019

Dopamine transporter cell surface localization facilitated by a direct interaction with the dopamine D2 receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01959

symporter activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01959

1 reference

8 April 2019

protein-containing complex binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01959

protease binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01959

signaling receptor binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01959

protein phosphatase 2A binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01959

dopamine:sodium symporter activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01959

4 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01959

8 April 2019

Effect of torsinA on membrane proteins reveals a loss of function and a dominant-negative phenotype of the dystonia-associated DeltaE-torsinA mutant

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01959

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01959

cell component

cytoplasm

TAS

1 reference

8 April 2019

Amphetamine-induced loss of human dopamine transporter activity: an internalization-dependent and cocaine-sensitive mechanism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01959

integral component of membrane

TAS

Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01959

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01959

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01959

8 April 2019

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01959&geneProductId=UniProtKB:Q01959

6 references

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01959&geneProductId=UniProtKB:Q01959

16 July 2018

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01959&geneProductId=UniProtKB:Q01959

16 July 2018

Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01959&geneProductId=UniProtKB:Q01959

16 July 2018

Modulation of dopamine transporter function by alpha-synuclein is altered by impairment of cell adhesion and by induction of oxidative stress

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01959&geneProductId=UniProtKB:Q01959

16 July 2018

The Plasma Membrane-Associated GTPase Rin Interacts with the Dopamine Transporter and Is Required for Protein Kinase C-Regulated Dopamine Transporter Trafficking

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01959&geneProductId=UniProtKB:Q01959

flotillin complex

1 reference

8 April 2019

Flotillin-1 is essential for PKC-triggered endocytosis and membrane microdomain localization of DAT

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01959

soma

1 reference

8 April 2019

Modulation of dopamine transporter function by alpha-synuclein is altered by impairment of cell adhesion and by induction of oxidative stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01959

membrane raft

1 reference

8 April 2019

The Plasma Membrane-Associated GTPase Rin Interacts with the Dopamine Transporter and Is Required for Protein Kinase C-Regulated Dopamine Transporter Trafficking

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01959

presynapse

1 reference

5 June 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01959&geneProductId=UniProtKB:Q01959

neuron projection

2 references

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01959&geneProductId=UniProtKB:Q01959

16 July 2018

The Plasma Membrane-Associated GTPase Rin Interacts with the Dopamine Transporter and Is Required for Protein Kinase C-Regulated Dopamine Transporter Trafficking

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01959&geneProductId=UniProtKB:Q01959

dopaminergic synapse

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01959

integral component of postsynaptic membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01959

integral component of presynaptic membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01959

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01959

7 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01959

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01959

8 April 2019

Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01959

8 April 2019

Modulation of dopamine transporter function by alpha-synuclein is altered by impairment of cell adhesion and by induction of oxidative stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01959

8 April 2019

The Plasma Membrane-Associated GTPase Rin Interacts with the Dopamine Transporter and Is Required for Protein Kinase C-Regulated Dopamine Transporter Trafficking

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01959

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01959

integral component of plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01959

1 reference

8 April 2019

cell surface

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01959

8 April 2019

Flotillin-1 is essential for PKC-triggered endocytosis and membrane microdomain localization of DAT

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01959

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01959

axon

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01959

8 April 2019

Modulation of dopamine transporter function by alpha-synuclein is altered by impairment of cell adhesion and by induction of oxidative stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01959

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01959

neuron projection

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01959

8 April 2019

The Plasma Membrane-Associated GTPase Rin Interacts with the Dopamine Transporter and Is Required for Protein Kinase C-Regulated Dopamine Transporter Trafficking

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01959

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01959

biological process

response to cocaine

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01959

prepulse inhibition

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01959

response to organic cyclic compound

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01959

locomotory behavior

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01959

dopamine biosynthetic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01959

response to nicotine

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01959

ageing

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01959

neurotransmitter biosynthetic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01959

1 reference

8 April 2019

TAS

monoamine transport

1 reference

8 April 2019

IRIP, a new ischemia/reperfusion-inducible protein that participates in the regulation of transporter activity

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01959

adenohypophysis development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01959

regulation of dopamine metabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01959

response to iron ion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01959

sensory perception of smell

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01959

dopamine uptake involved in synaptic transmission

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01959&geneProductId=UniProtKB:Q01959

1 reference

16 July 2018

dopamine catabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01959

positive regulation of multicellular organism growth

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01959

response to cAMP

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01959

lactation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01959

response to ethanol

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01959

dopamine uptake

1 reference

8 April 2019

The Plasma Membrane-Associated GTPase Rin Interacts with the Dopamine Transporter and Is Required for Protein Kinase C-Regulated Dopamine Transporter Trafficking

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01959

transmembrane transport

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01959

neurotransmitter uptake

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01959

physically interacts with

1 reference

7118

17 August 2016

1 reference

7135

17 August 2016

1 reference

2398

17 August 2016

1 reference

7158

17 August 2016

1 reference

2147

17 August 2016

1 reference

7554

17 August 2016

1 reference

4639

17 August 2016

1 reference

7435

17 August 2016

1 reference

4797

17 August 2016

1 reference

7236

17 August 2016

1 reference

4792

17 August 2016

1 reference

7266

17 August 2016

1 reference

2586

17 August 2016

1 reference

7317

17 August 2016

1 reference

4606

English

serdexmethylphenidate chloride

17 August 2016

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL4298139

dexmethylphenidate

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL827

dextroamphetamine

releasing agent

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL612

DL-amphetamine

releasing agent

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL405

liafensine

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL2364614

D-methamphetamine

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1201201

(RS)-diethylpropion

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1194666

mazindol

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL781

methylphenidate hydrochloride

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1722

dasotraline

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL3301595

diethylpropion hydrochloride

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1693

phenmetrazine hydrochloride

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1200483

Gene Atlas image

PBB GE SLC6A3 206836 at fs.png
732 × 530; 12 KB

0 references

facilitates flow of

dopamine

0 references

exact match

http://purl.uniprot.org/uniprot/Q01959

1 reference

D12.776.157.530.450.625.124

Identifiers.org

Commons category

Dopamine transporter

0 references

Identifiers

MeSH descriptor ID

D050483

subject named as

Dopamine Plasma Membrane Transport Proteins

0 references

MeSH tree code

0 references

D12.776.157.530.562.374.500.500

0 references

D12.776.157.530.937.500

0 references

D12.776.543.585.450.625.124

0 references

D12.776.543.585.562.374.500.500

0 references

D12.776.543.585.937.500

0 references

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

0 references

Microsoft Academic ID

0 references

0 references

1 reference

26 January 2022

https://docs.openalex.org/download-snapshot/snapshot-data-format

1 reference

26 January 2022

https://docs.openalex.org/download-snapshot/snapshot-data-format

Transporter Classification Database ID

2.A.22.1.3

2 references

Transporter Classification database

13 March 2020

Transporter Classification database