Pedigree Analysis
I what are
I
the
possible disorders ? I How to
identify these disorders ?
AUTOSOMAL SEX-LINKED AUTOSOMAL DOMINANT X-LINKED RECESSIVE FM
No is
--
W ↓
·
generation skipped Criss Cross
>
-
transfers"I
is
DOMINANT RECESSIVE
X -
LINKED Y-LINKED AUTOSOMAL RECESSIVE >
-
If a son mother should be
affected ,
Expression >
-
Can skip generation affected
Expression Expression
a daughtersaffected fa t h
her a
.
= =
Donn
-
REC only in X-LINKED DOMINANT
,
AA/Aa
.
aa
males > All
XPXP Xayd -
daughters of affected >
-
If a mother isaffected all her , sons
X *
Xd XaY father would beaffected. Wouldbe affecteda
Y
No
father to transfer
*
X Y >
- son
affected
.
only males
·
are
Now ,
try to analyse the given pedigree :
6)
1)
M
7)
2)
8)
3)
.
↑
9)
4)
- &
min
5)
10)
-
13)
I
>
-Ear
)
14.
(2)
·
-
·
15
)
solutions ?
1) b
·
a
A
d
b
&
d
d
d
A
b
b