Isocitrate dehydrogenase (NADP(+)) 2 (Q21116031)

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mammalian protein found in Homo sapiens

• ICD-M
• oxalosuccinate decarboxylase
• IDP
• IDH2
• isocitrate dehydrogenase [NADP], mitochondrial
• isocitrate dehydrogenase (NADP(+)) 2, mitochondrial
• isocitrate dehydrogenase 2 (NADP+), mitochondrial
• NADP(+)-specific ICDH

edit

Language	Label	Description	Also known as
default for all languages	No label defined	–
English	Isocitrate dehydrogenase (NADP(+)) 2	mammalian protein found in Homo sapiens	ICD-M oxalosuccinate decarboxylase IDP IDH2 isocitrate dehydrogenase [NADP], mitochondrial isocitrate dehydrogenase (NADP(+)) 2, mitochondrial isocitrate dehydrogenase 2 (NADP+), mitochondrial NADP(+)-specific ICDH

Statements

instance of

protein

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P48735

part of

Isocitrate dehydrogenase NADP-dependent

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P48735

Isopropylmalate dehydrogenase-like domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Isocitrate/isopropylmalate dehydrogenase, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

image

Protein IDH2 PDB 1lwd.png
928 × 643; 434 KB

0 references

found in taxon

Homo sapiens

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P48735

encoded by

IDH2

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P48735

molecular function

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48735

determination method or standard

IEA

oxidoreductase activity

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P48735

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48735

determination method or standard

IEA

isocitrate dehydrogenase activity

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48735

determination method or standard

IEA

NAD binding

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48735

determination method or standard

IEA

magnesium ion binding

determination method or standard

ISS

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P48735

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48735

determination method or standard

ISS

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48735

determination method or standard

IEA

metal ion binding

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P48735

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48735

determination method or standard

IEA

isocitrate dehydrogenase (NADP+) activity

determination method or standard

ISS

IDA

IEA

EXP

6 references

retrieved

26 September 2017

stated in

GOA

curator

UniProt

UniProt protein ID

P48735

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48735&geneProductId=UniProtKB:P48735

determination method or standard

ISS

retrieved

26 September 2017

stated in

GOA

curator

UniProt

UniProt protein ID

P48735

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48735&geneProductId=UniProtKB:P48735

determination method or standard

IEA

retrieved

26 September 2017

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48735&geneProductId=UniProtKB:P48735

determination method or standard

IEA

retrieved

26 September 2017

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48735&geneProductId=UniProtKB:P48735

determination method or standard

IEA

retrieved

26 September 2017

stated in

Altered expression levels of IDH2 are involved in the development of colon cancer

GOA

curator

Community Assessment of Community Annotation with Ontologies

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48735&geneProductId=UniProtKB:P48735

determination method or standard

IDA

retrieved

26 September 2017

stated in

Insights from retinitis pigmentosa into the roles of isocitrate dehydrogenases in the Krebs cycle

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48735&geneProductId=UniProtKB:P48735

determination method or standard

EXP

isocitrate dehydrogenase (NADP+) activity

determination method or standard

EXP

IBA

IDA

IEA

ISS

7 references

retrieved

1 January 2018

stated in

GOA

curator

UniProt

UniProt protein ID

P48735

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48735&geneProductId=UniProtKB:P48735

determination method or standard

ISS

retrieved

1 January 2018

stated in

GOA

curator

UniProt

UniProt protein ID

P48735

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48735&geneProductId=UniProtKB:P48735

determination method or standard

IEA

retrieved

1 January 2018

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48735&geneProductId=UniProtKB:P48735

determination method or standard

IEA

retrieved

1 January 2018

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48735&geneProductId=UniProtKB:P48735

determination method or standard

IEA

retrieved

1 January 2018

stated in

Altered expression levels of IDH2 are involved in the development of colon cancer

GOA

curator

Community Assessment of Community Annotation with Ontologies

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48735&geneProductId=UniProtKB:P48735

determination method or standard

IDA

retrieved

1 January 2018

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48735&geneProductId=UniProtKB:P48735

determination method or standard

IBA

retrieved

1 January 2018

stated in

Insights from retinitis pigmentosa into the roles of isocitrate dehydrogenases in the Krebs cycle

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48735&geneProductId=UniProtKB:P48735

determination method or standard

EXP

protein homodimerization activity

determination method or standard

IBA

1 reference

retrieved

1 January 2018

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48735

determination method or standard

IBA

isocitrate dehydrogenase (NADP+) activity

determination method or standard

IBA

IDA

IEA

ISS

6 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P48735

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48735

determination method or standard

ISS

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P48735

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48735

determination method or standard

IEA

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48735

determination method or standard

IEA

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48735

determination method or standard

IEA

retrieved

8 April 2019

stated in

Altered expression levels of IDH2 are involved in the development of colon cancer

GOA

curator

Community Assessment of Community Annotation with Ontologies

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48735

determination method or standard

IDA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48735

determination method or standard

IBA

cell component

mitochondrial inner membrane

determination method or standard

IEA

1 reference

retrieved

26 September 2017

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48735&geneProductId=UniProtKB:P48735

determination method or standard

IEA

cytosol

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48735

determination method or standard

IEA

mitochondrial matrix

determination method or standard

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48735

determination method or standard

TAS

peroxisome

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48735

determination method or standard

IEA

extracellular exosome

determination method or standard

IDA

1 reference

retrieved

26 September 2017

stated in

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

GOA

curator

UniProt

UniProt protein ID

P48735

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48735&geneProductId=UniProtKB:P48735

determination method or standard

IDA

mitochondrion

determination method or standard

IDA

IEA

4 references

retrieved

26 September 2017

stated in

GOA

curator

UniProt

UniProt protein ID

P48735

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48735&geneProductId=UniProtKB:P48735

determination method or standard

IEA

retrieved

26 September 2017

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48735&geneProductId=UniProtKB:P48735

determination method or standard

IEA

retrieved

26 September 2017

stated in

Phosphoproteome analysis of functional mitochondria isolated from resting human muscle reveals extensive phosphorylation of inner membrane protein complexes and enzymes

GOA

curator

UniProt

UniProt protein ID

P48735

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48735&geneProductId=UniProtKB:P48735

determination method or standard

IDA

retrieved

26 September 2017

stated in

GOA

curator

Human Protein Atlas

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48735&geneProductId=UniProtKB:P48735

determination method or standard

IDA

mitochondrion

determination method or standard

HDA

IBA

IDA

IEA

4 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P48735

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48735

determination method or standard

IEA

retrieved

8 April 2019

stated in

GOA

curator

Human Protein Atlas

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48735

determination method or standard

IDA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48735

determination method or standard

IBA

retrieved

8 April 2019

stated in

Phosphoproteome analysis of functional mitochondria isolated from resting human muscle reveals extensive phosphorylation of inner membrane protein complexes and enzymes

GOA

curator

UniProt

UniProt protein ID

P48735

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48735

determination method or standard

HDA

extracellular exosome

determination method or standard

HDA

1 reference

retrieved

8 April 2019

stated in

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

GOA

curator

UniProt

UniProt protein ID

P48735

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48735

determination method or standard

HDA

biological process

2-oxoglutarate metabolic process

determination method or standard

ISS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P48735

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48735

determination method or standard

ISS

glyoxylate cycle

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P48735

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48735

determination method or standard

IEA

isocitrate metabolic process

determination method or standard

ISS

IEA

2 references

retrieved

26 September 2017

stated in

GOA

curator

UniProt

UniProt protein ID

P48735

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48735&geneProductId=UniProtKB:P48735

determination method or standard

ISS

retrieved

26 September 2017

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48735&geneProductId=UniProtKB:P48735

determination method or standard

IEA

tricarboxylic acid cycle

determination method or standard

TAS

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48735

determination method or standard

TAS

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P48735

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48735

determination method or standard

IEA

NADP biosynthetic process

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48735

determination method or standard

IEA

negative regulation of glial cell proliferation

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48735

determination method or standard

IEA

negative regulation of glial cell migration

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48735

determination method or standard

IEA

negative regulation of matrix metallopeptidase secretion

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48735

determination method or standard

IEA

mitochondrion organization

determination method or standard

TAS

1 reference

retrieved

26 September 2017

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48735&geneProductId=UniProtKB:P48735

determination method or standard

TAS

carbohydrate metabolic process

determination method or standard

NAS

1 reference

retrieved

8 April 2019

stated in

Assignment of the human mitochondrial NADP(+)-specific isocitrate dehydrogenase (IDH2) gene to 15q26.1 by in situ hybridization

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48735

determination method or standard

NAS

isocitrate metabolic process

determination method or standard

IBA

IEA

ISS

3 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P48735

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48735

determination method or standard

ISS

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48735

determination method or standard

IEA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48735

determination method or standard

IBA

NADP metabolic process

determination method or standard

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48735

determination method or standard

IBA

has part(s)

Isocitrate/isopropylmalate dehydrogenase, conserved site

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P48735

Isopropylmalate dehydrogenase-like domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P48735

Identifiers

RefSeq protein ID

NP_001276839

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

3418

NP_001277043

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

3418

NP_002159

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

3418

UniProt protein ID

P48735

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P48735

Ensembl protein ID

ENSP00000331897

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000331897

ENSP00000446147

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000446147

ENSP00000453016

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000453016

ENSP00000453254

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000453254

Freebase ID

/m/03g__5d

0 references

OpenAlex ID

C2776059313

1 reference

stated in

OpenAlex

retrieved

26 January 2022

reference URL

https://docs.openalex.org/download-snapshot/snapshot-data-format

PDB structure ID

4JA8

1 reference

stated in

UniProt

UniProt protein ID

P48735

retrieved

15 June 2016

language of work or name

English

 

Sitelinks

Wikipedia(4 entries)

edit

• cywiki IDH2
• enwiki IDH2
• frwiki IDH2
• ukwiki Ізоцитратдегідрогеназа-2

Wikibooks(0 entries)

edit

Wikinews(0 entries)

edit

Wikiquote(0 entries)

edit

Wikisource(0 entries)

edit

Wikiversity(0 entries)

edit

Wikivoyage(0 entries)

edit

Wiktionary(0 entries)

edit

Multilingual sites(0 entries)

edit

Retrieved from "https://www.wikidata.org/w/index.php?title=Q21116031&oldid=2022964827"