A number of bacterial and plant toxins act by inhibiting protein synthesis in eukaryotic cells. The toxins of the Shiga and ricin family inactivate 60S ribosomal subunits by an N-glycosidic cleavage, which releases a specific adenine base from the sugar-phosphate backbone of 28S rRNA. Members of the family include shiga and shiga-like toxins, and type I (e.g. trichosanthin and luffin) and type II (e.g. ricin, agglutinin and abrin) ribosome inactivating proteins (RIPs). All these toxins are structurally related. RIPs have been of considerable interest because of their potential use, conjugated with monoclonal antibodies, as immunotoxins to treat cancers. Further, trichosanthin has been shown to have potent activity against HIV-1-infected T cells and macrophages. Elucidation of the structure-function relationships of RIPs has therefore become a major research effort. It is now known that RIPs are structurally related. A conserved glutamic residue has been implicated in the catalytic mechanism; this lies near a conserved arginine, which also plays a role in catalysis.
Fair use is any copying of copyrighted material done for a limited and “transformative” purpose, such as to comment upon, criticize, or parody a copyrighted work.
The purpose of this videos serves as a partial requirement of our subject, General Biology 2. It is used for educational purposes.
credits to the owner of some footage and audios.
published: 14 Feb 2018
RIPs (ABRIN): Who Cares??
Hello everyone.
In today's video, I provide a brief overview of ribosome-inactivating proteins with a special focus on a Type II RIP known as abrin, the estranged sibling of ricin (popularized by pop culture).
SUBSCRIBE: https://www.youtube.com/channel/UCa7omLhxddRpnv0WnILthyQ
OK :)
published: 19 May 2018
Ribosomes make Protein
What is a ribosome? A ribosome is an organelle found in plant, animal, and bacteria cells.
They are very small yet very important because they make proteins. Ribosomes use a process called translation to make proteins.
If you would like to learn more about proteins and their importance this video will help.
https://youtu.be/V_E7mq8bv4g
Transcript
https://youtu.be/pkKjDq2ATck
published: 21 Dec 2021
Medical vocabulary: What does Ribosome Inactivating Proteins mean
What does Ribosome Inactivating Proteins mean in English?
published: 20 Jan 2016
Medical vocabulary: What does Ribosome Inactivating Proteins, Type 1 mean
What does Ribosome Inactivating Proteins, Type 1 mean in English?
published: 20 Jan 2016
Medical vocabulary: What does Ribosome Inactivating Proteins, Type 2 mean
What does Ribosome Inactivating Proteins, Type 2 mean in English?
published: 20 Jan 2016
The ribosome inactivating proteins MAP30 and Momordin inhibit SARS CoV 2
Extended info: News #111780
News Source Crawler: digests, updates and bulletins from reliable sources, to keep the minds updated, of the busy and the knowledge hungry.
News videos are designed to fit all the necessary information with a simple title, prepared in English and in original language of the news source.
News sources from USA, UK, Australia, Canada, France, Spain, Mexico, Brazil, Israel Middle East, China, Korea, Japan are sifted for daily updates, for newsworthy information, to the global citizen.
published: 03 Jul 2023
Academia Lecture Series Talk 4 on RIBOSOMAL INACTIVATING PROTEINS MEDICAL APPLICATIONS 20220609
PG AND RESEARCH DEPARTMENT OF BIOTECHNOLOGY
Organizes and Cordially invite you all for
Academia Lecture Series Talk -4 On
RIBOSOMAL INACTIVATING PROTEINS: MEDICAL APPLICATIONS
Resource Person
Dr.J.Jannet Vennila Director,
Self Finance stream and Coordinator,
Computational laboratory,
MCC MRF Innovation Park, Madras Christian College, Chennai
published: 10 Jun 2022
Ribosome decay
kamikaze molecular model.
Left Plot - Ribosome Decay by action of ribosome-inactivating rRNAse domain of colicin E3.
Right Plot - abundance of kamikaze system proteins through time, GFP (Reporter protein), LuxI (Quorum sensing protein) and rRNAse domain of colicin E3 toxin.
published: 15 Oct 2009
Mechanism of action of Ricin #biochemistry #molecularbiology #toxins #lifescience #biology
Fair use is any copying of copyrighted material done for a limited and “transformative” purpose, such as to comment upon, criticize, or parody a copyrighted wor...
Fair use is any copying of copyrighted material done for a limited and “transformative” purpose, such as to comment upon, criticize, or parody a copyrighted work.
The purpose of this videos serves as a partial requirement of our subject, General Biology 2. It is used for educational purposes.
credits to the owner of some footage and audios.
Fair use is any copying of copyrighted material done for a limited and “transformative” purpose, such as to comment upon, criticize, or parody a copyrighted work.
The purpose of this videos serves as a partial requirement of our subject, General Biology 2. It is used for educational purposes.
credits to the owner of some footage and audios.
Hello everyone.
In today's video, I provide a brief overview of ribosome-inactivating proteins with a special focus on a Type II RIP known as abrin, the estra...
Hello everyone.
In today's video, I provide a brief overview of ribosome-inactivating proteins with a special focus on a Type II RIP known as abrin, the estranged sibling of ricin (popularized by pop culture).
SUBSCRIBE: https://www.youtube.com/channel/UCa7omLhxddRpnv0WnILthyQ
OK :)
Hello everyone.
In today's video, I provide a brief overview of ribosome-inactivating proteins with a special focus on a Type II RIP known as abrin, the estranged sibling of ricin (popularized by pop culture).
SUBSCRIBE: https://www.youtube.com/channel/UCa7omLhxddRpnv0WnILthyQ
OK :)
What is a ribosome? A ribosome is an organelle found in plant, animal, and bacteria cells.
They are very small yet very important because they make proteins. Ri...
What is a ribosome? A ribosome is an organelle found in plant, animal, and bacteria cells.
They are very small yet very important because they make proteins. Ribosomes use a process called translation to make proteins.
If you would like to learn more about proteins and their importance this video will help.
https://youtu.be/V_E7mq8bv4g
Transcript
https://youtu.be/pkKjDq2ATck
What is a ribosome? A ribosome is an organelle found in plant, animal, and bacteria cells.
They are very small yet very important because they make proteins. Ribosomes use a process called translation to make proteins.
If you would like to learn more about proteins and their importance this video will help.
https://youtu.be/V_E7mq8bv4g
Transcript
https://youtu.be/pkKjDq2ATck
Extended info: News #111780
News Source Crawler: digests, updates and bulletins from reliable sources, to keep the minds updated, of the busy and the knowledge...
Extended info: News #111780
News Source Crawler: digests, updates and bulletins from reliable sources, to keep the minds updated, of the busy and the knowledge hungry.
News videos are designed to fit all the necessary information with a simple title, prepared in English and in original language of the news source.
News sources from USA, UK, Australia, Canada, France, Spain, Mexico, Brazil, Israel Middle East, China, Korea, Japan are sifted for daily updates, for newsworthy information, to the global citizen.
Extended info: News #111780
News Source Crawler: digests, updates and bulletins from reliable sources, to keep the minds updated, of the busy and the knowledge hungry.
News videos are designed to fit all the necessary information with a simple title, prepared in English and in original language of the news source.
News sources from USA, UK, Australia, Canada, France, Spain, Mexico, Brazil, Israel Middle East, China, Korea, Japan are sifted for daily updates, for newsworthy information, to the global citizen.
PG AND RESEARCH DEPARTMENT OF BIOTECHNOLOGY
Organizes and Cordially invite you all for
Academia Lecture Series Talk -4 On
RIBOSOMAL INACTIVATING PROTEINS: MED...
PG AND RESEARCH DEPARTMENT OF BIOTECHNOLOGY
Organizes and Cordially invite you all for
Academia Lecture Series Talk -4 On
RIBOSOMAL INACTIVATING PROTEINS: MEDICAL APPLICATIONS
Resource Person
Dr.J.Jannet Vennila Director,
Self Finance stream and Coordinator,
Computational laboratory,
MCC MRF Innovation Park, Madras Christian College, Chennai
PG AND RESEARCH DEPARTMENT OF BIOTECHNOLOGY
Organizes and Cordially invite you all for
Academia Lecture Series Talk -4 On
RIBOSOMAL INACTIVATING PROTEINS: MEDICAL APPLICATIONS
Resource Person
Dr.J.Jannet Vennila Director,
Self Finance stream and Coordinator,
Computational laboratory,
MCC MRF Innovation Park, Madras Christian College, Chennai
kamikaze molecular model.
Left Plot - Ribosome Decay by action of ribosome-inactivating rRNAse domain of colicin E3.
Right Plot - abundance of kamikaze system p...
kamikaze molecular model.
Left Plot - Ribosome Decay by action of ribosome-inactivating rRNAse domain of colicin E3.
Right Plot - abundance of kamikaze system proteins through time, GFP (Reporter protein), LuxI (Quorum sensing protein) and rRNAse domain of colicin E3 toxin.
kamikaze molecular model.
Left Plot - Ribosome Decay by action of ribosome-inactivating rRNAse domain of colicin E3.
Right Plot - abundance of kamikaze system proteins through time, GFP (Reporter protein), LuxI (Quorum sensing protein) and rRNAse domain of colicin E3 toxin.
Fair use is any copying of copyrighted material done for a limited and “transformative” purpose, such as to comment upon, criticize, or parody a copyrighted work.
The purpose of this videos serves as a partial requirement of our subject, General Biology 2. It is used for educational purposes.
credits to the owner of some footage and audios.
Hello everyone.
In today's video, I provide a brief overview of ribosome-inactivating proteins with a special focus on a Type II RIP known as abrin, the estranged sibling of ricin (popularized by pop culture).
SUBSCRIBE: https://www.youtube.com/channel/UCa7omLhxddRpnv0WnILthyQ
OK :)
What is a ribosome? A ribosome is an organelle found in plant, animal, and bacteria cells.
They are very small yet very important because they make proteins. Ribosomes use a process called translation to make proteins.
If you would like to learn more about proteins and their importance this video will help.
https://youtu.be/V_E7mq8bv4g
Transcript
https://youtu.be/pkKjDq2ATck
Extended info: News #111780
News Source Crawler: digests, updates and bulletins from reliable sources, to keep the minds updated, of the busy and the knowledge hungry.
News videos are designed to fit all the necessary information with a simple title, prepared in English and in original language of the news source.
News sources from USA, UK, Australia, Canada, France, Spain, Mexico, Brazil, Israel Middle East, China, Korea, Japan are sifted for daily updates, for newsworthy information, to the global citizen.
PG AND RESEARCH DEPARTMENT OF BIOTECHNOLOGY
Organizes and Cordially invite you all for
Academia Lecture Series Talk -4 On
RIBOSOMAL INACTIVATING PROTEINS: MEDICAL APPLICATIONS
Resource Person
Dr.J.Jannet Vennila Director,
Self Finance stream and Coordinator,
Computational laboratory,
MCC MRF Innovation Park, Madras Christian College, Chennai
kamikaze molecular model.
Left Plot - Ribosome Decay by action of ribosome-inactivating rRNAse domain of colicin E3.
Right Plot - abundance of kamikaze system proteins through time, GFP (Reporter protein), LuxI (Quorum sensing protein) and rRNAse domain of colicin E3 toxin.
A number of bacterial and plant toxins act by inhibiting protein synthesis in eukaryotic cells. The toxins of the Shiga and ricin family inactivate 60S ribosomal subunits by an N-glycosidic cleavage, which releases a specific adenine base from the sugar-phosphate backbone of 28S rRNA. Members of the family include shiga and shiga-like toxins, and type I (e.g. trichosanthin and luffin) and type II (e.g. ricin, agglutinin and abrin) ribosome inactivating proteins (RIPs). All these toxins are structurally related. RIPs have been of considerable interest because of their potential use, conjugated with monoclonal antibodies, as immunotoxins to treat cancers. Further, trichosanthin has been shown to have potent activity against HIV-1-infected T cells and macrophages. Elucidation of the structure-function relationships of RIPs has therefore become a major research effort. It is now known that RIPs are structurally related. A conserved glutamic residue has been implicated in the catalytic mechanism; this lies near a conserved arginine, which also plays a role in catalysis.
... the Cami1 complex with the protein synthesis machine—the ribosome ... "Interestingly, the same capture mechanism to bind the ribosome is used by plant antiviral proteins that also inactivate ribosomes.