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Patho UGIB

This document describes the risk factors, symptoms, and pathophysiology of peptic ulcers. A 56-year-old Filipino man with a history of heart disease and kidney disease presents with joint pain and stiffness. His risk factors include an unhealthy diet, hypertension, use of NSAIDs, and a family history of heart and inflammatory conditions. Peptic ulcers develop when NSAIDs damage the mucosal barrier, decreasing mucus production and allowing acid to injure the stomach lining, potentially leading to ulceration and bleeding.

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KristineBungcag
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244 views3 pages

Patho UGIB

This document describes the risk factors, symptoms, and pathophysiology of peptic ulcers. A 56-year-old Filipino man with a history of heart disease and kidney disease presents with joint pain and stiffness. His risk factors include an unhealthy diet, hypertension, use of NSAIDs, and a family history of heart and inflammatory conditions. Peptic ulcers develop when NSAIDs damage the mucosal barrier, decreasing mucus production and allowing acid to injure the stomach lining, potentially leading to ulceration and bleeding.

Uploaded by

KristineBungcag
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd

Non- Modifiable

Gender: Male
Age : 56 years old
Ethnicity: Filipino
History of Myocardial
Infarction
, Chronic Kidney Disease,
Family History : Heart
attack, arthritis,
asthma,psoriasis

Modifiable
Diet : fatty foods
Environment
Hypertension

Psoriatic Plaque
Use of NSAIDs
Synovial Inflammation
Abnormal bone
remodeling
Psoriatic Arthritis

Pain and stiffness in


the joints

Elicit their effect on


cycloxygenase
Damaged mucosal
barrier
Decrease function of
mucosal cells ; low
quality of mucous

Back diffusion of acid into gastric


mucosa

Conversion of
pepsinogen to
pepsin

H.
Pylori

Mucosal
Injury

Mucosal
Erosion
Destruction of
blood vessels

Ulceration

Formation and liberation


of histamine
Increase acid
secretion

Stimulation of
cholinergic
intramural
plexus, causing
muscle spasm

Local vasodilation

Increased capillary
permeability
Loss of plasma protein
Mucosal Edema
Loss of plasma into gastric

Weakening and necrosis of


arterial wall

Development of pseudo
aneurysm

Weakening wall ruptures

Upper Gastrointestinal
Bleeding

Melena
Abdominal
pain

Vomiting of fresh
blackish material w/
associated reddish
clotted blood

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