R19M PharmPharmaceuticalChemistryISem
R19M PharmPharmaceuticalChemistryISem
R19M PharmPharmaceuticalChemistryISem
I YEAR I Semester
Course Code Course Title L T P Credits
Professional Advanced Organic Chemistry-I 3 0 0 3
Core-I
Professional Advanced Medicinal Chemistry-I 3 0 0 3
Core-II
Professional 1. Chemistry of Natural Products 3 0 0 3
Elective-I 2. Modern Pharmaceutical Analytical Techniques
3. Drug Regulatory Affairs
Professional 1. Drug Discovery & Design 3 0 0 3
Elective-II 2. Pharmaceuticals and Food Analysis
3. Spectral Analysis
MC Research methodology and IPR 2 0 0 2
Laboratory-I Advanced Organic Chemistry – I Lab 0 0 4 2
Laboratory-II Advanced Medicinal Chemistry – I Lab 0 0 4 2
Audit Audit Course – I 2 0 0 0
TOTAL 16 0 8 18
I YEAR II Semester
Course Code Course Title L T P Credits
Professional Advanced Organic Chemistry –II 3 0 0 3
Core-III
Professional Advanced Medicinal Chemistry II 3 0 0 3
Core-IV
Professional 1. Pharmaceutical Process Chemistry 3 0 0 3
Elective-III 2. Quality Control and Quality Assurance
3. Clinical Research and Pharmacovigilance
Professional 1. Screening Methods in Pharmacology 3 0 0 3
Elective-IV 2. Advanced Instrumental Analysis
3. Herbal Drug Technology
Laboratory-III Advanced Organic Chemistry - II Lab 0 0 4 2
Laboratory-IV Advanced Medicinal Chemistry - II Lab 0 0 4 2
-- Mini project with seminar 2 0 0 2
Audit Audit Course - II 2 0 0 0
TOTAL 16 0 8 18
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R19 M.PHARM PHARMACEUTICAL CHEMISTRY
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R19 M.PHARM PHARMACEUTICAL CHEMISTRY
Course Objectives: The course structure is designed to give the knowledge of organic chemistry at
an advanced level and mainly aimed at the stereochemistry and different organic named reactions
including preparations of reactive intermediates.
Course Outcome: The student would be in position to design a stereoselective synthesis of new
chemical entities (NCE) for the treatment of different diseases in new drug discovery Program.
UNIT I
a. Stereochemistry: a. Elements of symmetry, simple axis of symmetry. Notation, relative
configuration and absolute configuration. Compounds with a chiral carbon atom, compounds with
other quadrivalent chiral atoms. Optical isomerism in compounds containing no chiral atom,
biphenyl, allenes, compounds with exocylic double bonds and spirans.
b. Chirality due to helical shape.cis / trans, E – Z isomerism resulting from double bonds,
monocyclic compounds, fused ring system. Racemic modifications and methods for resolution of
racemic mixtures. Asymmetric synthesis and stereo – selective synthesis.
UNIT II
a. Reactive Intermediates: Definitions, generation, stability, structure and reactivity of free radicals
carbocations, carbanions, carbenes, Nitrenes/Nitrenium ions.
b. Concepts of aromaticity and antiaromaticity, nonbenzenoid aromatic compounds.
UNIT III
Mechanisms of organic reactions: Free radical, Electrophilic, Nucleophilic reactions of aliphatic and
aromatic compounds
UNIT IV
Elimination Reactions: E1, E2, E1CB and E2CB mechanisms, Mechanisms and orientation in pyrolytic
eliminations, effect of substrate structure, attacking base, leaving group and reaction bond, medium
and reactivity addition to carbon – carbon multiple bond reactions. Mechanisms, Orientation and
reactivity.
UNIT V
Electrocyclic, pericyclic and sigmotropic reactions: Introduction, terminology and mechanism,
with suitable examples.
RECOMMENDED BOOKS:
1. Francis A. Carey & Richard J. Sunberg, Advanced Org. Chemistry, III rd Edition, Par B;
Reactions and synthesis, Plenum Press, New York, London, Latest Edition.
2. Eliel I. Ernest and Samuel h, Stereochemistry of Org. Compounds, John Wiley and sons, New
York, 2003 Edition.
3. Roland E. Lehr & Alan P Marchard, Orbital Symmetry: A Problem-Solving approach,
Academic Press, New York Latest Edition.
4. J. March, Advanced Org. Chemistry, Reactions Mechanisms and Structure, 4th
5. Edition, John Wiley & Sons, New York Latest Edition
6. I. L. Finar, Organic Chemistry, ELBS
7. Herbert O. Modern Synthesis Reactions IInd Edition W.A. Beenamis Inc. Menco Park
California
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R19 M.PHARM PHARMACEUTICAL CHEMISTRY
8. W. Carruthers, Some Modern Methods of Org. Synthesis, III rd Edition, Cambridge University
Press, Cambridge.
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R19 M.PHARM PHARMACEUTICAL CHEMISTRY
Course Objectives: The course contents are mainly aimed to have advanced knowledge of rational
drug design including QSAR and molecular modeling and also aimed at the identification of lead
molecule from natural sources for the development of new drugs.
Course Outcome: The student would be in a position to have detailed knowledge of computer aided
drug design which is useful to involve in new drug discovery Program by the utilization of natural
leads and also with the help of structure-based drug design.
UNIT I
Modern methods of Drug Discovery target validation: Introduction to discovery of lead molecule,
methods, rational drug discovery models. Target structure, active site identification and methods of
validation.
UNIT II
Rational Drug Design: QSAR: Parameters involved in QSAR, lipophilicity (Polarisabiltiy, electronic
and steric parameters). Quantitative models. Hansch Analysis, Free Wilson Analysis and their
relationships, linear relationships and applications of Hansch and Free Wilson Analysis.
UNIT III
a. Computer aided drug design (CADD):
Virtual screening: concept, drug likeness screening, focused screening libraries for lead
identification, pharmacophore screening, structure based virtual screening and applications.
Molecular modeling: Molecular mechanics, quantam mechanics, modeling ligands for known
receptors and unknown receptors.
b. Drug Design: Introduction, Pharmacophase – based drug design, Known receptors, structure –
based drug design, homology modeling, unknown receptors.
UNIT IV
Natural Products as Leads for New Drugs: Introduction/History, approaches to discovery and
development of natural products as potential new drugs, selection and optimization of lead
compounds for further developments from CNS, anticancer antibiotics and cardiovascular drugs.
UNIT V
Structure based drug design: Inhibitors of HIV-I Prokinase, Structural studies of HIV-I Reverse
transcriptase and implications for drug design, Bradykinin receptor antagonists, Design of purine
nucleoside and Phosphorylase inhibitors, Aldose Reductase Inhibitors, Thrombin inhibitors.
Rhinoviral-Capsid-biding Inhibitors.
RECOMMENDED BOOKS:
1. Berger’s Medicinal Chemistry and Drug Design. 6th Edition.
2. Korolkovas Essentials of Medicinal Chemistry
3. Purcell Strategies of Drug Design
4. Corwin, Hansen Comprehensive Medicinal Chemistry
5. William O Foye Medicinal Chemistry
6. Structure based Drug Design by Pandi Veerapandion.
7. Stenlake, Foundation of Molecular Pharmacology- Pharma Med Press, volume I &II
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R19 M.PHARM PHARMACEUTICAL CHEMISTRY
Course Objective: The contents of Unit I mainly aimed to identify lead molecules from the natural
sources. The contents of Unit II &III are mainly designed to have the knowledge of alkaloids and
steroids especially structural elucidation of few important compounds. The contents of Unit IV and V
are to offer an understanding of utilization of natural products for the preparation of new molecules for
the treatment of different diseases like cancer, malaria etc.
Course Outcome: The student would be in a position to explore the natural lead compounds for the
treatment of different diseases like cancer, malaria, diabetes etc.
UNIT I
Natural products as leads for new drugs: Introduction/history, approaches to discovery and
development of natural products as potential new drugs selection and optimization of lead compounds
for further development with suitable examples from antibiotics, CNS, and cardiovascular agents.
UNIT II
Alkaloids: Introduction and general methods of structure elucidation.
From opium: morphine-structure elucidation, development of morphine analogues and morphine
antagonists.
From Rauwolfia: Reserpine-structure eludication, structural modifications and uses.
From vinca rosea: vincristine and vinblastine - structural modification, semisynthetic derivatives and
uses.
UNIT III
Steroids: Introduction, nomenclature, stereochemistry of steroids. Source and structure elucidation of
cholesterol and diosgenin.
Structures, structure modifications and therapeutic uses of steroidal anti-inflammatory agents and
antifertility agents.
UNIT IV
Polypeptides and proteins: introduction and general methods of separation, general methods of
degradation and end group analysis, general methods of synthesis of peptides. Primary, secondary,
tertiary and quaternary structure of proteins; chemistry of insulin.
UNIT V
Compounds of medicinal Interest: Structure, structural modifications, mechanism of action and
therapeutic uses of a) taxanes b) camptothecin c) artemisinin e) ginkgolides and f) gymnemic acids.
RECOMMENDED BOOKS:
1. Finar IL. Organic Chemistry-stereochemistry and the chemistry of natural products. 5th ed. vol 2.
Delhi: Dorling Kindersley (India) Pvt. Ltd., 2006.
2. Morrison RT, Boyd RN. Organic Chemistry. 6th ed. Delhi: Pearson education Pvt. Ltd., 2003.
3. Pelletier SW. Alkaloids-chemical & biological perspectives. vol 1-15. London: Pergamon; 2001.
4. Steroids by Fischer & Fischer.
th
5. Evans WC. Trease and evans pharmacognosy. 15 ed. Edinburgh: Saunders. 2004.
6. Ataur Rahman. Chemistry of natural products
7. Bhat SV, Nagasampagi BA, Sivakumar M. Chemistry of natural products. New Delhi: Narosa
Publishing House; 2005.
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R19 M.PHARM PHARMACEUTICAL CHEMISTRY
8. Agrawal OP. Organic chemistry-natural products. 30th ed. vol 1-2. Meerut: Goel Publishing
House; 2006.
9. Wallis TE. Textbook of pharmacognosy. 5th ed. New Delhi: CBS Publishers & Distributors; 2002.
10. Abraham DJ, editor. Burger’s medicinal chemistry and drug discovery. 6th ed. vol 1-6,
Singapore: John Wiley & Sons, 2007.
th
11. Lemke TL, Williams DA, Roche VF, Zito SW. Foye’s principles of medicinal chemistry. 6 ed.
New Delhi: Wolters Kluwer/ Lippincott Williams & Wilkins. 2008.
12. Block JH, Beale JM, editor. Wilson and Gisvold’s textbook of organic medicinal and
pharmaceutical chemistry. 11th ed. Baltimore: Lippincott Williams & Wilkins; 2004.
13. Jerry M. Advanced organic chemistry-reactions, mechanisms, and structure. 4th ed. Kundli:
Replika Press Pvt. Ltd; 2003.
14. Murray RK, Granner DK, Mayes PA, Rodwell VW. Harper’s Illustrated biochemistry. 26th ed.
New Delhi: Mc Graw Hill, 2003.
15. Rama Rao AVSS. A text book of biochemistry. 9th ed. Delhi: Rajkamal electric press, 2004.
16. Remington: The science and practice of pharmacy. 21st ed., vol. I & II, Lippincatt Willams &
Wilkings, New Delhi, 2005.
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R19 M.PHARM PHARMACEUTICAL CHEMISTRY
Course Objective: The course is designed to impart the knowledge in the field of Pharmaceutical
Analysis. The various modern analytical techniques like UV-Visible, IR, NMR, Mass, GC, HPLC,
different chromatographic methods and other important topics are taught to enable the students to
understand and apply the principles involved in the determination of different bulk drugs and their
formulation. In addition to the theoretical aspects, the basic practical knowledge relevant to the
analysis is also imparted.
Course Outcome: The appreciable knowledge will be gained by the students in the Modern
Analytical Techniques and can apply the theories in the Analysis of various bulk drugs and their
formulations. The students will also be in a position to apply their knowledge in developing the new
methods for the determination and validate the procedures.
UNIT I
Introduction to chromatography and classification of chromatographic methods based on the
mechanism of separation
a. Column Chromatography: Adsorption and partition, theory, preparation, procedure and
methods of detection
b. Thin Layer Chromatography: Theory, preparation, procedures, detection of compounds
c. Paper Chromatography: Theory, different techniques employed, filter papers used, qualitative
and quantitative detection
d. Counter – current extraction, solid phase extraction techniques, gel filtration
UNIT II
a. Gas chromatography: Introduction, fundamentals, instrumentation, columns: preparation and
operation, detection, dramatization.
b. HPLC: Principles and instrumentation, solvents and columns used, detection and
applications
c. HPTLC: Theory and principle, instrumentation, elution techniques and pharmaceutical
applications
UNIT III
a. UV-Visible spectroscopy: Introduction, electromagnetic spectrum, absorbance laws and
limitations, instrumentation-design and working principle, chromophore concept, auxochromes,
Wood-Fisher rules for calculating absorption maximum, applications of UV-Visible spectroscopy
b. IR spectroscopy: Basic principles - Molecular vibrations, vibrational frequency, factors influencing
vibrational frequencies, sampling techniques, instrumentation, interpretation of spectra, FT-IR,
theory and applications
UNIT IV
Mass spectroscopy: Theory, ionization techniques: electron impact ionization, chemical ionization,
field ionization, fast atom bombardment, plasma desorption, fragmentation process: types of fission,
resolution, GC/MS, interpretation of spectra and applications for identification and structure
determination.
UNIT V
NMR: Theory, instrumentation, chemical shift, shielding and deshielding effects, splitting of signals,
spin-spin coupling, proton exchange reactions, coupling constant(J), nuclear overhauser effect (NOE),
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CNMR spectra and its applications, 2D-NMR, COSY and applications in pharmacy.
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R19 M.PHARM PHARMACEUTICAL CHEMISTRY
REFERENCES:
1. Instrumental Methods of Chemical Analysis by B.K Sharma
2. Organic spectroscopy by Y.R Sharma
3. A Text book of Pharmaceutical Analysis by Kerrenth A. Connors
4. Vogel’s Text book of Quantitative Chemical Analysis by A.I. Vogel
5. Practical Pharmaceutical Chemistry by A.H. Beckett and J.B. Stenlake
6. Organic Chemistry by I. L. Finar
7. Organic spectroscopy by William Kemp
8. Quantitative Analysis of Drugs by D. C. Garrett
9. Quantitative Analysis of Drugs in Pharmaceutical Formulations by P. D. Sethi
10. Spectrophotometric identification of Organic Compounds by Silverstein
11. HPTLC by P.D. Seth
12. Indian Pharmacopoeia 2007
13. High Performance thin layer chromatography for the analysis of medicinal plants by Eike
Reich, Anne Schibli
14. Introduction to instrumental analysis by Robert. D. Braun
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R19 M.PHARM PHARMACEUTICAL CHEMISTRY
Course Objective: The topics which are present in the Drug regulatory affairs are very much useful
which increases the knowledge regarding the regulatory aspects in the pharmaceutical industries.
Course Outcome:
Students will come to know the different competent regulatory authorities globally.
Students be aware of technical aspects pertaining to the marketing authorization application
(MAA)
The regulatory guidelines and directions framed by the regulatory authorities will be helpful to
place the drug products in market for marketing approvals.
UNIT I
Drug Regulatory Aspects (India)
1. Indian drug regulatory authorities, Central and State regulatory bodies (FDA)
2. Drugs and Cosmmetics Act and Rules with latest Amendments (Selective)
3. Special emphasis – Schedule M and Y
4. New drugs – Importation, Registration, development, Clinical Trials, BE NOC & BE studies
5. Various Licences – Test Lic., Import lic., for testing of drugs and API’s, Manufacturing Contract
and Loan licence manufacturing.
UNIT II
Good Manufacturing Practices (GMP)
1. Indian GMP certification, WHO GMP certification.
2. ICH guidelines for stability testing and other relevant ones (Q1-Q10)
3. Export permissions and manufacturing for semi-regulated countries
4. Understanding of the plant layouts with special emphasis on the environment & safety (HVAC,
Water Systems, Stores Management, Effluent etc.)
5. Quality Assurance and Qulaity Control – Basic understanding for in-built quality.
UNIT III
A detailed study of regulatory aspects that affect drug product design, manufacture and distribution in
a developed country such as USA and in a developing country such as Brazil, Hatch Waxmann Act;
Bolar Provisions and other FDA Regulations. Regulatory aspects of pharmaceutical and bulk drug
manufacture, regulatory drug analysis.
UNIT IV
Documentation related to manufacturing, cleaning methods, retention samples and records, quality
control, batch release documents, distribution records, complaints and recalls.
Quality, safety and legislation for cosmetic products and herbal products.
UNIT V
Governing Regulatory Bodies across the globe.
Country Authority Submission
a. U.S Food & Drug Administration USDMF
b. Canada Therapeutic Product Directorate DMF
c. Europe
1) European Medicines Agency (EMEA/ National Authorities) EDMF
2) European Directorate for Quality of Medicines CEP/COS & Health Care Products.
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R19 M.PHARM PHARMACEUTICAL CHEMISTRY
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R19 M.PHARM PHARMACEUTICAL CHEMISTRY
Course Objective: The topics are framed to enhance the student’s knowledge in the various areas of
molecular modelling, molecular docking, pharmacophore concepts, drug design techniques with detail
concepts of all the mentioned areas.
Course Outcome: This enables the students to get a broad idea on the drug discovery mechanisms,
its related terms and concepts of designing of drugs.
UNIT - I
Molecular modelling: Molecuelar Mechanics, Quantum Mechanics, Energy minimization, geometry
optimization, conformational analysis, global conformational minima determination; approaches and
problems. Bioactive vs. Global minimum conformations. Automated methods of conformational
search. Advantages and limitations of available software. Molecular graphics. Molecular properties,
reactivity, Homo, Lumo, Electrostatic potential, Solvent accessible surface.
UNIT - II
Pharmacophore concept: Pharmacophore mapping, methods of conformational search used in
pharmacophore mapping. Comparison between the popular pharmacophore methods like
Catalyst/HipHop, DiscoTech, GASP with practical examples, 3D QSAR Techniques.
UNIT - III
Design of drugs for the following biological targets Agent acting on enzymes: DHFR, HIV-protease
HMG-CoA Reductase, Phosphodiesterase, ACE, Transpeptidase, β-lactamase. Agents acting on
receptors: PPAR, protein kinases. Agents acting on Nucleic acids: Topoisomerase, DNA and RNA
polymerase, HIV-Reverse transcriptase
UNIT - IV
Molecular docking: Rigid docking, flexible docking, manual docking. Advantages and disadvantages
of Flex-X, Flex-S, Autodock and Dock softwares, with successful examples. Molecular dynamics:
Dynamics of drugs, biomolecules, drug-receptor complexes, Monte Carlo simulations and Molecular
dynamics in performing conformational search and docking. Estimation of free energy from dynamical
methods.
UNIT - V
De Novo drug design techniques: Receptor/enzyme cavity size prediction. Predicting the functional
components of cavities, designing drugs fitting into cavity. Active site analysis structure – based drug
design. Informatics methods in drug design: Informatics methods in drug design: Brief introduction to
bioinformatics, chemoinformatics.
REFERENCES:
1. Robert GCK, ed., “Drug Action at the Molecular Level” University Prak Press Baltimore.
2. Martin YC. “Quantitative Drug Design” Dekker, New York.
3. Lien EJ. SAR “Side effects and Drug Design” Dekker, New York.
4. William H, Malick JB “Drug Discovery and Development” Humana Press Clifton.
5. Molecular Modelling, by A. R. Leach
6. Organic Chemistry of Drug Design and Drug Action, by R.B. Silverman
7. Practical Applications of computer aided drug design, by P.S. Charifson
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R19 M.PHARM PHARMACEUTICAL CHEMISTRY
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R19 M.PHARM PHARMACEUTICAL CHEMISTRY
Course Objective: This course is designed to impart knowledge on analysis of food constituents and
finished food products. The course includes application of instrumental analysis in the determination
of pesticides in variety of food products.
Course Outcome: At completion of this course student shall be able to understand various analytical
techniques in the determination of
Food constituents
Food additives
Finished food products
UNIT I
a. Carbohydrates: Classification and properties of food carbohydrates, General methods of
analysis of food carbohydrates,
b. Proteins: Chemistry and classification of amino acids and proteins, Physico-Chemical properties
of protein and their structure, general methods of analysis of proteins and amino acids
UNIT II
Probiotics: Definition, history, importance, mode of action, identification advantages and
disadvantages of probiotics. Applications of Probiotics
UNIT III
Lipids: Classification, general methods of analysis, refining of fats and oils; hydrogenation of
vegetable oils, Determination of adulteration in fats and oils.
UNIT IV
Vitamins: Classification of vitamins, methods of analysis of vitamins, Principles of microbial assay of
vitamins of B-series
UNIT V
b. General Analytical methods for milk, milk constituents and milk products like ice cream, milk
powder, butter, margarine, cheese including adulterants and contaminants of milk.
Pesticides in food
And also student shall have the knowledge on food regulations and legislations
TEXT BOOKS:
1. The chemical analysis of foods – David Pearson, Seventh edition, Churchill Livingstone,
Edinburgh London, 1976
2. Introduction to the Chemical analysis of foods – S. Nielsen, Jones & Bartlett publishers, Boston
London, 1994.
3. Official methods of analysis of AOAC International, sixth edition, Volume I & II, 1997.
4. Analysis of Food constituents – Multon, Wiley VCH.
5. Dr. William Horwitz, Official methods of analysis of AOAC International
6. 18th edition, 2005.Theory and Practice of Industrial Pharmacy by Lieberman and Lachman
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R19 M.PHARM PHARMACEUTICAL CHEMISTRY
REFERENCE BOOKS:
1. Remington’s Pharmaceutical Sciences by Alfonso and Gennaro
th
2. David Pearson. The Chemical Analysis of Foods, 7 ed., Churchill Livingstone, Edinburgh,
1976.
3. Nielsen S. Introduction to the chemical analysis of foods. Jones & Bartlett Publishers, Boston,
1974
4. Indian Pharmacopoeia 2012
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R19 M.PHARM PHARMACEUTICAL CHEMISTRY
Course Objective: The students will acquire the knowledge about the various aspects of X-Ray
diffraction methods, all types of IR methods, particle sizing methods, also DSC, DTA, TGA etc
Course Outcome: By the completion of topics the students will come out with the thorough
knowledge of various spectral aspects of X-Ray, IR, SEM, ORD etc which help them in further
projects works and also industrial opportunities.
UNIT - I
X-Ray diffraction methods: Origin of X-rays, basic aspects of crystals, X-ray crystallography, miller
indices, rotating crystal techniques, single crystal diffraction, power diffraction, structural elucidation
and applications.
UNIT - II
a) FT-NIR: Principle (overtones, combinations, fermi resonance, interferences etc.), instrumentation
(dispersion spectrometer and FT-NIR), advantage and disadvantage, qualitative and quantitative
applications, including PAT and non-destructive analysis.
b) ATR: Principle (total internal reflection, evanescent wave, etc.), instrumentation (ATR crystal, IR
beam), advantages and disadvantages, pharmaceutical applications.
UNIT - III
ELECTROMETRIC TECHNIQUES: Principle, instrumentation and applications of Potentiometer,
Amperometer, Conductometer and Polarography.
UNIT - IV
a) Spectroflourimetry: Theory of Fluorescence, Factors affecting fluorescence (Characteristics of
drugs that can be analysed by flourimetry), Quenchers, Instrumentation and Applications of
fluorescence spectrophotometer.
b) Flame emission spectroscopy and Atomic absorption spectroscopy: Principle,
Instrumentation, Interferences and applications.
UNIT - V
FT-Raman: Principle (absorption, diffraction, scattering and emission of wave, molecular
interaction), instrumentation (Dispersive Raman, FT-Raman), advantage and disadvantage,
pharmaceutical applications including detection of counterfeit
REFERENCES:
1. Instrumental Methods of Chemical Analysis by B.K Sharma
2. Organic spectroscopy by Y.R Sharma
3. A Text book of Pharmaceutical Analysis by Kerrenth A. Connors
4. Vogel’s Text book of Quantitative Chemical Analysis by A.I. Vogel
5. Practical Pharmaceutical Chemistry by A.H. Beckett and J.B. Stenlake
6. Organic Chemistry by I. L. Finar
7. Organic spectroscopy by William Kemp
8. Quantitative Analysis of Drugs by D. C. Garrett
9. Quantitative Analysis of Drugs in Pharmaceutical Formulations by P. D. Sethi
10. Spectrophotometric identification of Organic Compounds by Silverstein
11. HPTLC by P.D. Seth
12. Spectroscopy by Donald L Pavia, Gary M Lampman, George S Kriz, James A Vyvyan
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R19 M.PHARM PHARMACEUTICAL CHEMISTRY
Course Objectives:
To understand the research problem
To know the literature studies, plagiarism and ethics
To get the knowledge about technical writing
To analyze the nature of intellectual property rights and new developments
To know the patent rights
UNIT - I
Meaning of research problem, Sources of research problem, Criteria Characteristics of a good
research problem, Errors in selecting a research problem, Scope and objectives of research problem.
Approaches of investigation of solutions for research problem, data collection, analysis, interpretation,
Necessary instrumentations
UNIT - II
Effective literature studies approaches, analysis, Plagiarism, Research ethics
UNIT - III
Effective technical writing, how to write report, Paper Developing a Research Proposal, Format of
research proposal, a presentation and assessment by a review committee
UNIT - IV
Nature of Intellectual Property: Patents, Designs, Trade and Copyright. Process of Patenting and
Development: technological research, innovation, patenting, development. International Scenario:
International cooperation on Intellectual Property. Procedure for grants of patents, Patenting under
PCT.
UNIT-V:
Patent Rights: Scope of Patent Rights. Licensing and transfer of technology. Patent information
and databases. Geographical Indications. New Developments in IPR: Administration of Patent
System. New developments in IPR; IPR of Biological Systems, Computer Software etc. Traditional
knowledge Case Studies, IPR and IITs.
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R19 M.PHARM PHARMACEUTICAL CHEMISTRY
TEXT BOOKS:
1. Stuart Melville and Wayne Goddard, “Research methodology: an introduction for science
&engineering students’”
2. Wayne Goddard and Stuart Melville, “Research Methodology: An Introduction”
REFERENCES:
1. Ranjit Kumar, 2nd Edition, “Research Methodology: A Step by Step Guide for beginners”
2. Halbert, “Resisting Intellectual Property”, Taylor & Francis Ltd ,2007.
3. Mayall, “Industrial Design”, McGraw Hill, 1992.
4. Niebel, “Product Design”, McGraw Hill, 1974.
5. Asimov, “Introduction to Design”, Prentice Hall, 1962.
6. Robert P. Merges, Peter S. Menell, Mark A. Lemley, “Intellectual Property in New
Technological Age”, 2016.
7. T. Ramappa, “Intellectual Property Rights Under WTO”, S. Chand, 2008
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R19 M.PHARM PHARMACEUTICAL CHEMISTRY
REFERENCES:
1. Roth HJ, Kleemann A. Pharmaceutical Chemistry. Vol-I. Drug synthesis. New York: Ellis
Horwood Limited; 1988.
2. Mann FG, Saunders BC. Practical organic chemistry. 4th ed. New Delhi: Orient Longman;
2005.
3. Furniss BS, Hanaford AJ, Smith PWG, Tatchell AR. Vogel’s textbook of practical organic
chemistry. 5th ed. Singapore: Longman Singapore Publishers P Ltd; 1989.
4. Vogel A. Elementary practical organic chemistry. Part 1: Small scale preparations. 2nd ed.
New Delhi: CBS publishers and distributors; 2004.
th
5. Bansal RK. Laboratory manual of organic chemistry. 4 ed. New Delhi: New Age International
(P) limited; 2005.
6. Kar A. Advanced Practical Medicinal Chemistry. New Delhi: New Age International (P) limited;
2006.
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R19 M.PHARM PHARMACEUTICAL CHEMISTRY
List of Experiments:
1. Synthesis of any two drugs from the following classes of drugs (Minimum two from each
class)
a. Analgesics, NSAIDS and antipyretics
b. CNS and CVS drugs
2. QSAR Studies by using softwares
a. CoMFA – 3D QSAR method,
b. CODESSA,
c. descriptor software (all are free online sot wares) minimum of 3 experiments
3. Docking studies of drugs by using free online softwares like
a. AutoDock,
b. BLAST,
c. GPCR pred,
d. FASTA,
e. ATPINT,
f. Maestro,
g. ESLPRED2 (Minimum of 5 experiments)
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R19 M.PHARM PHARMACEUTICAL CHEMISTRY
Prerequisite: None
UNIT-I:
Planning and Preparation, Word Order, Breaking up long sentences, Structuring Paragraphs and
Sentences, Being Concise and Removing Redundancy, Avoiding Ambiguity and Vagueness
UNIT-II:
Clarifying Who Did What, Highlighting Your Findings, Hedging and Criticizing, Paraphrasing and
Plagiarism, Sections of a Paper, Abstracts. Introduction
UNIT-III:
Review of the Literature, Methods, Results, Discussion, Conclusions, The Final Check.
UNIT-IV:
key skills are needed when writing a Title, key skills are needed when writing an Abstract, key skills
are needed when writing an Introduction, skills needed when writing a Review of the Literature,
UNIT-V:
skills are needed when writing the Methods, skills needed when writing the Results, skills are needed
when writing the Discussion, skills are needed when writing the Conclusions. useful phrases, how to
ensure paper is as good as it could possibly be the first- time submission
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R19 M.PHARM PHARMACEUTICAL CHEMISTRY
Prerequisite: None
UNIT-I:
Introduction:
Disaster: Definition, Factors and Significance; Difference Between Hazard and Disaster; Natural and
Manmade Disasters: Difference, Nature, Types and Magnitude.
Disaster Prone Areas in India:
Study of Seismic Zones; Areas Prone to Floods and Droughts, Landslides and Avalanches; Areas
Prone to Cyclonic and Coastal Hazards with Special Reference to Tsunami; Post-Disaster Diseases
and Epidemics
UNIT-II:
Repercussions of Disasters and Hazards:
Economic Damage, Loss of Human and Animal Life, Destruction of Ecosystem. Natural Disasters:
Earthquakes, Volcanisms, Cyclones, Tsunamis, Floods, Droughts and Famines, Landslides and
Avalanches, Man-made disaster: Nuclear Reactor Meltdown, Industrial Accidents, Oil Slicks and
Spills, Outbreaks of Disease and Epidemics, War and Conflicts.
UNIT-III:
Disaster Preparedness and Management:
Preparedness: Monitoring of Phenomena Triggering A Disaster or Hazard; Evaluation of Risk:
Application of Remote Sensing, Data from Meteorological and Other Agencies, Media Reports:
Governmental and Community Preparedness.
UNIT-IV:
Risk Assessment Disaster Risk:
Concept and Elements, Disaster Risk Reduction, Global and National Disaster Risk Situation.
Techniques of Risk Assessment, Global Co-Operation in Risk Assessment and Warning, People’s
Participation in Risk Assessment. Strategies for Survival.
UNIT-V:
Disaster Mitigation:
Meaning, Concept and Strategies of Disaster Mitigation, Emerging Trends In Mitigation. Structural
Mitigation and Non-Structural Mitigation, Programs of Disaster Mitigation in India.
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R19 M.PHARM PHARMACEUTICAL CHEMISTRY
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R19 M.PHARM PHARMACEUTICAL CHEMISTRY
Prerequisite: None
Course Objectives:
To get a working knowledge in illustrious Sanskrit, the scientific language in the world
Learning of Sanskrit to improve brain functioning
Learning of Sanskrit to develop the logic in mathematics, science & other subjects enhancing
the memory power
The engineering scholars equipped with Sanskrit will be able to explore the huge knowledge
from ancient literature
UNIT-I:
Alphabets in Sanskrit,
UNIT-II:
Past/Present/Future Tense, Simple Sentences
UNIT-III:
Order, Introduction of roots,
UNIT-IV:
Technical information about Sanskrit Literature
UNIT-V:
Technical concepts of Engineering-Electrical, Mechanical, Architecture, Mathematics
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R19 M.PHARM PHARMACEUTICAL CHEMISTRY
Prerequisite: None
UNIT-I:
Values and self-development –Social values and individual attitudes. Work ethics, Indian vision of
humanism. Moral and non- moral valuation. Standards and principles. Value judgements
UNIT-II:
Importance of cultivation of values. Sense of duty. Devotion, Self-reliance. Confidence, Concentration.
Truthfulness, Cleanliness. Honesty, Humanity. Power of faith, National Unity. Patriotism. Love for
nature, Discipline
UNIT-III:
Personality and Behavior Development - Soul and Scientific attitude. Positive Thinking. Integrity and
discipline, Punctuality, Love and Kindness.
UNIT-IV:
Avoid fault Thinking. Free from anger, Dignity of labour. Universal brotherhood and religious
tolerance. True friendship. Happiness Vs suffering, love for truth. Aware of self-destructive habits.
Association and Cooperation. Doing best for saving nature
UNIT-V:
Character and Competence –Holy books vs Blind faith. Self-management and Good health. Science
of reincarnation, Equality, Nonviolence, Humility, Role of Women. All religions and same message.
Mind your Mind, Self-control. Honesty, Studying effectively
25
R19 M.PHARM PHARMACEUTICAL CHEMISTRY
Prerequisite: None
UNIT-I:
History of Making of the Indian Constitution: History Drafting Committee, (Composition &
Working), Philosophy of the Indian Constitution: Preamble, Salient Features.
UNIT-II:
Contours of Constitutional Rights & Duties: Fundamental Rights Right to Equality, Right to
Freedom, Right against Exploitation, Right to Freedom of Religion, Cultural and Educational Rights,
Right to Constitutional Remedies, Directive Principles of State Policy, Fundamental Duties.
UNIT-III:
Organs of Governance: Parliament, Composition, Qualifications and Disqualifications, Powers and
Functions, Executive, President, Governor, Council of Ministers, Judiciary, Appointment and Transfer
of Judges, Qualification, Powers and Functions.
UNIT-IV:
Local Administration: District’s Administration head: Role and Importance, Municipalities:
Introduction, Mayor and role of Elected Representative, CEO of Municipal Corporation. Pachayati raj:
Introduction, PRI: Zila Pachayat. Elected officials and their roles, CEO Zila Pachayat: Position and
role. Block level: Organizational Hierarchy (Different departments), Village level: Role of Elected and
Appointed officials, Importance of grass root democracy.
UNIT-V:
Election Commission: Election Commission: Role and Functioning. Chief Election Commissioner
and Election Commissioners. State Election Commission: Role and Functioning. Institute and Bodies
for the welfare of SC/ST/OBC and women.
26
R19 M.PHARM PHARMACEUTICAL CHEMISTRY
27
R19 M.PHARM PHARMACEUTICAL CHEMISTRY
Prerequisite: None
UNIT-I:
Introduction and Methodology: Aims and rationale, Policy background, Conceptual framework and
terminology Theories of learning, Curriculum, Teacher education. Conceptual framework, Research
questions. Overview of methodology and Searching.
UNIT-II:
Thematic overview: Pedagogical practices are being used by teachers in formal and informal
classrooms in developing countries. Curriculum, Teacher education.
UNIT-III:
Evidence on the effectiveness of pedagogical practices, Methodology for the indepth stage: quality
assessment of included studies. How can teacher education (curriculum and practicum) and the scho
curriculum and guidance materials best support effective pedagogy? Theory of change. Strength and
nature of the body of evidence for effective pedagogical practices. Pedagogic theory and pedagogical
approaches. Teachers’ attitudes and beliefs and Pedagogic strategies.
UNIT-IV:
Professional development: alignment with classroom practices and follow-up support, Peer support,
Support from the head teacher and the community. Curriculum and assessment, Barriers to learning:
limited resources and large class sizes
UNIT-V:
Research gaps and future directions: Research design, Contexts, Pedagogy, Teacher education,
Curriculum and assessment, Dissemination and research impact.
28
R19 M.PHARM PHARMACEUTICAL CHEMISTRY
29
R19 M.PHARM PHARMACEUTICAL CHEMISTRY
Prerequisite: None
Course Objectives:
To achieve overall health of body and mind
To overcome stress
UNIT-I:
Definitions of Eight parts of yog. (Ashtanga)
UNIT-II:
Yam and Niyam.
UNIT-III:
Do`s and Don’t’s in life.
i) Ahinsa, satya, astheya, bramhacharya and aparigraha
ii) Shaucha, santosh, tapa, swadhyay, ishwarpranidhan
UNIT-IV:
Asan and Pranayam
UNIT-V:
i) Various yog poses and their benefits for mind & body
ii) Regularization of breathing techniques and its effects-Types of pranayam
30
R19 M.PHARM PHARMACEUTICAL CHEMISTRY
UNIT-I:
Neetisatakam-Holistic development of personality
Verses- 19,20,21,22 (wisdom)
Verses- 29,31,32 (pride & heroism)
Verses- 26,28,63,65 (virtue)
UNIT-II:
Neetisatakam-Holistic development of personality
Verses- 52,53,59 (dont’s)
Verses- 71,73,75,78 (do’s)
UNIT-III:
Approach to day to day work and duties.
Shrimad Bhagwad Geeta: Chapter 2-Verses 41, 47,48,
Chapter 3-Verses 13, 21, 27, 35, Chapter 6-Verses 5,13,17, 23, 35,
Chapter 18-Verses 45, 46, 48.
UNIT-IV:
Statements of basic knowledge.
Shrimad Bhagwad Geeta: Chapter2-Verses 56, 62, 68
Chapter 12 -Verses 13, 14, 15, 16,17, 18
Personality of Role model. Shrimad Bhagwad Geeta:
UNIT-V:
Chapter2-Verses 17, Chapter 3-Verses 36,37,42,
Chapter 4-Verses 18, 38,39
Chapter18 – Verses 37,38,63
31