Heavy Chain Disease
A disorder of immunoglobulin synthesis in which large quantities of abnormal heavy chains are excreted in the urine. The amino acid sequences of the N-(amino-) terminal regions of these chains are normal, but they have a deletion extending from part of the variable domain through the first domain of the constant region, so that they cannot form cross-links to the light chains. The defect arises through faulty coupling of the variable (V) and constant (C) region genes.
Year introduced: 1966(1964)
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Subheadings:
Tree Number(s): C15.378.147.780.490, C15.604.515.435, C20.683.780.490
MeSH Unique ID: D006362
Entry Terms:
- Heavy Chain Diseases
- gamma-Chain Disease
- gamma Chain Disease
- gamma-Chain Diseases
- Franklin Disease
- Franklin's Disease
- Franklins Disease
- mu-Chain Disease
- mu Chain Disease
- mu-Chain Diseases
See Also: