AU-rich elements: characterization and importance in mRNA degradation (Q29547896)

Europe PubMed Central

title

AU-rich elements: characterization and importance in mRNA degradation (English)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=8578590

mRNA 3'-UTR AU-rich region binding

23 April 2017

main subject

1 reference

Gene Ontology release 2020-05-02

1 reference

Gene Ontology release 2020-05-02

Chen CY

1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=8578590

23 April 2017

Shyu AB

series ordinal

2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=8578590

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=8578590

23 April 2017

language of work or name

1 reference

23 April 2017

publication date

November 1995

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=8578590

Trends in Biochemical Sciences

23 April 2017

published in

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=8578590

23 April 2017

volume

20

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=8578590

23 April 2017

issue

11

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=8578590

23 April 2017

page(s)

465-70

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=8578590

Degradation of mRNA in eukaryotes

23 April 2017

cites work

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Interplay of two functionally and structurally distinct domains of the c-fos AU-rich element specifies its mRNA-destabilizing function

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Selective degradation of early-response-gene mRNAs: functional analyses of sequence features of the AU-rich elements

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AUUUA is not sufficient to promote poly(A) shortening and degradation of an mRNA: the functional sequence within AU-rich elements may be UUAUUUA(U/A)(U/A).

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The nonamer UUAUUUAUU is the key AU-rich sequence motif that mediates mRNA degradation

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Removal of poly(A) and consequent degradation of c-fos mRNA facilitated by 3' AU-rich sequences

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Two distinct destabilizing elements in the c-fos message trigger deadenylation as a first step in rapid mRNA decay

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mRNA decay mediated by two distinct AU-rich elements from c-fos and granulocyte-macrophage colony-stimulating factor transcripts: different deadenylation kinetics and uncoupling from translation

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Evidence for instability of mRNAs containing AUUUA motifs mediated through translation-dependent assembly of a > 20S degradation complex

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Selective destabilization of short-lived mRNAs with the granulocyte-macrophage colony-stimulating factor AU-rich 3' noncoding region is mediated by a cotranslational mechanism

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Rapid mRNA degradation mediated by the c-fos 3' AU-rich element and that mediated by the granulocyte-macrophage colony-stimulating factor 3' AU-rich element occur through similar polysome-associated mechanisms

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An A + U-rich element RNA-binding factor regulates c-myc mRNA stability in vitro

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An inducible cytoplasmic factor (AU-B) binds selectively to AUUUA multimers in the 3' untranslated region of lymphokine mRNA

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7 January 2021

AU-A, an RNA-binding activity distinct from hnRNP A1, is selective for AUUUA repeats and shuttles between the nucleus and the cytoplasm

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7 January 2021

Glyceraldehyde-3-phosphate dehydrogenase selectively binds AU-rich RNA in the NAD(+)-binding region (Rossmann fold).

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Purification, characterization, and cDNA cloning of an AU-rich element RNA-binding protein, AUF1

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7 January 2021

Shuttling of pre-mRNA binding proteins between nucleus and cytoplasm

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GM-CSF and oncogene mRNA stabilities are independently regulated in trans in a mouse monocytic tumor

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The AU-rich sequences in the 3' untranslated region mediate the increased turnover of interferon mRNA induced by glucocorticoids

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