Signal transduction occurs when an extracellular signaling molecule activates a specific receptor located on the cell surface or inside the cell. In turn, this receptor triggers a biochemical chain of events inside the cell, creating a response. Depending on the cell, the response alters the cell's metabolism, shape, gene expression, or ability to divide. The signal can be amplified at any step. Thus, one signaling molecule can cause many responses.
History
In 1970, Martin Rodbell examined the effects of glucagon on a rat's liver cell membrane receptor. He noted that guanosine triphosphate disassociated glucagon from this receptor and stimulated the G-protein, which strongly influenced the cell's metabolism. Thus, he deduced that the G-protein is a transducer that accepts glucagon molecules and affects the cell. For this, he shared the 1994 Nobel Prize in Physiology or Medicine with Alfred G. Gilman.
The earliest MEDLINE entry for "signal transduction" dates from 1972. Some early articles used the terms signal transmission and sensory transduction. In 2007, a total of 48,377 scientific papers—including 11,211 review papers—were published on the subject. The term first appeared in a paper's title in 1979. Widespread use of the term has been traced to a 1980 review article by Rodbell: Research papers focusing on signal transduction first appeared in large numbers in the late 1980s and early 1990s.
Receptors: Signal Transduction and Phosphorylation Cascade
Did you know that cells can talk to one another? One cell can send a molecule over to another cell, and a receptor protein in the cell membrane will receive it, just like molecular walkie-talkies. Check it out!
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published: 06 Sep 2016
Signal Transduction Pathways
038 - Signal Transduction Pathways.mov
Paul Andersen explains how signal transduction pathways are used by cells to convert chemical messages to cellular action. Epinephrine is used as a sample messenger to trigger the release of glucose from cells in the liver. The G-Protein, adenylyl cyclase, cAMP, and protein kinases are all used as illustrative examples of signal transduction. A review of the concepts is also included.
Do you speak another language? Help me translate my videos:
http://www.bozemanscience.com/translations/
Intro Music Atribution
Title: I4dsong_loop_main.wav
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Link to sound: http://www.freesound.org/people/CosmicD/sounds/72556/
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"File...
published: 21 Aug 2011
Cell Signal Transduction | A Preview | Endocrinology Series
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published: 04 Nov 2021
Signal Transduction Pathways (G-Protein, Receptor Tyrosine Kinase, cGMP)
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Some videos contain mild profanity and hyperbole solely used to assist with memorization. Viewer discretion advised.
Opinions are entirely my own.
published: 12 May 2021
Common cell signaling pathway
What are common cell signaling pathways? To make a multicellular organism, cells must be able to communicate with one another, and to do it cells often send out tiny chemical signals that act on the receptors on other cells. Signals can be classified according to the distance between the signaling cell and the target cell. Find our full video library only on Osmosis: http://osms.it/more.
Join millions of current and future clinicians who learn by Osmosis, along with hundreds of universities around the world who partner with Osmosis from Elseiver to make medical and health education more engaging and efficient. We have unparalleled tools and materials to prepare you for success in school, on your board exams, and as a future clinician. Sign up for a free trial at http://osms.it/more. If y...
published: 14 Oct 2020
Intro to Cell Signaling
Explore cell signaling with the Amoeba Sisters! This introductory video describes vocabulary such as ligand and receptor. It includes the stages of cell signaling (reception, transduction, and response) and different types of signaling including autocrine, paracrine, and endocrine. This is just an introduction to a series on signaling that we hope to expand on in the future!
Factual References:
OpenStax, Biology. OpenStax CNX. Jun 1, 2018 http://cnx.org/contents/[email protected].
Reece, J. B., & Campbell, N. A. (2011). Campbell biology. Boston: Benjamin Cummings / Pearson.
Further Reading Suggestion:
Want to learn more about autocrine signaling in cancer cells?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1002946/
The Amoeba Sisters videos demystify science w...
published: 30 Aug 2018
Signal Transduction AP Biology
4.2 From the AP Biology C.E.D.
published: 17 Aug 2022
Signal Transduction in Immune Cells: Receptor-Ligand Interactions
Now that we know some things about immune cell structure and function, we need to start understanding how these cells interact on the molecular level, and how signals are translated into cellular response. This means looking at receptor-ligand interactions. What is signal transduction?What are kinases? What are GTPases? What are G-proteins? We need to know about these important cellular components if we are going to understand the immune system, so let's take a closer look!
Script by Stephanie Melchor
Select images provided by BioRender.com
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published: 10 Jun 2021
Cell Signal Transduction (Biosignaling) - Quick Review - Biochemistry and Physiology
A brief animation explaining signal transduction in cells. Created for AP Biology class, 2010-2011. :)
(Disclaimer: I made this for a project in 11th grade so I apologize for any mistakes/inconsistencies/annoying background music)
Did you know that cells can talk to one another? One cell can send a molecule over to another cell, and a receptor protein in the cell membrane will receive it,...
Did you know that cells can talk to one another? One cell can send a molecule over to another cell, and a receptor protein in the cell membrane will receive it, just like molecular walkie-talkies. Check it out!
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Did you know that cells can talk to one another? One cell can send a molecule over to another cell, and a receptor protein in the cell membrane will receive it, just like molecular walkie-talkies. Check it out!
Watch the whole Biochemistry playlist: http://bit.ly/ProfDaveBiochem
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Check out "Is This Wi-Fi Organic?", my book on disarming pseudoscience!
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Bookshop: https://bit.ly/39cKADM
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038 - Signal Transduction Pathways.mov
Paul Andersen explains how signal transduction pathways are used by cells to convert chemical messages to cellular actio...
038 - Signal Transduction Pathways.mov
Paul Andersen explains how signal transduction pathways are used by cells to convert chemical messages to cellular action. Epinephrine is used as a sample messenger to trigger the release of glucose from cells in the liver. The G-Protein, adenylyl cyclase, cAMP, and protein kinases are all used as illustrative examples of signal transduction. A review of the concepts is also included.
Do you speak another language? Help me translate my videos:
http://www.bozemanscience.com/translations/
Intro Music Atribution
Title: I4dsong_loop_main.wav
Artist: CosmicD
Link to sound: http://www.freesound.org/people/CosmicD/sounds/72556/
Creative Commons Atribution License
All of the images are licensed under creative commons and public domain licensing:
"File:Dora and Boots.jpg." Wikipedia, the Free Encyclopedia, October 28, 2013. http://en.wikipedia.org/w/index.php?title=File:Dora_and_Boots.jpg&oldid=468219594.
"File:Jimi Hendrix 1967 Uncropped.jpg." Wikipedia, the Free Encyclopedia. Accessed December 9, 2013. http://en.wikipedia.org/wiki/File:Jimi_Hendrix_1967_uncropped.jpg.
"File:MarshallStack Slayer.jpg." Wikipedia, the Free Encyclopedia. Accessed December 9, 2013. http://en.wikipedia.org/wiki/File:MarshallStack_Slayer.jpg.
"File:Pickup-SSH.jpg." Wikipedia, the Free Encyclopedia. Accessed December 9, 2013. http://en.wikipedia.org/wiki/File:Pickup-SSH.jpg.
Juancoronado1974. English: Phospholipid Bilayer, November 23, 2013. Own work. http://commons.wikimedia.org/wiki/File:Bilayer.png.
038 - Signal Transduction Pathways.mov
Paul Andersen explains how signal transduction pathways are used by cells to convert chemical messages to cellular action. Epinephrine is used as a sample messenger to trigger the release of glucose from cells in the liver. The G-Protein, adenylyl cyclase, cAMP, and protein kinases are all used as illustrative examples of signal transduction. A review of the concepts is also included.
Do you speak another language? Help me translate my videos:
http://www.bozemanscience.com/translations/
Intro Music Atribution
Title: I4dsong_loop_main.wav
Artist: CosmicD
Link to sound: http://www.freesound.org/people/CosmicD/sounds/72556/
Creative Commons Atribution License
All of the images are licensed under creative commons and public domain licensing:
"File:Dora and Boots.jpg." Wikipedia, the Free Encyclopedia, October 28, 2013. http://en.wikipedia.org/w/index.php?title=File:Dora_and_Boots.jpg&oldid=468219594.
"File:Jimi Hendrix 1967 Uncropped.jpg." Wikipedia, the Free Encyclopedia. Accessed December 9, 2013. http://en.wikipedia.org/wiki/File:Jimi_Hendrix_1967_uncropped.jpg.
"File:MarshallStack Slayer.jpg." Wikipedia, the Free Encyclopedia. Accessed December 9, 2013. http://en.wikipedia.org/wiki/File:MarshallStack_Slayer.jpg.
"File:Pickup-SSH.jpg." Wikipedia, the Free Encyclopedia. Accessed December 9, 2013. http://en.wikipedia.org/wiki/File:Pickup-SSH.jpg.
Juancoronado1974. English: Phospholipid Bilayer, November 23, 2013. Own work. http://commons.wikimedia.org/wiki/File:Bilayer.png.
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My goal is to reduce educational disparities by making education FREE.
These videos help you score extra points on medical school exams (USMLE, COMLEX, etc.)
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Some videos contain mild profanity and hyperbole solely used to assist with memorization. Viewer discretion advised.
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My goal is to reduce educational disparities by making education FREE.
These videos help you score extra points on medical school exams (USMLE, COMLEX, etc.)
For educational purposes only; NOT medical or other advice.
Some videos contain mild profanity and hyperbole solely used to assist with memorization. Viewer discretion advised.
Opinions are entirely my own.
What are common cell signaling pathways? To make a multicellular organism, cells must be able to communicate with one another, and to do it cells often send out...
Explore cell signaling with the Amoeba Sisters! This introductory video describes vocabulary such as ligand and receptor. It includes the stages of cell signali...
Explore cell signaling with the Amoeba Sisters! This introductory video describes vocabulary such as ligand and receptor. It includes the stages of cell signaling (reception, transduction, and response) and different types of signaling including autocrine, paracrine, and endocrine. This is just an introduction to a series on signaling that we hope to expand on in the future!
Factual References:
OpenStax, Biology. OpenStax CNX. Jun 1, 2018 http://cnx.org/contents/[email protected].
Reece, J. B., & Campbell, N. A. (2011). Campbell biology. Boston: Benjamin Cummings / Pearson.
Further Reading Suggestion:
Want to learn more about autocrine signaling in cancer cells?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1002946/
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Explore cell signaling with the Amoeba Sisters! This introductory video describes vocabulary such as ligand and receptor. It includes the stages of cell signaling (reception, transduction, and response) and different types of signaling including autocrine, paracrine, and endocrine. This is just an introduction to a series on signaling that we hope to expand on in the future!
Factual References:
OpenStax, Biology. OpenStax CNX. Jun 1, 2018 http://cnx.org/contents/[email protected].
Reece, J. B., & Campbell, N. A. (2011). Campbell biology. Boston: Benjamin Cummings / Pearson.
Further Reading Suggestion:
Want to learn more about autocrine signaling in cancer cells?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1002946/
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Dutch captions by M. Torn
While we don't allow dubbing of our videos, we do gladly accept subtitle translations from our community. Some translated subtitles on our videos were translated by the community using YouTube's community-contributed subtitle feature. After the feature was discontinued by YouTube, we have another option for submitting translated subtitles here: https://www.amoebasisters.com/pinkys-ed-tech-favorites/community-contributed-subtitles We want to thank our amazing community for the generosity of their time in continuing to create translated subtitles. If you have a concern about community contributed contributions, please contact us.
Now that we know some things about immune cell structure and function, we need to start understanding how these cells interact on the molecular level, and how s...
Now that we know some things about immune cell structure and function, we need to start understanding how these cells interact on the molecular level, and how signals are translated into cellular response. This means looking at receptor-ligand interactions. What is signal transduction?What are kinases? What are GTPases? What are G-proteins? We need to know about these important cellular components if we are going to understand the immune system, so let's take a closer look!
Script by Stephanie Melchor
Select images provided by BioRender.com
Biochemistry tutorial on receptors: https://www.youtube.com/watch?v=VatdTJka3_M
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Check out "Is This Wi-Fi Organic?", my book on disarming pseudoscience!
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Book Depository: http://bit.ly/3aOVDlT
Now that we know some things about immune cell structure and function, we need to start understanding how these cells interact on the molecular level, and how signals are translated into cellular response. This means looking at receptor-ligand interactions. What is signal transduction?What are kinases? What are GTPases? What are G-proteins? We need to know about these important cellular components if we are going to understand the immune system, so let's take a closer look!
Script by Stephanie Melchor
Select images provided by BioRender.com
Biochemistry tutorial on receptors: https://www.youtube.com/watch?v=VatdTJka3_M
Watch the whole Immunology playlist: http://bit.ly/ProfDaveImmuno
General Chemistry Tutorials: http://bit.ly/ProfDaveGenChem
Organic Chemistry Tutorials: http://bit.ly/ProfDaveOrgChem
Biochemistry Tutorials: http://bit.ly/ProfDaveBiochem
Biology/Genetics Tutorials: http://bit.ly/ProfDaveBio
Anatomy & Physiology Tutorials: http://bit.ly/ProfDaveAnatPhys
Biopsychology Tutorials: http://bit.ly/ProfDaveBiopsych
Microbiology/Infectious Diseases Tutorials: http://bit.ly/ProfDaveMicrobio
History of Drugs Videos: http://bit.ly/ProfDaveHistoryDrugs
EMAIL► [email protected]
PATREON► http://patreon.com/ProfessorDaveExplains
Check out "Is This Wi-Fi Organic?", my book on disarming pseudoscience!
Amazon: https://amzn.to/2HtNpVH
Bookshop: https://bit.ly/39cKADM
Barnes and Noble: https://bit.ly/3pUjmrn
Book Depository: http://bit.ly/3aOVDlT
Cell Signal Transduction Quick Review (cell signaling).
🍱 Endocrine Pharmacology Course: https://www.medicosisperfectionalis.com/products/
📝 Download my handw...
Cell Signal Transduction Quick Review (cell signaling).
🍱 Endocrine Pharmacology Course: https://www.medicosisperfectionalis.com/products/
📝 Download my handwritten notes: www.medicosisperfectionalis.com/
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Cell Signal Transduction Quick Review (cell signaling).
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📖 Try Amazon Kindle unlimited for FREE, they have some good medical books that you can read for FREE. https://amzn.to/2UceoG2
--If you have joined my channel on youtube (the join button that's next to the subscribe button), then go to the "community tab" and you will find some member-only posts.
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A brief animation explaining signal transduction in cells. Created for AP Biology class, 2010-2011. :)
(Disclaimer: I made this for a project in 11th grade so ...
A brief animation explaining signal transduction in cells. Created for AP Biology class, 2010-2011. :)
(Disclaimer: I made this for a project in 11th grade so I apologize for any mistakes/inconsistencies/annoying background music)
A brief animation explaining signal transduction in cells. Created for AP Biology class, 2010-2011. :)
(Disclaimer: I made this for a project in 11th grade so I apologize for any mistakes/inconsistencies/annoying background music)
Did you know that cells can talk to one another? One cell can send a molecule over to another cell, and a receptor protein in the cell membrane will receive it, just like molecular walkie-talkies. Check it out!
Watch the whole Biochemistry playlist: http://bit.ly/ProfDaveBiochem
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Check out "Is This Wi-Fi Organic?", my book on disarming pseudoscience!
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Book Depository: http://bit.ly/3aOVDlT
038 - Signal Transduction Pathways.mov
Paul Andersen explains how signal transduction pathways are used by cells to convert chemical messages to cellular action. Epinephrine is used as a sample messenger to trigger the release of glucose from cells in the liver. The G-Protein, adenylyl cyclase, cAMP, and protein kinases are all used as illustrative examples of signal transduction. A review of the concepts is also included.
Do you speak another language? Help me translate my videos:
http://www.bozemanscience.com/translations/
Intro Music Atribution
Title: I4dsong_loop_main.wav
Artist: CosmicD
Link to sound: http://www.freesound.org/people/CosmicD/sounds/72556/
Creative Commons Atribution License
All of the images are licensed under creative commons and public domain licensing:
"File:Dora and Boots.jpg." Wikipedia, the Free Encyclopedia, October 28, 2013. http://en.wikipedia.org/w/index.php?title=File:Dora_and_Boots.jpg&oldid=468219594.
"File:Jimi Hendrix 1967 Uncropped.jpg." Wikipedia, the Free Encyclopedia. Accessed December 9, 2013. http://en.wikipedia.org/wiki/File:Jimi_Hendrix_1967_uncropped.jpg.
"File:MarshallStack Slayer.jpg." Wikipedia, the Free Encyclopedia. Accessed December 9, 2013. http://en.wikipedia.org/wiki/File:MarshallStack_Slayer.jpg.
"File:Pickup-SSH.jpg." Wikipedia, the Free Encyclopedia. Accessed December 9, 2013. http://en.wikipedia.org/wiki/File:Pickup-SSH.jpg.
Juancoronado1974. English: Phospholipid Bilayer, November 23, 2013. Own work. http://commons.wikimedia.org/wiki/File:Bilayer.png.
Cell Signal Transduction | A Preview | Endocrinology Playlist | Medicosis.
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🧠 CNS Pharmacology Course: https://www.medicosisperfectionalis.com/
👨🏫 Watch the first lecture of my CNS Pharmacology Course: https://youtu.be/tUShmUX-1IU/
🧪 Electrolytes Videos: https://www.medicosisperfectionalis.com/
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🎁 Small gift: here are 2 FREE audiobooks from Audible https://amzn.to/2FQurW0
📖 Try Amazon Kindle unlimited for FREE, they have some good medical books that you can read for FREE. https://amzn.to/2UceoG2
--If you have joined my channel on youtube (the join button that's next to the subscribe button), then go to the "community tab" and you will find some member-only posts.
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Thank you so much for supporting my channel! Love ❤️.
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My goal is to reduce educational disparities by making education FREE.
These videos help you score extra points on medical school exams (USMLE, COMLEX, etc.)
For educational purposes only; NOT medical or other advice.
Some videos contain mild profanity and hyperbole solely used to assist with memorization. Viewer discretion advised.
Opinions are entirely my own.
Explore cell signaling with the Amoeba Sisters! This introductory video describes vocabulary such as ligand and receptor. It includes the stages of cell signaling (reception, transduction, and response) and different types of signaling including autocrine, paracrine, and endocrine. This is just an introduction to a series on signaling that we hope to expand on in the future!
Factual References:
OpenStax, Biology. OpenStax CNX. Jun 1, 2018 http://cnx.org/contents/[email protected].
Reece, J. B., & Campbell, N. A. (2011). Campbell biology. Boston: Benjamin Cummings / Pearson.
Further Reading Suggestion:
Want to learn more about autocrine signaling in cancer cells?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1002946/
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Now that we know some things about immune cell structure and function, we need to start understanding how these cells interact on the molecular level, and how signals are translated into cellular response. This means looking at receptor-ligand interactions. What is signal transduction?What are kinases? What are GTPases? What are G-proteins? We need to know about these important cellular components if we are going to understand the immune system, so let's take a closer look!
Script by Stephanie Melchor
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A brief animation explaining signal transduction in cells. Created for AP Biology class, 2010-2011. :)
(Disclaimer: I made this for a project in 11th grade so I apologize for any mistakes/inconsistencies/annoying background music)
Signal transduction occurs when an extracellular signaling molecule activates a specific receptor located on the cell surface or inside the cell. In turn, this receptor triggers a biochemical chain of events inside the cell, creating a response. Depending on the cell, the response alters the cell's metabolism, shape, gene expression, or ability to divide. The signal can be amplified at any step. Thus, one signaling molecule can cause many responses.
History
In 1970, Martin Rodbell examined the effects of glucagon on a rat's liver cell membrane receptor. He noted that guanosine triphosphate disassociated glucagon from this receptor and stimulated the G-protein, which strongly influenced the cell's metabolism. Thus, he deduced that the G-protein is a transducer that accepts glucagon molecules and affects the cell. For this, he shared the 1994 Nobel Prize in Physiology or Medicine with Alfred G. Gilman.
The earliest MEDLINE entry for "signal transduction" dates from 1972. Some early articles used the terms signal transmission and sensory transduction. In 2007, a total of 48,377 scientific papers—including 11,211 review papers—were published on the subject. The term first appeared in a paper's title in 1979. Widespread use of the term has been traced to a 1980 review article by Rodbell: Research papers focusing on signal transduction first appeared in large numbers in the late 1980s and early 1990s.