- published: 17 Dec 2014
- views: 5219696
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Platelet
Platelets, also called thrombocytes (thromb- + -cyte, "blood clot cell"), are a component of blood whose function (along with the coagulation factors) is to stop bleeding by clumping and clotting blood vessel injuries. Platelets have no cell nucleus: they are fragments of cytoplasm that are derived from the megakaryocytes of the bone marrow, and then enter the circulation. These unactivated platelets are biconvex discoid (lens-shaped) structures, 2–3 µm in greatest diameter. Platelets are found only in mammals, whereas in other animals (e.g. birds, amphibians) thrombocytes circulate as intact mononuclear cells.
On a stained blood smear, platelets appear as dark purple spots, about 20% the diameter of red blood cells. The smear is used to examine platelets for size, shape, qualitative number, and clumping. The ratio of platelets to red blood cells in a healthy adult is 1:10 to 1:20.
The main function of platelets is to contribute to hemostasis: the process of stopping bleeding at the site of interrupted endothelium. They gather at the site and unless the interruption is physically too large, they plug the hole. First, platelets attach to substances outside the interrupted endothelium: adhesion. Second, they change shape, turn on receptors and secrete chemical messengers: activation. Third, they connect to each other through receptor bridges: aggregation. Formation of this platelet plug (primary hemostasis) is associated with activation of the coagulation cascade with resultant fibrin deposition and linking (secondary hemostasis). These processes may overlap: the spectrum is from a predominantly platelet plug, or "white clot" to a predominantly fibrin clot, or "red clot" or the more typical mixture. The final result is the clot. Some would add the subsequent clot retraction and platelet inhibition as fourth and fifth steps to the completion of the process and still others a sixth step wound repair.
This page contains text from Wikipedia, the Free Encyclopedia - https://wn.com/Platelet
Podcasts:
-
Platelet Activation and Factors for Clot Formation
Learn more about the process of platelet activation and the involved coagulation factors triggering clot formation? Find more about clot formation on: https://www.thrombosisadviser.com/arterial-thrombosis/ Approval Number: PP-XAR-ALL-2428-1
published: 17 Dec 2014 -
Platelet Adhesion and Aggregation
Developed and produced for http://www.MechanismsInHematology.com by Mechanisms in Medicine Inc. Animation description: Platelet adhesion and aggregation. In flowing blood, red cells predominate in the axial stream, while the biconvex disc-shaped platelets are marginated along the vessel wall where they are well-positioned to monitor the integrity of the endothelium. The normal endothelium provides a non-adhesive surface to circulating platelets. However, when vessel wall injury occurs, for example, by cutting or severing of a vessel, or as shown here, by a puncture, and there is endothelial damage, the initial response of platelets is that of adhesion to collagen fibres in the exposed subendothelium. Collagen is one of the most thrombogenic components of the subendothelial matrix res...
published: 08 Dec 2010 -
Low Platelets: Signs & Symptoms (Basics for Beginners)
Low Platelets: Signs & Symptoms (Basics for Beginners) Low Platelets (also known as Thrombocytopenia) is a condition where the number of platelets in your blood is too low, which can cause a variety of signs and symptoms. Platelets are important for making what we call a “platelet plug” to stop/reduce bleeding from cuts, etc. When there aren’t enough platelets around, stopping and reducing bleeding becomes more difficult, leading This is my first lesson where I am focusing more on non-healthcare professionals and the general public – please let me know what you think! Thanks JJ ------------------------------------------------------------------------------------------------------------- For books and more information on these topics https://www.amazon.com/shop/jjmedicine Check out t...
published: 22 Oct 2020 -
Thrombocytopaenia (low platelets) Overview - platelet physiology, classification, pathophysiology
Buy Images here: armandoh.org/shop "Thrombocytopenia which means low platelets is associated with a variety of conditions. Thrombocytopenia is defined as a platelet count below the lower limit of normal (less than 150,000/microL). Platelets are produced in the bone marrow from megakaryocytes. Each megakoryocyte produces 1000-5000 platelets. Platelets play a key role in hemostasis forming a temporary plug. Therefore if you have low platelets you are unable to for a temporary plug and tend to bleed more easily. In order to understand platelet function, we need to revise hemostasis. Hemostasis involves three main phases vasoconstriction, platelets plug formation and coagulation" Where do I get my information from: http://armandoh.org/resource Facebook: https://www.facebook.com/ArmandoHasud...
published: 29 Jan 2019 -
Platelets (Thrombocytes) - The Cell Pieces that Lack Nucleus - Hematology
😍🖼Animated Mnemonics (Picmonic): https://www.picmonic.com/viphookup/medicosis/ - With Picmonic, get your life back by studying less and remembering more. Medical and Nursing students say that Picmonic is the most comprehensive and effective way to bridge learning and test prep... Disclaimer: I use affiliate links.... ►👨🏫💊Antibiotics Lectures: https://www.medicosisperfectionalis.com/products/courses/antibiotics/ ... Check out my brand new "Electrolytes" course at https://www.medicosisperfectionalis.com/products/course/electrolytes/ and use the PROMO code: ELECTROLYTES50 to get a 50% discount. The first video in my NEW playlist “Bleeding and Coagulation"...See the entire playlist here: https://goo.gl/Dt41Bg Platelets (thrombocytes) are not cells, they are just pieces of the megakaryo...
published: 15 Feb 2019 -
Thrombocyte/Platelet Structure and Function
In this video, we will look at the structure and function of platelets/thrombocytes - important components in the blood that are involved in blood clotting/hemostasis. By the end of the video, you’ll have a good understanding of what platelets are and how they do what they do. 00:00 Intro 00:19 Hemostasis 00:49 Thrombocytes -- a misnomer 01:16 How Platelets are formed from Megakaryocutes 01:58 Platelet Structure 02:23 Other functions of platelets 03:09 Platelet disorders | Thrombocytopenia and Thrombocytosis Download a PDF copy of The Cardiac Cycle Made Easy here 👉 https://www.interactive-biology.com/cardiaccycle/ Download a PDF copy of The Cardiac Cycle Made Easy here 👉 https://www.interactive-biology.com/cardiaccycle/ . Download a PDF copy of The Cardiac Cycle Made Easy here 👉 https://...
published: 01 Feb 2022 -
Platelets & Blood Clotting | Biology | FuseSchool
Do you remember tripping over as a kid and cutting your knee? And then like magic the bleeding suddenly stops? Have you ever wondered why this happens? Our body is very clever and produces substances to seal off the open wound. In this video we are going to look at how and why blood clots. Clotting prevents us from bleeding to death, and also protects us from nasty disease-causing organisms, called pathogens, entering our body. When we injure ourselves, we can damage the blood vessels just below our skin. This can cause blood to either leak into our tissue and form a bruise, or, if the skin is broken to openly bleed. To prevent these horrible things happening, blood clotting occurs. So let’s have a look at how this happens. Starting with platelets. These are tiny cell fragments ...
published: 11 Oct 2018 -
Decode Your Blood Test: Platelets 💉 | Merck Manual Consumer Version
Find out why platelets are so important and what could happen if your platelet count becomes too low or too high. Get more information in the links below: Overview of Blood Disorders: https://mrkmnls.co/2Osv3n0 Laboratory Tests for Blood Disorders: https://mrkmnls.co/2TZESyP About The Merck Manuals: First published in 1899 as a small reference book for physicians and pharmacists, The Merck Manual grew in size and scope to become one of the world's most widely used comprehensive medical resources for professionals and consumers. As The Manual evolved, it continually expanded the reach and depth of its offerings to reflect the mission of providing the best medical information to a wide cross-section of users, including medical professionals and students, veterinarians and veterinary s...
published: 01 Jun 2020 -
Platelets Explained in Two Minutes
Platelets are tiny cells in your blood that form clots and stop bleeding. For millions of Americans, they are essential to surviving and fighting cancer, chronic diseases, and traumatic injuries. About 2 million units of platelets are transfused each year in the U.S. Every 15 seconds someone in the U.S. needs platelets. You can help by donating platelets through the American Red Cross. Visit http://redcrossblood.org/platelets or call 1-800-RED CROSS for more information.
published: 30 Aug 2016 -
What are Platelets and when do they decrease? - Dr. Satish Kumar
Platelets are small cells in the body which help the blood to clot. There are three types of cells, red cells, white cells and platelets in the cells. These blood cells called platelets help the blood to clot. Whenever we have a small cut, it helps the blood to clot. The platelets are instrumental in forming the clot. Whenever the platelet count goes down, there is a risk of bleeding, but then again, people have a lot of myths about platelets though the normal platelet count is one lakh fifty thousand, to four lakh fifty thousand, unless and until the platelet count falls to less than 20000 or 10000. There will not be any risk of significant internal bleeding. The most common cause if low platelet count, nowadays we see is due to dengue fever. But apart from infections. The most common cau...
published: 28 Sep 2017
developed with YouTube
2:08
Platelet Activation and Factors for Clot Formation
- Order: Reorder
- Duration: 2:08
- Uploaded Date: 17 Dec 2014
- views: 5219696
Learn more about the process of platelet activation and the involved coagulation factors triggering clot formation? Find more about clot formation on: https://w...
Learn more about the process of platelet activation and the involved coagulation factors triggering clot formation? Find more about clot formation on: https://www.thrombosisadviser.com/arterial-thrombosis/
Approval Number: PP-XAR-ALL-2428-1
https://wn.com/Platelet_Activation_And_Factors_For_Clot_Formation
Learn more about the process of platelet activation and the involved coagulation factors triggering clot formation? Find more about clot formation on: https://www.thrombosisadviser.com/arterial-thrombosis/
Approval Number: PP-XAR-ALL-2428-1
4:42
Platelet Adhesion and Aggregation
- Order: Reorder
- Duration: 4:42
- Uploaded Date: 08 Dec 2010
- views: 403499
Developed and produced for http://www.MechanismsInHematology.com by Mechanisms in Medicine Inc.
Animation description: Platelet adhesion and aggregation.
In...
Developed and produced for http://www.MechanismsInHematology.com by Mechanisms in Medicine Inc.
Animation description: Platelet adhesion and aggregation.
In flowing blood, red cells predominate in the axial stream, while the biconvex disc-shaped platelets are marginated along the vessel wall where they are well-positioned to monitor the integrity of the endothelium. The normal endothelium provides a non-adhesive surface to circulating platelets.
However, when vessel wall injury occurs, for example, by cutting or severing of a vessel, or as shown here, by a puncture, and there is endothelial damage, the initial response of platelets is that of adhesion to collagen fibres in the exposed subendothelium.
Collagen is one of the most thrombogenic components of the subendothelial matrix responsible for the initiation of platelet adhesion. A number of adhesive receptors on the platelet surface membrane interact either directly or indirectly with collagen.
Initial binding of platelets is considered to occur via the integrin α2β1 (GPIa-IIa) receptor, which allows for further binding to collagen via the GPVI receptor, initiating transmembrane and, subsequently, intracellular signalling. Adhesion of platelets to the exposed subendothelium is influenced by shear rates. At high shear, α2β1 and GPVI are not sufficient to initiate binding to collagen, and binding of the GPIb-IX-V receptor to von Willebrand factor -- abbreviated here as V.W.F. -- that is immobilized on collagen, becomes essential in platelet adhesion.
Platelet adhesion at the site of vessel wall damage initiates activation events that result in aggregation. Adherent platelets undergo a dramatic shape change to an irregular sphere with multiple filipodia spreading on the subendothelium increasing their area of surface contact.
Adherent platelets also secrete or release the contents of their storage granules -- the alpha- and dense granules -- by an exocytic process. This provides a high local concentration of effector molecules essential for platelet plug formation at the site of vascular injury. For example, the aggregating agent A.D.P. is released from the dense granules.
Platelet activation stimulates the formation of another aggregating agent, thromboxane A2 -- abbreviated here as T.X.A2 -- via the arachidonic acid cascade -- details are shown in Figure 26-5.
A.D.P., thromboxane A2 and thrombin bind to specific platelet membrane receptors -- details are shown in Table 26-1 -- and stimulate aggregation on and around the platelets adherent to the subendothelium via receptor-mediated signal transduction events. Aggregation is an active metabolic process: binding of any of the agonists to their respective membrane receptors initiates signalling pathways that ultimately convert integrin αIIbβ3 -- or GPIIb-IIIa - from a low affinity resting state to a high-affinity activated state for binding extracellular soluble ligands such as plasma fibrinogen and von Willebrand factor -- fibrinogen is shown here.
The transmission of an intracellular signal leads to disruption of the complex between the cytoplasmic tails of αIIbβ3, followed by a conformational change in its extracellular globular head domains from a bent to an extended state, promoting the binding to fibrinogen and von Willebrand factor.
Divalent fibrinogen and multivalent von Willebrand factor function as bridges between αIIbβ3 receptors on adjacent activated platelets, thus allowing platelet aggregation to proceed.
In this way, the large and complex metabolic repertoire of platelets allows them to effectively perform their primary physiological role, that of supporting hemostasis upon tissue trauma to form a platelet plug that arrests blood loss from a vascular injury.
To learn more, go to http://www.MechanismsInHematology.com -- a freely available, educational resource that combines the clinical expertise of hematologists, oncologists, and related researchers with instructive visuals and animations. Essential concepts pertaining to the science and biology of clinical hematology are presented.
https://wn.com/Platelet_Adhesion_And_Aggregation
Developed and produced for http://www.MechanismsInHematology.com by Mechanisms in Medicine Inc.
Animation description: Platelet adhesion and aggregation.
In flowing blood, red cells predominate in the axial stream, while the biconvex disc-shaped platelets are marginated along the vessel wall where they are well-positioned to monitor the integrity of the endothelium. The normal endothelium provides a non-adhesive surface to circulating platelets.
However, when vessel wall injury occurs, for example, by cutting or severing of a vessel, or as shown here, by a puncture, and there is endothelial damage, the initial response of platelets is that of adhesion to collagen fibres in the exposed subendothelium.
Collagen is one of the most thrombogenic components of the subendothelial matrix responsible for the initiation of platelet adhesion. A number of adhesive receptors on the platelet surface membrane interact either directly or indirectly with collagen.
Initial binding of platelets is considered to occur via the integrin α2β1 (GPIa-IIa) receptor, which allows for further binding to collagen via the GPVI receptor, initiating transmembrane and, subsequently, intracellular signalling. Adhesion of platelets to the exposed subendothelium is influenced by shear rates. At high shear, α2β1 and GPVI are not sufficient to initiate binding to collagen, and binding of the GPIb-IX-V receptor to von Willebrand factor -- abbreviated here as V.W.F. -- that is immobilized on collagen, becomes essential in platelet adhesion.
Platelet adhesion at the site of vessel wall damage initiates activation events that result in aggregation. Adherent platelets undergo a dramatic shape change to an irregular sphere with multiple filipodia spreading on the subendothelium increasing their area of surface contact.
Adherent platelets also secrete or release the contents of their storage granules -- the alpha- and dense granules -- by an exocytic process. This provides a high local concentration of effector molecules essential for platelet plug formation at the site of vascular injury. For example, the aggregating agent A.D.P. is released from the dense granules.
Platelet activation stimulates the formation of another aggregating agent, thromboxane A2 -- abbreviated here as T.X.A2 -- via the arachidonic acid cascade -- details are shown in Figure 26-5.
A.D.P., thromboxane A2 and thrombin bind to specific platelet membrane receptors -- details are shown in Table 26-1 -- and stimulate aggregation on and around the platelets adherent to the subendothelium via receptor-mediated signal transduction events. Aggregation is an active metabolic process: binding of any of the agonists to their respective membrane receptors initiates signalling pathways that ultimately convert integrin αIIbβ3 -- or GPIIb-IIIa - from a low affinity resting state to a high-affinity activated state for binding extracellular soluble ligands such as plasma fibrinogen and von Willebrand factor -- fibrinogen is shown here.
The transmission of an intracellular signal leads to disruption of the complex between the cytoplasmic tails of αIIbβ3, followed by a conformational change in its extracellular globular head domains from a bent to an extended state, promoting the binding to fibrinogen and von Willebrand factor.
Divalent fibrinogen and multivalent von Willebrand factor function as bridges between αIIbβ3 receptors on adjacent activated platelets, thus allowing platelet aggregation to proceed.
In this way, the large and complex metabolic repertoire of platelets allows them to effectively perform their primary physiological role, that of supporting hemostasis upon tissue trauma to form a platelet plug that arrests blood loss from a vascular injury.
To learn more, go to http://www.MechanismsInHematology.com -- a freely available, educational resource that combines the clinical expertise of hematologists, oncologists, and related researchers with instructive visuals and animations. Essential concepts pertaining to the science and biology of clinical hematology are presented.
- published: 08 Dec 2010
- views: 403499
5:02
Low Platelets: Signs & Symptoms (Basics for Beginners)
- Order: Reorder
- Duration: 5:02
- Uploaded Date: 22 Oct 2020
- views: 521673
Low Platelets: Signs & Symptoms (Basics for Beginners)
Low Platelets (also known as Thrombocytopenia) is a condition where the number of platelets in your bloo...
Low Platelets: Signs & Symptoms (Basics for Beginners)
Low Platelets (also known as Thrombocytopenia) is a condition where the number of platelets in your blood is too low, which can cause a variety of signs and symptoms. Platelets are important for making what we call a “platelet plug” to stop/reduce bleeding from cuts, etc. When there aren’t enough platelets around, stopping and reducing bleeding becomes more difficult, leading
This is my first lesson where I am focusing more on non-healthcare professionals and the general public – please let me know what you think!
Thanks
JJ
-------------------------------------------------------------------------------------------------------------
For books and more information on these topics
https://www.amazon.com/shop/jjmedicine
Check out the best tool to help grow your YouTube channel (it’s helped me!)
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Follow me on Twitter! ➜ https://twitter.com/JJ_Medicine
Come join me on Facebook! ➜ https://www.facebook.com/JJ-Medicine-100642648161192/
-------------------------------------------------------------------------------------------------------------
EXCLAIMER: The content used in this lesson is used in accordance with Fair Use laws and is intended for educational purposes only.
**MEDICAL DISCLAIMER**: JJ Medicine does not provide medical advice, and the information available on this channel does not offer a diagnosis or advice regarding treatment. Information presented in these lessons is for EDUCATIONAL PURPOSES ONLY, and information presented here is NOT TO BE USED as an alternative to a healthcare professional’s diagnosis and treatment of any person/animal.
Only a physician or other licensed healthcare professional are able to determine the requirement for medical assistance to be given to a patient. Please seek the advice of your physician or other licensed healthcare provider if you have any questions regarding a medical condition.
-------------------------------------------------------------------------------------------------------------
Check out some of my other lessons.
Medical Terminology - The Basics - Lesson 1:
https://www.youtube.com/watch?v=04Wh2E9oNug
Infectious Disease Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwW0Bkc6c66uDACkzotaK26b
Dermatology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwW3dgORRNmk_MZvnWpZx_lW
Pharmacology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwWPWcV9lZTh-Qxv0gYakQXR
Hematology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwW8Ajo1dmxdj4EYEKcbtGju
Rheumatology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwWDvuhasXsuTFXJp05wwUle
Endocrinology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwUuRSzhploohnaWVvbVZ7ZP
Nephrology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwXRSwrFQK5WwWZLk1Las8v8
---------------------------------------------------------------------------------------
*Although I try my best to present accurate information, there may be mistakes in this video. If you do see any mistakes with information in this lesson, please comment and let me know.*
https://wn.com/Low_Platelets_Signs_Symptoms_(Basics_For_Beginners)
Low Platelets: Signs & Symptoms (Basics for Beginners)
Low Platelets (also known as Thrombocytopenia) is a condition where the number of platelets in your blood is too low, which can cause a variety of signs and symptoms. Platelets are important for making what we call a “platelet plug” to stop/reduce bleeding from cuts, etc. When there aren’t enough platelets around, stopping and reducing bleeding becomes more difficult, leading
This is my first lesson where I am focusing more on non-healthcare professionals and the general public – please let me know what you think!
Thanks
JJ
-------------------------------------------------------------------------------------------------------------
For books and more information on these topics
https://www.amazon.com/shop/jjmedicine
Check out the best tool to help grow your YouTube channel (it’s helped me!)
https://www.tubebuddy.com/jjmedicine
*Subscribe for more free medical lessons* https://www.youtube.com/channel/UCFPvnkCZbHfBvV8ApBBE0vA?sub_confirmation=1
Follow me on Twitter! ➜ https://twitter.com/JJ_Medicine
Come join me on Facebook! ➜ https://www.facebook.com/JJ-Medicine-100642648161192/
-------------------------------------------------------------------------------------------------------------
EXCLAIMER: The content used in this lesson is used in accordance with Fair Use laws and is intended for educational purposes only.
**MEDICAL DISCLAIMER**: JJ Medicine does not provide medical advice, and the information available on this channel does not offer a diagnosis or advice regarding treatment. Information presented in these lessons is for EDUCATIONAL PURPOSES ONLY, and information presented here is NOT TO BE USED as an alternative to a healthcare professional’s diagnosis and treatment of any person/animal.
Only a physician or other licensed healthcare professional are able to determine the requirement for medical assistance to be given to a patient. Please seek the advice of your physician or other licensed healthcare provider if you have any questions regarding a medical condition.
-------------------------------------------------------------------------------------------------------------
Check out some of my other lessons.
Medical Terminology - The Basics - Lesson 1:
https://www.youtube.com/watch?v=04Wh2E9oNug
Infectious Disease Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwW0Bkc6c66uDACkzotaK26b
Dermatology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwW3dgORRNmk_MZvnWpZx_lW
Pharmacology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwWPWcV9lZTh-Qxv0gYakQXR
Hematology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwW8Ajo1dmxdj4EYEKcbtGju
Rheumatology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwWDvuhasXsuTFXJp05wwUle
Endocrinology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwUuRSzhploohnaWVvbVZ7ZP
Nephrology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwXRSwrFQK5WwWZLk1Las8v8
---------------------------------------------------------------------------------------
*Although I try my best to present accurate information, there may be mistakes in this video. If you do see any mistakes with information in this lesson, please comment and let me know.*
- published: 22 Oct 2020
- views: 521673
10:01
Thrombocytopaenia (low platelets) Overview - platelet physiology, classification, pathophysiology
- Order: Reorder
- Duration: 10:01
- Uploaded Date: 29 Jan 2019
- views: 212770
Buy Images here: armandoh.org/shop
"Thrombocytopenia which means low platelets is associated with a variety of
conditions. Thrombocytopenia is defined as a pla...
Buy Images here: armandoh.org/shop
"Thrombocytopenia which means low platelets is associated with a variety of
conditions. Thrombocytopenia is defined as a platelet count below the lower limit of
normal (less than 150,000/microL). Platelets are produced in the bone marrow from
megakaryocytes. Each megakoryocyte produces 1000-5000 platelets.
Platelets play a key role in hemostasis forming a temporary plug. Therefore if you
have low platelets you are unable to for a temporary plug and tend to bleed more
easily. In order to understand platelet function, we need to revise hemostasis.
Hemostasis involves three main phases vasoconstriction, platelets plug formation
and coagulation"
Where do I get my information from: http://armandoh.org/resource
Facebook:
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Support me:
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Patreon members
https://wn.com/Thrombocytopaenia_(Low_Platelets)_Overview_Platelet_Physiology,_Classification,_Pathophysiology
Buy Images here: armandoh.org/shop
"Thrombocytopenia which means low platelets is associated with a variety of
conditions. Thrombocytopenia is defined as a platelet count below the lower limit of
normal (less than 150,000/microL). Platelets are produced in the bone marrow from
megakaryocytes. Each megakoryocyte produces 1000-5000 platelets.
Platelets play a key role in hemostasis forming a temporary plug. Therefore if you
have low platelets you are unable to for a temporary plug and tend to bleed more
easily. In order to understand platelet function, we need to revise hemostasis.
Hemostasis involves three main phases vasoconstriction, platelets plug formation
and coagulation"
Where do I get my information from: http://armandoh.org/resource
Facebook:
https://www.facebook.com/ArmandoHasudungan
Support me:
http://www.patreon.com/armando
Instagram:
http://instagram.com/armandohasudungan
Twitter:
https://twitter.com/Armando71021105
SPECIAL THANKS:
Patreon members
- published: 29 Jan 2019
- views: 212770
11:39
Platelets (Thrombocytes) - The Cell Pieces that Lack Nucleus - Hematology
- Order: Reorder
- Duration: 11:39
- Uploaded Date: 15 Feb 2019
- views: 281176
😍🖼Animated Mnemonics (Picmonic): https://www.picmonic.com/viphookup/medicosis/
- With Picmonic, get your life back by studying less and remembering more. Medi...
😍🖼Animated Mnemonics (Picmonic): https://www.picmonic.com/viphookup/medicosis/
- With Picmonic, get your life back by studying less and remembering more. Medical and Nursing students say that Picmonic is the most comprehensive and effective way to bridge learning and test prep...
Disclaimer: I use affiliate links....
►👨🏫💊Antibiotics Lectures: https://www.medicosisperfectionalis.com/products/courses/antibiotics/ ... Check out my brand new "Electrolytes" course at https://www.medicosisperfectionalis.com/products/course/electrolytes/ and use the PROMO code: ELECTROLYTES50 to get a 50% discount. The first video in my NEW playlist “Bleeding and Coagulation"...See the entire playlist here: https://goo.gl/Dt41Bg
Platelets (thrombocytes) are not cells, they are just pieces of the megakaryocytes (their mighty parents).
Platelets are called thrombocytes because they will help form a clot (thrombus)...At least they form a temporary platelet plug to stop bleeding in small vessels (primary hemostasis).
The normal platelet count is 150,000 to 400,000/ microliter.
Get all of my notes at https://www.patreon.com/medicosis/
Hemostasis is defined as "cessation of blood bleeding”
There are 2 types of hemostasis:
1. Primary hemostasis: formation of weak, temporary platelet plug (by platelets)
2. Secondary hemostasis: formation of stronger fibrin meshwork (by coagulation factors).
Check my full playlist on "bleeding and coagulation" here: https://goo.gl/Dt41Bg
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https://wn.com/Platelets_(Thrombocytes)_The_Cell_Pieces_That_Lack_Nucleus_Hematology
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►👨🏫💊Antibiotics Lectures: https://www.medicosisperfectionalis.com/products/courses/antibiotics/ ... Check out my brand new "Electrolytes" course at https://www.medicosisperfectionalis.com/products/course/electrolytes/ and use the PROMO code: ELECTROLYTES50 to get a 50% discount. The first video in my NEW playlist “Bleeding and Coagulation"...See the entire playlist here: https://goo.gl/Dt41Bg
Platelets (thrombocytes) are not cells, they are just pieces of the megakaryocytes (their mighty parents).
Platelets are called thrombocytes because they will help form a clot (thrombus)...At least they form a temporary platelet plug to stop bleeding in small vessels (primary hemostasis).
The normal platelet count is 150,000 to 400,000/ microliter.
Get all of my notes at https://www.patreon.com/medicosis/
Hemostasis is defined as "cessation of blood bleeding”
There are 2 types of hemostasis:
1. Primary hemostasis: formation of weak, temporary platelet plug (by platelets)
2. Secondary hemostasis: formation of stronger fibrin meshwork (by coagulation factors).
Check my full playlist on "bleeding and coagulation" here: https://goo.gl/Dt41Bg
Books that I use for this series:
► Guyton and Hall Medical Physiology Textbook https://goo.gl/yZoeS9
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- published: 15 Feb 2019
- views: 281176
4:06
Thrombocyte/Platelet Structure and Function
- Order: Reorder
- Duration: 4:06
- Uploaded Date: 01 Feb 2022
- views: 35768
In this video, we will look at the structure and function of platelets/thrombocytes - important components in the blood that are involved in blood clotting/hemo...
In this video, we will look at the structure and function of platelets/thrombocytes - important components in the blood that are involved in blood clotting/hemostasis. By the end of the video, you’ll have a good understanding of what platelets are and how they do what they do.
00:00 Intro
00:19 Hemostasis
00:49 Thrombocytes -- a misnomer
01:16 How Platelets are formed from Megakaryocutes
01:58 Platelet Structure
02:23 Other functions of platelets
03:09 Platelet disorders | Thrombocytopenia and Thrombocytosis Download a PDF copy of The Cardiac Cycle Made Easy here 👉 https://www.interactive-biology.com/cardiaccycle/ Download a PDF copy of The Cardiac Cycle Made Easy here 👉 https://www.interactive-biology.com/cardiaccycle/ .
Download a PDF copy of The Cardiac Cycle Made Easy here 👉 https://www.interactive-biology.com/cardiaccycle/
https://wn.com/Thrombocyte_Platelet_Structure_And_Function
In this video, we will look at the structure and function of platelets/thrombocytes - important components in the blood that are involved in blood clotting/hemostasis. By the end of the video, you’ll have a good understanding of what platelets are and how they do what they do.
00:00 Intro
00:19 Hemostasis
00:49 Thrombocytes -- a misnomer
01:16 How Platelets are formed from Megakaryocutes
01:58 Platelet Structure
02:23 Other functions of platelets
03:09 Platelet disorders | Thrombocytopenia and Thrombocytosis Download a PDF copy of The Cardiac Cycle Made Easy here 👉 https://www.interactive-biology.com/cardiaccycle/ Download a PDF copy of The Cardiac Cycle Made Easy here 👉 https://www.interactive-biology.com/cardiaccycle/ .
Download a PDF copy of The Cardiac Cycle Made Easy here 👉 https://www.interactive-biology.com/cardiaccycle/
- published: 01 Feb 2022
- views: 35768
3:10
Platelets & Blood Clotting | Biology | FuseSchool
- Order: Reorder
- Duration: 3:10
- Uploaded Date: 11 Oct 2018
- views: 830396
Do you remember tripping over as a kid and cutting your knee? And then like magic the bleeding suddenly stops? Have you ever wondered why this happens?
Our bod...
Do you remember tripping over as a kid and cutting your knee? And then like magic the bleeding suddenly stops? Have you ever wondered why this happens?
Our body is very clever and produces substances to seal off the open wound.
In this video we are going to look at how and why blood clots.
Clotting prevents us from bleeding to death, and also protects us from nasty disease-causing organisms, called pathogens, entering our body.
When we injure ourselves, we can damage the blood vessels just below our skin. This can cause blood to either leak into our tissue and form a bruise, or, if the skin is broken to openly bleed.
To prevent these horrible things happening, blood clotting occurs.
So let’s have a look at how this happens.
Starting with platelets. These are tiny cell fragments that float around in our blood.
When a blood vessel is damaged, collagen is exposed. This collagen exposure attracts platelets to the injured area. The platelets then stick together to form a plug.
They’ve quickly built a little barrier that stops us from losing too much blood. However, this platelet plug isn’t that strong. So it needs to be made stronger.
A protein called fibrin does exactly that.
In our blood there are soluble fibrinogen proteins. At a wound, these soluble fibrinogen proteins are exposed to outside chemicals that aren’t normally found in blood vessels. Like with the collagen and platelets, this exposure causes the fibrinogen proteins to turn into sticky fibrin fibres.
The fibrin fibres form a mesh, holding all the platelets together and making a much stronger clot.
More platelets, red blood cells and other components in our blood, all get stuck in the mesh making it even stronger. This clot stops more blood escaping the body. And also prevents nasty pathogens entering our body from the outside.
The clot develops into a scab, which protects the wound as it heals and new layers of skin form underneath. So really, all a scab is is just platelets trapped in the fibrin mesh!
When the new skin is fully formed, the scab will fall off, revealing the lovely brand new skin underneath.
Remember that I said the exposure to collagen causes the platelets to stick together? And the exposure to outside chemicals causes the fibrinogen to turn into sticky fibrin?
Both the platelets and the fibrin only become sticky AFTER the exposure. This means that in a normal, healthy blood vessel they won’t randomly cause clots.
So from this video, you should understand the magic of blood clotting. Platelets are first to the scene closely followed by fibrin fibres. Our blood clots so that we don’t lose a lot of blood and don’t let lots of nasty pathogens into our body if we cut ourselves.
SUBSCRIBE to the FuseSchool YouTube channel for many more educational videos. Our teachers and animators come together to make fun & easy-to-understand videos in Chemistry, Biology, Physics, Maths & ICT.
VISIT us at www.fuseschool.org, where all of our videos are carefully organised into topics and specific orders, and to see what else we have on offer. Comment, like and share with other learners. You can both ask and answer questions, and teachers will get back to you.
These videos can be used in a flipped classroom model or as a revision aid.
Find all of our Chemistry videos here:
https://www.youtube.com/watch?v=cRnpKjHpFyg&list=PLW0gavSzhMlReKGMVfUt6YuNQsO0bqSMV
Find all of our Biology videos here:
https://www.youtube.com/watch?v=tjkHzEVcyrE&list=PLW0gavSzhMlQYSpKryVcEr3ERup5SxHl0
Find all of our Maths videos here:
https://www.youtube.com/watch?v=hJq_cdz_L00&list=PLW0gavSzhMlTyWKCgW1616v3fIywogoZQ
Twitter: https://twitter.com/fuseSchool
Access a deeper Learning Experience in the FuseSchool platform and app: www.fuseschool.org
Follow us: http://www.youtube.com/fuseschool
Friend us: http://www.facebook.com/fuseschool
This Open Educational Resource is free of charge, under a Creative Commons License: Attribution-NonCommercial CC BY-NC ( View License Deed: http://creativecommons.org/licenses/by-nc/4.0/ ). You are allowed to download the video for nonprofit, educational use. If you would like to modify the video, please contact us: [email protected]
https://wn.com/Platelets_Blood_Clotting_|_Biology_|_Fuseschool
Do you remember tripping over as a kid and cutting your knee? And then like magic the bleeding suddenly stops? Have you ever wondered why this happens?
Our body is very clever and produces substances to seal off the open wound.
In this video we are going to look at how and why blood clots.
Clotting prevents us from bleeding to death, and also protects us from nasty disease-causing organisms, called pathogens, entering our body.
When we injure ourselves, we can damage the blood vessels just below our skin. This can cause blood to either leak into our tissue and form a bruise, or, if the skin is broken to openly bleed.
To prevent these horrible things happening, blood clotting occurs.
So let’s have a look at how this happens.
Starting with platelets. These are tiny cell fragments that float around in our blood.
When a blood vessel is damaged, collagen is exposed. This collagen exposure attracts platelets to the injured area. The platelets then stick together to form a plug.
They’ve quickly built a little barrier that stops us from losing too much blood. However, this platelet plug isn’t that strong. So it needs to be made stronger.
A protein called fibrin does exactly that.
In our blood there are soluble fibrinogen proteins. At a wound, these soluble fibrinogen proteins are exposed to outside chemicals that aren’t normally found in blood vessels. Like with the collagen and platelets, this exposure causes the fibrinogen proteins to turn into sticky fibrin fibres.
The fibrin fibres form a mesh, holding all the platelets together and making a much stronger clot.
More platelets, red blood cells and other components in our blood, all get stuck in the mesh making it even stronger. This clot stops more blood escaping the body. And also prevents nasty pathogens entering our body from the outside.
The clot develops into a scab, which protects the wound as it heals and new layers of skin form underneath. So really, all a scab is is just platelets trapped in the fibrin mesh!
When the new skin is fully formed, the scab will fall off, revealing the lovely brand new skin underneath.
Remember that I said the exposure to collagen causes the platelets to stick together? And the exposure to outside chemicals causes the fibrinogen to turn into sticky fibrin?
Both the platelets and the fibrin only become sticky AFTER the exposure. This means that in a normal, healthy blood vessel they won’t randomly cause clots.
So from this video, you should understand the magic of blood clotting. Platelets are first to the scene closely followed by fibrin fibres. Our blood clots so that we don’t lose a lot of blood and don’t let lots of nasty pathogens into our body if we cut ourselves.
SUBSCRIBE to the FuseSchool YouTube channel for many more educational videos. Our teachers and animators come together to make fun & easy-to-understand videos in Chemistry, Biology, Physics, Maths & ICT.
VISIT us at www.fuseschool.org, where all of our videos are carefully organised into topics and specific orders, and to see what else we have on offer. Comment, like and share with other learners. You can both ask and answer questions, and teachers will get back to you.
These videos can be used in a flipped classroom model or as a revision aid.
Find all of our Chemistry videos here:
https://www.youtube.com/watch?v=cRnpKjHpFyg&list=PLW0gavSzhMlReKGMVfUt6YuNQsO0bqSMV
Find all of our Biology videos here:
https://www.youtube.com/watch?v=tjkHzEVcyrE&list=PLW0gavSzhMlQYSpKryVcEr3ERup5SxHl0
Find all of our Maths videos here:
https://www.youtube.com/watch?v=hJq_cdz_L00&list=PLW0gavSzhMlTyWKCgW1616v3fIywogoZQ
Twitter: https://twitter.com/fuseSchool
Access a deeper Learning Experience in the FuseSchool platform and app: www.fuseschool.org
Follow us: http://www.youtube.com/fuseschool
Friend us: http://www.facebook.com/fuseschool
This Open Educational Resource is free of charge, under a Creative Commons License: Attribution-NonCommercial CC BY-NC ( View License Deed: http://creativecommons.org/licenses/by-nc/4.0/ ). You are allowed to download the video for nonprofit, educational use. If you would like to modify the video, please contact us: [email protected]
- published: 11 Oct 2018
- views: 830396
0:49
Decode Your Blood Test: Platelets 💉 | Merck Manual Consumer Version
- Order: Reorder
- Duration: 0:49
- Uploaded Date: 01 Jun 2020
- views: 13982
Find out why platelets are so important and what could happen if your platelet count becomes too low or too high. Get more information in the links below:
Over...
Find out why platelets are so important and what could happen if your platelet count becomes too low or too high. Get more information in the links below:
Overview of Blood Disorders: https://mrkmnls.co/2Osv3n0
Laboratory Tests for Blood Disorders: https://mrkmnls.co/2TZESyP
About The Merck Manuals:
First published in 1899 as a small reference book for physicians and pharmacists, The Merck Manual grew in size and scope to become one of the world's most widely used comprehensive medical resources for professionals and consumers. As The Manual evolved, it continually expanded the reach and depth of its offerings to reflect the mission of providing the best medical information to a wide cross-section of users, including medical professionals and students, veterinarians and veterinary students, and consumers.
• Merck Manual Consumer Version: http://www.MerckManuals.com/Home
• Facebook for Consumers: https://www.facebook.com/MerckManualHomeUS/
• Twitter for Consumers: http://www.Twitter.com/MerckManualHome
https://wn.com/Decode_Your_Blood_Test_Platelets_💉_|_Merck_Manual_Consumer_Version
Find out why platelets are so important and what could happen if your platelet count becomes too low or too high. Get more information in the links below:
Overview of Blood Disorders: https://mrkmnls.co/2Osv3n0
Laboratory Tests for Blood Disorders: https://mrkmnls.co/2TZESyP
About The Merck Manuals:
First published in 1899 as a small reference book for physicians and pharmacists, The Merck Manual grew in size and scope to become one of the world's most widely used comprehensive medical resources for professionals and consumers. As The Manual evolved, it continually expanded the reach and depth of its offerings to reflect the mission of providing the best medical information to a wide cross-section of users, including medical professionals and students, veterinarians and veterinary students, and consumers.
• Merck Manual Consumer Version: http://www.MerckManuals.com/Home
• Facebook for Consumers: https://www.facebook.com/MerckManualHomeUS/
• Twitter for Consumers: http://www.Twitter.com/MerckManualHome
- published: 01 Jun 2020
- views: 13982
1:47
Platelets Explained in Two Minutes
- Order: Reorder
- Duration: 1:47
- Uploaded Date: 30 Aug 2016
- views: 224083
Platelets are tiny cells in your blood that form clots and stop bleeding. For millions of Americans, they are essential to surviving and fighting cancer, chroni...
Platelets are tiny cells in your blood that form clots and stop bleeding. For millions of Americans, they are essential to surviving and fighting cancer, chronic diseases, and traumatic injuries. About 2 million units of platelets are transfused each year in the U.S. Every 15 seconds someone in the U.S. needs platelets. You can help by donating platelets through the American Red Cross.
Visit http://redcrossblood.org/platelets or call 1-800-RED CROSS for more information.
https://wn.com/Platelets_Explained_In_Two_Minutes
Platelets are tiny cells in your blood that form clots and stop bleeding. For millions of Americans, they are essential to surviving and fighting cancer, chronic diseases, and traumatic injuries. About 2 million units of platelets are transfused each year in the U.S. Every 15 seconds someone in the U.S. needs platelets. You can help by donating platelets through the American Red Cross.
Visit http://redcrossblood.org/platelets or call 1-800-RED CROSS for more information.
- published: 30 Aug 2016
- views: 224083
2:02
What are Platelets and when do they decrease? - Dr. Satish Kumar
- Order: Reorder
- Duration: 2:02
- Uploaded Date: 28 Sep 2017
- views: 85464
Platelets are small cells in the body which help the blood to clot. There are three types of cells, red cells, white cells and platelets in the cells. These blo...
Platelets are small cells in the body which help the blood to clot. There are three types of cells, red cells, white cells and platelets in the cells. These blood cells called platelets help the blood to clot. Whenever we have a small cut, it helps the blood to clot. The platelets are instrumental in forming the clot. Whenever the platelet count goes down, there is a risk of bleeding, but then again, people have a lot of myths about platelets though the normal platelet count is one lakh fifty thousand, to four lakh fifty thousand, unless and until the platelet count falls to less than 20000 or 10000. There will not be any risk of significant internal bleeding. The most common cause if low platelet count, nowadays we see is due to dengue fever. But apart from infections. The most common cause of low platelet count Is immune thrombocytopenia where our own immunity destroys our platelets. So we give medicines to suppress the immunity and to prevent the platelet destruction. That condition is called as ITP or immune thrombocytopenia. In ITP, the goal of treatment is to keep the platelet count at a safe level, which is anywhere more than 30000. The dictum of treatment in ITP is do not treat the platelet counts, treat the symptoms.
https://wn.com/What_Are_Platelets_And_When_Do_They_Decrease_Dr._Satish_Kumar
Platelets are small cells in the body which help the blood to clot. There are three types of cells, red cells, white cells and platelets in the cells. These blood cells called platelets help the blood to clot. Whenever we have a small cut, it helps the blood to clot. The platelets are instrumental in forming the clot. Whenever the platelet count goes down, there is a risk of bleeding, but then again, people have a lot of myths about platelets though the normal platelet count is one lakh fifty thousand, to four lakh fifty thousand, unless and until the platelet count falls to less than 20000 or 10000. There will not be any risk of significant internal bleeding. The most common cause if low platelet count, nowadays we see is due to dengue fever. But apart from infections. The most common cause of low platelet count Is immune thrombocytopenia where our own immunity destroys our platelets. So we give medicines to suppress the immunity and to prevent the platelet destruction. That condition is called as ITP or immune thrombocytopenia. In ITP, the goal of treatment is to keep the platelet count at a safe level, which is anywhere more than 30000. The dictum of treatment in ITP is do not treat the platelet counts, treat the symptoms.
- published: 28 Sep 2017
- views: 85464
2:08
Platelet Activation and Factors for Clot Formation
Learn more about the process of platelet activation and the involved coagulation factors t...
published: 17 Dec 2014
Platelet Activation and Factors for Clot Formation
Platelet Activation and Factors for Clot Formation
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- published: 17 Dec 2014
- views: 5219696
Learn more about the process of platelet activation and the involved coagulation factors triggering clot formation? Find more about clot formation on: https://www.thrombosisadviser.com/arterial-thrombosis/
Approval Number: PP-XAR-ALL-2428-1
4:42
Platelet Adhesion and Aggregation
Developed and produced for http://www.MechanismsInHematology.com by Mechanisms in Medicine...
published: 08 Dec 2010
Platelet Adhesion and Aggregation
Platelet Adhesion and Aggregation
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- published: 08 Dec 2010
- views: 403499
Developed and produced for http://www.MechanismsInHematology.com by Mechanisms in Medicine Inc.
Animation description: Platelet adhesion and aggregation.
In flowing blood, red cells predominate in the axial stream, while the biconvex disc-shaped platelets are marginated along the vessel wall where they are well-positioned to monitor the integrity of the endothelium. The normal endothelium provides a non-adhesive surface to circulating platelets.
However, when vessel wall injury occurs, for example, by cutting or severing of a vessel, or as shown here, by a puncture, and there is endothelial damage, the initial response of platelets is that of adhesion to collagen fibres in the exposed subendothelium.
Collagen is one of the most thrombogenic components of the subendothelial matrix responsible for the initiation of platelet adhesion. A number of adhesive receptors on the platelet surface membrane interact either directly or indirectly with collagen.
Initial binding of platelets is considered to occur via the integrin α2β1 (GPIa-IIa) receptor, which allows for further binding to collagen via the GPVI receptor, initiating transmembrane and, subsequently, intracellular signalling. Adhesion of platelets to the exposed subendothelium is influenced by shear rates. At high shear, α2β1 and GPVI are not sufficient to initiate binding to collagen, and binding of the GPIb-IX-V receptor to von Willebrand factor -- abbreviated here as V.W.F. -- that is immobilized on collagen, becomes essential in platelet adhesion.
Platelet adhesion at the site of vessel wall damage initiates activation events that result in aggregation. Adherent platelets undergo a dramatic shape change to an irregular sphere with multiple filipodia spreading on the subendothelium increasing their area of surface contact.
Adherent platelets also secrete or release the contents of their storage granules -- the alpha- and dense granules -- by an exocytic process. This provides a high local concentration of effector molecules essential for platelet plug formation at the site of vascular injury. For example, the aggregating agent A.D.P. is released from the dense granules.
Platelet activation stimulates the formation of another aggregating agent, thromboxane A2 -- abbreviated here as T.X.A2 -- via the arachidonic acid cascade -- details are shown in Figure 26-5.
A.D.P., thromboxane A2 and thrombin bind to specific platelet membrane receptors -- details are shown in Table 26-1 -- and stimulate aggregation on and around the platelets adherent to the subendothelium via receptor-mediated signal transduction events. Aggregation is an active metabolic process: binding of any of the agonists to their respective membrane receptors initiates signalling pathways that ultimately convert integrin αIIbβ3 -- or GPIIb-IIIa - from a low affinity resting state to a high-affinity activated state for binding extracellular soluble ligands such as plasma fibrinogen and von Willebrand factor -- fibrinogen is shown here.
The transmission of an intracellular signal leads to disruption of the complex between the cytoplasmic tails of αIIbβ3, followed by a conformational change in its extracellular globular head domains from a bent to an extended state, promoting the binding to fibrinogen and von Willebrand factor.
Divalent fibrinogen and multivalent von Willebrand factor function as bridges between αIIbβ3 receptors on adjacent activated platelets, thus allowing platelet aggregation to proceed.
In this way, the large and complex metabolic repertoire of platelets allows them to effectively perform their primary physiological role, that of supporting hemostasis upon tissue trauma to form a platelet plug that arrests blood loss from a vascular injury.
To learn more, go to http://www.MechanismsInHematology.com -- a freely available, educational resource that combines the clinical expertise of hematologists, oncologists, and related researchers with instructive visuals and animations. Essential concepts pertaining to the science and biology of clinical hematology are presented.
5:02
Low Platelets: Signs & Symptoms (Basics for Beginners)
Low Platelets: Signs & Symptoms (Basics for Beginners)
Low Platelets (also known as Throm...
published: 22 Oct 2020
Low Platelets: Signs & Symptoms (Basics for Beginners)
Low Platelets: Signs & Symptoms (Basics for Beginners)
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- published: 22 Oct 2020
- views: 521673
Low Platelets: Signs & Symptoms (Basics for Beginners)
Low Platelets (also known as Thrombocytopenia) is a condition where the number of platelets in your blood is too low, which can cause a variety of signs and symptoms. Platelets are important for making what we call a “platelet plug” to stop/reduce bleeding from cuts, etc. When there aren’t enough platelets around, stopping and reducing bleeding becomes more difficult, leading
This is my first lesson where I am focusing more on non-healthcare professionals and the general public – please let me know what you think!
Thanks
JJ
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**MEDICAL DISCLAIMER**: JJ Medicine does not provide medical advice, and the information available on this channel does not offer a diagnosis or advice regarding treatment. Information presented in these lessons is for EDUCATIONAL PURPOSES ONLY, and information presented here is NOT TO BE USED as an alternative to a healthcare professional’s diagnosis and treatment of any person/animal.
Only a physician or other licensed healthcare professional are able to determine the requirement for medical assistance to be given to a patient. Please seek the advice of your physician or other licensed healthcare provider if you have any questions regarding a medical condition.
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Check out some of my other lessons.
Medical Terminology - The Basics - Lesson 1:
https://www.youtube.com/watch?v=04Wh2E9oNug
Infectious Disease Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwW0Bkc6c66uDACkzotaK26b
Dermatology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwW3dgORRNmk_MZvnWpZx_lW
Pharmacology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwWPWcV9lZTh-Qxv0gYakQXR
Hematology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwW8Ajo1dmxdj4EYEKcbtGju
Rheumatology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwWDvuhasXsuTFXJp05wwUle
Endocrinology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwUuRSzhploohnaWVvbVZ7ZP
Nephrology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwXRSwrFQK5WwWZLk1Las8v8
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*Although I try my best to present accurate information, there may be mistakes in this video. If you do see any mistakes with information in this lesson, please comment and let me know.*
10:01
Thrombocytopaenia (low platelets) Overview - platelet physiology, classification, pathophysiology
Buy Images here: armandoh.org/shop
"Thrombocytopenia which means low platelets is associa...
published: 29 Jan 2019
Thrombocytopaenia (low platelets) Overview - platelet physiology, classification, pathophysiology
Thrombocytopaenia (low platelets) Overview - platelet physiology, classification, pathophysiology
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- published: 29 Jan 2019
- views: 212770
Buy Images here: armandoh.org/shop
"Thrombocytopenia which means low platelets is associated with a variety of
conditions. Thrombocytopenia is defined as a platelet count below the lower limit of
normal (less than 150,000/microL). Platelets are produced in the bone marrow from
megakaryocytes. Each megakoryocyte produces 1000-5000 platelets.
Platelets play a key role in hemostasis forming a temporary plug. Therefore if you
have low platelets you are unable to for a temporary plug and tend to bleed more
easily. In order to understand platelet function, we need to revise hemostasis.
Hemostasis involves three main phases vasoconstriction, platelets plug formation
and coagulation"
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11:39
Platelets (Thrombocytes) - The Cell Pieces that Lack Nucleus - Hematology
😍🖼Animated Mnemonics (Picmonic): https://www.picmonic.com/viphookup/medicosis/
- With Pi...
published: 15 Feb 2019
Platelets (Thrombocytes) - The Cell Pieces that Lack Nucleus - Hematology
Platelets (Thrombocytes) - The Cell Pieces that Lack Nucleus - Hematology
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- published: 15 Feb 2019
- views: 281176
😍🖼Animated Mnemonics (Picmonic): https://www.picmonic.com/viphookup/medicosis/
- With Picmonic, get your life back by studying less and remembering more. Medical and Nursing students say that Picmonic is the most comprehensive and effective way to bridge learning and test prep...
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►👨🏫💊Antibiotics Lectures: https://www.medicosisperfectionalis.com/products/courses/antibiotics/ ... Check out my brand new "Electrolytes" course at https://www.medicosisperfectionalis.com/products/course/electrolytes/ and use the PROMO code: ELECTROLYTES50 to get a 50% discount. The first video in my NEW playlist “Bleeding and Coagulation"...See the entire playlist here: https://goo.gl/Dt41Bg
Platelets (thrombocytes) are not cells, they are just pieces of the megakaryocytes (their mighty parents).
Platelets are called thrombocytes because they will help form a clot (thrombus)...At least they form a temporary platelet plug to stop bleeding in small vessels (primary hemostasis).
The normal platelet count is 150,000 to 400,000/ microliter.
Get all of my notes at https://www.patreon.com/medicosis/
Hemostasis is defined as "cessation of blood bleeding”
There are 2 types of hemostasis:
1. Primary hemostasis: formation of weak, temporary platelet plug (by platelets)
2. Secondary hemostasis: formation of stronger fibrin meshwork (by coagulation factors).
Check my full playlist on "bleeding and coagulation" here: https://goo.gl/Dt41Bg
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4:06
Thrombocyte/Platelet Structure and Function
In this video, we will look at the structure and function of platelets/thrombocytes - impo...
published: 01 Feb 2022
Thrombocyte/Platelet Structure and Function
Thrombocyte/Platelet Structure and Function
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- published: 01 Feb 2022
- views: 35768
In this video, we will look at the structure and function of platelets/thrombocytes - important components in the blood that are involved in blood clotting/hemostasis. By the end of the video, you’ll have a good understanding of what platelets are and how they do what they do.
00:00 Intro
00:19 Hemostasis
00:49 Thrombocytes -- a misnomer
01:16 How Platelets are formed from Megakaryocutes
01:58 Platelet Structure
02:23 Other functions of platelets
03:09 Platelet disorders | Thrombocytopenia and Thrombocytosis Download a PDF copy of The Cardiac Cycle Made Easy here 👉 https://www.interactive-biology.com/cardiaccycle/ Download a PDF copy of The Cardiac Cycle Made Easy here 👉 https://www.interactive-biology.com/cardiaccycle/ .
Download a PDF copy of The Cardiac Cycle Made Easy here 👉 https://www.interactive-biology.com/cardiaccycle/
3:10
Platelets & Blood Clotting | Biology | FuseSchool
Do you remember tripping over as a kid and cutting your knee? And then like magic the blee...
published: 11 Oct 2018
Platelets & Blood Clotting | Biology | FuseSchool
Platelets & Blood Clotting | Biology | FuseSchool
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- published: 11 Oct 2018
- views: 830396
Do you remember tripping over as a kid and cutting your knee? And then like magic the bleeding suddenly stops? Have you ever wondered why this happens?
Our body is very clever and produces substances to seal off the open wound.
In this video we are going to look at how and why blood clots.
Clotting prevents us from bleeding to death, and also protects us from nasty disease-causing organisms, called pathogens, entering our body.
When we injure ourselves, we can damage the blood vessels just below our skin. This can cause blood to either leak into our tissue and form a bruise, or, if the skin is broken to openly bleed.
To prevent these horrible things happening, blood clotting occurs.
So let’s have a look at how this happens.
Starting with platelets. These are tiny cell fragments that float around in our blood.
When a blood vessel is damaged, collagen is exposed. This collagen exposure attracts platelets to the injured area. The platelets then stick together to form a plug.
They’ve quickly built a little barrier that stops us from losing too much blood. However, this platelet plug isn’t that strong. So it needs to be made stronger.
A protein called fibrin does exactly that.
In our blood there are soluble fibrinogen proteins. At a wound, these soluble fibrinogen proteins are exposed to outside chemicals that aren’t normally found in blood vessels. Like with the collagen and platelets, this exposure causes the fibrinogen proteins to turn into sticky fibrin fibres.
The fibrin fibres form a mesh, holding all the platelets together and making a much stronger clot.
More platelets, red blood cells and other components in our blood, all get stuck in the mesh making it even stronger. This clot stops more blood escaping the body. And also prevents nasty pathogens entering our body from the outside.
The clot develops into a scab, which protects the wound as it heals and new layers of skin form underneath. So really, all a scab is is just platelets trapped in the fibrin mesh!
When the new skin is fully formed, the scab will fall off, revealing the lovely brand new skin underneath.
Remember that I said the exposure to collagen causes the platelets to stick together? And the exposure to outside chemicals causes the fibrinogen to turn into sticky fibrin?
Both the platelets and the fibrin only become sticky AFTER the exposure. This means that in a normal, healthy blood vessel they won’t randomly cause clots.
So from this video, you should understand the magic of blood clotting. Platelets are first to the scene closely followed by fibrin fibres. Our blood clots so that we don’t lose a lot of blood and don’t let lots of nasty pathogens into our body if we cut ourselves.
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0:49
Decode Your Blood Test: Platelets 💉 | Merck Manual Consumer Version
Find out why platelets are so important and what could happen if your platelet count becom...
published: 01 Jun 2020
Decode Your Blood Test: Platelets 💉 | Merck Manual Consumer Version
Decode Your Blood Test: Platelets 💉 | Merck Manual Consumer Version
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- published: 01 Jun 2020
- views: 13982
Find out why platelets are so important and what could happen if your platelet count becomes too low or too high. Get more information in the links below:
Overview of Blood Disorders: https://mrkmnls.co/2Osv3n0
Laboratory Tests for Blood Disorders: https://mrkmnls.co/2TZESyP
About The Merck Manuals:
First published in 1899 as a small reference book for physicians and pharmacists, The Merck Manual grew in size and scope to become one of the world's most widely used comprehensive medical resources for professionals and consumers. As The Manual evolved, it continually expanded the reach and depth of its offerings to reflect the mission of providing the best medical information to a wide cross-section of users, including medical professionals and students, veterinarians and veterinary students, and consumers.
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1:47
Platelets Explained in Two Minutes
Platelets are tiny cells in your blood that form clots and stop bleeding. For millions of ...
published: 30 Aug 2016
Platelets Explained in Two Minutes
Platelets Explained in Two Minutes
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- published: 30 Aug 2016
- views: 224083
Platelets are tiny cells in your blood that form clots and stop bleeding. For millions of Americans, they are essential to surviving and fighting cancer, chronic diseases, and traumatic injuries. About 2 million units of platelets are transfused each year in the U.S. Every 15 seconds someone in the U.S. needs platelets. You can help by donating platelets through the American Red Cross.
Visit http://redcrossblood.org/platelets or call 1-800-RED CROSS for more information.
2:02
What are Platelets and when do they decrease? - Dr. Satish Kumar
Platelets are small cells in the body which help the blood to clot. There are three types ...
published: 28 Sep 2017
What are Platelets and when do they decrease? - Dr. Satish Kumar
What are Platelets and when do they decrease? - Dr. Satish Kumar
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- published: 28 Sep 2017
- views: 85464
Platelets are small cells in the body which help the blood to clot. There are three types of cells, red cells, white cells and platelets in the cells. These blood cells called platelets help the blood to clot. Whenever we have a small cut, it helps the blood to clot. The platelets are instrumental in forming the clot. Whenever the platelet count goes down, there is a risk of bleeding, but then again, people have a lot of myths about platelets though the normal platelet count is one lakh fifty thousand, to four lakh fifty thousand, unless and until the platelet count falls to less than 20000 or 10000. There will not be any risk of significant internal bleeding. The most common cause if low platelet count, nowadays we see is due to dengue fever. But apart from infections. The most common cause of low platelet count Is immune thrombocytopenia where our own immunity destroys our platelets. So we give medicines to suppress the immunity and to prevent the platelet destruction. That condition is called as ITP or immune thrombocytopenia. In ITP, the goal of treatment is to keep the platelet count at a safe level, which is anywhere more than 30000. The dictum of treatment in ITP is do not treat the platelet counts, treat the symptoms.
Platelet
Platelets, also called thrombocytes (thromb- + -cyte, "blood clot cell"), are a component of blood whose function (along with the coagulation factors) is to stop bleeding by clumping and clotting blood vessel injuries. Platelets have no cell nucleus: they are fragments of cytoplasm that are derived from the megakaryocytes of the bone marrow, and then enter the circulation. These unactivated platelets are biconvex discoid (lens-shaped) structures, 2–3 µm in greatest diameter. Platelets are found only in mammals, whereas in other animals (e.g. birds, amphibians) thrombocytes circulate as intact mononuclear cells.
On a stained blood smear, platelets appear as dark purple spots, about 20% the diameter of red blood cells. The smear is used to examine platelets for size, shape, qualitative number, and clumping. The ratio of platelets to red blood cells in a healthy adult is 1:10 to 1:20.
The main function of platelets is to contribute to hemostasis: the process of stopping bleeding at the site of interrupted endothelium. They gather at the site and unless the interruption is physically too large, they plug the hole. First, platelets attach to substances outside the interrupted endothelium: adhesion. Second, they change shape, turn on receptors and secrete chemical messengers: activation. Third, they connect to each other through receptor bridges: aggregation. Formation of this platelet plug (primary hemostasis) is associated with activation of the coagulation cascade with resultant fibrin deposition and linking (secondary hemostasis). These processes may overlap: the spectrum is from a predominantly platelet plug, or "white clot" to a predominantly fibrin clot, or "red clot" or the more typical mixture. The final result is the clot. Some would add the subsequent clot retraction and platelet inhibition as fourth and fifth steps to the completion of the process and still others a sixth step wound repair.
This page contains text from Wikipedia, the Free Encyclopedia - https://wn.com/Platelet
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