integrin subunit alpha 5 (Q21110097)

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mammalian protein found in Homo sapiens
  • CD49 antigen-like family member E
  • fibronectin receptor, alpha polypeptide
  • integrin alpha-F
  • VLA-5
  • integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
  • very late activation protein 5, alpha subunit
  • fibronectin receptor subunit alpha
  • integrin alpha-5
  • fibronectin receptor, alpha subunit
  • ITGA5
  • ITGA5/SLC9B1 fusion
  • Integrin alpha5
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Language Label Description Also known as
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No label defined
    English
    integrin subunit alpha 5
    mammalian protein found in Homo sapiens
    • CD49 antigen-like family member E
    • fibronectin receptor, alpha polypeptide
    • integrin alpha-F
    • VLA-5
    • integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
    • very late activation protein 5, alpha subunit
    • fibronectin receptor subunit alpha
    • integrin alpha-5
    • fibronectin receptor, alpha subunit
    • ITGA5
    • ITGA5/SLC9B1 fusion
    • Integrin alpha5

    Statements

    molecular function
    protein binding
    determination method or standard
    IPI
    14 references
    retrieved
    8 April 2019
    stated in
    Integrin alpha(v)beta(3) is a pleiotrophin receptor required for pleiotrophin-induced endothelial cell migration through receptor protein tyrosine phosphatase beta/zeta.
    GOA
    curator
    UniProt
    UniProt protein ID
    P08648
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08648
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Cell adhesion to fibrillin-1 molecules and microfibrils is mediated by alpha 5 beta 1 and alpha v beta 3 integrins
    GOA
    curator
    UniProt
    UniProt protein ID
    P08648
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08648
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Cartilage oligomeric matrix protein/thrombospondin 5 supports chondrocyte attachment through interaction with integrins
    GOA
    curator
    UniProt
    UniProt protein ID
    P08648
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08648
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    alphaVbeta6 is a novel receptor for human fibrillin-1. Comparative studies of molecular determinants underlying integrin-rgd affinity and specificity
    GOA
    curator
    UniProt
    UniProt protein ID
    P08648
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08648
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Identification of novel integrin binding partners for calcium and integrin binding protein 1 (CIB1): structural and thermodynamic basis of CIB1 promiscuity
    GOA
    curator
    UniProt
    UniProt protein ID
    P08648
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08648
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    CCN3 (NOV) Is a Novel Angiogenic Regulator of the CCN Protein Family
    GOA
    curator
    UniProt
    UniProt protein ID
    P08648
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08648
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08648
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Endoglin mediates fibronectin/α5β1 integrin and TGF-β pathway crosstalk in endothelial cells
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08648
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Neuropilin-1/GIPC1 signaling regulates alpha5beta1 integrin traffic and function in endothelial cells.
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08648
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Basic amino-acid side chains regulate transmembrane integrin signalling
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08648
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    SHARPIN is an endogenous inhibitor of β1-integrin activation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08648
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Ganglioside GM3 Inhibits Matrix Metalloproteinase-9 Activation and Disrupts Its Association with Integrin
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08648
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Murine lipid phosphate phosphohydrolase-3 acts as a cell-associated integrin ligand
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08648
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Integrin alpha5beta1 and ADAM-17 interact in vitro and co-localize in migrating HeLa cells
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08648
    determination method or standard
    IPI
    cell component
    cell surface
    determination method or standard
    IDA
    IEA
    7 references
    retrieved
    17 October 2017
    stated in
    GOA
    curator
    UniProt
    UniProt protein ID
    P08648
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P08648&geneProductId=UniProtKB:P08648
    determination method or standard
    IEA
    retrieved
    17 October 2017
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P08648&geneProductId=UniProtKB:P08648
    determination method or standard
    IEA
    retrieved
    17 October 2017
    stated in
    Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance
    GOA
    curator
    UniProt
    UniProt protein ID
    P08648
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P08648&geneProductId=UniProtKB:P08648
    determination method or standard
    IDA
    retrieved
    17 October 2017
    stated in
    Integrin expression and integrin-mediated adhesion in vitro of human multipotent stromal cells (MSCs) to endothelial cells from various blood vessels
    GOA
    curator
    UniProt
    UniProt protein ID
    P08648
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P08648&geneProductId=UniProtKB:P08648
    determination method or standard
    IDA
    retrieved
    17 October 2017
    stated in
    Regulation of endodermal differentiation of human embryonic stem cells through integrin-ECM interactions
    GOA
    curator
    UniProt
    UniProt protein ID
    P08648
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P08648&geneProductId=UniProtKB:P08648
    determination method or standard
    IDA
    retrieved
    17 October 2017
    stated in
    Quantitative proteomics identifies a Dab2/integrin module regulating cell migration
    GOA
    curator
    UniProt
    UniProt protein ID
    P08648
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P08648&geneProductId=UniProtKB:P08648
    determination method or standard
    IDA
    retrieved
    17 October 2017
    stated in
    alphaVbeta6 is a novel receptor for human fibrillin-1. Comparative studies of molecular determinants underlying integrin-rgd affinity and specificity
    GOA
    curator
    UniProt
    UniProt protein ID
    P08648
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P08648&geneProductId=UniProtKB:P08648
    determination method or standard
    IDA
    focal adhesion
    determination method or standard
    HDA
    IDA
    IEA
    5 references
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    UniProt
    UniProt protein ID
    P08648
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08648
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    alphaVbeta6 is a novel receptor for human fibrillin-1. Comparative studies of molecular determinants underlying integrin-rgd affinity and specificity
    GOA
    curator
    UniProt
    UniProt protein ID
    P08648
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08648
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    The WD40-domain containing protein CORO2B is specifically enriched in glomerular podocytes and regulates the ventral actin cytoskeleton.
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08648
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Integrin alpha5beta1 and ADAM-17 interact in vitro and co-localize in migrating HeLa cells
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08648
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation
    GOA
    curator
    UniProt
    UniProt protein ID
    P08648
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08648
    determination method or standard
    HDA
    cell surface
    determination method or standard
    HDA
    IDA
    IEA
    7 references
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    UniProt
    UniProt protein ID
    P08648
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08648
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08648
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    Regulation of endodermal differentiation of human embryonic stem cells through integrin-ECM interactions
    GOA
    curator
    UniProt
    UniProt protein ID
    P08648
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08648
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    alphaVbeta6 is a novel receptor for human fibrillin-1. Comparative studies of molecular determinants underlying integrin-rgd affinity and specificity
    GOA
    curator
    UniProt
    UniProt protein ID
    P08648
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08648
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Integrin expression and integrin-mediated adhesion in vitro of human multipotent stromal cells (MSCs) to endothelial cells from various blood vessels
    GOA
    curator
    UniProt
    UniProt protein ID
    P08648
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08648
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Quantitative proteomics identifies a Dab2/integrin module regulating cell migration
    GOA
    curator
    UniProt
    UniProt protein ID
    P08648
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08648
    determination method or standard
    HDA
    retrieved
    8 April 2019
    stated in
    Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance
    GOA
    curator
    UniProt
    UniProt protein ID
    P08648
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08648
    determination method or standard
    HDA
    biological process

    Identifiers

    MeSH descriptor ID
    D039482
    subject named as
    Integrin alpha5
    0 references
    Freebase ID
    /m/03cw4bp
    0 references
     
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