U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Abnormal metabolism

MedGen UID:
1703500
•Concept ID:
C5139220
•
Finding
HPO: HP:0032245

Definition

An abnormality in the function of the chemical reactions related to processes including conversion of food to enter, synthesis of proteins, lipids, nucleic acids, and carbohydrates, or the elimination of waste products. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal metabolism

Professional guidelines

PubMed

Gout and Diet: A Comprehensive Review of Mechanisms and Management.
Zhang Y, Chen S, Yuan M, Xu Y, Xu H
Nutrients 2022 Aug 26;14(17) doi: 10.3390/nu14173525. PMID: 36079783Free PMC Article
Pancreatic Cancer: A Review of Risk Factors, Diagnosis, and Treatment.
Zhao Z, Liu W
Technol Cancer Res Treat 2020 Jan-Dec;19:1533033820962117. doi: 10.1177/1533033820962117. PMID: 33357065Free PMC Article
Diagnosis and treatment of heart failure in hereditary transthyretin amyloidosis.
Puig-Carrion GD, Reyentovich A, Katz SD
Clin Auton Res 2019 Sep;29(Suppl 1):45-53. Epub 2019 Aug 26 doi: 10.1007/s10286-019-00629-5. PMID: 31452023Free PMC Article

Recent clinical studies

Etiology

Gout and Diet: A Comprehensive Review of Mechanisms and Management.
Zhang Y, Chen S, Yuan M, Xu Y, Xu H
Nutrients 2022 Aug 26;14(17) doi: 10.3390/nu14173525. PMID: 36079783Free PMC Article
Pancreatic Cancer: A Review of Risk Factors, Diagnosis, and Treatment.
Zhao Z, Liu W
Technol Cancer Res Treat 2020 Jan-Dec;19:1533033820962117. doi: 10.1177/1533033820962117. PMID: 33357065Free PMC Article
Kyrle's disease.
Ataseven A, Ozturk P, Kucukosmanoglu I, Kurtipek GS
BMJ Case Rep 2014 Jan 15;2014 doi: 10.1136/bcr-2013-009905. PMID: 24429045Free PMC Article
Definition and classification of cancer cachexia: an international consensus.
Fearon K, Strasser F, Anker SD, Bosaeus I, Bruera E, Fainsinger RL, Jatoi A, Loprinzi C, MacDonald N, Mantovani G, Davis M, Muscaritoli M, Ottery F, Radbruch L, Ravasco P, Walsh D, Wilcock A, Kaasa S, Baracos VE
Lancet Oncol 2011 May;12(5):489-95. Epub 2011 Feb 4 doi: 10.1016/S1470-2045(10)70218-7. PMID: 21296615
Alpha-thalassaemia.
Harteveld CL, Higgs DR
Orphanet J Rare Dis 2010 May 28;5:13. doi: 10.1186/1750-1172-5-13. PMID: 20507641Free PMC Article

Diagnosis

Pancreatic Cancer: A Review of Risk Factors, Diagnosis, and Treatment.
Zhao Z, Liu W
Technol Cancer Res Treat 2020 Jan-Dec;19:1533033820962117. doi: 10.1177/1533033820962117. PMID: 33357065Free PMC Article
Hypoxic Pulmonary Vasoconstriction: From Molecular Mechanisms to Medicine.
Dunham-Snary KJ, Wu D, Sykes EA, Thakrar A, Parlow LRG, Mewburn JD, Parlow JL, Archer SL
Chest 2017 Jan;151(1):181-192. Epub 2016 Sep 16 doi: 10.1016/j.chest.2016.09.001. PMID: 27645688Free PMC Article
Fibrinolysis and the control of blood coagulation.
Chapin JC, Hajjar KA
Blood Rev 2015 Jan;29(1):17-24. Epub 2014 Sep 16 doi: 10.1016/j.blre.2014.09.003. PMID: 25294122Free PMC Article
Kyrle's disease.
Ataseven A, Ozturk P, Kucukosmanoglu I, Kurtipek GS
BMJ Case Rep 2014 Jan 15;2014 doi: 10.1136/bcr-2013-009905. PMID: 24429045Free PMC Article
Definition and classification of cancer cachexia: an international consensus.
Fearon K, Strasser F, Anker SD, Bosaeus I, Bruera E, Fainsinger RL, Jatoi A, Loprinzi C, MacDonald N, Mantovani G, Davis M, Muscaritoli M, Ottery F, Radbruch L, Ravasco P, Walsh D, Wilcock A, Kaasa S, Baracos VE
Lancet Oncol 2011 May;12(5):489-95. Epub 2011 Feb 4 doi: 10.1016/S1470-2045(10)70218-7. PMID: 21296615

Therapy

Protein tyrosine kinase inhibitor resistance in malignant tumors: molecular mechanisms and future perspective.
Yang Y, Li S, Wang Y, Zhao Y, Li Q
Signal Transduct Target Ther 2022 Sep 17;7(1):329. doi: 10.1038/s41392-022-01168-8. PMID: 36115852Free PMC Article
Neurotoxicity and Underlying Mechanisms of Endogenous Neurotoxins.
Cao Y, Li B, Ismail N, Smith K, Li T, Dai R, Deng Y
Int J Mol Sci 2021 Nov 26;22(23) doi: 10.3390/ijms222312805. PMID: 34884606Free PMC Article
Insight into the complex pathophysiology of sickle cell anaemia and possible treatment.
Piccin A, Murphy C, Eakins E, Rondinelli MB, Daves M, Vecchiato C, Wolf D, Mc Mahon C, Smith OP
Eur J Haematol 2019 Apr;102(4):319-330. Epub 2019 Feb 21 doi: 10.1111/ejh.13212. PMID: 30664257
Definition and classification of cancer cachexia: an international consensus.
Fearon K, Strasser F, Anker SD, Bosaeus I, Bruera E, Fainsinger RL, Jatoi A, Loprinzi C, MacDonald N, Mantovani G, Davis M, Muscaritoli M, Ottery F, Radbruch L, Ravasco P, Walsh D, Wilcock A, Kaasa S, Baracos VE
Lancet Oncol 2011 May;12(5):489-95. Epub 2011 Feb 4 doi: 10.1016/S1470-2045(10)70218-7. PMID: 21296615
Free radical-induced pathology.
Clark IA, Cowden WB, Hunt NH
Med Res Rev 1985 Jul-Sep;5(3):297-332. doi: 10.1002/med.2610050303. PMID: 3894833

Prognosis

PHGDH Inhibits Ferroptosis and Promotes Malignant Progression by Upregulating SLC7A11 in Bladder Cancer.
Shen L, Zhang J, Zheng Z, Yang F, Liu S, Wu Y, Chen Y, Xu T, Mao S, Yan Y, Li W, Zhang W, Yao X
Int J Biol Sci 2022;18(14):5459-5474. Epub 2022 Aug 29 doi: 10.7150/ijbs.74546. PMID: 36147463Free PMC Article
Gout and Diet: A Comprehensive Review of Mechanisms and Management.
Zhang Y, Chen S, Yuan M, Xu Y, Xu H
Nutrients 2022 Aug 26;14(17) doi: 10.3390/nu14173525. PMID: 36079783Free PMC Article
Pancreatic Cancer: A Review of Risk Factors, Diagnosis, and Treatment.
Zhao Z, Liu W
Technol Cancer Res Treat 2020 Jan-Dec;19:1533033820962117. doi: 10.1177/1533033820962117. PMID: 33357065Free PMC Article
Cardiovascular risk factors in China: a nationwide population-based cohort study.
Li X, Wu C, Lu J, Chen B, Li Y, Yang Y, Hu S, Li J
Lancet Public Health 2020 Dec;5(12):e672-e681. doi: 10.1016/S2468-2667(20)30191-2. PMID: 33271080
Fibrinolysis and the control of blood coagulation.
Chapin JC, Hajjar KA
Blood Rev 2015 Jan;29(1):17-24. Epub 2014 Sep 16 doi: 10.1016/j.blre.2014.09.003. PMID: 25294122Free PMC Article

Clinical prediction guides

PHGDH Inhibits Ferroptosis and Promotes Malignant Progression by Upregulating SLC7A11 in Bladder Cancer.
Shen L, Zhang J, Zheng Z, Yang F, Liu S, Wu Y, Chen Y, Xu T, Mao S, Yan Y, Li W, Zhang W, Yao X
Int J Biol Sci 2022;18(14):5459-5474. Epub 2022 Aug 29 doi: 10.7150/ijbs.74546. PMID: 36147463Free PMC Article
Pancreatic Cancer: A Review of Risk Factors, Diagnosis, and Treatment.
Zhao Z, Liu W
Technol Cancer Res Treat 2020 Jan-Dec;19:1533033820962117. doi: 10.1177/1533033820962117. PMID: 33357065Free PMC Article
Cardiovascular risk factors in China: a nationwide population-based cohort study.
Li X, Wu C, Lu J, Chen B, Li Y, Yang Y, Hu S, Li J
Lancet Public Health 2020 Dec;5(12):e672-e681. doi: 10.1016/S2468-2667(20)30191-2. PMID: 33271080
Fibrinolysis and the control of blood coagulation.
Chapin JC, Hajjar KA
Blood Rev 2015 Jan;29(1):17-24. Epub 2014 Sep 16 doi: 10.1016/j.blre.2014.09.003. PMID: 25294122Free PMC Article
Alpha-thalassaemia.
Harteveld CL, Higgs DR
Orphanet J Rare Dis 2010 May 28;5:13. doi: 10.1186/1750-1172-5-13. PMID: 20507641Free PMC Article

Recent systematic reviews

Kynurenine metabolite changes in individuals with alcohol use disorder: A systematic review and meta-analysis.
Wang Z, Huang S, Li L, Wen Y, Shang D
Drug Alcohol Depend 2023 Aug 1;249:110821. Epub 2023 Jun 11 doi: 10.1016/j.drugalcdep.2023.110821. PMID: 37327508
Folic acid supplementation and malaria susceptibility and severity among people taking antifolate antimalarial drugs in endemic areas.
Crider K, Williams J, Qi YP, Gutman J, Yeung L, Mai C, Finkelstain J, Mehta S, Pons-Duran C, Menéndez C, Moraleda C, Rogers L, Daniels K, Green P
Cochrane Database Syst Rev 2022 Feb 1;2(2022) doi: 10.1002/14651858.CD014217. PMID: 36321557Free PMC Article
Catheter Ablation for Atrial Fibrillation in Patients with Chronic Kidney Disease and on Dialysis: A Meta-Analysis and Review.
Chung I, Khan Y, Warrens H, Seshasai RK, Sohal M, Banerjee D
Cardiorenal Med 2022;12(4):155-172. Epub 2022 Jul 12 doi: 10.1159/000525388. PMID: 35820393
[18F]FDG brain PET and clinical symptoms in different autoantibodies of autoimmune encephalitis: a systematic review.
Nabizadeh F, Ramezannezhad E, Sardaripour A, Seyedi SA, Salehi N, Rezaeimanesh N, Naser Moghadasi A
Neurol Sci 2022 Aug;43(8):4701-4718. Epub 2022 Apr 29 doi: 10.1007/s10072-022-06094-9. PMID: 35486333
Mineral bone disorders in chronic kidney disease.
Hou YC, Lu CL, Lu KC
Nephrology (Carlton) 2018 Oct;23 Suppl 4:88-94. doi: 10.1111/nep.13457. PMID: 30298663

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...