Genetic breakthrough paves the way for a male birth control pill
Source: Study Finds
A ground-breaking contraceptive pill for men could be just around the corner after a major genetic breakthrough. Scientists at Washington State University have identified a gene which temporarily renders sperm infertile after they remove it.
The research team discovered a protein encoded by this gene, found solely in the testicular tissue of most mammals, which reduced sperm counts and deformed remaining sperm to make them incapable of fertilizing an egg when altered. The potentially historic breakthrough contraceptive pill would also have no hormonal side-effects and could be additionally help control animal overpopulation — replacing castration.
Crucially, the destabilization of the infertility protein is not permanent, meaning sperm will recover once the person or animal stops taking the treatment. Scientists have hailed the discovery as potentially important for the future of the human race. In their study, researchers identified the expression of a gene called Arrdc5 in the testicular tissue of mice, pigs, cattle, and humans.
Read more: https://studyfinds.org/genetic-male-birth-control-pill/
Abstract from technical paper.
https://www.nature.com/articles/s41467-023-36119-6
Abstract
Nearly half of all pregnancies are unintended; thus, existing family planning options are inadequate. For men, the only choices are condoms and vasectomy, and most current efforts to develop new contraceptives for men impact sperm development, meaning that contraception requires months of continuous pretreatment. Here, we provide proof-of-concept for an innovative strategy for on-demand contraception, where a man would take a birth control pill shortly before sex, only as needed. Soluble adenylyl cyclase (sAC) is essential for sperm motility and maturation. We show a single dose of a safe, acutely-acting sAC inhibitor with long residence time renders male mice temporarily infertile. Mice exhibit normal mating behavior, and full fertility returns the next day. These studies define sAC inhibitors as leads for on-demand contraceptives for men, and they provide in vivo proof-of-concept for previously untested paradigms in contraception; on-demand contraception after just a single dose and pharmacological contraception for men.
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Gee, this seems so fair.....
This a male dominated planet and nothing will change thousands of years of male domination in every society and culture. "Man" should not be in the word "human" since they act like animals, thinking with the "brain" in their pants, not their heads.
