Critical Cleaning Experts

CRITICAL CLEANING GUIDE

How to select and use detergents for critical cleaning applications

Pharmaceutical & Biotechnology Medical Device Manufacturing Healthcare & Veterinary Devices Passivation Laboratory Environmental

Electronics & Photovoltaic Precision Manufacturing Optics Food & Beverage Manufacturing Restaurant & Food Service Cosmetics

I
Inside Solving critical cleaning problems
for more than 70 years
Pharmaceutical & Biotechnology 1
This guide gives you the benefit of our more than half-century of experience—
Medical Device Manufacturing 2 including a method-by-method review of critical cleaning procedures, and a
selection matrix to identify the right Alconox Inc. detergent for your application.
Healthcare, Veterinary &
3
Medical Device Reprocessing Get started with Alconox:
Passivation 4 • Free Samples: Receive free samples of Alconox Inc. detergents and/or
The Aqueous Cleaning Handbook.
Laboratory 5 • Purchase: Alconox Inc. detergents are available from leading healthcare,
laboratory and industrial suppliers. See our website for U.S. and international
Environmental 6 distributors.
Electronics & Photovoltaic 7 • Support: Call our Technical Service Department for consultation on your
cleaning problems.
Precision Manufacturing 8 • Online Information: Technical bulletins and Material Safety Data Sheets.
Certificates of analysis. Cleaning validation references. Inhibitory residue test
Optics 9 and lab accreditation (CAP/NELAP) info. Chinese, French, German, and Spanish
language support.
Food, Beverage Manufacturing &
10
Water Purification
++914.948.4040 | [email protected] | alconox.com
Restaurant & Food Service 11

Cosmetics 12

Detergent Selection Guide 13

ALCONOX®, ALCOJET®, ALCOTABS®, CITRAJET®, CITRANOX®, DETERGENT 8®, DETOJET®, DETONOX®, LUMINOX®,
Directions for Using Alconox Cleaners 14 LIQUINOX®, SOLUJET®, TERGAZYME®, and TERGAJET® are registered trademarks of Alconox Inc. ©2016 Alconox Inc.

Optimizing Your Cleaning Process 16

II
PHARMACEUTICAL & BIOTECHNOLOGY
Handle tough critical cleaning jobs, from tablet presses to mixing tanks

If you have pharmaceutical or biotechnology production machinery that must be

clean and free of interfering residues, Alconox Inc. has an acidic, neutral or alkaline
biodegradable detergent for the job, including meeting applicable disposal requirements.
Whether your process is manual, immersion or circulate CIP, almost any glass, plastic,
metal, rubber or porcelain surface can be safely, effectively and economically cleaned
with an Alconox Inc. detergent.
Alconox Inc. detergents are available worldwide with consistent formulations, certifi
cates of analysis, ingredient toxicity data, shelf life information, residue sampling
techniques, ingredients disclosure, analytical methods, lot number tracking, and
validation support. Customer support also can include cooperation with audits and
vendor questionnaires.
Clean all processing surfaces, difficult residues and types
of processing equipment
Manual, Soak, Ultrasonic Machine Washer, Spray, Clean in Place (and combined manual) Before:
Equipment to Clean Contaminants Recommended Equipment to Clean Contaminants Recommended Coating residue from
Detergent Detergent pharmaceutical tablet
Acid-Labile Compounds Acid-Labile Compounds presses and packaging
Capsule Granulators Amines Bicarbonates Capsule fillers Granulators Amines Bicarbonates
Fillers Kettles Alkaloids Metal Complexes Centrifuges Kettles Alkaloids Metal Complexes
equipment can be tough
Centrifuges Mills CITRANOX Comminuters Mills CITRAJET to clean.
Amphoteric Metal Oxides or Amphoteric Metal Oxides or
Comminuters Mixers Proteins Hydroxides Compactors Mixers Proteins Hydroxides
Compactors Reactors Starches Eudragit* Conveyors Reactors Starches Eudragit*
Conveyors Tablet (E/RL/RS/E100) Dryers Tablet (E/RL/RS/E100) After:
Carbonates Carbonates
Dryers Punches & Coatings Filling lines Punches & Coatings Tablet presses and
Filling lines Dies Dies
Filters packaging equipment
Filters Emulsified or Base-Labile ALCONOX
Compounds Powder Base-Labile Compounds cleaned with CITRANOX
ALCOJET
Oils Organic Acids Oils Titanium Dioxide Powder meet stringent
Fats Acid Salts Fats Petrolatum pharmaceutical cleaning
Greases Steroids Greases Some Proteins
Alcohols N-heterocyclics LIQUINOX Alcohols Amino Acids
validation standards.
Amino Acids Eudragit* Liquid SOLUJET
(E/RL/RS/100) Eudragit* Phosphates Liquid
Some Proteins
Polyols Coatings (L/S/L30/D55/NE30D) Organic Acids
Titanium Dioxide Coatings Acid Salts
Troubleshooting and Validation Services
Phosphates
Petrolatum Contact Alconox Inc. for critical cleaning,
residue-interference troubleshooting, and
Protease Labile Compounds cleaning-validation assistance services.
Eurdragit is a ® trademark
of Toehm GmbH & Co.
Proteins Biowastes
TERGAZYME ++914.948.4040 | [email protected]
Biofilms Fermentation
Residues
1
MEDICAL DEVICE MANUFACTURING
Effectively clean medical equipment to critical regulated standards
Manufactured medical devices for human or veterinary health often must be cleaned to
implantable standards during manufacturing. Alconox Inc. cleaners are expressly formulated to get
these products critically clean without leaving interfering residues, whether the product is for
biomechanical or electronic use.
Before:
Medical devices such as
the prosthetic hip joint
shown here must be
critically pre-cleaned prior
to coating and packaging.

After:
Swab tests validate
successful cleaning ALCONOX cleaners for medical equipment manufacturing applications
with ALCONOX-brand
detergents. Manual/Ultrasonic or Spray Cleaning Special-Case Plastics
Recommended Recommended
Equipment to Clean Contaminants Process Detergent Equipment to Clean Contaminants Process Detergent

Stainless Steel Dye Penetrants Manual/ ALCONOX

Powder Acrylic Coolants
Cobalt Chrome Coolants Ultrasonic
Polycarbonate Particulates All Cleaning
Titanium Buffing Rouge Processes
Aluminum Compounds LIQUINOX Other Plastics Oils DETOJET
Pressure/ Liquid Subject to
Composites Tapping Oils Spray Fingerprints
Stress Cracking
Most plastics Contaminating Low Foam
Residues SOLUJET

Manual/Ultrasonic or Spray Cleaning

Recommended
Equipment to Clean Contaminants Process Detergent
Manual/
Die Penetrants Ultrasonic
CITRANOX
Coolants
Aluminum Buffing Rouge
Brass Compounds Pressure/
Spray
Copper Tapping Oils
Low Foam
Contaminating CITRAJET
Residues

2
HEALTHCARE, VETERINARY & MEDICAL DEVICE REPROCESSING
Meet the most demanding criteria for effective cleaning of reusable instruments
and equipment prior to sterilization
Healthcare cleaning procedures are intended to keep instruments and equipment clean and
ready for sterilization, prolong their working life, minimize cross-contamination and reduce
medical waste.
Before:
When proteinaceous soils such as blood or mucus must be removed, Blood dried onto scalpel
adding an enzyme to the detergent formula allows instruments to clean handles is difficult to
thoroughly remove.
via soaking and gentle cleaning, rather than by abrasive scrubbing. This
prolongs their working life and decreases the chance of microbial contamination. Corrosion After:
inhibited detergents give effective low-foam cleaning in automated washers and cage washers. Soaking in TERGAZYME,
followed by gentle
cleaning, prepares surgical
The right cleaner for every medical device reprocessing application instruments for effective
sterilization and prolongs
Manual, Ultrasonic, Soak Animal Cage Cleaning instrument life.
Recommended Recommended
Equipment to Clean Contaminants Process Detergent Equipment to Clean Contaminants Method Detergent
Manual, Manual, Soak
Reprocessed ALCONOX Organic Bioresidues TERGAZYME
Ultrasonic, Powder
Medical Devices Soak Feces
Cage Washer
Biological/ Animal Cages Blood, Tissue
Surgical and DETOJET
Proteinaceous and Equipment
Examining LIQUINOX
Soils Liquid
Equipment
Endoscopes Enzymatic Manual, Soak
Soak CITRANOX
Dental Equipment
Manual/ TERGAZYME Urine Scale Cage Washer
Ultrasonic
CITRAJET
Automatic Washers and Spray Rinse
Recommended
Contaminants Process Method Detergent
Detergent ALCOJET
Small undercounter
washers with Powder
Biosoils
powder dosing cup Acid Troubleshooting and Validation Services
Blood CITRAJET
Tissue Liquid Contact Alconox Inc. for critical cleaning,
Body Fluids Larger washers residue-interference troubleshooting, and
etc. with liquid dosing Detergent CITRAJET
cleaning-validation assistance services.
systems SOLUJET Acid Rinse ++914.948.4040 | [email protected]

3
PASSIVATION
Using acid to protect stainless steel parts from corrosion
Passivation is the process of forming a passive layer of chromium oxide on the surface of stainless
steel to protect it from corrosion. This is done by adding a chemical that removes free iron and
allows chromium oxide to form. The reference for passivation of stainless steel is ASTM A967. See
the Critical Cleaning Procedures section of this guide for passivation tests.
Before:
Oven parts show corrosion
and structural issues,
in part from excessive
chloride in water supply. CITRANOX and CITRAJET for passivation applications—
safety, efficacy and ease of use
After: • May be used at a 30% concentration in water at a temperature of 140 degrees F for 20–30
Cleaning with CITRAJET minutes
has removed corrosion
and repassivated internal
• Exact conditions will vary depending upon the type of stainless steel and surface finishing
oven parts. • Recommended for manual soaking or soaking in an ultrasonic tank
• If applied by a spray system where there is agitation of the air, CITRAJET
should be used at the same conditions listed for CITRANOX
• Much safer and effective than using nitric acid formulations
for passivation

4
LABORATORY
Clean and prolong the life of reusable labware, while eliminating residues
Laboratory procedures can be compromised by interfering residues that prevent reliable results. At the same
time, labware and instrumentation budgets are wasted by cleaners that etch, cloud or damage labware
surfaces. Alconox Inc. detergents remove interfering residues without causing equipment deterioration—even
when handling tough proteinaceous soils or radioisotope decontamination.
Formulated for all lab cleaning applications, Alconox, Inc. products work effectively and economically without Before:
the hazards of strong acids and solvents, and they are free rinsing, corrosion inhibiting and biodegradable. Dirt, bacteria, reagents,
Alconox, Inc. cleaners
Alconox Inc. cleaners meet
meet state
state requirements
requirements for
for lot-specifi
lot-specific inhibitory residue tests, and are supported with reaction products and
residues can stick to lab
rinse-water detection methods for accreditation per the College of
glassware.
American Pathologist (CAP) inspection questionnaire.
See www.alconox.com for more information. After:
LIQUINOX gets laboratory
soils out, leaving no
Alconox cleaners handle everything from lab glassware interfering residue.
to ceramics and metal Surfaces stay clear, clean
and readable.
Manual Lab Washing
Recommended
Equipment to Clean Contaminants Detergent

Glassware Organics, Oils, Fats, LIQUINOX

Solvents, etc. Liquid
Tissue Cultureware
Stainless Steel
Instruments ALCONOX
Inorganics, Salts, Powder
Sampling Apparatus
Metal Complexes,
Tubing Oxides, and Acid
CITRANOX

Machine Washing
Equipment to Clean Contaminants Process Recommended Detergent

Small Washer ALCOJET CITRAJET

Glassware Acid Rinse
Automatic Siphon Pipet Washer
Tissue Cultureware Troubleshooting and Validation Services
Stainless Steel Equipment to Clean Process Recommended
Lab-Generated Large CITRAJET Detergent Contact Alconox Inc. for critical cleaning,
Instruments Contaminants Acid Rinse Automatic Siphon
Washer with
Pipette Washer residue-interference troubleshooting, and
Sampling Apparatus Liquid-Dosing Pipettes & Tubes ALCOTABS cleaning-validation assistance services.
Tubing System SOLUJET
++914.948.4040 | [email protected]

5
ENVIRONMENTAL
The practical, safe choice for cleaning field sampling equipment without
cross-contamination
Accurate environmental testing of ground or surface water, soil or sediment requires the use of clean
instruments, free of cross-contamination. From delicate pH meter probes to bailers, split-spoon
ow-throughcells,
samplers, augers, dredges and flow-through cells,each
eachrequires
requiresthe
theappropriate
appropriateprocess
process
Before: and detergent. Alconox
Alconox,Inc.
Inc.aqueous
aqueousdetergents
detergentshelp
helpmaintain
maintainthe
thelevel
levelofoftesting
testingaccuracy
accuracyrequired
Environmental field tests required by EPA guidelines—without
by EPA guidelines—without the risks the
andrisks and associated
hazards hazards associated with solvents.
with solvents. The The
subject equipment to following equipment is subject to laboratory detergent cleaning guidelines:
chemically aggressive
• Automatic wastewater sampling equipment
environments.
• Silastic rubber pump tubing
After: • Sounders for measuring ground-water levels
Mass-spec equipment • Submersible pumps and hoses for purging ground-water wells
blanks show LIQUINOX • Portable augers
leaves no interfering trace • All miscellaneous sampling and flow-measuring equipment
levels of contaminants.
Specifically, United States EPA Environmental Services Division
standard cleaning procedures require a “phosphate-free laboratory
detergent such as LIQUINOX” for Teflon®, glass and stainless steel
equipment used to sample trace organic compounds or metals.

ALCONOX environmental cleaning products for field and lab applications

LIQUINOX • High-emulsifying phosphate-free formulation, with a unique blend of free-rinsing ingredients

• No post-rinse contaminating residues; no interference with phosphate-sensitive analytical equipment
• Convenient handling—small quantities can be safely disposed of after use without special procedures
or precautions
SOLUJET TERGAJET • Reliable results in laboratory dishwasher cleaning of sampling equipment and containers
Liquid Powder
• Phosphate-free
CITRAJET • Tergajet for under-counter washers with powder cup dosing
Acid Rinse
• Solujet for larger washers with liquid dosing systems
TERGAZYME • Recommended for samples containing biological contamination

6
ELECTRONICS & PHOTOVOLTAIC
High-performance aqueous cleaners for exacting electronic applications—
without hazardous chemicals or volatile solvents
The bottom-line requirement when cleaning circuit boards, electronic
parts or assemblies is that the cleaning method can not leave any
conductive residues. For example, in circuit board fabrication, a typical
check for impurities may employ an omega-meter or iconography Before:
Oils, resins, rosins and
to detect metal salts in the board rinse water. Boards cleaned with
flux contaminate soldered
DETERGENT 8 and rinsed with deionized water meet this exacting connections on printed
standard of cleanliness. circuit boards.

After:
DETERGENT 8 de-fluxes
and removes ionic
contamination without the
problems associated with
CFCs or solvents.

ALCONOX detergents: No conductive residues.

No environmental footprint.

Electronic Components and Assemblies Photovoltaic Panels

Materials to Clean Contaminants Process Recommended Materials to Clean Contaminants Recommended
Detergent Detergent
Glass substrates Manufacturing
Manual/
before diachronic Ultrasonic Oils DETOJET
coating of electronic Oils Debris
parts Thin Film
Resins
Infrared detectors Monocrystalline
Rosins
during manufacturing DETERGENT 8 In the Field
Flux Polycrystalline Troubleshooting and Validation Services
and assembly
Environmental
Electrical contacts Conductive
Contaminants LIQUINOX Contact Alconox Inc. for critical cleaning,
Residues
and leads Spray
Dirt
residue-interference troubleshooting, and
Ceramic insulators cleaning-validation assistance services.
and components Oils
++914.948.4040 | [email protected]

7
PRECISION MANUFACTURING
Alconox detergents work without solvents or strong acids

In precision manufacturing, surfaces free of interfering

Alconox Inc.
residues are critical to processes and quality. Alconox, Inc.
detergents provide manufacturers easy-to-use, biodegradable
agents for precision manufacturing applications such as
Before:
cleaning oil from machine rollers, removing mold-release
Brass forgings corrode
and lose their bright agents from plastic parts, cleaning stampings and castings,
appearance unless they’re and many more. Almost any glass, plastic, metal, rubber, or
bright-dipped. porcelain surface can be safely, effectively and economically
cleaned with an Alconox Inc. detergent.
After:
CITRANOX cleans,
removes corrosion and
brightens metal surfaces
without the disposal
problems associated with
solvents.

Alconox cleaners for applications from plasma

lasers to aluminum parts

CITRAJET
• Cuts through surface oils to brighten and remove
oxides, scales and corrosion from brass, copper, and stainless steel

CITRANOX • Removes everything from cutting oils to trace impurities from precision parts, brightens brass, copper, and
stainless steel

DETONOX
• Ultimate surfactant system for manual oil removal
• Rinses freely to an interfering residue-free surface

LUMINOX
• Use for cleaning aluminum in parts washers

SOLUJET
• Superior surfactant system for high-efficiency oil removal
• Rinses freely to an interfering residue-free surface
8
OPTICS
Ensuring the accuracy of data acquired through optical devices

Alconox Inc.
Alconox, Inc. cleaning
cleaning agents
agents meet
meet the
the two
two key
key criteria
criteria for
for optical
optical
applications. First, they contain no abrasive substances that could 90
90

damage glass or quartz surfaces. Second, Alconox,

Alconox Inc. detergents 88
88
86
86

leave no residues to affect light transmission or spectral sensitivity.

(%)
(%)
84

REFLECTANCE(%
84

REFLECTANCE
82
82
Before:
Alconox Inc.
Alconox, Inc. products
products have
have been
been successfully
successfully used
used inin aa wide
wide range
range

REFLECT
80
80
78
78 Reflectance of calibrating

HEMISPHERICAL
of optical industries and applications, such as cleaning the fiber-opticber-

HEMISPHERICAL
76
76
74
74 screen in the ultra-violet
optic glass
glass for endoscopes
for endoscopes and borescopes,
and borescopes, removing
removing liquid liquid
monomers 72
72
70
70350
to the near-infrared region
450 550 650 750 850 950 1050 1150 1250

monomers
used in the used in the manufacture
manufacture of microscope
of microscope and telescope
and telescope
350 450 550 650 750 850 950 1050 1150 1250

90
WAVELENGTH (NANOMETERS)
WAVELENGTH (NANOMETERS)
WA
before cleaning with
lenses, and cleaning calibration screens in light- LIQUINOX.
90
88
88
86
86

detection instruments.

(%)
(%
ANCE(%)
84
84

REFLECTANCE
HEMISPHERICALREFLECTANCE
82
82
After:

REFLECT
80
80
78
78 After cleaning with

HEMISPHERICAL
76
76
74
74
72
LIQUINOX, the material
shows no adverse
72
70
70350 450 550 650 750 850 950 1050 1150 1250
350 450 550 650 750 850 950 1050 1150 1250

change in hemispherical
WA
WAVELENGTH (NANOMETERS)
WAVELENGTH (NANOMETERS)

reflectance or change in
wavelength.

Alconox detergents for maintaining the performance

of sensitive optics in manual, soak and ultrasonic cleaning

ALCONOX • Free-rinsing, with no abrading compounds

Powder
• Clean without leaving films, oils or other data-corrupting residues
LIQUINOX • Prolong the life of costly equipment through repeated cleanings
Liquid

CITRANOX • Mild acid removal of metal oxides

Troubleshooting and Validation Services
Contact Alconox Inc. for critical cleaning,
residue-interference troubleshooting, and
cleaning-validation assistance services.
++914.948.4040 | [email protected]

9
FOOD, BEVERAGE & WATER PURIFICATION
Maintain sanitary processing conditions in accordance with stringent guidelines
Critical cleaning of food, beverage and dairy processing equipment has a direct impact on
the quality of food and beverage products. Alconox,
Alconox Inc.
Inc. food-grade
food-grade cleaners
cleaners are
are effective
effective for
for
cleaning and prolonging the service life of food processing equipment—including difficult
food-grade dairy cleaning, or UF and RO installations.
Before: Alconox, Inc.detergents
Alconox Inc. detergentsare
areauthorized
authorizedbybythe
theUnited
UnitedStates
StatesDepartment
DepartmentofofAgriculture
Agriculture
Reverse osmosis
membranes must be
(USDA) for use in federally inspected meat and poultry plants. And many food and beverage
cleaned to yield required beverage
processorsprocessors preferInc.
prefer Alconox Alconox, Inc. detergents
detergents for their
for their ability ability to
to remove removemeat
stubborn stubborn
and milk
flow-through rates without soils without leaving interfering residues.
contaminating food
products.
From pilot labs to full production, packaging and bottling, Alconox manual, automatic and
clean-in-place detergents help food, dairy and beverage processors maintain product
After: purity to agar-plate-proven standards, increase throughput and improve profitability.
After cleaning with
TERGAZYME, diaphragm Helping achieve higher yields with less waste
shows required drop in
Food Processing Equipment
pressure differential and
Recommended
increased permeation flow. Equipment to Clean Contaminants Process Detergent
Filtration Processes
Slicers Sight ALCONOX
Powder Recommended
Food Gauges Manual Equipment to Clean Contaminants Process Detergent
Oils
Extruders Piping
Organic Manual
Mixers Glassware Compounds RO and UF
LIQUINOX
Grinders Other Meat and Liquid Filtration Protein Deposits
Wrappers Food- Protein Soils Pressure Filtered Milk
Contact Spray Biofilm TERGAZYME
Food Purified Water
Equipment DETOJET
Tables
Low-Pressure Pumping

Dairy Processing Equipment Sodas, Teas, Sport & Other Drinks

Recommended Recommended
Equipment to Clean Contaminants Process Detergent Equipment to Clean Contaminants Process Detergent

Piping Manual Piping ALCONOX

Glassware CITRANOX Glassware
Powder
Acids Manual
Tanks Milkstone Tanks Sugars
Pumps Calcium Scale Pressure Pumps Manufacturing LIQUINOX
Liquid
Bottlers Spray Bottlers Residuals Pressure
Other Equipment
CITRAJET Other Equipment Spray
DETOJET

10
RESTAURANT & FOOD SERVICE
The right recipe for effectively solving
critical restaurant cleaning challenges
From quick service restaurants to wine tasting rooms, when
restaurant owners, managers, chefs, and culinary school
managers are faced with a stubborn cleaning issue, they Before:
put in an order for Alconox Inc. cleaners. Fryer shows excessive
carbon build up and
Alconox Inc. detergents ensure food service providers with stubborn oil residues.
reliable and consistent results in easy-to-use and safer formulas.

After:
Cleaning with ALCONOX
easily removes both
Alconox, Inc. cleaners deliver powerful and reliable results using safer, gentler formulas carbon and oil-degrading
residues.
Cooking Equipment Raw Protein
Recommended Recommended
Equipment to Clean Contaminants Process Detergent Equipment to Clean Contaminants Process Detergent

Soak or ALCONOX Raw Meat

Manual Countertops
Fryers Oils Cleaning Proteinaceous Manual
Cookware Food Prep Areas Biological TERGAZYME
Food-prep Carbon Floors and Walls Microbial
Equipment Heavy-duty
Soak,
Manual or ALCOJET
Spray Wash

Scale, Starch and Milkstone Fine Glassware

Recommended Recommended
Equipment to Clean Contaminants Process Detergent Equipment to Clean Contaminants Process Detergent

Manual Wine Residues and Hand Wash

Rethermalizer Water Spots CITRANOX Wine Glasses LIQUINOX
Sediment Alconox Foodservice Solutions
Pasta Cookpot Scale Flutes Food Residues Visit www.AlconoxFoodService.com
Holding Cabinet Starch Carafes
Steamer
Fats and Oils Automated to learn about our full line of foodservice
Milkstone Spray Decanters Fingerprints Wash products and applications with easy-to-use
Stainless Steel Corrosion CITRAJET Barware Lipstick ALCOJET
instructions and videos.
Water Spots
11
COSMETICS
Shorten cleaning time for silicon, titanium dioxide and other
hard-to-clean residues
Concentrated for economical use, Alconox Inc. detergents
make critical cleaning for cosmetic applications faster,
easier and more efficient. Whether you’re scrubbing
Before:
Titanium dioxide and other
1,500-gallon kettles or wrestling with plastic tubes
cosmetic ingredients can and fillers, proven detergents such as CITRANOX,
be tough to remove from TERGAZYME, and ALCONOX wash away the most
stainless steel kettles. tenacious materials without leaving residues.

After: Our experts can help you improve your cleaning

SOLUJET removes procedures, install new procedures, eliminate cross-
titanium oxides ensuring contamination and ensure compliance with FDA
clean surfaces for your standards. Whatever your cosmetic-related cleaning
next batch. problem, Alconox Inc. can help you solve it.

Shorten or eliminate manual scrubbing times with Alconox cleaners

Cosmetics Cleaning Processes Special Applications

Recommended Recommended
Equipment to Clean Contaminants Process Detergent Contaminants Process Detergent
Cold Spray CIP
Kettles ALCONOX Titanium Dioxide (TiO2) 5% SOLUJET
Powder
Mills Suntan Lotions Manual
Mixers Cremes Cold Spray CIP
Ointments DETONOX Zinc Oxide (ZnO) 5% CITRAJET
Feeders Liquid
Pumps Powders Pressure
Tubes Mascara Spray/CIP Manual/Soak/Ultrasonic
SOLUJET Proteinaceous Materials TERGAZYME
Fillers
Presses
Glassware

12
DETERGENT SELECTION GUIDE
INDUSTRY/APPLICATION KEY CONCERNS ARTICLES CLEANED/SOIL REMOVED CLEANING METHOD CLEANER: Powder Liquid
Healthcare/Veterinary Surgical, anaesthetic, and examining instruments and equipment. Catheters and tubes. Manual, Ultrasonic, Soak ALCONOX LIQUINOX
Effective preparation for sterilization, longer Machine washer, sani-sterilizer ALCOJET DETOJET
instrument life. Reduce waste.
Blood, body fluids, tissue on instruments. Manual, Ultrasonic, Soak TERGAZYME
Pharmaceutical/Medical Device/ Titanium dioxide, petrolatum, oils, emulsions, ointments, carbopols, lacquers, zinc oxides, Manual, Ultrasonic, Soak ALCONOX LIQUINOX
Biotechnology proteins, steroids, alcohols, sugars, and Eudragit* (L/S/L30/D55/NE30D) polymers. Machine washer, power wash, CIP ALCOJET SOLUJET
Passing cleaning validation for FDA good TERGAJET (p-free)
manufacturing practices. For stainless steel,
glass, plastic, elastomer cleaning. Inorganic residues, salts, metallics, pigments. Eudragit* (E/RL/RS/E100) polymers, Manual, Ultrasonic, Soak CITRANOX
amphoterics, coatings, amines, ethers, starches, alkaloids. Machine washer, power wash, CIP CITRAJET
Protein/ferment residues. R/O, U/F membranes. Manual, Ultrasonic, Soak TERGAZYME SOLUJET
Laboratory/Environmental Glass, metal, plastic labware, ceramics, tissue culture, porcelain, clean rooms, animal Manual, Ultrasonic, Soak ALCONOX LIQUINOX (p-free)
Reproducible results, no interfering residues, cages, bioreactors, tubing, benches, safety equipment. Machine, power spray, labware washer, ALCOJET DETOJET
extending equipment life. Keep laboratory washer-sterilizer, cage-washers TERGAJET (p-free) SOLUJET (p-free)
accreditation. Laboratory safety.
Tubes, reusable pipets. Siphon-type washer-rinsers ALCOTABS (tablet)
Microbiology, water lab, and environmental sampling. Phosphate-sensitive labware. Field, Manual, Ultrasonic, Soak TERGAJET LIQUINOX
EPA procedures. (Acid for water rinse cycle.) Machine washer, labware washer TERGAJET SOLUJET-base
CITRAJET-acid
Radioactive equipment/contaminants. Stopcock grease. Manual, Ultrasonic, Soak ALCONOX LIQUINOX
Machine washer, warewasher ALCOJET SOLUJET
Trace metals, metal oxides, scale, salts, starches, amines. Manual, Ultrasonic, Soak CITRANOX
Machine washer, warewasher CITRAJET
Proteinaceous soils, bio-wastes, tissue, blood and other body fluids, fermentation residues. Manual, Ultrasonic, Soak TERGAZYME
Glassware washer ALCOJET SOLUJET
Metalworking/Precision Manufacturing/ Glass, ceramic, porcelain, stainless steel, plastic, rubber. Oils, chemicals, particulates. Manual, Ultrasonic, Soak ALCONOX LIQUINOX (p-free)
Optics DETONOX
Clean parts, avoid volatile solvents, strong acids, Machine washer, power wash ALCOJET DETOJET
and other hazardous chemicals. TERGAJET (p-free) SOLUJET (p-free)
Aluminum, brass, copper, and other soft metal parts. Oils, chemicals, particulates (acid for Manual, Ultrasonic, Soak ALCONOX LIQUINOX-base
oxides, salts, buffing compounds). TERGAJET (p-free) CITRANOX-acid
Parts washer, power wash ALCOJET SOLUJET-base
TERGAJET (p-free) CITRAJET-acid
Inorganics, metallic complexes, trace metals and oxides, scale, salts, metal brightening. Manual, Ultrasonic, Soak CITRANOX
Parts washer, power wash CITRAJET
Silicone oils, mold-release agents, buffing compounds. Manual, Ultrasonic, Soak ALCONOX CITRANOX
Parts washer, pressure spray ALCOJET SOLUJET
Delicate substrates/neutral for waste. Manual, Ultrasonic, Soak LUMINOX
Machine wash, pressure spray (Neutral pH)
Electronics Circuit boards, assemblies, screens, parts, conductive residues, resins, rosins, fluxes, Manual, Ultrasonic, Soak DETERGENT 8
Avoid conductive residues, avoid CFCs, pass particulates, salts. Machine washer, power spray
cleaning criteria. board and screen washers
Ceramic insulators and components. Manual, Ultrasonic, Soak ALCONOX LIQUINOX
Parts washers ALCOJET SOLUJET
Foodservice & Food Manufacturing Stainless steel, glass, and food production equipment. Manual, Ultrasonic, Soak ALCONOX LIQUINOX
Avoid interfering residues on food-contact Machine wash, pressure wash, CIP ALCOJET
equipment and effectively remove soils
commonly found in food operations. For Oxides, scale, trace metals, salts, milkstone and corrosion. Manual, Ultrasonic, Soak CITRANOX
complete foodservice detergent selection guide, Machine wash, pressure wash, CIP CITRAJET
visit AlconoxFoodservice.com . Filter membranes, proteins, biofouling. Manual, Ultrasonic, Soak TERGAZYME
Cosmetics Product contact surfaces (acids for pigments and salts). Manual, Ultrasonic, Soak ALCONOX DETONOX-base
Avoid cross-contamination. CITRANOX-acid
Parts washers, power spray ALCOJET SOLUJET-base
CITRAJET-acid
Nuclear Reactor cavities, pipes, tools, protective equipment. Manual, Soak, Spray DETERGENT 8
Avoid waste interference
p-free = phosphate-free * Eudragit is a ® registered trademark of Roehm GmbH & Co. To purchase detergent contact your laboratory, healthcare, or industrial supply company. 13
DIRECTIONS FOR USING ALCONOX CLEANERS

DIRECTIONS FOR ALCONOX DETERGENTS

Directions: Dilute detergent (see chart) using warm (about 120°F or 50°C) or hot (about 140°F or 60°C) water. Ambient temperature water may be acceptable, especially for pre-soak. For difficult soils, use very hot water (above
150°F or 65°C) and double the recommended amount of detergent. When cleaning solution may be reused, make up fresh solutions frequently as needed.

Recommended Amount Minimum Wash Usual Wash Maximum Wash

Product Form Foam Dilution (%) Oz/Gal gm/l or ml/l Temperature Temperature Temperature
ALCONOX Powder Yes 1 1 1/4 10 Ambient Warm Boiling
TERGAZYME Powder Yes 1 1 1/4 10 Ambient 110–120˚ F 130˚ F
LIQUINOX Liquid Yes 1 1 1/4 10 Ambient Warm Boiling
CITRANOX Liquid Yes 1–2 1–3 10–20 Ambient Hot Boiling
DETERGENT 8 Liquid No 2–5 2–6 20–50 Ambient Hot Boiling
ALCOJET Powder No 1/2–1 1/2–1 1/4 5–10 Warm Hot Boiling
DETOJET Liquid No 1/2–1 1/2–1 1/4 5–10 Ambient Hot Boiling
ALCOTABS Tablet Yes (1 tablet per use) Ambient Ambient Boiling
LUMINOX Liquid No 2–5 2–6 20–50 Ambient Warm Boiling
CITRAJET Liquid No 1–2 1–3 10–20 Ambient Hot Boiling
TERGAJET Powder No 1/2–1 1/2–1 1/4 5–10 Warm Hot Boiling
SOLUJET Liquid No 1/2–1 1/2–1 1/4 5–10 Ambient Hot Boiling
DETONOX Liquid Yes 1–3 1–4 10–30 Ambient Warm Boiling

DETONOX CITRANOX LUMINOX ALCOJET DETOJET CITRAJET TERGAJET SOLUJET DETERGENT 8

SOAKING Recommended:
ALCONOX LIQUINOX TERGAZYME

Typical Use: To clean small items—hospital catheters and tubes, small metal parts—and large Directions: Soak, completely submerged in solution, until clean. This may take several hours,
tank interiors, including pharmaceutical and other blending tanks. An excellent pretreatment method depending on the type of soil. Remove and rinse thoroughly.
for loosening soils and preventing drying prior to further cleaning—especially for labware or medical
instruments.
Advantages: Very little physical effort or expense.
Concerns: Extremely dirty articles or difficult soils may require further cleaning.

ALCONOX LIQUINOX DETONOX CITRANOX TERGAZYME LUMINOX ALCOJET DETOJET CITRAJET TERGAJET SOLUJET DETERGENT 8
MANUAL CLEANING Recommended:

Typical Use: For cleaning small articles such as medical examination instruments, labware or circuit Directions: Make up cleaning solution as below, or use undiluted detergent on a warm, wet cloth or
boards, and large articles such as process equipment. sponge for nonabrasive scouring. Clean as follows:
Advantages: Versatile, inexpensive, effective. • Wet the article with solution by dunking or using a soaked cloth or sponge.
Concerns: Time consuming and labor-intensive. May not be effective on difficult-to-reach areas • Clean with a cloth, sponge, cotton swab, brush, or pad that agitates surface soils without marring
requiring presoak, ultrasonic, or machine cleaning. the surface.
• Rinse thoroughly. Wear gloves, eye protection, and other safety equipment if recommended.

14
ULTRASONIC CLEANING Recommended: ALCONOX LIQUINOX DETONOX CITRANOX TERGAZYME LUMINOX ALCOJET DETOJET CITRAJET TERGAJET SOLUJET DETERGENT 8

Typical Use: To clean multiple batches of articles or for fast, convenient cleaning. Directions: Make up detergent solution in a separate container.
Advantages: Fast, effective, reproducible, penetrating cleaning. • Add detergent, run machine 10 minutes to degas, allow heater to heat.
Concerns: Capital cost, material tolerance for ultrasonic agitation. • Place groups of small articles in racks or baskets.
• Align irregularly shaped articles so the long axis of any part faces the ultrasonic transducer (usually
the bottom).
• Immerse articles to be cleaned for 2–10 minutes, or longer, as needed. Remove and rinse thoroughly.
• Orient or rotate parts to release air from blind holes.

ALCONOX LIQUINOX DETONOX CITRANOX TERGAZYME LUMINOX ALCOJET DETOJET CITRAJET TERGAJET SOLUJET DETERGENT 8
CLEAN-IN-PLACE Recommended:
Typical Use: For pipe, tank, and filtration systems. Directions: Make up cleaning solution as above.
Advantages: Assures clean systems without disassembly. • Circulate solution slowly for at least 1/2 hour. Allow several hours for large systems (thousands of
Concerns: Good circulation in system. gallons), especially with ambient temperature water.
• Drain by pumping in one full system capacity of water.
• Rinse by circulating and draining at least two times the system’s water capacity. Some filtration units
may require more rinsing.
• For spray clean-in-place use a low foaming detergent to clean. Rinse and flush thoroughly.

ALCOJET DETOJET CITRAJET TERGAJET SOLUJET DETERGENT 8

MACHINE WASHERS Recommended:
Typical Use: For high-volume cleaning using washer-sanitizers, Directions: Load articles into racks so that open ends face toward spray nozzles. Place difficult-to-
warewashers, conveyor-washers, or spray and pressure washers. clean articles with narrow necks and openings near the center of the rack, open-side down, preferably
Advantages: Fast, effective, high volume cleaning. on special racks with spray nozzles pointing directly into them. Minimize touching between articles.
Concerns: Capital cost; article’s ability to withstand machine washing conditions. Minimize fluid trapping orientation of parts—optimize drainage.
• Group small articles in baskets to prevent dislodging by spray action.
• Use only low foaming detergent as per machine manufacturer dose instructions. If no instructions,
use a 1% solution or 1 1/4 oz. per gallon of wash water. Use more or less as needed.
• Use hot water (above 140°F or 60°C).
• Use CITRAJET as an acid rinse and neutralizer where desired.
Most machines have at least three rinse cycles. Refer to machine manufacturer’s directions.
AUTOMATIC SIPHON PIPET WASHING Recommended:
ALCOTABS

Typical Use: Washing pipets in laboratories. Directions: Completely immerse pipets immediately after use in a presoak solution of ALCOTABS,
Advantages: Effective batch pipet cleaning. ALCONOX, or LIQUINOX solution. When ready to clean:
Concerns: Pre-soak pipets for best results. • Drop an ALCOTAB into bottom of washer.
• Place pipets in holder into the washer.
• Turn on cold or warm water at a rate that will fill the washer and completely cover all pipets, then
drain to the bottom during each cycle.
• Run water until ALCOTAB has completely dissolved, continue running water to rinse thoroughly (may
take an hour to complete washing and rinsing).
For analytical or tissue culture work use distilled or deionized water for final rinse.

15
OPTIMIZING YOUR CLEANING PROCESS

BATH-O-CARD: Corrosion inhibition the same bath. Intact stainless steel is generally OK as a
This acronym is formed from the first letter in each of Corrosion during cleaning is accelerated by the same things mixed metal, but iron, steel, brass, aluminum, bronze and
the nine critical variables in cleaning. And each offers that accelerate cleaning: heat, aggressive chemicals, time, other metals can be a problem mixed with other metals.
opportunities for cleaning process optimization. and agitation. To reduce metal corrosion, in approximate
Before cleaning — Presoak, prevent residues from
order of effect, use less heat, corrosion inhibited detergents, Bath life extension and control
lower pH or pH appropriate detergents, shorter cleaning For the highest levels of critical cleaning, especially to avoid
drying and hardening, or stop any pre-cleaning procedures time, and less agitation. Avoid mixed metals in the same cross contamination, only freshly prepared solutions should
that make cleaning more difficult bath that form batteries and deposit galvanic oxides. The be used. For industrial cleaning applications, however, bath
Agitation — The more agitation, the better. Add or following techniques may work to limit corrosion, based on life can be extended while still achieving high levels of
increase scrubbing, ultrasonic, spraying or flowing. the material and/or process involved: cleaning.
• Metal: Use the mildest pH detergent and avoid mixed
Time — The longer the cleaning, the more available metals in the same bath. Bath life extension techniques:
cleaning capacity is used. Until you run out. • Aluminum: After abrasion exposes pure metal surface, • Filtering particulates
Heat — Every 10 degree C increase in cleaning allow air passivation time prior to cleaning. Use mild acid • Cooling and settling of sludge
temperature, doubles the cleaning speed. Clean as hot as cleaners such as CITRANOX or CITRAJET to avoid alkaline • Cooling and skimming oils
practical, without damaging your substrate. attack. • Adding half again as much detergent as the initial load
• Plastic: Use less aggressive cleaners, containing after partially depleting the cleaning life of a bath
Orientation — Surfaces must be oriented to contact less solvent or surfactant character. Or use lower
cleaning solution and rinse water. Also, rotate parts to Conductivity, pH and % solids by refractometer can be
concentrations of those cleaners, lower cleaning
release air in blind holes, and rack to prevent holding liquid used to measure bath detergent concentration. In general, a
temperatures, less contact time, and less agitation. For
between surfaces. pH change of 1 unit toward neutral indicates an exhausted
stressed polycarbonate and acrylic use surfactant-free
cleaning solution. Under frequent daily use, detergent
Chemistry — Use detergent suitable for the type of DETOJET for cleaning. Unstressed material is not a
solutions can rarely be used more than a week, even when
residue (acid or alkaline) and cleaning method (low foam concern. Avoid alkaline cleaners on polyurethane.
being extended.
for high agitation; high foam for immersion and ultrasonic). • Mild sensitive steel: Avoid “flash rusting” by rinsing
with cold water and using rapid water-removing drying Free-alkalinity titration can be used to extend bath life
After cleaning — Avoid recontamination and corrosion- techniques such as dipping in isopropyl alcohol to form where the soils deplete free alkalinity, as follows:
causing humidity and heat. an evaporating azeotrope that removes water safely, • Titrate a fresh solution to determine free alkalinity
centrifuge dry, wipe dry, air knives, and drying with • Titrate the used solution to determine the percent drop in
Rinse — Use suitably pure rinse water to avoid rinse- oxygen-free gas such as dry nitrogen. Or add a suitable free alkalinity
water residues. Hot rinse avoids breaking emulsion and
corrosion inhibitor to the rinse water, as long as you • Add detergent to the used bath to bring the free alkalinity
redepositing. Cold rinse reduces corrosion.
can tolerate corrosion-inhibitor residues. Do not use back to the new-solution level
Dry — Removing water by alcohol dip, wiping, blowing evaporative drying such as air drying or oven drying. For example if your initial solution contains 100 ml
or centrifuge reduces rinse-water residues and corrosion. • Sensitive steel: Clean with an inhibited cleaner and of cleaner concentrate and there is a 25% drop in free
(See following section for more information.) isopropyl alcohol rinse (or add a corrosion inhibitor to the alkalinity, try adding 25 ml of cleaner concentrate to
rinse water). recharge the solution. Perform a new free-alkalinity titration
• Galvanic corrosion: Avoid mixed metals in the same the first few times to confirm that the detergent is linear
bath that can form a battery and deposit oxides on one with respect to free free-alkalinity depletion. This bath-
of the metals. For example, many metals will plate out life extension cannot be repeated indefinitely: sludge will
their oxides on aluminum if the two metals are cleaned in eventually form, requiring a fresh solution.

16
Try a free sample of Alconox detergents
To request free samples:
• Call ++914.948.4040. Please refer to the Detergent Selection
Guide on page 13 of this booklet.
• Go to www.alconox.com. Click Get Sample to use our sample
request form.

To place an order for Alconox detergent:

• Call your local Alconox dealer. See our website for U.S. and
international distributors.
• Visit www.alconox.com

For technical support:

• Contact the Alconox Technical Service Department for help in
selecting the best detergent samples for your application.
• Call ++914.948.4040, email [email protected] or fill out
the “Ask Alconox” questionnaire at www.alconox.com .

17
FREE BOOK ($39.95 value) & SAMPLE OFFER NOTE:
of Alconox critical cleaning detergents Please complete
all sections so we
Receive a FREE copy of The Aqueous Cleaning Handbook just for testing the Alconox cleaners.
can send the right
Authoritative and based on real-world application experience, this practical guide explains what aqueous
samples for your
cleaners are, how they work, how to select and test them, and how to specify cleaning systems.
application.
Please fill out, save, and email PDF file to: [email protected]

Cleaning requirements and use Detergent

What surfaces are you cleaning? Do you currently use an Alconox, Inc. detergent? Yes No
Polycarbonate, acrylic, and other sensitive plastics
Filters, membranes, RO or UF systems Which are you using?_______________________________________________
PC boards, wafers, electronic components Issues, comments, concerns
Pipets in syphon washers Are you having any problems with the cleaner?_______________________
Soft metals: aluminum, copper, brass, other non-ferrous ______________________________________________________________
Stainless steel, iron, nickel
Glass, ceramic, porcelain, rubber, fiberglass, plastic Any special waste treatment/disposal concerns?______________________
Other (please describe)__________________________________________ ______________________________________________________________
What soils are you removing? Your principal activity:
Proteinaceous soils, blood and other body fluids, tissue Healthcare or Veterinary Optical
Inorganic soils, scale, salts, metallic complexes, metal oxides, trace metals Laboratory Nuclear
Silicone oils, mold-release agents, buffing compounds, radioisotopes, radioactive Environmental & Water Testing Educational Institution
contaminants Electronics Medical Device Manufacturing
Oils, cutting fluids, chemical, solvents, bio-residues, particulates, laboratory soils Pharmaceutical Precision Manufacturing
Heavy oils, greases, baked-on residues Food & Beverage Food Service
Conductive residues, resins, rosins, solder, fluxes, particulates, salts Cosmetics Tattoo
Other (please describe)__________________________________________ Metalworking Other
If Other, please describe: ____________________________________________
What would you use the cleaner for?
Household uses L arge manufacturing equipment Your primary job function:
Labware Manufactured items Administrative Assistant QC/QA Validation
Field sampling equipment Selling/distribution Consultant Restaurant Manager
Other re-usable items/instruments Restaurant equipment and facilities Corporate Management Safety/Regulatory Compliance
Filtration membranes None of the above Engineer Sales/Marketing/Distribution
Healthcare Scientist/Researcher/Teacher
How are you cleaning? Laboratory Manager Stockroom/Store/Warehouse
What type of cleaner do you want to use? Plant Manager Technician
Liquid cleaner Purchasing Other
Powder cleaner If Other, please describe: _____________________________________________
Either / not sure
Special complimentary book offer ($39.95 value)
If you clean by immersion, how? The Aqueous Cleaning Handbook
Method Brand Age (yrs) 1. I agree to try the samples being sent as a result of this request
By Hand 2. I agree to let Alconox know the results of my sample trial by completing the sample
Soak or circulate clean-in-place report card (will be included with samples)
Syphon pipet washer 3. I understand that I will be billed $39.95 for the book if I fail to try out the samples and
Ultrasonic _____________ _________ report the results of my trial
Other non-spray _____________ _________ Please SEND me The Aqueous Cleaning Handbook. I agree to terms stated above.
If you clean by machine, which do you use? To purchase the book, order on our website or call 1-877-877-2526.
Type Brand Age (yrs)
Comments:
Glassware washer _____________ _________
PC board washer _____________ _________
CIP spray
Parts washer _____________ _________
Washer/sanitizer _____________ _________
Power spray wand
Solvent vapor/soak _____________ _________
Other _____________ _________
Is there an acid rinse cycle? Yes No
Are you willing to receive hazardous corrosive liquid Contact Information
detergent samples if the questionnaire indicates that
they should be tested for your application? Yes No Name

If you use cleaning machinery, are you planning to Title

purchase new, upgrade, or replace it in the near future? Yes No
Company
What size/how often do you purchase high-quality cleaners?
Street City Region/Province/State
________units (single boxes or bottles) Wkly Mthly Yrly
________cases (of boxes or bottles) Wkly Mthly Yrly Postal/ZIP Code Country
________medium sizes (50-100 lb or 5-15 gal drum) Wkly Mthly Yrly
Phone Fax
________bulk sizes (300 lb or 55 gal drum) Wkly Mthly Yrly
Email Web
Estimated annual purchases of high-quality cleaners (US $): ________________