duvelisib (Q27077129)

Duvelisib (English)

3 October 2016

C₂₂H₁₇ClN₆O

1 reference

Duvelisib (English)

3 October 2016

CC(C1=CC2=C(C(=CC=C2)Cl)C(=O)N1C3=CC=CC=C3)NC4=NC=NC5=C4NC=N5

1 reference

Duvelisib (English)

3 October 2016

C[C@@H](C1=CC2=C(C(=CC=C2)Cl)C(=O)N1C3=CC=CC=C3)NC4=NC=NC5=C4NC=N5

1 reference

https://www.drugs.com/copiktra.html

Duvelisib (English)

3 October 2016

1 reference

medical condition treated

23 October 2018

chronic lymphocytic leukemia

0 references

follicular lymphoma

0 references

physically interacts with

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma

subject has role

reaction inhibitor

1 reference

Open Targets Platform

https://platform.opentargets.org/drug/CHEMBL3039502

14 August 2023

reference URL

legal status (medicine)

boxed warning

1 reference

reference URL

https://nctr-crs.fda.gov/fdalabel/ui/spl-summaries/criteria/343802

LiverTox likelihood score

FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links. (English)

LiverTox toxicity likelihood category E*

1 reference

8 April 2021

https://www.ncbi.nlm.nih.gov/books/n/livertox/Duvelisib

last update

23 January 2019

subject has role

protein kinase inhibitors

0 references

phosphoinositide-3 kinase inhibitor

1 reference

The phase 3 DUO trial: duvelisib versus ofatumumab in relapsed and refractory CLL/SLL

different from

Duvelisib

0 references

Commons category

Duvelisib

0 references

Identifiers

InChI

InChI=1S/C22H17ClN6O/c1-13(28-21-19-20(25-11-24-19)26-12-27-21)17-10-14-6-5-9-16(23)18(14)22(30)29(17)15-7-3-2-4-8-15/h2-13H,1H3,(H2,24,25,26,27,28)/t13-/m0/s1

1 reference

Duvelisib (English)

3 October 2016

2 references

Duvelisib (English)

3 October 2016

ChEBI release 2020-09-01

CAS Registry Number

1201438-56-3

2 references

Global Substance Registration System

UNII

610V23S0JI

DUVELISIB (English)

3 October 2016

https://commonchemistry.cas.org/detail?cas_rn=1201438-56-3

8 April 2021

1 reference

duvelisib (English)

3 October 2016

2 references

English

Duvelisib (English)

3 October 2016

ChEBI ID

131169

mapping relation type

2 references

English

8-chloro-2-phenyl-3-[(1S)-1-(7H-purin-6-ylamino)ethyl]-1-isoquinolinone (English)

3 October 2016

International Chemical Identifier

InChI

InChI=1S/C22H17ClN6O/c1-13(28-21-19-20(25-11-24-19)26-12-27-21)17-10-14-6-5-9-16(23)18(14)22(30)29(17)15-7-3-2-4-8-15/h2-13H,1H3,(H2,24,25,26,27,28)/t13-/m0/s1

1 reference

DUVELISIB (English)

3 October 2016

2 references

inferred from InChIKey

SCHEMBL153543

2 references

based on heuristic

inferred from InChIKey

Mapping file of InChIStrings, InChIKeys and DTXSIDs for the EPA CompTox Dashboard

1 reference

2 references

DSSTOX compound identifier

0 references

0 references

1 reference

ECHA Substance Infocard database

ECHA Substance Infocard ID

100.245.560

27 December 2018

ECHA Substance Infocard ID

8-chloro-2-phenyl-3-[(1S)-1-(7H-purin-6-ylamino)ethyl]isoquinolin-1(2H)-one (English)

quotation

CAS no.: 1201438-56-3 (English)

100.245.560

1 reference

ECHA Substance Infocard database

ECHA Substance Infocard ID

100.245.560

20 December 2018

Guide to Pharmacology Ligand ID

8-chloro-2-phenyl-3-[(1S)-1-(7H-purin-6-ylamino)ethyl]isoquinolin-1(2H)-one (English)

quotation

CAS no.: 1201438-56-3 (English)

7795

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

7795

duvelisib (English)

3 October 2016

1 reference

UNII

610V23S0JI

2 references

Global Substance Registration System

UNII

610V23S0JI

English

DUVELISIB (English)

3 October 2016