Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Apr;37(2):667-674.
doi: 10.1016/j.clnu.2017.02.010. Epub 2017 Feb 28.

Associations between dietary intakes of iron, copper and zinc with risk of type 2 diabetes mellitus: A large population-based prospective cohort study

Ehab S Eshak  1 , Hiroyasu Iso  2 , Koutatsu Maruyama  3 , Isao Muraki  4 , Akiko Tamakoshi  5
Affiliations
Free article

Associations between dietary intakes of iron, copper and zinc with risk of type 2 diabetes mellitus: A large population-based prospective cohort study

Ehab S Eshak et al. Clin Nutr. 2018 Apr.
Free article

Abstract

Background & aims: Abnormal homeostasis of iron, copper and zinc has been included in the pathogenesis of type 2 diabetes mellitus (T2DM). However, the evidence of associations between dietary intakes of these elements and T2DM is limited. We thought to examine the association between dietary intakes of iron, copper and zinc with risk of T2DM in Japanese population.

Methods: A prospective study encompassing 16,160 healthy Japanese men and women aged 40-65 years in whom the associations between dietary intakes of iron, copper and zinc, determined by a validated self-administered food frequency questionnaire, with risk of 5-year cumulative incidence of validated physician-diagnosed T2DM, were evaluated by logistic regression model.

Results: We ascertained 396 self-reported new cases of diabetes within 5-year period. Dietary intakes of iron (total and nonheme but not heme iron) and copper were positively associated with risk of T2DM; the multivariable OR in the highest versus lowest quartiles of intakes were 1.32 (1.04, 1.70; P-trend = 0.03) and 1.55 (1.13, 2.02; P-trend = 0.003), respectively. These associations were more evident in the high risk group; older, overweight, smokers and those with family history of diabetes. The dietary intake of zinc was inversely associated with risk of T2DM; the multivariable OR was 0.64 (0.54, 1.00; P-trend = 0.003), and such association was evident among younger subjects (age 40-55 years) only.

Conclusions: Dietary intakes of iron and copper were associated with a higher risk, while dietary intake of zinc was associated with a reduced risk of T2DM in Japanese population.

Keywords: Cohort study; Copper; Iron; Japanese; Type 2 diabetes mellitus; Zinc.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

Publication types