Cystic Fibrosis

An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION.

Year introduced: 1967

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Tree Number(s): C06.689.202, C08.381.187, C16.320.190, C16.614.213

MeSH Unique ID: D003550

Entry Terms:

• Fibrosis, Cystic
• Mucoviscidosis
• Pancreatic Cystic Fibrosis
• Cystic Fibrosis, Pancreatic
• Cystic Fibrosis of Pancreas
• Fibrocystic Disease of Pancreas
• Pancreas Fibrocystic Disease
• Pancreas Fibrocystic Diseases
• Pulmonary Cystic Fibrosis
• Cystic Fibrosis, Pulmonary

See Also:

• Mice, Inbred CFTR
• Cystic Fibrosis Transmembrane Conductance Regulator

All MeSH Categories
Diseases Category
Digestive System Diseases
Pancreatic Diseases
Cystic Fibrosis

All MeSH Categories
Diseases Category
Respiratory Tract Diseases
Lung Diseases
Cystic Fibrosis

All MeSH Categories
Diseases Category
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Genetic Diseases, Inborn
Cystic Fibrosis

All MeSH Categories
Diseases Category
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Infant, Newborn, Diseases
Cystic Fibrosis