Treatment of interdigital tinea pedis with 25% and 50% tea tree oil solution: a randomized, placebo-controlled, blinded study
- PMID: 12121393
- DOI: 10.1046/j.1440-0960.2002.00590.x
Treatment of interdigital tinea pedis with 25% and 50% tea tree oil solution: a randomized, placebo-controlled, blinded study
Abstract
Tea tree oil has been shown to have activity against dermatophytes in vitro. We have conducted a randomized, controlled, double-blinded study to determine the efficacy and safety of 25% and 50% tea tree oil in the treatment of interdigital tinea pedis. One hundred and fifty-eight patients with tinea pedis clinically and microscopy suggestive of a dermatophyte infection were randomized to receive either placebo, 25% or 50% tea tree oil solution. Patients applied the solution twice daily to affected areas for 4 weeks and were reviewed after 2 and 4 weeks of treatment. There was a marked clinical response seen in 68% of the 50% tea tree oil group and 72% of the 25% tea tree oil group, compared to 39% in the placebo group. Mycological cure was assessed by culture of skin scrapings taken at baseline and after 4 weeks of treatment. The mycological cure rate was 64% in the 50% tea tree oil group, compared to 31% in the placebo group. Four (3.8%) patients applying tea tree oil developed moderate to severe dermatitis that improved quickly on stopping the study medication.
Similar articles
-
Tea tree oil in the treatment of tinea pedis.Australas J Dermatol. 1992;33(3):145-9. doi: 10.1111/j.1440-0960.1992.tb00103.x. Australas J Dermatol. 1992. PMID: 1303075 Clinical Trial.
-
Ciclopirox gel in the treatment of patients with interdigital tinea pedis.Int J Dermatol. 2003 Sep;42 Suppl 1:29-35. doi: 10.1046/j.1365-4362.42.s1.6.x. Int J Dermatol. 2003. PMID: 14567368 Clinical Trial.
-
Naftifine Hydrochloride Gel 2%: An Effective Topical Treatment for Moccasin-Type Tinea Pedis.J Drugs Dermatol. 2015 Oct;14(10):1138-44. J Drugs Dermatol. 2015. PMID: 26461826
-
[Treatment of interdigital tinea pedis].Dtsch Med Wochenschr. 2003 Sep 5;128(36):1819-24. doi: 10.1055/s-2003-41969. Dtsch Med Wochenschr. 2003. PMID: 12964099 Review. German.
-
Is tea tree oil effective at eradicating MRSA colonization? A review.Br J Community Nurs. 2005 Mar;10(3):123-6. doi: 10.12968/bjcn.2005.10.3.17615. Br J Community Nurs. 2005. PMID: 15824699 Review.
Cited by
-
Efficacy and safety of Melaleuca alternifolia (tea tree) oil for human health-A systematic review of randomized controlled trials.Front Pharmacol. 2023 Mar 24;14:1116077. doi: 10.3389/fphar.2023.1116077. eCollection 2023. Front Pharmacol. 2023. PMID: 37033604 Free PMC article.
-
Appraisal on the wound healing potential of Melaleuca alternifolia and Rosmarinus officinalis L. essential oil-loaded chitosan topical preparations.PLoS One. 2019 Sep 16;14(9):e0219561. doi: 10.1371/journal.pone.0219561. eCollection 2019. PLoS One. 2019. PMID: 31525200 Free PMC article.
-
Fungal Infections From Human and Animal Contact.J Patient Cent Res Rev. 2017 Apr 25;4(2):78-89. doi: 10.17294/2330-0698.1418. eCollection 2017 Spring. J Patient Cent Res Rev. 2017. PMID: 31413974 Free PMC article. Review.
-
Commercial Essential Oils as Potential Antimicrobials to Treat Skin Diseases.Evid Based Complement Alternat Med. 2017;2017:4517971. doi: 10.1155/2017/4517971. Epub 2017 May 4. Evid Based Complement Alternat Med. 2017. PMID: 28546822 Free PMC article. Review.
-
Topical treatments for fungal infections of the skin and nails of the foot.Cochrane Database Syst Rev. 2007 Jul 18;2007(3):CD001434. doi: 10.1002/14651858.CD001434.pub2. Cochrane Database Syst Rev. 2007. PMID: 17636672 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
