Placenta Growth Factor
An angiogenic protein belonging to the Vascular Endothelial Growth Factor family of growth factors originally isolated and cloned from human placental cDNA library. There are four isoforms of PLGF 1-4 which result from alternative splicing. Placenta Growth Factor is secreted as a glycosylated homodimer which acts as a mitogen for endothelial cells, and its expression is markedly upregulated during hypoxia and in tissue inflammation and cancer.
Year introduced: 2017 (1991)
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Subheadings:
Tree Number(s): D12.644.276.100.800.100, D12.776.780.551
MeSH Unique ID: D000072483
Registry Number: 144589-93-5
Entry Terms:
- Factor, Placenta Growth
- Growth Factor, Placenta
- Placenta Growth Factor, PLGF-3 Isoform
- Placenta Growth Factor, PLGF 3 Isoform
- Placenta Growth Factor, PLGF-1 Isoform
- Placenta Growth Factor, PLGF 1 Isoform
- Placenta Growth Factor, PLGF-2 Isoform
- Placenta Growth Factor, PLGF 2 Isoform
- Placenta Growth Factor, PLGF-4 Isoform
- Placenta Growth Factor, PLGF 4 Isoform