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Cold intolerance

MedGen UID:
1053472
•Concept ID:
CN378002
•
Finding
Synonym: Cold sensitivity
 
HPO: HP:6000855

Definition

The inability to maintain a comfortable body temperature in a cold environment or cold temperatures. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCold intolerance

Professional guidelines

PubMed

Hypothyroidism: Diagnosis and Treatment.
Wilson SA, Stem LA, Bruehlman RD
Am Fam Physician 2021 May 15;103(10):605-613. PMID: 33983002
Raynaud's phenomenon-an update on diagnosis, classification and management.
Pauling JD, Hughes M, Pope JE
Clin Rheumatol 2019 Dec;38(12):3317-3330. Epub 2019 Aug 16 doi: 10.1007/s10067-019-04745-5. PMID: 31420815
Myxedema coma: diagnosis and treatment.
Wall CR
Am Fam Physician 2000 Dec 1;62(11):2485-90. PMID: 11130234

Recent clinical studies

Etiology

Describing post-polio syndrome.
Sáinz MP, Pelayo R, Laxe S, Castaño B, Capdevilla E, Portell E
Neurologia (Engl Ed) 2022 Jun;37(5):346-354. Epub 2021 May 5 doi: 10.1016/j.nrleng.2019.03.023. PMID: 35672121
Pro-Angiogenesis Therapy and Aging: A Mini-Review.
Ambrose CT
Gerontology 2017;63(5):393-400. Epub 2017 Jun 1 doi: 10.1159/000477402. PMID: 28564651
Cryofibrinogenemia.
Michaud M, Pourrat J
J Clin Rheumatol 2013 Apr;19(3):142-8. doi: 10.1097/RHU.0b013e318289e06e. PMID: 23519183
Hypopituitarism.
Ascoli P, Cavagnini F
Pituitary 2006;9(4):335-42. doi: 10.1007/s11102-006-0416-5. PMID: 17077946
Myxedema coma: diagnosis and treatment.
Wall CR
Am Fam Physician 2000 Dec 1;62(11):2485-90. PMID: 11130234

Diagnosis

Hypothyroidism.
Taylor PN, Medici MM, Hubalewska-Dydejczyk A, Boelaert K
Lancet 2024 Oct 5;404(10460):1347-1364. doi: 10.1016/S0140-6736(24)01614-3. PMID: 39368843
Hypothyroidism: Diagnosis and Treatment.
Wilson SA, Stem LA, Bruehlman RD
Am Fam Physician 2021 May 15;103(10):605-613. PMID: 33983002
Raynaud's phenomenon-an update on diagnosis, classification and management.
Pauling JD, Hughes M, Pope JE
Clin Rheumatol 2019 Dec;38(12):3317-3330. Epub 2019 Aug 16 doi: 10.1007/s10067-019-04745-5. PMID: 31420815
Cold intolerance after nerve injury.
Novak CB
J Hand Ther 2018 Apr-Jun;31(2):195-200. Epub 2018 Feb 9 doi: 10.1016/j.jht.2018.01.003. PMID: 29433764
Myxedema coma: diagnosis and treatment.
Wall CR
Am Fam Physician 2000 Dec 1;62(11):2485-90. PMID: 11130234

Therapy

Hypothyroidism.
Taylor PN, Medici MM, Hubalewska-Dydejczyk A, Boelaert K
Lancet 2024 Oct 5;404(10460):1347-1364. doi: 10.1016/S0140-6736(24)01614-3. PMID: 39368843
Cold intolerance and hand-arm vibration syndrome.
Cooke RA, Lawson IJ
Occup Med (Lond) 2022 Apr 19;72(3):152-153. doi: 10.1093/occmed/kqab071. PMID: 35438157
Hypothyroidism: Diagnosis and Treatment.
Wilson SA, Stem LA, Bruehlman RD
Am Fam Physician 2021 May 15;103(10):605-613. PMID: 33983002
Cold intolerance after nerve injury.
Novak CB
J Hand Ther 2018 Apr-Jun;31(2):195-200. Epub 2018 Feb 9 doi: 10.1016/j.jht.2018.01.003. PMID: 29433764
Myxedema coma: diagnosis and treatment.
Wall CR
Am Fam Physician 2000 Dec 1;62(11):2485-90. PMID: 11130234

Prognosis

Managing cold intolerance after hand injury: A systematic review.
Greene BHC, Gudimella R, Corkum JP, Boone H, Samargandi OA, Williams J
Hand Surg Rehabil 2023 Apr;42(2):109-114. Epub 2023 Jan 28 doi: 10.1016/j.hansur.2023.01.007. PMID: 36720347
Prevalence, characteristics and natural history of cold intolerance after the reverse digital artery flap.
Sun YC, Chen QZ, Chen J, Qian ZW, Kong J, Gong YP
J Hand Surg Eur Vol 2016 Feb;41(2):171-6. Epub 2015 Jul 28 doi: 10.1177/1753193415596438. PMID: 26221010
Cold intolerance following median and ulnar nerve injuries: prognosis and predictors.
Ruijs AC, Jaquet JB, van Riel WG, Daanen HA, Hovius SE
J Hand Surg Eur Vol 2007 Aug;32(4):434-9. Epub 2007 May 4 doi: 10.1016/J.JHSB.2007.02.012. PMID: 17482322
Vibration damage to the hand: clinical presentation, prognosis and length and severity of vibration required.
Fridén J
J Hand Surg Br 2001 Oct;26(5):471-4. doi: 10.1054/jhsb.2001.0633. PMID: 11560431
Myxedema coma: diagnosis and treatment.
Wall CR
Am Fam Physician 2000 Dec 1;62(11):2485-90. PMID: 11130234

Clinical prediction guides

Describing post-polio syndrome.
Sáinz MP, Pelayo R, Laxe S, Castaño B, Capdevilla E, Portell E
Neurologia (Engl Ed) 2022 Jun;37(5):346-354. Epub 2021 May 5 doi: 10.1016/j.nrleng.2019.03.023. PMID: 35672121
Nonfreezing Cold Injury and Cold Intolerance in Paddlesport.
Oakley B, Brown HL, Johnson N, Bainbridge C
Wilderness Environ Med 2022 Jun;33(2):187-196. Epub 2022 Apr 29 doi: 10.1016/j.wem.2022.03.003. PMID: 35501230
Defining abnormal cold sensitivity using the Cold Intolerance Symptom Severity questionnaire: a population study.
Stjernbrandt A, Liljelind I, Nilsson T, Wahlström J
J Hand Surg Eur Vol 2021 Sep;46(7):731-737. Epub 2021 Mar 12 doi: 10.1177/1753193421996221. PMID: 33709819Free PMC Article
Prospective assessment of function and cold-intolerance following revascularization for hypothenar hammer syndrome.
Malsagova AT, van Burink MV, Smits ES, Zöphel OT, Stassen CM, Botman JMJ, Rakhorst HA
J Plast Reconstr Aesthet Surg 2020 Dec;73(12):2164-2170. Epub 2020 May 25 doi: 10.1016/j.bjps.2020.05.050. PMID: 32565138
Cold intolerance and neuropathic pain after peripheral nerve injury in upper extremity.
Magistroni E, Parodi G, Fop F, Battiston B, Dahlin LB
J Peripher Nerv Syst 2020 Jun;25(2):184-190. Epub 2020 Apr 28 doi: 10.1111/jns.12376. PMID: 32297385

Recent systematic reviews

Managing cold intolerance after hand injury: A systematic review.
Greene BHC, Gudimella R, Corkum JP, Boone H, Samargandi OA, Williams J
Hand Surg Rehabil 2023 Apr;42(2):109-114. Epub 2023 Jan 28 doi: 10.1016/j.hansur.2023.01.007. PMID: 36720347
Bioengineered nerve conduits and wraps for peripheral nerve repair of the upper limb.
Thomson SE, Ng NY, Riehle MO, Kingham PJ, Dahlin LB, Wiberg M, Hart AM
Cochrane Database Syst Rev 2022 Dec 7;12(12):CD012574. doi: 10.1002/14651858.CD012574.pub2. PMID: 36477774Free PMC Article
Diagnostic Criteria for Symptomatic Neuroma.
Arnold DMJ, Wilkens SC, Coert JH, Chen NC, Ducic I, Eberlin KR
Ann Plast Surg 2019 Apr;82(4):420-427. doi: 10.1097/SAP.0000000000001796. PMID: 30855369
A Systematic Review of Outcomes after Revision Amputation for Treatment of Traumatic Finger Amputation.
Yuan F, McGlinn EP, Giladi AM, Chung KC
Plast Reconstr Surg 2015 Jul;136(1):99-113. doi: 10.1097/PRS.0000000000001487. PMID: 26111316Free PMC Article
Selenium supplementation for Hashimoto's thyroiditis.
van Zuuren EJ, Albusta AY, Fedorowicz Z, Carter B, Pijl H
Cochrane Database Syst Rev 2013 Jun 6;2013(6):CD010223. doi: 10.1002/14651858.CD010223.pub2. PMID: 23744563Free PMC Article

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