The Efficacy of Kinesio Taping As An Adjunct To.72 PDF
The Efficacy of Kinesio Taping As An Adjunct To.72 PDF
The Efficacy of Kinesio Taping As An Adjunct To.72 PDF
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trials
∗
Guangchen Sun, MB, Qiliang Lou, MB
Astract
Background: Kinesio taping (KT) is a relatively new treatment method for chronic low back pain (CLBP). The effectiveness of KT as
an adjunct to physical therapy (PT) for CLBP remains controversial.
Objective: The aim of this updated meta-analysis was to critically examine and evaluate the evidence of recent randomized
controlled trials regarding the effectiveness of KT as an adjunct to PT for CLBP for at least 2 weeks.
Methods: This systematic review and meta-analysis was written following the Preferred Reporting Items for Systematic Reviews
and Meta-Analyses (PRISMA) statement guidelines. Seven electronic databases including Web of Science, Embase, PubMed,
Wanfang Data, Scopus, Science Direct, Cochrane Library were searched in September 2020 by two independent reviewers. The risk
of bias was assessed using the Cochrane Collaboration’s tool. Data analysis was performed with Review Manager Software.
Results: Twelve randomized controlled trials with a total of 676 patients were included in our study. Mean improvements were
significantly higher in the KT+PT group than the PT group for pain score (SMD, 0.73 [95% CI, 0.37–1.08], P < .00001) and disability
(SMD, 1.01 [95% CI, 0.42–1.59], P = .0007). Of 12 studies based on the pain score, 7 reported KT+PT patients to have significantly
less pain at latest follow-up when compared with PA patients (P < .05). Of 11 studies based on the disability, 8 reported KT+PT
patients to have significantly better improvements at latest follow-up when compared with PA patients (P < .05).
Conclusion: Kinesio taping combined with physical therapy provided better therapeutic effects regarding pain reduction and
disability improvement compared with physical therapy alone in individuals with chronic low back pain.
Limitation:
1. Included studies and sample sizes were small and most studies were with moderate evidence level;
2. several important outcomes such as range of motion and distance walked were lack;
3. heterogeneity among the included studies was unavoidable.
Abbreviations: CI = confidence interval, CLBP = chronic low back pain, KT = kinesio taping, PRISMA = Preferred Reporting
Items for Systematic Reviews and Meta-Analyses, PT = physical therapy, RCTs = randomized controlled trials, SMD = standardized
mean differences.
Keywords: chronic low back pain, kinesio taping, meta, pain control, physical therapy, review
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disability.[1–3] disability;
Several treatment strategies for CLBP are provided in the 5. study design: randomized controlled trials.
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current literature, which including limited bed rest, pharmaco- The exclusion criteria were as follows:
logical therapy, acupuncture, and general exercises. A relatively
new treatment method for CLBP is Kinesio taping (KT), which is 1. outcomes which assessed pain intensity or disability were not
being widely used as a relatively novel band-aid method to reduce reported;
the pain of musculoskeletal disorders.[4] KT is an elastic bonding 2. no direct comparison of KT+PT and PT;
material containing high tensile capacity, which ensures the free 3. studies with the following types: case reports, comments or
movement of the application area without the need of drugs or letters, biochemical trials, protocols, conference abstracts,
chemicals.[5–7] Studies have shown that KT improves blood and reviews, and retrospective studies or prospective non-
lymph circulation, mitigates pain, adjusts joints, and relives randomized studies.
muscle tension.[8]
One meta-analysis demonstrated that KT could improve pain
2.3. Study selection
and function in patients with CLBP compared with sham
taping.[9] Another recent meta-analysis investigated the effects of Articles were exported to EndNote, and duplicates removed. Two
KT in patients with CLBP and found no evidence to support the independent authors screened the titles and abstracts of
use of KT in clinical practice for patients with CLBP.[10] The other potentially relevant studies to determine their eligibility based
reviews could not reach conclusive evidence of bright side of on the criteria. Disagreements were resolved through a discussion
KT.[11] To the best of our knowledge, only a meta-analysis has with a third review author.
compared the therapeutic efficacy of KT combined with physical
therapy (PT) and PT alone for pain control in patients with 2.4. Data extraction
CLBP.[10] However, only 5 studies were included in the meta-
analysis,[12–16] and a good number of new trials have been Data were extracted by review of each study for population,
published since then. Therefore, the aim of this updated meta- mean age, gender, follow-up duration, study design, publishing
analysis was to critically examine and evaluate the evidence of date, KT and PT characteristics, and outcomes assessment. The
recent randomized controlled trials regarding the effectiveness of two reviewers created a study-specific speadsheet in Excel
KT as an adjunct to PT for CLBP for at least 2 weeks. The results (Microsoft Corp., USA) for data collection. Data extraction
of this study will provide new information about the usefulness of was performed independently, and any conflict was resolved
KT as an additional component of a guideline-endorsed before final analysis. Any disagreements between the two
physiotherapy program in patients with CLBP. reviewers were discussed and, if necessary, the third author
was referred to for arbitration. If the data were missing or could
not be extracted directly, authors were contacted by email.
2. Materials and methods Otherwise, we calculated them with the guideline of Cochrane
2.1. Selection of studies Handbook for Systematic Reviews of Interventions 5.1.0. If
necessary, we would abandon the extraction of incomplete data.
This systematic review and meta-analysis was written following
the Preferred Reporting Items for Systematic Reviews and Meta-
Analyses (PRISMA) statement guidelines. Seven electronic 2.5. Quality assessment
databases including Web of Science, Embase, PubMed, Wanfang The GRADE system (Grading of Recommendations Assessment,
Data, Scopus, Science Direct, Cochrane Library were searched in Development and Evaluation) was used by two independent
September 2020 by two independent reviewers (lasting for 1 reviewers to rate the overall quality of evidence in each pooled
week). For search on PubMed, the search terms used were analysis. The following 7 items were used to assess the quality of
“Kinesio taping OR Kinesio tape OR Kinesiotape AND chronic randomized controlled trials: random sequence generation,
low back pain OR chronic non-specific low back pain OR non- allocation concealment, blinding of participants and personnel,
specific low back pain.” The reference lists of the included studies blinding of outcome assessment, incomplete outcome data,
were also checked for additional studies that were not identified selective reporting, and other bias. The quality rating high is
with the database search. There was no restriction in the dates of reserved for evidence based on randomized controlled trials. The
publication or language in the search. No ethical approval was quality rating moderate, low, or very low were rated depending
required in our study because all analyses were based on on the following four factors: risk of bias, inconsistency of effect,
aggregate data from previously published studies. imprecision, and indirectness. When the heterogeneity was high,
inconsistency was considered serious. When there was no direct
comparison between KT + PA and PA alone, indirectness was
2.2. Inclusion and exclusion criteria
considered serious and researchers had to make comparisons
Study included in this systematic review and meta-analysis had to across studies. When there was fewer than 400 participants for
meet all of the following inclusion criteria in the PICOS order: each outcome, imprecision was considered an appreciable risk.
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Any controversy was resolved by discussing with a third author patients were included (Fig. 1).[12–23] Among the 12 RCTs, a total
to reach a final consensus. Kappa values were used to measure the of 676 patients participated (339 randomized to the intervention
degree of agreement between the 2 reviewers and were rated as group, 337 randomized to a control group) with a follow-up rate
follows: fair, 0.40 to 0.59; good, 0.60 to 0.74; and excellent, 0.75 of 100%. The frequency weighted mean age of participants was
or more. 43.2 years, and 52.7% were female. The follow-up period ranged
from 2 weeks to 6 months. Nine of the studies assessed pain using
2.6. Statistical analysis the visual analog scale (VAS),[12,13,15–19,22,23] whereas only 3
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Denmark). As outcomes which assessed pain intensity and studies used Roland-Morris Disability Questionnaire
disability were reported on different scores, we used the (RMDQ),[12,13,16] and only 1 study used Oswestry Physical
standardized mean difference (SMD) with a 95% confidence Disability Questionnaire (OPDQ).[23] A detailed description of all
interval (CI) to assess for these outcomes. A P value < .05 was included studies can be found in Table 1.
considered statistically significant. All outcomes were pooled on
random-effect model. The statistical heterogeneity was assessed by
using the Cochrane Q test and I2 statistic. The low, moderate, and 3.2. Methodologic quality assessment
high heterogeneity were assigned to I2 values of 0% to 25%, 26% The critical appraisal of the included trials using the Cochrane risk
to 74%, and above 75%. A meta-analysis was conducted when 4 of bias tool is detailed in Figure 2A and summarised using a stacked
or more trials reported an outcome of interest. A subanalysis was bar chart in Figure 2B. Allocation concealment was adequately
performed to isolate results from patients who received KT+PT and reported by Added et al,[12] except in 11 studies where the
PT alone. A sensitivity analysis was planned by different follow-up concealment of allocation from the investigators was unclear
periods. Begg’s funnel plot was used to assess publication bias. If (unclear risk of bias).[13–23] All of 12 trials failed to blind both the
publication bias exists, the Begg’s funnel plot is asymmetric. therapists and participants.[12–23] Among trials included in this
review, all trials described clear inclusion and exclusion criteria.
3. Results Adequate random sequence generation was reported in 10
trials.[12,14–20,22,23] The outcome assessors were blinded in only
3.1. Study selection, characteristics 3 studies.[12,16,17] Trial registration number or study protocol was
The initial search used very broad terms and resulted in 573 total available for 1 trial. The proportion of patients lost to follow-up
articles. Twelve studies met inclusion and exclusion criteria and was <20% in all studies, indicating low attrition bias. All studies
were included in our study. Briefly, 12 RCTs with a total of 676 did report results of all predefined measures, indicating low
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Table 1
Study characteristics and patient demographic details.
No. Female Mean age
Study Design (KT + PT, PT) (KT + PT, PT) (KT + PT, PT) Intervention (KT + PT) Control (PT) Outcomes
Added 2016 RCT 74, 74 53, 53 45.6, 44.6 KT: lasting for 5 weeks, 3 months, PT: exercise and manual VAS,
and 6 months; PT: exercise and therapy, lasting for 5 RMDQ
manual therapy, lasting for 5 weeks, 3 months, and
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reporting bias. None of other bias was detected. The overall kappa for pain intensity reduction was 78%, suggesting that moderate
value regarding the evaluation of risk of bias was 0.814, meaning to high heterogeneity may be present. A meta-analysis of 11
an excellent degree of agreement between the two reviewers. studies[12–16,18–23] comparing patients treated with KT + PT
versus PT alone showed that the disability reduction in the KT +
PT group was significantly greater than that in the PT group for
3.3. Quantitative analysis and GRADE summary
at least 2 weeks after initial treatments (SMD, 1.01 [95% CI,
A meta-analysis of 12 trials[12–23] comparing patients treated 0.42–1.59], P = .0007) (Fig. 4). The I2 statistic for disability
with KT + PT versus PT alone showed that the pain intensity reduction was 91%, suggesting that high heterogeneity may be
reduction in the KT + PT group was significantly greater than that present. The GRADE system was used to evaluate the quality of
in the PT group for at least 2 weeks after initial treatments (SMD, outcomes in this study. The quality of evidence regarding the
0.73 [95% CI, 0.37–1.08], P < .00001) (Fig. 3). The I2 statistic outcomes was low. The factors that lowered the quality
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B
Figure 2. (A) Risk of bias summary; (B) risk of bias graph.
according to the GRADE were the high statistical heterogeneity, 3.4. Subanalysis and sensitivity analysis
and the unclear risk of selection, and the high risk of 3.4.1. Subanalysis on outcome of pain intensity reduction.
performance bias. The details of the results are summarized Of the 12 studies that utilized pain scores,[12–23] 9 studies[12,13,15–
19,22,23]
in Table 2. reported VAS scores and 3 studies reported NRS
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Figure 3. Forest plots of the pain intensity reduction between KT + PT group and PT group after CLBP.
Figure 4. Forest plots of the disability reduction between KT + PT group and PT group after CLBP.
scores.[14,20,21] All 12 studies reporting on pain intensity ODI scores,[14,15,18–22] 3 studies reported RMDQ scores,[12,13,16]
reduction found KT + PT patients to improve significantly from and 1 study utilized OPDQ scores.[23] All 7 studies reporting on ODI
baseline to final follow-up. When comparing KT + PT and PT scores, 2 of the 3 studies reporting on RMDQ scores, and 1 study
patients at latest follow-up, 7 of the possible 12 outcome scores reporting on OPDQ scores found KT + PT patients to improve
(58.3%) demonstrated significant improvement in patients significantly from baseline to final follow-up. When comparing
undergoing treatment with KT + PT when compared with PT, KT + PT and PT patients at latest follow-up, 8 [14,15,18,19–23] of
while none (0%) demonstrated superiority with PT.[13,15,17–20,23] the possible 11 outcome scores (72.7%) demonstrated significant
improvement in patients undergoing treatment with KT + PT
3.4.2. Subanalysis on outcome of disability reduction. Of the when compared with PT, while only 1 of the possible 11 outcome
11 studies that assessed disability,[12–16,18–23] 7 studies reported scores (9.1%) demonstrated superiority with PT.
Table 2
GRADE summary of findings.
Summary of results Quality of the evidence (GRADE)
Outcomes Participants (trials), n SMD (95% CI) P Design Inconsistency Indirectness Imprecision Quality
∗ †
Pain intensity reduction 676 (12) 0.73 (0.37 to 1.08) <.00001 Limitations Yes No No Low
∗
Disability reduction 647 (11) 1.01 (0.42 to 1.59) .0007 Limitations Yes† No No Low
GRADE = Grading of Recommendations Assessment, Development and Evaluation; SMD = standard mean difference.
∗
Lack of blinding of participants and personnel.
†
Large statistical heterogeneity, I2 > 75%.
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Figure 5. Forest plots of the pain intensity reduction between KT + PT group and PT group after CLBP between 2 weeks and 4 weeks.
Figure 6. Forest plots of the disability reduction between KT + PT group and PT group after CLBP between 2 weeks and 4 weeks.
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Figure 7. (A) Funnel plot of publication bias for the disability reduction between KT + PT group and PT group after CLBP. There was symmetry, suggesting that
there was not a significant publication bias; (B) Funnel plot of publication bias for the pain intensity reduction between KT + PT group and PT group after CLBP.
There was not symmetry, suggesting that there was a significant publication bias.
myelinated fibers) and thus inhibit pain transmission according to that KT was no better than any other intervention for most the
the gate control theory. outcomes assessed in patients with CLBP.[10,11]
Numerous reviews and meta-analyses have been published The findings from our meta-analysis were not in line with
comparing the efficacy of KT in individuals with CLBP. In a meta- findings from a previous meta-analysis.[10] These differences
analysis that included 10 randomized controlled trials, Li et al resulted from limited studies included in their analysis. The
showed that KT was not superior to placebo taping for pain authors showed that there were no significant differences for pain
relief, but could significantly improve disability when compared intensity and disability between KT + PT and PT alone groups,
to the placebo taping.[24] Sheng et al included 8 studies to and thus concluded that there was no evidence to support the use
compare placebo taping with KT and found that significant of KT in clinical practice for patients with CLBP. However,
differences in mean pain level and disability, reporting that KT compared to 12 studies with 676 patients in our study, only 5
may be a new, simple and convenient choice for intervention in studies with relatively small sample size (396 patients) was
low back pain.[9] However, the other 2 meta-analysis showed included in their meta-analysis,[12–16] which might not powerful
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to discover the statistical differences between the two techniques. [5] Luz Junior MA, Sousa MV, Neves LA, et al. Kinesio Taping (is not better
than placebo in reducing pain and disability in patients with chronic non-
In addition, adequate subgroup analyses and sensitivity analyses
specific low back pain: a randomized controlled trial. Braz J Phys Ther
were not performed in their study. 2015;19:482–90.
Several limitations of the meta-analysis should be noted. First, [6] Alikhajeh Y, Barabadi E, Mohammad Rahimi GR. A comparison of 6
some important outcomes were not evaluated, such as range of weeks of aquatic exercise and Kinesio Taping in patients with chronic
motion and distance walked. However, there was a paucity of nonspecific low back pain. J Sport Rehabil 2020;21:1–6.
[7] Araujo AC, do Carmo Silva Parreira P, Junior LCH, et al. Medium term
studies on these functional assessment tools; thus, it was difficult effects of kinesio taping in patients with chronic non-specific low back
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to perform further analyses. Second, the total quality of included pain: A randomized controlled trial. Physiotherapy 2018;104:149–51.
studies was rated as moderate, and overall confidence in the [8] Macedo LB, Richards J, Borges DT, et al. Kinesio Taping reduces pain
outcomes was low, which may lead to overestimation of effect and improves disability in low back pain patients: A randomised
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