Glutamate ionotropic receptor NMDA type subunit 2A (Q21115815)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q12879

ionotropic glutamate receptor, metazoa

2 references

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q12879

Transporter Classification Database ID

1.A.10.1.20

2 October 2019

hierarchical database ID heuristic

Receptor, ligand binding region, protein family

1 reference

Ionotropic glutamate receptor domain, protein family

1 reference

Glutamate [NMDA] receptor, epsilon subunit, C-terminal domain, protein family

1 reference

Ionotropic glutamate receptor, L-glutamate and glycine-binding domain, protein family

1 reference

1 reference

13 November 2019

1 reference

13 November 2019

calcium channel activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12879

zinc ion binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12879

1 reference

9 May 2019

ISS

metal ion binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12879

1 reference

9 May 2019

ion channel activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12879

1 reference

9 May 2019

protein binding

3 references

9 May 2019

Analysis of NR3A receptor subunits in human native NMDA receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12879

9 May 2019

Selectivity and promiscuity of the first and second PDZ domains of PSD-95 and synapse-associated protein 102

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12879

9 May 2019

HIV-tat induces formation of an LRP-PSD-95- NMDAR-nNOS complex that promotes apoptosis in neurons and astrocytes

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12879

ionotropic glutamate receptor activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12879

1 reference

9 May 2019

cation channel activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12879

extracellularly glutamate-gated ion channel activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12879&geneProductId=UniProtKB:Q12879

1 reference

26 September 2017

amyloid-beta binding

1 reference

9 May 2019

Amyloid-β Receptors: The Good, the Bad, and the Prion Protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12879

NMDA glutamate receptor activity

Cloning and functional characterization of human heteromeric N-methyl-D-aspartate receptors

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12879

9 May 2019

Fyn-mediated phosphorylation of NR2B Tyr-1336 controls calpain-mediated NR2B cleavage in neurons and heterologous systems

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12879

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12879

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12879

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12879

glutamate-gated calcium ion channel activity

IBA

signaling receptor activity

IMP

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12879

1 reference

9 May 2019

integral component of membrane

cell component

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12879

1 reference

9 May 2019

membrane

synaptic vesicle

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12879

postsynaptic density

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12879&geneProductId=UniProtKB:Q12879

integral component of plasma membrane

1 reference

26 September 2017

Cloning and functional characterization of human heteromeric N-methyl-D-aspartate receptors

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12879&geneProductId=UniProtKB:Q12879

NMDA selective glutamate receptor complex

cell surface

ISS

cell junction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12879

1 reference

9 May 2019

endoplasmic reticulum

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12879

neuron projection

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12879

presynaptic membrane

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12879

postsynaptic density membrane

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12879&geneProductId=UniProtKB:Q12879

integral component of postsynaptic density membrane

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12879

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12879

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12879

9 May 2019

9 May 2019

Mechanistic Insight into NMDA Receptor Dysregulation by Rare Variants in the GluN2A and GluN2B Agonist Binding Domains

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12879

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12879

integral component of plasma membrane

IBA

postsynaptic density

NMDA selective glutamate receptor complex

ISS

Fyn-mediated phosphorylation of NR2B Tyr-1336 controls calpain-mediated NR2B cleavage in neurons and heterologous systems

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12879

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12879

9 May 2019

Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12879

9 May 2019

Biochemical evidence for the co-association of three N-methyl-D-aspartate (NMDA) R2 subunits in recombinant NMDA receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12879

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12879

IBA

glutamatergic synapse

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12879

cell projection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12879

1 reference

9 May 2019

dendritic spine

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12879

1 reference

9 May 2019

biological process

visual learning

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12879

protein localization

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12879&geneProductId=UniProtKB:Q12879

glutamate receptor signaling pathway

1 reference

9 May 2019

Cloning and functional characterization of human heteromeric N-methyl-D-aspartate receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12879

neurogenesis

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12879

startle response

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12879

regulation of sensory perception of pain

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12879

positive regulation of long-term synaptic potentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12879

negative regulation of protein catabolic process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12879

response to amphetamine

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12879

regulation of membrane potential

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12879

directional locomotion

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12879

modulation of chemical synaptic transmission

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12879

memory

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12879

serotonin metabolic process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12879

learning

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12879

cation transmembrane transport

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12879&geneProductId=UniProtKB:Q12879

MAPK cascade

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12879&geneProductId=UniProtKB:Q12879

1 reference

1 January 2018

regulation of synaptic plasticity

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12879&geneProductId=UniProtKB:Q12879

sleep

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12879

dopamine metabolic process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12879

ionotropic glutamate receptor signaling pathway

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12879

response to wounding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12879

calcium ion transmembrane transport

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12879&geneProductId=UniProtKB:Q12879

locomotion

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12879

regulation of postsynaptic membrane potential

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12879

excitatory postsynaptic potential

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12879&geneProductId=UniProtKB:Q12879

positive regulation of apoptotic process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12879

sensory perception of pain

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12879

calcium ion transport

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12879

long-term potentiation

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12879&geneProductId=UniProtKB:Q12879

positive regulation of GTPase activity

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12879&geneProductId=UniProtKB:Q12879

ion transmembrane transport

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12879&geneProductId=UniProtKB:Q12879

regulation of ion transmembrane transport

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12879&geneProductId=UniProtKB:Q12879

brain development

1 reference

9 May 2019

Fyn-mediated phosphorylation of NR2B Tyr-1336 controls calpain-mediated NR2B cleavage in neurons and heterologous systems

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12879

calcium-mediated signaling

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12879

activation of cysteine-type endopeptidase activity

1 reference

9 May 2019

Fyn-mediated phosphorylation of NR2B Tyr-1336 controls calpain-mediated NR2B cleavage in neurons and heterologous systems

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12879

calcium ion transmembrane import into cytosol

excitatory chemical synaptic transmission

IMP

1 reference

9 May 2019

Fyn-mediated phosphorylation of NR2B Tyr-1336 controls calpain-mediated NR2B cleavage in neurons and heterologous systems

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12879

protein localization to postsynaptic membrane

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12879

cellular response to amyloid-beta

IGI

1 reference

9 May 2019

A β‐amyloid oligomer directly modulates P/Q‐type calcium currents in Xenopus oocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12879

regulation of NMDA receptor activity

IGI

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12879

1 reference

9 May 2019

physically interacts with

1 reference

727

17 August 2016

1 reference

3309

17 August 2016

1 reference

4216

17 August 2016

1 reference

4068

17 August 2016

N-methyl-D-aspartic acid

has use

agonist

1 reference

4268

5,7-dichlorokynurenic acid

17 August 2016

has use

1 reference

2361

17 August 2016

1 reference

4170

17 August 2016

1 reference

4155

17 August 2016

1 reference

4128

17 August 2016

1 reference

2403

17 August 2016

1 reference

4233

17 August 2016

1 reference

4282

17 August 2016

lanicemine

channel blocker

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL467084

neboglamine

positive allosteric modullator

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1255840

priralfinamide

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL2107771

esketamine

negative allosteric modulator

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL395091

ketamine

negative allosteric modulator

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL742

cns-5161

channel blocker

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL41306

ketamine hydrochloride

negative allosteric modulator

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1714

amantadine hydrochloride

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1569

orphenadrine citrate

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1200395

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

Transporter Classification Database ID

1.A.10.1.20

2 references

Transporter Classification database

13 March 2020

Transporter Classification database