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Decreased resting energy expenditure

MedGen UID:
868548
•Concept ID:
C4022947
•
Finding
HPO: HP:0012340

Definition

A reduction in the number of calories used per unit time. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased resting energy expenditure

Conditions with this feature

Inherited obesity
MedGen UID:
885912
•Concept ID:
C4054476
•
Sign or Symptom
Obesity associated with an identifiable mutation in a single gene.
See: Condition Record
Inherited obesity

Professional guidelines

PubMed

Diagnosis and management of sleep disorders in Prader-Willi syndrome.
Duis J, Pullen LC, Picone M, Friedman N, Hawkins S, Sannar E, Pfalzer AC, Shelton AR, Singh D, Zee PC, Glaze DG, Revana A
J Clin Sleep Med 2022 Jun 1;18(6):1687-1696. doi: 10.5664/jcsm.9938. PMID: 35172921Free PMC Article
Italian and North American dietary intake after ivacaftor treatment for Cystic Fibrosis Gating Mutations.
Sainath NN, Schall J, Bertolaso C, McAnlis C, Stallings VA
J Cyst Fibros 2019 Jan;18(1):135-143. Epub 2018 Jul 6 doi: 10.1016/j.jcf.2018.06.004. PMID: 29983355

Recent clinical studies

Etiology

Thermogenic T cells: a cell therapy for obesity?
Beier UH, Baker DJ, Baur JA
Am J Physiol Cell Physiol 2022 Jun 1;322(6):C1085-C1094. Epub 2022 Apr 27 doi: 10.1152/ajpcell.00034.2022. PMID: 35476503Free PMC Article
Overweight and obesity in children and adolescents with Down syndrome-prevalence, determinants, consequences, and interventions: A literature review.
Bertapelli F, Pitetti K, Agiovlasitis S, Guerra-Junior G
Res Dev Disabil 2016 Oct;57:181-92. Epub 2016 Jul 19 doi: 10.1016/j.ridd.2016.06.018. PMID: 27448331
The efficacy and safety of adrenergic blockade after burn injury: A systematic review and meta-analysis.
Flores O, Stockton K, Roberts JA, Muller MJ, Paratz JD
J Trauma Acute Care Surg 2016 Jan;80(1):146-55. doi: 10.1097/TA.0000000000000887. PMID: 26517779
Relationship between thyroid hormones, resting energy expenditure and cardiometabolic risk factors in euthyroid subjects.
Spadafranca A, Cappelletti C, Leone A, Vignati L, Battezzati A, Bedogni G, Bertoli S
Clin Nutr 2015 Aug;34(4):674-8. Epub 2014 Aug 4 doi: 10.1016/j.clnu.2014.07.014. PMID: 25176403
Decreased resting energy expenditure in patients with Duchenne muscular dystrophy.
Shimizu-Fujiwara M, Komaki H, Nakagawa E, Mori-Yoshimura M, Oya Y, Fujisaki T, Tokita Y, Kubota N, Shimazaki R, Sato K, Ishikawa T, Goto K, Mochizuki H, Takanoha S, Ogata K, Kawai M, Konagaya M, Miyazaki T, Tatara K, Sugai K, Sasaki M
Brain Dev 2012 Mar;34(3):206-12. Epub 2011 May 31 doi: 10.1016/j.braindev.2011.05.005. PMID: 21632191

Diagnosis

Diagnosis and management of sleep disorders in Prader-Willi syndrome.
Duis J, Pullen LC, Picone M, Friedman N, Hawkins S, Sannar E, Pfalzer AC, Shelton AR, Singh D, Zee PC, Glaze DG, Revana A
J Clin Sleep Med 2022 Jun 1;18(6):1687-1696. doi: 10.5664/jcsm.9938. PMID: 35172921Free PMC Article
UCP2, SHBG, Leptin, and T3 Levels are Associated with Resting Energy Expenditure in Obese Women.
Ahmadi S, Pishva H, Eshraghian MR, Hedayati M
Endocr Metab Immune Disord Drug Targets 2020;20(2):234-241. doi: 10.2174/1871530319666190723154147. PMID: 31340742
Meal timing affects glucose tolerance, substrate oxidation and circadian-related variables: A randomized, crossover trial.
Bandín C, Scheer FA, Luque AJ, Ávila-Gandía V, Zamora S, Madrid JA, Gómez-Abellán P, Garaulet M
Int J Obes (Lond) 2015 May;39(5):828-33. Epub 2014 Oct 14 doi: 10.1038/ijo.2014.182. PMID: 25311083
Relationship between thyroid hormones, resting energy expenditure and cardiometabolic risk factors in euthyroid subjects.
Spadafranca A, Cappelletti C, Leone A, Vignati L, Battezzati A, Bedogni G, Bertoli S
Clin Nutr 2015 Aug;34(4):674-8. Epub 2014 Aug 4 doi: 10.1016/j.clnu.2014.07.014. PMID: 25176403
Is UCP2 gene polymorphism associated with decreased resting energy expenditure in nondialyzed chronic kidney disease patients?
Avesani CM, Kamimura MA, Utaka S, Pecoits-Filho R, Nordfors L, Stenvinkel P, Lindholm B, Draibe SA, Cuppari L
J Ren Nutr 2008 Nov;18(6):489-94. doi: 10.1053/j.jrn.2008.08.009. PMID: 18940651

Therapy

Improved Muscle Function in Duchenne Muscular Dystrophy through L-Arginine and Metformin: An Investigator-Initiated, Open-Label, Single-Center, Proof-Of-Concept-Study.
Hafner P, Bonati U, Erne B, Schmid M, Rubino D, Pohlman U, Peters T, Rutz E, Frank S, Neuhaus C, Deuster S, Gloor M, Bieri O, Fischmann A, Sinnreich M, Gueven N, Fischer D
PLoS One 2016;11(1):e0147634. Epub 2016 Jan 22 doi: 10.1371/journal.pone.0147634. PMID: 26799743Free PMC Article
The efficacy and safety of adrenergic blockade after burn injury: A systematic review and meta-analysis.
Flores O, Stockton K, Roberts JA, Muller MJ, Paratz JD
J Trauma Acute Care Surg 2016 Jan;80(1):146-55. doi: 10.1097/TA.0000000000000887. PMID: 26517779
Meal timing affects glucose tolerance, substrate oxidation and circadian-related variables: A randomized, crossover trial.
Bandín C, Scheer FA, Luque AJ, Ávila-Gandía V, Zamora S, Madrid JA, Gómez-Abellán P, Garaulet M
Int J Obes (Lond) 2015 May;39(5):828-33. Epub 2014 Oct 14 doi: 10.1038/ijo.2014.182. PMID: 25311083
Serum ghrelin levels are increased in hypothyroid patients and become normalized by L-thyroxine treatment.
Gjedde S, Vestergaard ET, Gormsen LC, Riis AL, Rungby J, Møller N, Weeke J, Jørgensen JO
J Clin Endocrinol Metab 2008 Jun;93(6):2277-80. Epub 2008 Apr 1 doi: 10.1210/jc.2007-2619. PMID: 18381578
Nutrition therapy of organic acidaemias with amino acid-based formulas: emphasis on methylmalonic and propionic acidaemia.
Yannicelli S
J Inherit Metab Dis 2006 Apr-Jun;29(2-3):281-7. doi: 10.1007/s10545-006-0267-2. PMID: 16763889

Prognosis

Relationship between thyroid hormones, resting energy expenditure and cardiometabolic risk factors in euthyroid subjects.
Spadafranca A, Cappelletti C, Leone A, Vignati L, Battezzati A, Bedogni G, Bertoli S
Clin Nutr 2015 Aug;34(4):674-8. Epub 2014 Aug 4 doi: 10.1016/j.clnu.2014.07.014. PMID: 25176403
Five-year outcomes after oxandrolone administration in severely burned children: a randomized clinical trial of safety and efficacy.
Porro LJ, Herndon DN, Rodriguez NA, Jennings K, Klein GL, Mlcak RP, Meyer WJ, Lee JO, Suman OE, Finnerty CC
J Am Coll Surg 2012 Apr;214(4):489-502; discussion 502-4. doi: 10.1016/j.jamcollsurg.2011.12.038. PMID: 22463890Free PMC Article
Is UCP2 gene polymorphism associated with decreased resting energy expenditure in nondialyzed chronic kidney disease patients?
Avesani CM, Kamimura MA, Utaka S, Pecoits-Filho R, Nordfors L, Stenvinkel P, Lindholm B, Draibe SA, Cuppari L
J Ren Nutr 2008 Nov;18(6):489-94. doi: 10.1053/j.jrn.2008.08.009. PMID: 18940651
Effects of Roux-en-Y gastric bypass on resting energy expenditure in women.
de Castro Cesar M, de Lima Montebelo MI, Rasera I Jr, de Oliveira AV Jr, Gomes Gonelli PR, Aparecida Cardoso G
Obes Surg 2008 Nov;18(11):1376-80. Epub 2008 Mar 5 doi: 10.1007/s11695-008-9460-8. PMID: 18320289

Clinical prediction guides

UCP2, SHBG, Leptin, and T3 Levels are Associated with Resting Energy Expenditure in Obese Women.
Ahmadi S, Pishva H, Eshraghian MR, Hedayati M
Endocr Metab Immune Disord Drug Targets 2020;20(2):234-241. doi: 10.2174/1871530319666190723154147. PMID: 31340742
Improved Muscle Function in Duchenne Muscular Dystrophy through L-Arginine and Metformin: An Investigator-Initiated, Open-Label, Single-Center, Proof-Of-Concept-Study.
Hafner P, Bonati U, Erne B, Schmid M, Rubino D, Pohlman U, Peters T, Rutz E, Frank S, Neuhaus C, Deuster S, Gloor M, Bieri O, Fischmann A, Sinnreich M, Gueven N, Fischer D
PLoS One 2016;11(1):e0147634. Epub 2016 Jan 22 doi: 10.1371/journal.pone.0147634. PMID: 26799743Free PMC Article
Relationship between thyroid hormones, resting energy expenditure and cardiometabolic risk factors in euthyroid subjects.
Spadafranca A, Cappelletti C, Leone A, Vignati L, Battezzati A, Bedogni G, Bertoli S
Clin Nutr 2015 Aug;34(4):674-8. Epub 2014 Aug 4 doi: 10.1016/j.clnu.2014.07.014. PMID: 25176403
Is UCP2 gene polymorphism associated with decreased resting energy expenditure in nondialyzed chronic kidney disease patients?
Avesani CM, Kamimura MA, Utaka S, Pecoits-Filho R, Nordfors L, Stenvinkel P, Lindholm B, Draibe SA, Cuppari L
J Ren Nutr 2008 Nov;18(6):489-94. doi: 10.1053/j.jrn.2008.08.009. PMID: 18940651
Effects of Roux-en-Y gastric bypass on resting energy expenditure in women.
de Castro Cesar M, de Lima Montebelo MI, Rasera I Jr, de Oliveira AV Jr, Gomes Gonelli PR, Aparecida Cardoso G
Obes Surg 2008 Nov;18(11):1376-80. Epub 2008 Mar 5 doi: 10.1007/s11695-008-9460-8. PMID: 18320289

Recent systematic reviews

The efficacy and safety of adrenergic blockade after burn injury: A systematic review and meta-analysis.
Flores O, Stockton K, Roberts JA, Muller MJ, Paratz JD
J Trauma Acute Care Surg 2016 Jan;80(1):146-55. doi: 10.1097/TA.0000000000000887. PMID: 26517779

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