- published: 29 Aug 2014
- views: 297326
Sickle-cell disease
Sickle-cell disease (SCD), also known as sickle-cell anaemia (SCA), is a hereditary blood disorder, caused by an abnormality in the oxygen-carrying protein haemoglobin found in red blood cells. This leads to a propensity for the cells to assume an abnormal, rigid, sickle-like shape under certain circumstances. Sickle-cell disease is associated with a number of acute and chronic health problems, such as severe infections, attacks of severe pain ("sickle-cell crisis"), stroke, and an increased risk of death.
Sickle-cell disease occurs when a person inherits two abnormal copies of the haemoglobin gene, one from each parent. Several subtypes exist, depending on the exact mutation in each haemoglobin gene. A person with a single abnormal copy does not experience symptoms and is said to have sickle-cell trait. Such people are also referred to as carriers.
The complications of sickle-cell disease can be prevented to a large extent with vaccination, preventive antibiotics, blood transfusion, and the drug hydroxyurea/hydroxycarbamide. A small proportion of patients require a transplant of bone marrow cells.
This page contains text from Wikipedia, the Free Encyclopedia - https://wn.com/Sickle-cell_disease
Sickle Cell Anemia, a Molecular Disease
"Sickle Cell Anemia, a Molecular Disease" is a 1949 scientific paper by Linus Pauling, Harvey A. Itano, Seymour J. Singer and Ibert C. Wells that established sickle-cell anemia as a genetic disease in which affected individuals have a different form of the metalloprotein hemoglobin in their blood. The paper, published in the November 25, 1949 issue of Science, reports a difference in electrophoretic mobility between hemoglobin from healthy individuals and those with sickle-cell anemia, with those with sickle cell trait having a mixture of the two types. The paper suggests that the difference in electrophoretic mobility is probably due to a different number of ionizable amino acid residues in the protein portion of hemoglobin (which was confirmed in 1956 by Vernon Ingram), and that this change in molecular structure is responsible for the sickling process. It also reports the genetic basis for the disease, consistent with the simultaneous genealogical study by James V. Neel: those with sickle-cell anemia are homozygous for the disease gene, while heterozygous individuals exhibit the usually asymptomatic condition of sickle cell trait.
This page contains text from Wikipedia, the Free Encyclopedia - https://wn.com/Sickle_Cell_Anemia,_a_Molecular_Disease
Podcasts:
-
What is Sickle Cell Anemia?
Sickle cell anemia is a disease in which the blood cells become deformed and are unable to function properly. To learn more about sickle cell anemia and other blood disorders, visit http://hematology.org/Patients. This clip was excerpted from the documentary film "Blood Detectives." To learn more about the film, visit http://hematology.org/Patients/Blood-Detectives.aspx.
published: 29 Aug 2014 -
Sickle Cell Disease, Animation
(USMLE topics, cardiology, blood disorders) Genetics, different forms of SCD, pathophysiology, and treatment. Purchase a license to download a non-watermarked version of this video on AlilaMedicalMedia(dot)com Check out our new Alila Academy - AlilaAcademy(dot)com - complete video courses with quizzes, PDFs, and downloadable images. ©Alila Medical Media. All rights reserved. Voice by Ashley Fleming All images/videos by Alila Medical Media are for information purposes ONLY and are NOT intended to replace professional medical advice, diagnosis or treatment. Always seek the advice of a qualified healthcare provider with any questions you may have regarding a medical condition. Sickle cell disease is a group of inherited blood disorders in which the body produces abnormally-shaped red bl...
published: 17 Sep 2019 -
Living with Sickle Cell Disease- Personal Stories
Listen to your peers talk about their own experiences living with sickle cell disease.
published: 23 Dec 2020 -
Sickle Cell Anemia: A Patient's Journey
As a young child, Alexandria, now age 17, endured near-constant feelings of exhaustion and general sickness, which turned into severe pain at night. After experiencing a "silent stroke" as a young girl, Alexandria was diagnosed with sickle cell anemia, a disease in which the blood cells become deformed and unable to function properly. To learn more about SCA and other blood disorders, visit ASH's patient resources webpage http://hematology.org/Patients/. This clip was excerpted from the documentary film "Blood Detectives." To learn more about the film, visit http://www.hematology.org/Publications/Blood-Detectives/5246.aspx
published: 07 Sep 2010 -
Sickle Cell Disease
Sickle Cell Anemia. Written by Paulo César Naoum and Alia F. M. Naoum. A São José do Rio Preto's Science and Technology Academy video. www.ciencianews.com.br Animated by Birdo Studio www.birdo.com.br Full Credits: Production: Birdo Script: Dr. Paulo César Naoum, Aliá F. M. Naoum Direction: Luciana Eguti, Paulo Muppet Storyboard: Paulo Muppet Design: Rafael Gallardo Animation and additional design: Antonio Linhares, Fernando Finamore, Pedro Eboli, Rafael Gallardo, William Iamazi Ferro Sound design: Rafael Gallardo, Antonio Linhares 2011
published: 25 Feb 2011 -
Sickle Cell Disease | Pathophysiology, Symptoms and Treatment
Lesson on sickle cell disease. Sickle cell disease is a group of heritable blood disorders with characteristic sickle-cell shaped red blood cells. Sickle cell disease leads to chronic, compensated hemolytic anemia with vaso-occlusion from sickling of red blood cells. I hope you find this video helpful. If you do, please like and subscribe for more videos like this one. :) JJ *Subscribe for more free medical lessons* https://www.youtube.com/channel/UCFPvnkCZbHfBvV8ApBBE0vA?sub_confirmation=1 ------------------------------------------------------------------------------------------------------------- For books and more information on these topics https://www.amazon.com/shop/jjmedicine Support future lessons (and get other cool stuff) ➜ https://www.patreon.com/jjmedicine Follow me on ...
published: 03 Apr 2018 -
Family appeals for Shs 15M for two bone marrow transplants their two children
JOSDAVIS FAMILY NEED YOUR HELP Sh 15 million is required for two bone marrow transplants Their two children were diagnosed with sickle cell anemia Connect with KBC Online; Subscribe to our channel: https://t.ly/86BKN Follow us on Twitter: https://twitter.om/KBCChannel1 Find us on Facebook: https://www.facebook.com/kbcchannel1TV Check our website: https://www.kbc.co.ke/ #kbcchannel1 #news #kbclive
published: 28 Jul 2024 -
What is Sickle Cell Disease?
What is sickle cell disease? Watch this video to learn more about this lifelong blood disorder and test your knowledge with a quiz at the end.
published: 15 Oct 2015 -
Sickle cell disease: What it is and how to fight it | DW News
People with sickle cell disorder produce red blood cells that are unusually shaped like crescents or sickles, as the name suggests. These can block blood vessels, and cause chronic pain and often death. The condition is particularly common among people with African or Caribbean background. 300,000 children are born with sickle cell anemia each year, with around three-quarters of those in Africa. Nigeria is the worst affected country. But there are attempts to sound the alarm, as DW correspondent Olisa Chukwumah reports. Subscribe: https://www.youtube.com/user/deutschewelleenglish?sub_confirmation=1 For more news go to: http://www.dw.com/en/ Follow DW on social media: ►Facebook: https://www.facebook.com/deutschewellenews/ ►Twitter: https://twitter.com/dwnews ►Instagram: https://www.inst...
published: 18 Jun 2022 -
Living with Sickle Cell Disease
Damali and Amiel Reid are two siblings who are living with sickle cell anemia. Listen as they talk about their struggles with the disease and their hope for a cure.
published: 21 Jan 2011
developed with YouTube
0:41
What is Sickle Cell Anemia?
- Order: Reorder
- Duration: 0:41
- Uploaded Date: 29 Aug 2014
- views: 297326
Sickle cell anemia is a disease in which the blood cells become deformed and are unable to function properly. To learn more about sickle cell anemia and other b...
Sickle cell anemia is a disease in which the blood cells become deformed and are unable to function properly. To learn more about sickle cell anemia and other blood disorders, visit http://hematology.org/Patients.
This clip was excerpted from the documentary film "Blood Detectives." To learn more about the film, visit http://hematology.org/Patients/Blood-Detectives.aspx.
https://wn.com/What_Is_Sickle_Cell_Anemia
Sickle cell anemia is a disease in which the blood cells become deformed and are unable to function properly. To learn more about sickle cell anemia and other blood disorders, visit http://hematology.org/Patients.
This clip was excerpted from the documentary film "Blood Detectives." To learn more about the film, visit http://hematology.org/Patients/Blood-Detectives.aspx.
4:58
Sickle Cell Disease, Animation
- Order: Reorder
- Duration: 4:58
- Uploaded Date: 17 Sep 2019
- views: 269777
(USMLE topics, cardiology, blood disorders) Genetics, different forms of SCD, pathophysiology, and treatment.
Purchase a license to download a non-watermarked...
(USMLE topics, cardiology, blood disorders) Genetics, different forms of SCD, pathophysiology, and treatment.
Purchase a license to download a non-watermarked version of this video on AlilaMedicalMedia(dot)com
Check out our new Alila Academy - AlilaAcademy(dot)com - complete video courses with quizzes, PDFs, and downloadable images.
©Alila Medical Media. All rights reserved.
Voice by Ashley Fleming
All images/videos by Alila Medical Media are for information purposes ONLY and are NOT intended to replace professional medical advice, diagnosis or treatment. Always seek the advice of a qualified healthcare provider with any questions you may have regarding a medical condition.
Sickle cell disease is a group of inherited blood disorders in which the body produces abnormally-shaped red blood cells that look like crescent moons or sickles. Sickle cells have a shorter-than-normal life span; their premature destruction results in shortage of red cells, known as anemia. Signs of anemia include shortness of breath, fatigue, and delayed growth in children. Unlike normal red cells which are pliant, sickle cells are rigid and also sticky. They may clump together and stick to the walls of blood vessels, causing obstruction in small vessels and subsequent reduced oxygen supply to various organs. This happens repeatedly and manifests as periodic episodes of pain, called crises, which can last hours to days, and may result in organ damage, especially in the eyes, lungs, kidneys, bones and brain. The spleen has to handle large numbers of dead red cells and becomes enlarged and fibrous, its immune function declines, making the body more vulnerable to infections. In an attempt to compensate for blood cell loss, the bone marrow tries to produce more cells and grows larger, causing bones to weaken. Other signs include jaundice, a result of rapid destruction of heme.
Hemoglobin is the major component of red blood cells and is responsible for oxygen transport. The adult hemoglobin, or hemoglobin A, is composed of 4 protein chains: 2 alpha and 2 beta. The beta subunit is encoded by the HBB gene. Several mutations in HBB gene are responsible for the disease. Each individual has two copies of HBB gene. The disease develops when both copies are mutated, producing no normal beta globin. The 2 copies may be mutated differently, producing two different forms of abnormal beta subunits in the same person. Various combinations of these mutations produce different forms of sickle cell disease, but the most common and also most severe, called sickle cell anemia, is caused by 2 copies of the same mutation producing the mutated hemoglobin S. Each copy comes from a parent. The 2 parents each carry one copy of the mutated gene, but they typically do not show any symptoms. This pattern of inheritance is called autosomal recessive.
Hemoglobin S has the tendency to form polymers under low oxygen conditions. This process is called sickling, or gelation, for the gel-like consistency of the resulting polymer. As the polymer filaments grow, they eventually involve the cell membrane and distort the cell into the characteristic crescent shape. Apart from oxygen tension, the presence of other hemoglobins also seems to affect the sickling process. Normal adult hemoglobin inhibits sickling and this explains why heterozygous parents, who produce both mutated hemoglobin S and normal hemoglobin A, do not usually develop the disease. Fetal hemoglobin F, which has 2 gamma chains in place of 2 beta chains, also suppresses sickling. Infants born with the condition seem to benefit from high levels of fetal hemoglobin in the first few months of life: they do not develop symptoms until the age of 6 months or so, when fetal hemoglobin levels drop.
Bone marrow transplantation is currently the only known cure for sickle cell disease. It involves replacing the diseased stem cells in the bone marrow with healthy cells from an eligible donor, usually a relative. The procedure however is complex and finding a suitable donor can be difficult. In most cases, treatments aim to avoid crises, relieve symptoms and prevent complications.
https://wn.com/Sickle_Cell_Disease,_Animation
(USMLE topics, cardiology, blood disorders) Genetics, different forms of SCD, pathophysiology, and treatment.
Purchase a license to download a non-watermarked version of this video on AlilaMedicalMedia(dot)com
Check out our new Alila Academy - AlilaAcademy(dot)com - complete video courses with quizzes, PDFs, and downloadable images.
©Alila Medical Media. All rights reserved.
Voice by Ashley Fleming
All images/videos by Alila Medical Media are for information purposes ONLY and are NOT intended to replace professional medical advice, diagnosis or treatment. Always seek the advice of a qualified healthcare provider with any questions you may have regarding a medical condition.
Sickle cell disease is a group of inherited blood disorders in which the body produces abnormally-shaped red blood cells that look like crescent moons or sickles. Sickle cells have a shorter-than-normal life span; their premature destruction results in shortage of red cells, known as anemia. Signs of anemia include shortness of breath, fatigue, and delayed growth in children. Unlike normal red cells which are pliant, sickle cells are rigid and also sticky. They may clump together and stick to the walls of blood vessels, causing obstruction in small vessels and subsequent reduced oxygen supply to various organs. This happens repeatedly and manifests as periodic episodes of pain, called crises, which can last hours to days, and may result in organ damage, especially in the eyes, lungs, kidneys, bones and brain. The spleen has to handle large numbers of dead red cells and becomes enlarged and fibrous, its immune function declines, making the body more vulnerable to infections. In an attempt to compensate for blood cell loss, the bone marrow tries to produce more cells and grows larger, causing bones to weaken. Other signs include jaundice, a result of rapid destruction of heme.
Hemoglobin is the major component of red blood cells and is responsible for oxygen transport. The adult hemoglobin, or hemoglobin A, is composed of 4 protein chains: 2 alpha and 2 beta. The beta subunit is encoded by the HBB gene. Several mutations in HBB gene are responsible for the disease. Each individual has two copies of HBB gene. The disease develops when both copies are mutated, producing no normal beta globin. The 2 copies may be mutated differently, producing two different forms of abnormal beta subunits in the same person. Various combinations of these mutations produce different forms of sickle cell disease, but the most common and also most severe, called sickle cell anemia, is caused by 2 copies of the same mutation producing the mutated hemoglobin S. Each copy comes from a parent. The 2 parents each carry one copy of the mutated gene, but they typically do not show any symptoms. This pattern of inheritance is called autosomal recessive.
Hemoglobin S has the tendency to form polymers under low oxygen conditions. This process is called sickling, or gelation, for the gel-like consistency of the resulting polymer. As the polymer filaments grow, they eventually involve the cell membrane and distort the cell into the characteristic crescent shape. Apart from oxygen tension, the presence of other hemoglobins also seems to affect the sickling process. Normal adult hemoglobin inhibits sickling and this explains why heterozygous parents, who produce both mutated hemoglobin S and normal hemoglobin A, do not usually develop the disease. Fetal hemoglobin F, which has 2 gamma chains in place of 2 beta chains, also suppresses sickling. Infants born with the condition seem to benefit from high levels of fetal hemoglobin in the first few months of life: they do not develop symptoms until the age of 6 months or so, when fetal hemoglobin levels drop.
Bone marrow transplantation is currently the only known cure for sickle cell disease. It involves replacing the diseased stem cells in the bone marrow with healthy cells from an eligible donor, usually a relative. The procedure however is complex and finding a suitable donor can be difficult. In most cases, treatments aim to avoid crises, relieve symptoms and prevent complications.
- published: 17 Sep 2019
- views: 269777
12:35
Living with Sickle Cell Disease- Personal Stories
- Order: Reorder
- Duration: 12:35
- Uploaded Date: 23 Dec 2020
- views: 82810
Listen to your peers talk about their own experiences living with sickle cell disease.
Listen to your peers talk about their own experiences living with sickle cell disease.
https://wn.com/Living_With_Sickle_Cell_Disease_Personal_Stories
Listen to your peers talk about their own experiences living with sickle cell disease.
- published: 23 Dec 2020
- views: 82810
5:58
Sickle Cell Anemia: A Patient's Journey
- Order: Reorder
- Duration: 5:58
- Uploaded Date: 07 Sep 2010
- views: 700187
As a young child, Alexandria, now age 17, endured near-constant feelings of exhaustion and general sickness, which turned into severe pain at night. After exper...
As a young child, Alexandria, now age 17, endured near-constant feelings of exhaustion and general sickness, which turned into severe pain at night. After experiencing a "silent stroke" as a young girl, Alexandria was diagnosed with sickle cell anemia, a disease in which the blood cells become deformed and unable to function properly. To learn more about SCA and other blood disorders, visit ASH's patient resources webpage http://hematology.org/Patients/.
This clip was excerpted from the documentary film "Blood Detectives." To learn more about the film, visit http://www.hematology.org/Publications/Blood-Detectives/5246.aspx
https://wn.com/Sickle_Cell_Anemia_A_Patient's_Journey
As a young child, Alexandria, now age 17, endured near-constant feelings of exhaustion and general sickness, which turned into severe pain at night. After experiencing a "silent stroke" as a young girl, Alexandria was diagnosed with sickle cell anemia, a disease in which the blood cells become deformed and unable to function properly. To learn more about SCA and other blood disorders, visit ASH's patient resources webpage http://hematology.org/Patients/.
This clip was excerpted from the documentary film "Blood Detectives." To learn more about the film, visit http://www.hematology.org/Publications/Blood-Detectives/5246.aspx
- published: 07 Sep 2010
- views: 700187
5:29
Sickle Cell Disease
- Order: Reorder
- Duration: 5:29
- Uploaded Date: 25 Feb 2011
- views: 888698
Sickle Cell Anemia. Written by Paulo César Naoum and Alia F. M. Naoum.
A São José do Rio Preto's Science and Technology Academy video.
www.ciencianews.com.br...
Sickle Cell Anemia. Written by Paulo César Naoum and Alia F. M. Naoum.
A São José do Rio Preto's Science and Technology Academy video.
www.ciencianews.com.br
Animated by Birdo Studio
www.birdo.com.br
Full Credits:
Production: Birdo
Script: Dr. Paulo César Naoum, Aliá F. M. Naoum
Direction: Luciana Eguti, Paulo Muppet
Storyboard: Paulo Muppet
Design: Rafael Gallardo
Animation and additional design: Antonio Linhares, Fernando Finamore, Pedro Eboli, Rafael Gallardo, William Iamazi Ferro
Sound design: Rafael Gallardo, Antonio Linhares
2011
https://wn.com/Sickle_Cell_Disease
Sickle Cell Anemia. Written by Paulo César Naoum and Alia F. M. Naoum.
A São José do Rio Preto's Science and Technology Academy video.
www.ciencianews.com.br
Animated by Birdo Studio
www.birdo.com.br
Full Credits:
Production: Birdo
Script: Dr. Paulo César Naoum, Aliá F. M. Naoum
Direction: Luciana Eguti, Paulo Muppet
Storyboard: Paulo Muppet
Design: Rafael Gallardo
Animation and additional design: Antonio Linhares, Fernando Finamore, Pedro Eboli, Rafael Gallardo, William Iamazi Ferro
Sound design: Rafael Gallardo, Antonio Linhares
2011
- published: 25 Feb 2011
- views: 888698
12:56
Sickle Cell Disease | Pathophysiology, Symptoms and Treatment
- Order: Reorder
- Duration: 12:56
- Uploaded Date: 03 Apr 2018
- views: 167884
Lesson on sickle cell disease. Sickle cell disease is a group of heritable blood disorders with characteristic sickle-cell shaped red blood cells. Sickle cell d...
Lesson on sickle cell disease. Sickle cell disease is a group of heritable blood disorders with characteristic sickle-cell shaped red blood cells. Sickle cell disease leads to chronic, compensated hemolytic anemia with vaso-occlusion from sickling of red blood cells.
I hope you find this video helpful. If you do, please like and subscribe for more videos like this one. :)
JJ
*Subscribe for more free medical lessons* https://www.youtube.com/channel/UCFPvnkCZbHfBvV8ApBBE0vA?sub_confirmation=1
-------------------------------------------------------------------------------------------------------------
For books and more information on these topics
https://www.amazon.com/shop/jjmedicine
Support future lessons (and get other cool stuff) ➜ https://www.patreon.com/jjmedicine
Follow me on Twitter! ➜ https://twitter.com/JJ_Medicine
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Check out some of my other lessons.
Medical Terminology - The Basics - Lesson 1:
https://www.youtube.com/watch?v=04Wh2E9oNug
Fatty Acid Synthesis Pathway:
https://www.youtube.com/watch?v=WuQS_LpNMzo
Wnt/B Catenin Signaling Pathway:
https://www.youtube.com/watch?v=NGVP4J9jpgs
Upper vs. Lower Motor Neuron Lesions:
https://www.youtube.com/watch?v=itNd74V53ng
Lesson on the Purine Synthesis and Salvage Pathway:
https://www.youtube.com/watch?v=e2KFVvI8Akk
Gastrulation | Formation of Germ Layers:
https://www.youtube.com/watch?v=d6Kkn0SECJ4
Introductory lesson on Autophagy (Macroautophagy):
https://www.youtube.com/watch?v=UmSVKzHc5yA
Infectious Disease Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwW0Bkc6c66uDACkzotaK26b
Dermatology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwW3dgORRNmk_MZvnWpZx_lW
Pharmacology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwWPWcV9lZTh-Qxv0gYakQXR
Hematology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwW8Ajo1dmxdj4EYEKcbtGju
Rheumatology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwWDvuhasXsuTFXJp05wwUle
Endocrinology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwUuRSzhploohnaWVvbVZ7ZP
Nephrology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwXRSwrFQK5WwWZLk1Las8v8
----------------------------------------------------------------------------------------------------
**MEDICAL DISCLAIMER**: JJ Medicine does not provide medical advice, and the information available on this channel does not offer a diagnosis or advice regarding treatment. Information presented in these lessons is for educational purposes ONLY, and information presented here is not to be used as an alternative to a healthcare professional’s diagnosis and treatment of any person/animal.
Only a physician or other licensed healthcare professional are able to determine the requirement for medical assistance to be given to a patient. Please seek the advice of your physician or other licensed healthcare provider if you have any questions regarding a medical condition.
----------------------------------------------------------------------------------------------------
*Although I try my best to present accurate information, there may be mistakes in this video. If you do see any mistakes with information in this lesson, please comment and let me know.*
I am always looking for ways to improve my lessons! Please don't hesitate to leave me feedback and comments - all of your feedback is greatly appreciated! :) And please don't hesitate to send me any messages if you need any help - I will try my best to be here to help you guys :)
Thanks for watching! If you found this video helpful, please like and subscribe!
JJ
https://wn.com/Sickle_Cell_Disease_|_Pathophysiology,_Symptoms_And_Treatment
Lesson on sickle cell disease. Sickle cell disease is a group of heritable blood disorders with characteristic sickle-cell shaped red blood cells. Sickle cell disease leads to chronic, compensated hemolytic anemia with vaso-occlusion from sickling of red blood cells.
I hope you find this video helpful. If you do, please like and subscribe for more videos like this one. :)
JJ
*Subscribe for more free medical lessons* https://www.youtube.com/channel/UCFPvnkCZbHfBvV8ApBBE0vA?sub_confirmation=1
-------------------------------------------------------------------------------------------------------------
For books and more information on these topics
https://www.amazon.com/shop/jjmedicine
Support future lessons (and get other cool stuff) ➜ https://www.patreon.com/jjmedicine
Follow me on Twitter! ➜ https://twitter.com/JJ_Medicine
Come join me on Facebook! ➜ https://www.facebook.com/JJ-Medicine-100642648161192/
Start your own website with BlueHost ➜ https://www.bluehost.com/track/jjmedicine/
Check out the best tool to help grow your YouTube channel (it’s helped me!)
https://www.tubebuddy.com/jjmedicine
-------------------------------------------------------------------------------------------------------------
Check out some of my other lessons.
Medical Terminology - The Basics - Lesson 1:
https://www.youtube.com/watch?v=04Wh2E9oNug
Fatty Acid Synthesis Pathway:
https://www.youtube.com/watch?v=WuQS_LpNMzo
Wnt/B Catenin Signaling Pathway:
https://www.youtube.com/watch?v=NGVP4J9jpgs
Upper vs. Lower Motor Neuron Lesions:
https://www.youtube.com/watch?v=itNd74V53ng
Lesson on the Purine Synthesis and Salvage Pathway:
https://www.youtube.com/watch?v=e2KFVvI8Akk
Gastrulation | Formation of Germ Layers:
https://www.youtube.com/watch?v=d6Kkn0SECJ4
Introductory lesson on Autophagy (Macroautophagy):
https://www.youtube.com/watch?v=UmSVKzHc5yA
Infectious Disease Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwW0Bkc6c66uDACkzotaK26b
Dermatology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwW3dgORRNmk_MZvnWpZx_lW
Pharmacology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwWPWcV9lZTh-Qxv0gYakQXR
Hematology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwW8Ajo1dmxdj4EYEKcbtGju
Rheumatology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwWDvuhasXsuTFXJp05wwUle
Endocrinology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwUuRSzhploohnaWVvbVZ7ZP
Nephrology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwXRSwrFQK5WwWZLk1Las8v8
----------------------------------------------------------------------------------------------------
**MEDICAL DISCLAIMER**: JJ Medicine does not provide medical advice, and the information available on this channel does not offer a diagnosis or advice regarding treatment. Information presented in these lessons is for educational purposes ONLY, and information presented here is not to be used as an alternative to a healthcare professional’s diagnosis and treatment of any person/animal.
Only a physician or other licensed healthcare professional are able to determine the requirement for medical assistance to be given to a patient. Please seek the advice of your physician or other licensed healthcare provider if you have any questions regarding a medical condition.
----------------------------------------------------------------------------------------------------
*Although I try my best to present accurate information, there may be mistakes in this video. If you do see any mistakes with information in this lesson, please comment and let me know.*
I am always looking for ways to improve my lessons! Please don't hesitate to leave me feedback and comments - all of your feedback is greatly appreciated! :) And please don't hesitate to send me any messages if you need any help - I will try my best to be here to help you guys :)
Thanks for watching! If you found this video helpful, please like and subscribe!
JJ
- published: 03 Apr 2018
- views: 167884
3:29
Family appeals for Shs 15M for two bone marrow transplants their two children
- Order: Reorder
- Duration: 3:29
- Uploaded Date: 28 Jul 2024
- views: 300
JOSDAVIS FAMILY NEED YOUR HELP
Sh 15 million is required for two bone marrow transplants
Their two children were diagnosed with sickle cell anemia
Connect wi...
JOSDAVIS FAMILY NEED YOUR HELP
Sh 15 million is required for two bone marrow transplants
Their two children were diagnosed with sickle cell anemia
Connect with KBC Online;
Subscribe to our channel: https://t.ly/86BKN
Follow us on Twitter: https://twitter.om/KBCChannel1
Find us on Facebook: https://www.facebook.com/kbcchannel1TV
Check our website: https://www.kbc.co.ke/
#kbcchannel1 #news #kbclive
https://wn.com/Family_Appeals_For_Shs_15M_For_Two_Bone_Marrow_Transplants_Their_Two_Children
JOSDAVIS FAMILY NEED YOUR HELP
Sh 15 million is required for two bone marrow transplants
Their two children were diagnosed with sickle cell anemia
Connect with KBC Online;
Subscribe to our channel: https://t.ly/86BKN
Follow us on Twitter: https://twitter.om/KBCChannel1
Find us on Facebook: https://www.facebook.com/kbcchannel1TV
Check our website: https://www.kbc.co.ke/
#kbcchannel1 #news #kbclive
- published: 28 Jul 2024
- views: 300
2:30
What is Sickle Cell Disease?
- Order: Reorder
- Duration: 2:30
- Uploaded Date: 15 Oct 2015
- views: 63221
What is sickle cell disease? Watch this video to learn more about this lifelong blood disorder and test your knowledge with a quiz at the end.
What is sickle cell disease? Watch this video to learn more about this lifelong blood disorder and test your knowledge with a quiz at the end.
https://wn.com/What_Is_Sickle_Cell_Disease
What is sickle cell disease? Watch this video to learn more about this lifelong blood disorder and test your knowledge with a quiz at the end.
- published: 15 Oct 2015
- views: 63221
7:38
Sickle cell disease: What it is and how to fight it | DW News
- Order: Reorder
- Duration: 7:38
- Uploaded Date: 18 Jun 2022
- views: 22313
People with sickle cell disorder produce red blood cells that are unusually shaped like crescents or sickles, as the name suggests. These can block blood vessel...
People with sickle cell disorder produce red blood cells that are unusually shaped like crescents or sickles, as the name suggests. These can block blood vessels, and cause chronic pain and often death.
The condition is particularly common among people with African or Caribbean background.
300,000 children are born with sickle cell anemia each year, with around three-quarters of those in Africa. Nigeria is the worst affected country. But there are attempts to sound the alarm, as DW correspondent Olisa Chukwumah reports.
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#SickleCell #Nigeria #HereditaryDiseases
https://wn.com/Sickle_Cell_Disease_What_It_Is_And_How_To_Fight_It_|_Dw_News
People with sickle cell disorder produce red blood cells that are unusually shaped like crescents or sickles, as the name suggests. These can block blood vessels, and cause chronic pain and often death.
The condition is particularly common among people with African or Caribbean background.
300,000 children are born with sickle cell anemia each year, with around three-quarters of those in Africa. Nigeria is the worst affected country. But there are attempts to sound the alarm, as DW correspondent Olisa Chukwumah reports.
Subscribe: https://www.youtube.com/user/deutschewelleenglish?sub_confirmation=1
For more news go to: http://www.dw.com/en/
Follow DW on social media:
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#SickleCell #Nigeria #HereditaryDiseases
- published: 18 Jun 2022
- views: 22313
2:56
Living with Sickle Cell Disease
- Order: Reorder
- Duration: 2:56
- Uploaded Date: 21 Jan 2011
- views: 96289
Damali and Amiel Reid are two siblings who are living with sickle cell anemia. Listen as they talk about their struggles with the disease and their hope for a c...
Damali and Amiel Reid are two siblings who are living with sickle cell anemia. Listen as they talk about their struggles with the disease and their hope for a cure.
https://wn.com/Living_With_Sickle_Cell_Disease
Damali and Amiel Reid are two siblings who are living with sickle cell anemia. Listen as they talk about their struggles with the disease and their hope for a cure.
- published: 21 Jan 2011
- views: 96289
0:41
What is Sickle Cell Anemia?
Sickle cell anemia is a disease in which the blood cells become deformed and are unable to...
published: 29 Aug 2014
What is Sickle Cell Anemia?
What is Sickle Cell Anemia?
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- published: 29 Aug 2014
- views: 297326
Sickle cell anemia is a disease in which the blood cells become deformed and are unable to function properly. To learn more about sickle cell anemia and other blood disorders, visit http://hematology.org/Patients.
This clip was excerpted from the documentary film "Blood Detectives." To learn more about the film, visit http://hematology.org/Patients/Blood-Detectives.aspx.
4:58
Sickle Cell Disease, Animation
(USMLE topics, cardiology, blood disorders) Genetics, different forms of SCD, pathophysiol...
published: 17 Sep 2019
Sickle Cell Disease, Animation
Sickle Cell Disease, Animation
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- published: 17 Sep 2019
- views: 269777
(USMLE topics, cardiology, blood disorders) Genetics, different forms of SCD, pathophysiology, and treatment.
Purchase a license to download a non-watermarked version of this video on AlilaMedicalMedia(dot)com
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All images/videos by Alila Medical Media are for information purposes ONLY and are NOT intended to replace professional medical advice, diagnosis or treatment. Always seek the advice of a qualified healthcare provider with any questions you may have regarding a medical condition.
Sickle cell disease is a group of inherited blood disorders in which the body produces abnormally-shaped red blood cells that look like crescent moons or sickles. Sickle cells have a shorter-than-normal life span; their premature destruction results in shortage of red cells, known as anemia. Signs of anemia include shortness of breath, fatigue, and delayed growth in children. Unlike normal red cells which are pliant, sickle cells are rigid and also sticky. They may clump together and stick to the walls of blood vessels, causing obstruction in small vessels and subsequent reduced oxygen supply to various organs. This happens repeatedly and manifests as periodic episodes of pain, called crises, which can last hours to days, and may result in organ damage, especially in the eyes, lungs, kidneys, bones and brain. The spleen has to handle large numbers of dead red cells and becomes enlarged and fibrous, its immune function declines, making the body more vulnerable to infections. In an attempt to compensate for blood cell loss, the bone marrow tries to produce more cells and grows larger, causing bones to weaken. Other signs include jaundice, a result of rapid destruction of heme.
Hemoglobin is the major component of red blood cells and is responsible for oxygen transport. The adult hemoglobin, or hemoglobin A, is composed of 4 protein chains: 2 alpha and 2 beta. The beta subunit is encoded by the HBB gene. Several mutations in HBB gene are responsible for the disease. Each individual has two copies of HBB gene. The disease develops when both copies are mutated, producing no normal beta globin. The 2 copies may be mutated differently, producing two different forms of abnormal beta subunits in the same person. Various combinations of these mutations produce different forms of sickle cell disease, but the most common and also most severe, called sickle cell anemia, is caused by 2 copies of the same mutation producing the mutated hemoglobin S. Each copy comes from a parent. The 2 parents each carry one copy of the mutated gene, but they typically do not show any symptoms. This pattern of inheritance is called autosomal recessive.
Hemoglobin S has the tendency to form polymers under low oxygen conditions. This process is called sickling, or gelation, for the gel-like consistency of the resulting polymer. As the polymer filaments grow, they eventually involve the cell membrane and distort the cell into the characteristic crescent shape. Apart from oxygen tension, the presence of other hemoglobins also seems to affect the sickling process. Normal adult hemoglobin inhibits sickling and this explains why heterozygous parents, who produce both mutated hemoglobin S and normal hemoglobin A, do not usually develop the disease. Fetal hemoglobin F, which has 2 gamma chains in place of 2 beta chains, also suppresses sickling. Infants born with the condition seem to benefit from high levels of fetal hemoglobin in the first few months of life: they do not develop symptoms until the age of 6 months or so, when fetal hemoglobin levels drop.
Bone marrow transplantation is currently the only known cure for sickle cell disease. It involves replacing the diseased stem cells in the bone marrow with healthy cells from an eligible donor, usually a relative. The procedure however is complex and finding a suitable donor can be difficult. In most cases, treatments aim to avoid crises, relieve symptoms and prevent complications.
12:35
Living with Sickle Cell Disease- Personal Stories
Listen to your peers talk about their own experiences living with sickle cell disease.
published: 23 Dec 2020
Living with Sickle Cell Disease- Personal Stories
Living with Sickle Cell Disease- Personal Stories
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- published: 23 Dec 2020
- views: 82810
Listen to your peers talk about their own experiences living with sickle cell disease.
5:58
Sickle Cell Anemia: A Patient's Journey
As a young child, Alexandria, now age 17, endured near-constant feelings of exhaustion and...
published: 07 Sep 2010
Sickle Cell Anemia: A Patient's Journey
Sickle Cell Anemia: A Patient's Journey
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- published: 07 Sep 2010
- views: 700187
As a young child, Alexandria, now age 17, endured near-constant feelings of exhaustion and general sickness, which turned into severe pain at night. After experiencing a "silent stroke" as a young girl, Alexandria was diagnosed with sickle cell anemia, a disease in which the blood cells become deformed and unable to function properly. To learn more about SCA and other blood disorders, visit ASH's patient resources webpage http://hematology.org/Patients/.
This clip was excerpted from the documentary film "Blood Detectives." To learn more about the film, visit http://www.hematology.org/Publications/Blood-Detectives/5246.aspx
5:29
Sickle Cell Disease
Sickle Cell Anemia. Written by Paulo César Naoum and Alia F. M. Naoum.
A São José do Rio...
published: 25 Feb 2011
Sickle Cell Disease
Sickle Cell Disease
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- published: 25 Feb 2011
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Sickle Cell Anemia. Written by Paulo César Naoum and Alia F. M. Naoum.
A São José do Rio Preto's Science and Technology Academy video.
www.ciencianews.com.br
Animated by Birdo Studio
www.birdo.com.br
Full Credits:
Production: Birdo
Script: Dr. Paulo César Naoum, Aliá F. M. Naoum
Direction: Luciana Eguti, Paulo Muppet
Storyboard: Paulo Muppet
Design: Rafael Gallardo
Animation and additional design: Antonio Linhares, Fernando Finamore, Pedro Eboli, Rafael Gallardo, William Iamazi Ferro
Sound design: Rafael Gallardo, Antonio Linhares
2011
12:56
Sickle Cell Disease | Pathophysiology, Symptoms and Treatment
Lesson on sickle cell disease. Sickle cell disease is a group of heritable blood disorders...
published: 03 Apr 2018
Sickle Cell Disease | Pathophysiology, Symptoms and Treatment
Sickle Cell Disease | Pathophysiology, Symptoms and Treatment
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Lesson on sickle cell disease. Sickle cell disease is a group of heritable blood disorders with characteristic sickle-cell shaped red blood cells. Sickle cell disease leads to chronic, compensated hemolytic anemia with vaso-occlusion from sickling of red blood cells.
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3:29
Family appeals for Shs 15M for two bone marrow transplants their two children
JOSDAVIS FAMILY NEED YOUR HELP
Sh 15 million is required for two bone marrow transplants
...
published: 28 Jul 2024
Family appeals for Shs 15M for two bone marrow transplants their two children
Family appeals for Shs 15M for two bone marrow transplants their two children
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- published: 28 Jul 2024
- views: 300
JOSDAVIS FAMILY NEED YOUR HELP
Sh 15 million is required for two bone marrow transplants
Their two children were diagnosed with sickle cell anemia
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2:30
What is Sickle Cell Disease?
What is sickle cell disease? Watch this video to learn more about this lifelong blood diso...
published: 15 Oct 2015
What is Sickle Cell Disease?
What is Sickle Cell Disease?
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- published: 15 Oct 2015
- views: 63221
What is sickle cell disease? Watch this video to learn more about this lifelong blood disorder and test your knowledge with a quiz at the end.
7:38
Sickle cell disease: What it is and how to fight it | DW News
People with sickle cell disorder produce red blood cells that are unusually shaped like cr...
published: 18 Jun 2022
Sickle cell disease: What it is and how to fight it | DW News
Sickle cell disease: What it is and how to fight it | DW News
- Report rights infringement
- published: 18 Jun 2022
- views: 22313
People with sickle cell disorder produce red blood cells that are unusually shaped like crescents or sickles, as the name suggests. These can block blood vessels, and cause chronic pain and often death.
The condition is particularly common among people with African or Caribbean background.
300,000 children are born with sickle cell anemia each year, with around three-quarters of those in Africa. Nigeria is the worst affected country. But there are attempts to sound the alarm, as DW correspondent Olisa Chukwumah reports.
Subscribe: https://www.youtube.com/user/deutschewelleenglish?sub_confirmation=1
For more news go to: http://www.dw.com/en/
Follow DW on social media:
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#SickleCell #Nigeria #HereditaryDiseases
2:56
Living with Sickle Cell Disease
Damali and Amiel Reid are two siblings who are living with sickle cell anemia. Listen as t...
published: 21 Jan 2011
Living with Sickle Cell Disease
Living with Sickle Cell Disease
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- published: 21 Jan 2011
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Damali and Amiel Reid are two siblings who are living with sickle cell anemia. Listen as they talk about their struggles with the disease and their hope for a cure.
Sickle-cell disease
Sickle-cell disease (SCD), also known as sickle-cell anaemia (SCA), is a hereditary blood disorder, caused by an abnormality in the oxygen-carrying protein haemoglobin found in red blood cells. This leads to a propensity for the cells to assume an abnormal, rigid, sickle-like shape under certain circumstances. Sickle-cell disease is associated with a number of acute and chronic health problems, such as severe infections, attacks of severe pain ("sickle-cell crisis"), stroke, and an increased risk of death.
Sickle-cell disease occurs when a person inherits two abnormal copies of the haemoglobin gene, one from each parent. Several subtypes exist, depending on the exact mutation in each haemoglobin gene. A person with a single abnormal copy does not experience symptoms and is said to have sickle-cell trait. Such people are also referred to as carriers.
The complications of sickle-cell disease can be prevented to a large extent with vaccination, preventive antibiotics, blood transfusion, and the drug hydroxyurea/hydroxycarbamide. A small proportion of patients require a transplant of bone marrow cells.
This page contains text from Wikipedia, the Free Encyclopedia - https://wn.com/Sickle-cell_disease
What is Sickle Cell Anemia?...
Sickle Cell Disease, Animation...
Living with Sickle Cell Disease- Personal Stories...
Sickle Cell Anemia: A Patient's Journey...
Sickle Cell Disease...
Sickle Cell Disease | Pathophysiology, Symptoms an...
Family appeals for Shs 15M for two bone marrow tra...
What is Sickle Cell Disease?...
Sickle cell disease: What it is and how to fight i...
Living with Sickle Cell Disease...
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