-
Tupac Shakur Death Scene | All Eyez on Me (2017) | Movie Clip 4K
Tells the true and untold story of prolific rapper, actor, poet and activist Tupac Shakur.
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Action : https://tinyurl.com/2ddk8y3k
Thriller : https://tinyurl.com/yy8kpyzu
Horror : https://tinyurl.com/2fnybzh8
Romance : https://tinyurl.com/2p4echfw
Drama : https://tinyurl.com/2emhur4e
Crime : https://tinyurl.com/mujjwmww
Comedy : https://tinyurl.com/3fk3kbr6
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Visit ...
published: 21 Feb 2024
-
2Pac - Changes ft. Talent
Official Music Video for “Changes” from 2Pac (feat. Talent)
Stream more 2Pac releases: https://www.2pac.com/discography/
Celebrate the 30th anniversary of 2Pac’s rap crew Thug Life’s debut album “Thug Life: Volume 1” IVC Edition - https://2pac.lnk.to/ivcthuglifevol1
http://2pac.com
http://instagram.com/2pac
http://twitter.com/2pac
http://facebook.com/tupacshakur
#2Pac #Tupac #Changes
published: 05 Jul 2011
-
2Pac - Dear Mama
2Pac’s album ‘Me Against The World’ featuring “Dear Mama”
Get the album on iTunes http://smarturl.it/2PacAgainstTheWorld
Google Play http://smarturl.it/AgainstTheWorld-GP
Amazon http://smarturl.it/AgainstTheWorldEX
Listen on Spotify http://smarturl.it/2pacMATWstream
Stream more 2Pac releases: https://www.2pac.com/discography/
Celebrate the 30th anniversary of 2Pac’s rap crew Thug Life’s debut album “Thug Life: Volume 1” IVC Edition - https://2pac.lnk.to/ivcthuglifevol1
http://2pac.com
http://instagram.com/2pac
http://twitter.com/2pac
http://facebook.com/tupacshakur
#2Pac #Tupac #DearMama
published: 05 Jul 2011
-
2Pac - Hit 'Em Up (Dirty) (Music Video) HD
Music video by 2Pac performing Hit 'Em Up (Dirty)
Listen to the full Official "All Eyez On Me" Album from 2Pac : https://www.youtube.com/playlist?list=PLNvnh4cN6-ATtLWZMdVVkEwms-srSDCAz
(C) 1996 Death Row
#2Pac2020 #2Pac #Tupac
published: 28 Mar 2013
-
2Pac - So Many Tears (Official Music Video)
REMASTERED IN HD!
Official Music Video for So Many Tears performed by 2Pac.
Follow 2Pac:
Official Website: https://www.2pac.com/us
Instagram: https://www.instagram.com/2pac
Facebook: https://www.facebook.com/tupacshakur
Twitter: https://twitter.com/2PAC
Watch more 2Pac Official Videos: https://www.youtube.com/watch?v=Mb1ZvUDvLDY&list=PLkBNq2iX07mzACJ2GSaEsxIOfwmvNW1mm&index=2&t=0s
#2Pac #SoManyTears #Remastered
published: 13 Mar 2020
-
2Pac ft. Dr. Dre - California Love (Official Video) [Full Length Version]
2Pac ft. Dr. Dre - California Love (Full Video) from the album "All Eyez On Me" (1996)
🔔 Subscribe to UPROXX Video and ring the bell to turn on notifications: https://uproxx.it/5rzazsh
🎙️ New Episodes of People’s Party with Talib Kweli every Monday 9AMet/6AMpt. Watch all the episodes here: https://uproxx.it/avxtjgf
More Hip-Hop Heads Playlists:
90's Hip Hop ▶️ http://bit.ly/90sHipHopPlaylist
2000's Hip Hop ▶️ http://bit.ly/2000sHipHopPlaylist
90's R&B Hits ▶️ http://bit.ly/90sRBPlaylist
The UPROXX Family
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Lyrics:
California love
California ...
published: 16 Jun 2018
-
BEST OF 2PAC MIXTAPE ( TUPAC ) DJ LIGHTER
#djlightervevo #2pac
published: 05 Jun 2022
-
2Pac's last photo before the tragedy 😔 | 📸: Leonard Jefferson
published: 05 Nov 2022
-
Are The Feds Connecting Diddy To The Murder Of Tupac Shakur?
In this episode of "Hidden Killers With Tony Brueski," retired FBI Special Agent Robin Dreeke discusses the ongoing investigation into Sean "Diddy" Combs, focusing on the sex trafficking allegations and potential connections to other crimes, including the murder of Tupac Shakur. Dreeke explains the complexities of handling such high-profile cases, emphasizing the importance of prioritizing the most impactful charges—in this case, the sex trafficking allegations. He notes that charging Diddy with other crimes, like murder, could interfere with the broader investigation into sex trafficking by causing key witnesses to lawyer up. The discussion also covers the challenges of securing witness safety, particularly given the potential threats from a powerful figure like Diddy. Dreeke explains tha...
published: 16 Aug 2024
-
Tupac Shakur 1994 Exclusive Interview With Ed Gordon
Happy Birthday to the legendary Tupac Shakur. In honor of the revolutionary rapper, here is an exclusive 1994 interview with BET Host Ed Gordon. #Tupac #HappyBirthdayTupac
SUBSCRIBE to #BET NOW! ►► http://bit.ly/1U0v9xG
#BETAwards2018 #BETAwards #MeekMill #Migos #YG #2Chainz #BigSean #NickiMinaj #Miguel #JayRock #EllaMai #JaimeFoxx #Ledisi #SnoopDogg #TyeTribbett
Download the BET NOW app for full episodes of your favorite BET shows and exclusive content!
Connect with BET
Web: http://www.BET.com
Facebook: http://www.facebook.com/BET
Twitter: http://www.twitter.com/BET
Instagram: http://www.instagram.com/BET
Google+: http://www.bet.us/gplusBET
published: 16 Jun 2020
3:14
Tupac Shakur Death Scene | All Eyez on Me (2017) | Movie Clip 4K
Tells the true and untold story of prolific rapper, actor, poet and activist Tupac Shakur.
Want to be notified of all the latest free movies & trailers?
Subscr...
Tells the true and untold story of prolific rapper, actor, poet and activist Tupac Shakur.
Want to be notified of all the latest free movies & trailers?
Subscribe to our channel : https://www.youtube.com/channel/UCn4TjkLaraasteupSPdhYCw?sub_confirmation=1
Browse our entire catalog of free movies by genre :
Action : https://tinyurl.com/2ddk8y3k
Thriller : https://tinyurl.com/yy8kpyzu
Horror : https://tinyurl.com/2fnybzh8
Romance : https://tinyurl.com/2p4echfw
Drama : https://tinyurl.com/2emhur4e
Crime : https://tinyurl.com/mujjwmww
Comedy : https://tinyurl.com/3fk3kbr6
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#FullFreeMovies #FreeYoutubeMovies #VVSFilms
Under license from VVS Films. All rights reserved
#tupac #tupacshakur #alleyezonme #rap #hiphop #biggie #truestory #drama
https://wn.com/Tupac_Shakur_Death_Scene_|_All_Eyez_On_Me_(2017)_|_Movie_Clip_4K
Tells the true and untold story of prolific rapper, actor, poet and activist Tupac Shakur.
Want to be notified of all the latest free movies & trailers?
Subscribe to our channel : https://www.youtube.com/channel/UCn4TjkLaraasteupSPdhYCw?sub_confirmation=1
Browse our entire catalog of free movies by genre :
Action : https://tinyurl.com/2ddk8y3k
Thriller : https://tinyurl.com/yy8kpyzu
Horror : https://tinyurl.com/2fnybzh8
Romance : https://tinyurl.com/2p4echfw
Drama : https://tinyurl.com/2emhur4e
Crime : https://tinyurl.com/mujjwmww
Comedy : https://tinyurl.com/3fk3kbr6
& Don't forget to follow us on Social :
Facebook : https://www.facebook.com/vvsfilms/
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Twitter : https://twitter.com/vvs_films
TikTok: https://www.tiktok.com/@vvsfilms
Visit our Website : https://vvs.ca/
#FullFreeMovies #FreeYoutubeMovies #VVSFilms
Under license from VVS Films. All rights reserved
#tupac #tupacshakur #alleyezonme #rap #hiphop #biggie #truestory #drama
- published: 21 Feb 2024
- views: 1196330
4:31
2Pac - Changes ft. Talent
Official Music Video for “Changes” from 2Pac (feat. Talent)
Stream more 2Pac releases: https://www.2pac.com/discography/
Celebrate the 30th anniversary of 2Pa...
Official Music Video for “Changes” from 2Pac (feat. Talent)
Stream more 2Pac releases: https://www.2pac.com/discography/
Celebrate the 30th anniversary of 2Pac’s rap crew Thug Life’s debut album “Thug Life: Volume 1” IVC Edition - https://2pac.lnk.to/ivcthuglifevol1
http://2pac.com
http://instagram.com/2pac
http://twitter.com/2pac
http://facebook.com/tupacshakur
#2Pac #Tupac #Changes
https://wn.com/2Pac_Changes_Ft._Talent
Official Music Video for “Changes” from 2Pac (feat. Talent)
Stream more 2Pac releases: https://www.2pac.com/discography/
Celebrate the 30th anniversary of 2Pac’s rap crew Thug Life’s debut album “Thug Life: Volume 1” IVC Edition - https://2pac.lnk.to/ivcthuglifevol1
http://2pac.com
http://instagram.com/2pac
http://twitter.com/2pac
http://facebook.com/tupacshakur
#2Pac #Tupac #Changes
- published: 05 Jul 2011
- views: 407181462
4:36
2Pac - Dear Mama
2Pac’s album ‘Me Against The World’ featuring “Dear Mama”
Get the album on iTunes http://smarturl.it/2PacAgainstTheWorld
Google Play http://smarturl.it/AgainstT...
2Pac’s album ‘Me Against The World’ featuring “Dear Mama”
Get the album on iTunes http://smarturl.it/2PacAgainstTheWorld
Google Play http://smarturl.it/AgainstTheWorld-GP
Amazon http://smarturl.it/AgainstTheWorldEX
Listen on Spotify http://smarturl.it/2pacMATWstream
Stream more 2Pac releases: https://www.2pac.com/discography/
Celebrate the 30th anniversary of 2Pac’s rap crew Thug Life’s debut album “Thug Life: Volume 1” IVC Edition - https://2pac.lnk.to/ivcthuglifevol1
http://2pac.com
http://instagram.com/2pac
http://twitter.com/2pac
http://facebook.com/tupacshakur
#2Pac #Tupac #DearMama
https://wn.com/2Pac_Dear_Mama
2Pac’s album ‘Me Against The World’ featuring “Dear Mama”
Get the album on iTunes http://smarturl.it/2PacAgainstTheWorld
Google Play http://smarturl.it/AgainstTheWorld-GP
Amazon http://smarturl.it/AgainstTheWorldEX
Listen on Spotify http://smarturl.it/2pacMATWstream
Stream more 2Pac releases: https://www.2pac.com/discography/
Celebrate the 30th anniversary of 2Pac’s rap crew Thug Life’s debut album “Thug Life: Volume 1” IVC Edition - https://2pac.lnk.to/ivcthuglifevol1
http://2pac.com
http://instagram.com/2pac
http://twitter.com/2pac
http://facebook.com/tupacshakur
#2Pac #Tupac #DearMama
- published: 05 Jul 2011
- views: 456164013
5:23
2Pac - Hit 'Em Up (Dirty) (Music Video) HD
Music video by 2Pac performing Hit 'Em Up (Dirty)
Listen to the full Official "All Eyez On Me" Album from 2Pac : https://www.youtube.com/playlist?list=PLNvnh4c...
Music video by 2Pac performing Hit 'Em Up (Dirty)
Listen to the full Official "All Eyez On Me" Album from 2Pac : https://www.youtube.com/playlist?list=PLNvnh4cN6-ATtLWZMdVVkEwms-srSDCAz
(C) 1996 Death Row
#2Pac2020 #2Pac #Tupac
https://wn.com/2Pac_Hit_'Em_Up_(Dirty)_(Music_Video)_Hd
Music video by 2Pac performing Hit 'Em Up (Dirty)
Listen to the full Official "All Eyez On Me" Album from 2Pac : https://www.youtube.com/playlist?list=PLNvnh4cN6-ATtLWZMdVVkEwms-srSDCAz
(C) 1996 Death Row
#2Pac2020 #2Pac #Tupac
- published: 28 Mar 2013
- views: 752069867
3:59
2Pac - So Many Tears (Official Music Video)
REMASTERED IN HD!
Official Music Video for So Many Tears performed by 2Pac.
Follow 2Pac:
Official Website: https://www.2pac.com/us
Instagram: https://www.inst...
REMASTERED IN HD!
Official Music Video for So Many Tears performed by 2Pac.
Follow 2Pac:
Official Website: https://www.2pac.com/us
Instagram: https://www.instagram.com/2pac
Facebook: https://www.facebook.com/tupacshakur
Twitter: https://twitter.com/2PAC
Watch more 2Pac Official Videos: https://www.youtube.com/watch?v=Mb1ZvUDvLDY&list=PLkBNq2iX07mzACJ2GSaEsxIOfwmvNW1mm&index=2&t=0s
#2Pac #SoManyTears #Remastered
https://wn.com/2Pac_So_Many_Tears_(Official_Music_Video)
REMASTERED IN HD!
Official Music Video for So Many Tears performed by 2Pac.
Follow 2Pac:
Official Website: https://www.2pac.com/us
Instagram: https://www.instagram.com/2pac
Facebook: https://www.facebook.com/tupacshakur
Twitter: https://twitter.com/2PAC
Watch more 2Pac Official Videos: https://www.youtube.com/watch?v=Mb1ZvUDvLDY&list=PLkBNq2iX07mzACJ2GSaEsxIOfwmvNW1mm&index=2&t=0s
#2Pac #SoManyTears #Remastered
- published: 13 Mar 2020
- views: 42390829
6:52
2Pac ft. Dr. Dre - California Love (Official Video) [Full Length Version]
2Pac ft. Dr. Dre - California Love (Full Video) from the album "All Eyez On Me" (1996)
🔔 Subscribe to UPROXX Video and ring the bell to turn on notifications: ...
2Pac ft. Dr. Dre - California Love (Full Video) from the album "All Eyez On Me" (1996)
🔔 Subscribe to UPROXX Video and ring the bell to turn on notifications: https://uproxx.it/5rzazsh
🎙️ New Episodes of People’s Party with Talib Kweli every Monday 9AMet/6AMpt. Watch all the episodes here: https://uproxx.it/avxtjgf
More Hip-Hop Heads Playlists:
90's Hip Hop ▶️ http://bit.ly/90sHipHopPlaylist
2000's Hip Hop ▶️ http://bit.ly/2000sHipHopPlaylist
90's R&B Hits ▶️ http://bit.ly/90sRBPlaylist
The UPROXX Family
🎧 UPROXX Music https://youtube.com/uproxxmusic
🎥 UPROXX Studio https://youtube.com/uproxx
FOLLOW
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➕Twitter: https://twitter.com/uproxx
➕Facebook: https://facebook.com/uproxx
Lyrics:
California love
California knows how to party
California knows how to party
In the city of L.A
In the city of good ol' Watts
In the city, the city of Compton
We keep it rockin', we keep it rockin'
Now let me welcome everybody to the Wild Wild West
A state that's untouchable like Eliot Ness
The track hits your eardrum like a slug to your chest
Pack a vest for your Jimmy in the city of sex
We in that Sunshine State where the bomb-ass hemp be
The state where you never find a dance floor empty
And pimps be on a mission for them greens
Lean mean money-making-machines servin' fiends
I been in the game for 10 years makin' rap tunes
Ever since honeys was wearin' Sassoon
Now it's '95 and they clock me and watch me
Diamonds shinin', lookin' like I robbed Liberace
It's all good, from Diego to the Bay
Your city is the bomb if your city makin' pay
Throw up a finger if you feel the same way
Dre puttin' it down for Californ-i-a
California knows how to party
California knows how to party (Yes, they do)
In the city of L.A
In the city of good ol' Watts
In the city, the city of Compton
We keep it rockin', we keep it rockin'
Shake, shake it, baby
Shake, shake it, shake it baby
Shake, shake it, mama
Shake it, Cali
Shake, shake it, baby
Shake, shake it
Shake, shake it mama
Shake it
Out on bail, fresh out of jail, California dreamin'
Soon as I step on the scene, I'm hearin' hoochies screamin'
Fiendin' for money and alcohol, the life of a Westside player
Where cowards die and the strong ball
Only in Cali where we riot, not rally, to live and die
In L.A. we wearin' Chucks, not Ballys (yeah, that's right)
Dressed in Locs and Khaki suits, and ride is what we do
Flossin' but have caution: we collide with other crews
Famous because we program
Worldwide, let them recognize from Long Beach to Rosecrans
Bumpin' and grindin' like a slow jam
It's Westside, so you know the Row won't bow down to no man
Say what you say, but give me that bomb beat from Dre
Let me serenade the streets of L.A
From Oakland to Sac-town, the Bay Area and back down
Cali is where they put their mack down; give me love!
California knows how to party
California knows how to party
In the city of L.A
In the city of good ol' Watts
In the city, the city of Compton
We keep it rockin', we keep it rockin'
Shake, shake it, baby
Shake, shake it
Shake, shake it, mama
Shake it, Cali
Shake, shake it, baby
Shake, shake it
Shake, shake it mama
Shake it, Cali
Uh, yeah, uh, uh, Long Beach in the house
Uh, yeah, Oaktown
Oakland definitely in the house
Frisco, Frisco
And you know L.A. up in this
Pasadena, where you at?
Yeah, Inglewood
Inglewood always up to no good
Even Hollywood tryin' to get a piece, baby
Sacramento, Sacramento where you at?
Throw it up, y'all! Throw it up, throw it up!
I can't see ya
Let's show these fools how we do it on this Westside
'Cause you and I know it's the best side
Yeah, that's right
West Coast, West Coast
California love
California love, yeah
California knows how to party
California knows how to party
In the city of L.A
In the city of good ol' Watts
In the city, the city of Compton
We keep 'em rockin', we keep 'em rockin'
Just come on shake, shake it, baby
Baby, baby, shake it mama, shake it mama, shake it mama
ABOUT UPROXX VIDEO:
UPROXX Video celebrates Hip-Hop, Style, and Creativity through a mix of original shows and music videos from the biggest artists, entertainers, and innovators from our culture.
PEOPLE'S PARTY WITH TALIB KWELI
People's Party is a weekly interview show hosted by Talib Kweli and Jasmin Leigh. Guests range from the biggest names in hip-hop, to global entertainers, to the most progressive minds moving our culture forward. The audio podcast is available on Apple and Spotify.
https://wn.com/2Pac_Ft._Dr._Dre_California_Love_(Official_Video)_Full_Length_Version
2Pac ft. Dr. Dre - California Love (Full Video) from the album "All Eyez On Me" (1996)
🔔 Subscribe to UPROXX Video and ring the bell to turn on notifications: https://uproxx.it/5rzazsh
🎙️ New Episodes of People’s Party with Talib Kweli every Monday 9AMet/6AMpt. Watch all the episodes here: https://uproxx.it/avxtjgf
More Hip-Hop Heads Playlists:
90's Hip Hop ▶️ http://bit.ly/90sHipHopPlaylist
2000's Hip Hop ▶️ http://bit.ly/2000sHipHopPlaylist
90's R&B Hits ▶️ http://bit.ly/90sRBPlaylist
The UPROXX Family
🎧 UPROXX Music https://youtube.com/uproxxmusic
🎥 UPROXX Studio https://youtube.com/uproxx
FOLLOW
➕UPROXX.com: https://uproxx.com
➕Instagram: https://instagram.com/uproxx
➕Twitter: https://twitter.com/uproxx
➕Facebook: https://facebook.com/uproxx
Lyrics:
California love
California knows how to party
California knows how to party
In the city of L.A
In the city of good ol' Watts
In the city, the city of Compton
We keep it rockin', we keep it rockin'
Now let me welcome everybody to the Wild Wild West
A state that's untouchable like Eliot Ness
The track hits your eardrum like a slug to your chest
Pack a vest for your Jimmy in the city of sex
We in that Sunshine State where the bomb-ass hemp be
The state where you never find a dance floor empty
And pimps be on a mission for them greens
Lean mean money-making-machines servin' fiends
I been in the game for 10 years makin' rap tunes
Ever since honeys was wearin' Sassoon
Now it's '95 and they clock me and watch me
Diamonds shinin', lookin' like I robbed Liberace
It's all good, from Diego to the Bay
Your city is the bomb if your city makin' pay
Throw up a finger if you feel the same way
Dre puttin' it down for Californ-i-a
California knows how to party
California knows how to party (Yes, they do)
In the city of L.A
In the city of good ol' Watts
In the city, the city of Compton
We keep it rockin', we keep it rockin'
Shake, shake it, baby
Shake, shake it, shake it baby
Shake, shake it, mama
Shake it, Cali
Shake, shake it, baby
Shake, shake it
Shake, shake it mama
Shake it
Out on bail, fresh out of jail, California dreamin'
Soon as I step on the scene, I'm hearin' hoochies screamin'
Fiendin' for money and alcohol, the life of a Westside player
Where cowards die and the strong ball
Only in Cali where we riot, not rally, to live and die
In L.A. we wearin' Chucks, not Ballys (yeah, that's right)
Dressed in Locs and Khaki suits, and ride is what we do
Flossin' but have caution: we collide with other crews
Famous because we program
Worldwide, let them recognize from Long Beach to Rosecrans
Bumpin' and grindin' like a slow jam
It's Westside, so you know the Row won't bow down to no man
Say what you say, but give me that bomb beat from Dre
Let me serenade the streets of L.A
From Oakland to Sac-town, the Bay Area and back down
Cali is where they put their mack down; give me love!
California knows how to party
California knows how to party
In the city of L.A
In the city of good ol' Watts
In the city, the city of Compton
We keep it rockin', we keep it rockin'
Shake, shake it, baby
Shake, shake it
Shake, shake it, mama
Shake it, Cali
Shake, shake it, baby
Shake, shake it
Shake, shake it mama
Shake it, Cali
Uh, yeah, uh, uh, Long Beach in the house
Uh, yeah, Oaktown
Oakland definitely in the house
Frisco, Frisco
And you know L.A. up in this
Pasadena, where you at?
Yeah, Inglewood
Inglewood always up to no good
Even Hollywood tryin' to get a piece, baby
Sacramento, Sacramento where you at?
Throw it up, y'all! Throw it up, throw it up!
I can't see ya
Let's show these fools how we do it on this Westside
'Cause you and I know it's the best side
Yeah, that's right
West Coast, West Coast
California love
California love, yeah
California knows how to party
California knows how to party
In the city of L.A
In the city of good ol' Watts
In the city, the city of Compton
We keep 'em rockin', we keep 'em rockin'
Just come on shake, shake it, baby
Baby, baby, shake it mama, shake it mama, shake it mama
ABOUT UPROXX VIDEO:
UPROXX Video celebrates Hip-Hop, Style, and Creativity through a mix of original shows and music videos from the biggest artists, entertainers, and innovators from our culture.
PEOPLE'S PARTY WITH TALIB KWELI
People's Party is a weekly interview show hosted by Talib Kweli and Jasmin Leigh. Guests range from the biggest names in hip-hop, to global entertainers, to the most progressive minds moving our culture forward. The audio podcast is available on Apple and Spotify.
- published: 16 Jun 2018
- views: 102365476
10:39
Are The Feds Connecting Diddy To The Murder Of Tupac Shakur?
In this episode of "Hidden Killers With Tony Brueski," retired FBI Special Agent Robin Dreeke discusses the ongoing investigation into Sean "Diddy" Combs, focus...
In this episode of "Hidden Killers With Tony Brueski," retired FBI Special Agent Robin Dreeke discusses the ongoing investigation into Sean "Diddy" Combs, focusing on the sex trafficking allegations and potential connections to other crimes, including the murder of Tupac Shakur. Dreeke explains the complexities of handling such high-profile cases, emphasizing the importance of prioritizing the most impactful charges—in this case, the sex trafficking allegations. He notes that charging Diddy with other crimes, like murder, could interfere with the broader investigation into sex trafficking by causing key witnesses to lawyer up. The discussion also covers the challenges of securing witness safety, particularly given the potential threats from a powerful figure like Diddy. Dreeke explains that while witness protection measures are available, they are often limited and depend on the perceived level of threat. The conversation highlights the intricate, resource-intensive nature of these investigations and the importance of maintaining anonymity and security for those involved. The episode ends with speculation on how an arrest might trigger more witnesses to come forward, feeling safer once Diddy is behind bars.
**Main Points:**
- Discussion of the ongoing investigation into Sean "Diddy" Combs, focusing on sex trafficking and potential connections to other crimes.
- The importance of prioritizing sex trafficking allegations due to their widespread impact.
- Charging Diddy with other crimes could complicate the broader investigation.
- Challenges of securing witness safety in high-profile cases, including the limitations of witness protection.
- The intricate and resource-intensive nature of these investigations.
- The potential for more witnesses to come forward if Diddy is arrested and charged.
- Victim assistance programs are crucial in providing security and support to those involved in such cases.
#SeanCombs #Diddy #TupacShakur #RobinDreeke #TonyBrueski #SexTrafficking
Subscribe & Listen on Apple Podcasts: https://shorturl.at/opFUZ
Spotify: https://shorturl.at/eksC5
Follow Us On Social Media:
Instagram: https://www.instagram.com/hiddenkillerspod/
TikTok: https://www.tiktok.com/@hiddenkillerspod
Facebook: https://www.facebook.com/hiddenkillerspod/
#truecrime #truecrimecommunity #murdermystery #unsolvedmysteries
#coldcase #truecrimepodcast #documentary #justicefor #truecrimeaddict #crimejunkie
https://wn.com/Are_The_Feds_Connecting_Diddy_To_The_Murder_Of_Tupac_Shakur
In this episode of "Hidden Killers With Tony Brueski," retired FBI Special Agent Robin Dreeke discusses the ongoing investigation into Sean "Diddy" Combs, focusing on the sex trafficking allegations and potential connections to other crimes, including the murder of Tupac Shakur. Dreeke explains the complexities of handling such high-profile cases, emphasizing the importance of prioritizing the most impactful charges—in this case, the sex trafficking allegations. He notes that charging Diddy with other crimes, like murder, could interfere with the broader investigation into sex trafficking by causing key witnesses to lawyer up. The discussion also covers the challenges of securing witness safety, particularly given the potential threats from a powerful figure like Diddy. Dreeke explains that while witness protection measures are available, they are often limited and depend on the perceived level of threat. The conversation highlights the intricate, resource-intensive nature of these investigations and the importance of maintaining anonymity and security for those involved. The episode ends with speculation on how an arrest might trigger more witnesses to come forward, feeling safer once Diddy is behind bars.
**Main Points:**
- Discussion of the ongoing investigation into Sean "Diddy" Combs, focusing on sex trafficking and potential connections to other crimes.
- The importance of prioritizing sex trafficking allegations due to their widespread impact.
- Charging Diddy with other crimes could complicate the broader investigation.
- Challenges of securing witness safety in high-profile cases, including the limitations of witness protection.
- The intricate and resource-intensive nature of these investigations.
- The potential for more witnesses to come forward if Diddy is arrested and charged.
- Victim assistance programs are crucial in providing security and support to those involved in such cases.
#SeanCombs #Diddy #TupacShakur #RobinDreeke #TonyBrueski #SexTrafficking
Subscribe & Listen on Apple Podcasts: https://shorturl.at/opFUZ
Spotify: https://shorturl.at/eksC5
Follow Us On Social Media:
Instagram: https://www.instagram.com/hiddenkillerspod/
TikTok: https://www.tiktok.com/@hiddenkillerspod
Facebook: https://www.facebook.com/hiddenkillerspod/
#truecrime #truecrimecommunity #murdermystery #unsolvedmysteries
#coldcase #truecrimepodcast #documentary #justicefor #truecrimeaddict #crimejunkie
- published: 16 Aug 2024
- views: 60
22:59
Tupac Shakur 1994 Exclusive Interview With Ed Gordon
Happy Birthday to the legendary Tupac Shakur. In honor of the revolutionary rapper, here is an exclusive 1994 interview with BET Host Ed Gordon. #Tupac #HappyBi...
Happy Birthday to the legendary Tupac Shakur. In honor of the revolutionary rapper, here is an exclusive 1994 interview with BET Host Ed Gordon. #Tupac #HappyBirthdayTupac
SUBSCRIBE to #BET NOW! ►► http://bit.ly/1U0v9xG
#BETAwards2018 #BETAwards #MeekMill #Migos #YG #2Chainz #BigSean #NickiMinaj #Miguel #JayRock #EllaMai #JaimeFoxx #Ledisi #SnoopDogg #TyeTribbett
Download the BET NOW app for full episodes of your favorite BET shows and exclusive content!
Connect with BET
Web: http://www.BET.com
Facebook: http://www.facebook.com/BET
Twitter: http://www.twitter.com/BET
Instagram: http://www.instagram.com/BET
Google+: http://www.bet.us/gplusBET
https://wn.com/Tupac_Shakur_1994_Exclusive_Interview_With_Ed_Gordon
Happy Birthday to the legendary Tupac Shakur. In honor of the revolutionary rapper, here is an exclusive 1994 interview with BET Host Ed Gordon. #Tupac #HappyBirthdayTupac
SUBSCRIBE to #BET NOW! ►► http://bit.ly/1U0v9xG
#BETAwards2018 #BETAwards #MeekMill #Migos #YG #2Chainz #BigSean #NickiMinaj #Miguel #JayRock #EllaMai #JaimeFoxx #Ledisi #SnoopDogg #TyeTribbett
Download the BET NOW app for full episodes of your favorite BET shows and exclusive content!
Connect with BET
Web: http://www.BET.com
Facebook: http://www.facebook.com/BET
Twitter: http://www.twitter.com/BET
Instagram: http://www.instagram.com/BET
Google+: http://www.bet.us/gplusBET
- published: 16 Jun 2020
- views: 1528614
-
90's Hip Hop Mix #01 | Best of Old School Rap Songs | Throwback Rap Classics | Westcoast | Eastcoast
The best of 90's Hip Hop! Strictly Old School Rap Songs from the Eastcoast all the way to the Westcoast. Rap Classics by some of the greatest rappers of all time non-stop in the mix!
New mixes every week on this channel. If you don't want to miss the next one ➜ Subscribe
My Instagram ➜ https://www.instagram.com/djnoizemusic
My Spotify Playlists ➜ https://open.spotify.com/user/djnoizemixtapes
My DJ Equipment:
Mixer ➜ https://amzn.to/3ccQDYU
Turntables ➜ https://amzn.to/3kWAFpM
Phase ➜ https://amzn.to/3lX3Edy
Headphones ➜ https://amzn.to/3kY0Dt2
Studio Speakers ➜ https://amzn.to/30o88zR
Computer ➜ https://amzn.to/3em8grP
Disclaimer: This description contains affiliate links. If you purchase a product with them I receive a small commission. There's no additional charge for you.
published: 23 Feb 2019
-
GloRilla - TGIF (Official Music Video)
Stream ""TGIF"" out now: https://GloRilla.lnk.to/TGIF
Stream 'Ehhthang Ehhthang' out everywhere: https://glorilla.lnk.to/EhhthangEhhthang
Follow #GloRilla:
Instagram: https://www.instagram.com/glorillapimp/
Twitter: https://twitter.com/GloTheofficial
TikTok: https://www.tiktok.com/@glorilla03
Facebook: https://www.facebook.com/gloyaltygirl
Merch: https://shop.glorillaofficial.com/
Mailing List: https://www.glorillaofficial.com/subscribe/#/
Keep up with GloRilla on #GloRidaz:
Instagram: https://www.instagram.com/gloridazofficial/
Twitter: https://twitter.com/RealGloridaz
TikTok: https://www.tiktok.com/@gloridazofficial
#Glorilla #EhhthangEhhthang #CMGTheLabel #TGIF
Music video by GloRilla performing TGIF. © 2024 CMG Enterprises/Interscope Records
http://vevo.ly/5ZyGEF
published: 24 Jun 2024
-
DaBaby - BOP on Broadway (Hip Hop Musical)
BOP on Broadway
Listen: https://dababy.lnk.to/DababyKIRK
Apple Music: https://dababy.lnk.to/DababyKIRK/applemusic
Spotify: https://dababy.lnk.to/DababyKIRK/spotify
Amazon Music: https://dababy.lnk.to/DababyKIRK/amazonmusic
Watch more: https://DaBaby.lnk.to/MusicVideos
Connect:
https://www.instagram.com/dababy/
https://twitter.com/DaBabyDaBaby
https://www.facebook.com/babyjesus704
https://officialdababy.com/
Produced by Jetsonmade
Video Produced by Reel Goats
Dir x Reel Goats
Edited by Reel Goats
Shoutout every single dancer that came out to be great.Shout Cherry and Danileigh for the Choreography.
Much love to Paramount for letting us run wild on their studio lot.
#Dababy #BOP #BopOnBroadway
published: 15 Nov 2019
-
Kendrick Lamar - Not Like Us
Kendrick Lamar “Not Like Us”
Directed by Dave Free & Kendrick Lamar
Production Company: pgLang / project3
Executive Producers: Kendrick Lamar, Dave Free
Producers: Sam Canter, Jack Begert, Jamie Rabineau,
Cornell Brown, Anthony Saleh, Jared Heinke
Associate Producer: Charm La’Donna
Director of Photography: Xiaolong Liu
1st AD Los Angeles: Michael Pierrard
1st AD Compton: Kenneth Taylor
Production Designer: Freyja Bardell
Choreographer: Charm La’Donna
Wardrobe Department Head: Karizza Sanchez
KL Stylist: Taylor McNeill
Talent Stylist: Jessica Willis
Talent Stylist: Telsha Anderson-Boone
Stunts: Craig Jensen
Talent Grooming: Emily Cheng
Talent Hairstylist: Flipper Moore
Barber: Chris Donato Smith
Cast HMU: Camille Ariane
Location Manager: Derek Tramont
Editor: Chaz Smedley, Eddy Street Po...
published: 04 Jul 2024
-
OLD SCHOOL HIP HOP MIX 2024 ~ Best of 90's Hip Hop Mix Playlist 🎵2Pac, Dr. Dre, Snoop Dogg, 50 Cent
🎵OLD SCHOOL HIP HOP MIX 2024 ~ Best of 90's Hip Hop Mix Playlist 🎵Dr. Dre, Snoop Dogg, 50 Cent
🎵 Welcome to the ultimate destination for Hip Hop enthusiasts, where the beats are fresh, the rhymes are tight, and the vibes are unmistakably 90s and 2000s.
Step into a world where urban culture thrives, as we pay homage to the iconic sounds that shaped an entire generation. From the gritty streets of New York to the West Coast swagger of LA, our channel is a melting pot of lyrical prowess and innovative production. Join us as we take a trip down memory lane, revisiting the classics that continue to resonate with fans worldwide. From legendary artists like Tupac and Biggie to trailblazers like Jay-Z and Nas, our playlist is a testament to the enduring influence of Hip Hop's golden era.
So wh...
published: 19 May 2024
-
Future - SKI (Official Music Video)
Future - SKI (Official Music Video)
"MIXTAPE PLUTO" available at: https://future.lnk.to/MIXTAPEPLUTO
Follow Future:
Facebook: https://Future.lnk.to/followFI
Twitter: https://Future.lnk.to/followTI
Instagram: https://Future.lnk.to/followII
Website: https://Future.lnk.to/followWI
Spotify: https://Future.lnk.to/followSI
(C) 2024 Wilburn Holding Co. under exclusive license to Epic Records, a division of Sony Music Entertainment.
#Future #SKI #MIXTAPEPLUTO
published: 30 Sep 2024
-
Megan Thee Stallion - Mamushi (feat. Yuki Chiba) [Official Video]
The official video for Megan Thee Stallion's "Mamushi" featuring Yuki Chiba - OUT NOW!
Stream "Mamushi": https://mts.lnk.to/megan
Text Megan Thee Stallion:
(832) 210-1202
Follow Megan Thee Stallion:
https://www.instagram.com/theestallion
https://twitter.com/theestallion
https://www.facebook.com/theestallionn
https://soundcloud.com/megan-thee-stallion
--
#MeganTheeStallion #Mamushi #YukiChiba #OfficialVideo
published: 09 Aug 2024
-
Lil Durk - All My Life ft. J. Cole
Music video by Lil Durk performing All My Life. (C) 2023 Alamo Records, LLC/Sony Music Entertainment
published: 12 May 2023
-
50 Cent - In Da Club (Official Music Video)
CELEBRATING ONE BILLION VIEWS!!
REMASTERED IN HD! UP TO 4K!!
Get your 50 Cent & G-Unit Merch here: https://www.gunitbrands.com/
Best Of: https://50Cent.lnk.to/YTBestOf
Subscribe: https://50Cent.lnk.to/YTSubscribe
Stream: https://stream.lnk.to/50Cent
Music video by 50 Cent performing In Da Club. (C) 2003 Shady Records/Aftermath Records/Interscope Records
#50Cent #InDaClub #Remastered #BransonCognac #LeCheminDuRoi #GUnit #PowerTV #ForLife #ThisIs50 #BillionViewsClub
published: 16 Jun 2009
-
HIP HOP MIX (EMINEM, 2PAC, SNOOP DOGG, 50 CENT, USHER, COOLIO, BEP, HOUSE OF PAIN) DJ DOO
Volví a subir el mix Hip hop por algunos problemas de Copyright.
No olviden compartir para poder subir la parte 2 pronto! :)
Track List:
00:00 Coolio - Gangsta's Paradise
02:56 Wiz Khalifa - Black And Yellow
05:58 50 Cent – Pimp
08:34 Jay Z & Alicia Keys - Empire State Of Mind
12:09 50 Cent - In Da Club
13:49 2Pac - California Love
16:05 Dr. Dree Ft. Snoop Dog – Still
20:20 50 Cent - Candy Shop
23:05 Black Eyed Peas = Lets Get It Started
26:26 Eminem - The Real Slim Shady
28:24 Usher Feat Lil' Jon & Ludacris - Yeah!
32:01 Will Smith - Gettin Jiggy Wit it
34:04 Eminem - Without Me
37:23 House Of Pain - Jump Around
Colaboración al Yape 966691971, mil gracias :)
published: 01 Aug 2024
56:19
90's Hip Hop Mix #01 | Best of Old School Rap Songs | Throwback Rap Classics | Westcoast | Eastcoast
The best of 90's Hip Hop! Strictly Old School Rap Songs from the Eastcoast all the way to the Westcoast. Rap Classics by some of the greatest rappers of all tim...
The best of 90's Hip Hop! Strictly Old School Rap Songs from the Eastcoast all the way to the Westcoast. Rap Classics by some of the greatest rappers of all time non-stop in the mix!
New mixes every week on this channel. If you don't want to miss the next one ➜ Subscribe
My Instagram ➜ https://www.instagram.com/djnoizemusic
My Spotify Playlists ➜ https://open.spotify.com/user/djnoizemixtapes
My DJ Equipment:
Mixer ➜ https://amzn.to/3ccQDYU
Turntables ➜ https://amzn.to/3kWAFpM
Phase ➜ https://amzn.to/3lX3Edy
Headphones ➜ https://amzn.to/3kY0Dt2
Studio Speakers ➜ https://amzn.to/30o88zR
Computer ➜ https://amzn.to/3em8grP
Disclaimer: This description contains affiliate links. If you purchase a product with them I receive a small commission. There's no additional charge for you.
https://wn.com/90's_Hip_Hop_Mix_01_|_Best_Of_Old_School_Rap_Songs_|_Throwback_Rap_Classics_|_Westcoast_|_Eastcoast
The best of 90's Hip Hop! Strictly Old School Rap Songs from the Eastcoast all the way to the Westcoast. Rap Classics by some of the greatest rappers of all time non-stop in the mix!
New mixes every week on this channel. If you don't want to miss the next one ➜ Subscribe
My Instagram ➜ https://www.instagram.com/djnoizemusic
My Spotify Playlists ➜ https://open.spotify.com/user/djnoizemixtapes
My DJ Equipment:
Mixer ➜ https://amzn.to/3ccQDYU
Turntables ➜ https://amzn.to/3kWAFpM
Phase ➜ https://amzn.to/3lX3Edy
Headphones ➜ https://amzn.to/3kY0Dt2
Studio Speakers ➜ https://amzn.to/30o88zR
Computer ➜ https://amzn.to/3em8grP
Disclaimer: This description contains affiliate links. If you purchase a product with them I receive a small commission. There's no additional charge for you.
- published: 23 Feb 2019
- views: 54903859
2:45
GloRilla - TGIF (Official Music Video)
Stream ""TGIF"" out now: https://GloRilla.lnk.to/TGIF
Stream 'Ehhthang Ehhthang' out everywhere: https://glorilla.lnk.to/EhhthangEhhthang
Follow #GloRilla:
In...
Stream ""TGIF"" out now: https://GloRilla.lnk.to/TGIF
Stream 'Ehhthang Ehhthang' out everywhere: https://glorilla.lnk.to/EhhthangEhhthang
Follow #GloRilla:
Instagram: https://www.instagram.com/glorillapimp/
Twitter: https://twitter.com/GloTheofficial
TikTok: https://www.tiktok.com/@glorilla03
Facebook: https://www.facebook.com/gloyaltygirl
Merch: https://shop.glorillaofficial.com/
Mailing List: https://www.glorillaofficial.com/subscribe/#/
Keep up with GloRilla on #GloRidaz:
Instagram: https://www.instagram.com/gloridazofficial/
Twitter: https://twitter.com/RealGloridaz
TikTok: https://www.tiktok.com/@gloridazofficial
#Glorilla #EhhthangEhhthang #CMGTheLabel #TGIF
Music video by GloRilla performing TGIF. © 2024 CMG Enterprises/Interscope Records
http://vevo.ly/5ZyGEF
https://wn.com/Glorilla_Tgif_(Official_Music_Video)
Stream ""TGIF"" out now: https://GloRilla.lnk.to/TGIF
Stream 'Ehhthang Ehhthang' out everywhere: https://glorilla.lnk.to/EhhthangEhhthang
Follow #GloRilla:
Instagram: https://www.instagram.com/glorillapimp/
Twitter: https://twitter.com/GloTheofficial
TikTok: https://www.tiktok.com/@glorilla03
Facebook: https://www.facebook.com/gloyaltygirl
Merch: https://shop.glorillaofficial.com/
Mailing List: https://www.glorillaofficial.com/subscribe/#/
Keep up with GloRilla on #GloRidaz:
Instagram: https://www.instagram.com/gloridazofficial/
Twitter: https://twitter.com/RealGloridaz
TikTok: https://www.tiktok.com/@gloridazofficial
#Glorilla #EhhthangEhhthang #CMGTheLabel #TGIF
Music video by GloRilla performing TGIF. © 2024 CMG Enterprises/Interscope Records
http://vevo.ly/5ZyGEF
- published: 24 Jun 2024
- views: 67777814
3:04
DaBaby - BOP on Broadway (Hip Hop Musical)
BOP on Broadway
Listen: https://dababy.lnk.to/DababyKIRK
Apple Music: https://dababy.lnk.to/DababyKIRK/applemusic
Spotify: https://dababy.lnk.to/DababyKIRK/spo...
BOP on Broadway
Listen: https://dababy.lnk.to/DababyKIRK
Apple Music: https://dababy.lnk.to/DababyKIRK/applemusic
Spotify: https://dababy.lnk.to/DababyKIRK/spotify
Amazon Music: https://dababy.lnk.to/DababyKIRK/amazonmusic
Watch more: https://DaBaby.lnk.to/MusicVideos
Connect:
https://www.instagram.com/dababy/
https://twitter.com/DaBabyDaBaby
https://www.facebook.com/babyjesus704
https://officialdababy.com/
Produced by Jetsonmade
Video Produced by Reel Goats
Dir x Reel Goats
Edited by Reel Goats
Shoutout every single dancer that came out to be great.Shout Cherry and Danileigh for the Choreography.
Much love to Paramount for letting us run wild on their studio lot.
#Dababy #BOP #BopOnBroadway
https://wn.com/Dababy_Bop_On_Broadway_(Hip_Hop_Musical)
BOP on Broadway
Listen: https://dababy.lnk.to/DababyKIRK
Apple Music: https://dababy.lnk.to/DababyKIRK/applemusic
Spotify: https://dababy.lnk.to/DababyKIRK/spotify
Amazon Music: https://dababy.lnk.to/DababyKIRK/amazonmusic
Watch more: https://DaBaby.lnk.to/MusicVideos
Connect:
https://www.instagram.com/dababy/
https://twitter.com/DaBabyDaBaby
https://www.facebook.com/babyjesus704
https://officialdababy.com/
Produced by Jetsonmade
Video Produced by Reel Goats
Dir x Reel Goats
Edited by Reel Goats
Shoutout every single dancer that came out to be great.Shout Cherry and Danileigh for the Choreography.
Much love to Paramount for letting us run wild on their studio lot.
#Dababy #BOP #BopOnBroadway
- published: 15 Nov 2019
- views: 554384363
5:55
Kendrick Lamar - Not Like Us
Kendrick Lamar “Not Like Us”
Directed by Dave Free & Kendrick Lamar
Production Company: pgLang / project3
Executive Producers: Kendrick Lamar, Dave Free
Produ...
Kendrick Lamar “Not Like Us”
Directed by Dave Free & Kendrick Lamar
Production Company: pgLang / project3
Executive Producers: Kendrick Lamar, Dave Free
Producers: Sam Canter, Jack Begert, Jamie Rabineau,
Cornell Brown, Anthony Saleh, Jared Heinke
Associate Producer: Charm La’Donna
Director of Photography: Xiaolong Liu
1st AD Los Angeles: Michael Pierrard
1st AD Compton: Kenneth Taylor
Production Designer: Freyja Bardell
Choreographer: Charm La’Donna
Wardrobe Department Head: Karizza Sanchez
KL Stylist: Taylor McNeill
Talent Stylist: Jessica Willis
Talent Stylist: Telsha Anderson-Boone
Stunts: Craig Jensen
Talent Grooming: Emily Cheng
Talent Hairstylist: Flipper Moore
Barber: Chris Donato Smith
Cast HMU: Camille Ariane
Location Manager: Derek Tramont
Editor: Chaz Smedley, Eddy Street Post
Colorist: Mikey Rossiter
VFX: Karen Arakelian
Additional VFX: Sunset Edit, SUPERCONTINENT
Sound Design: Matt Yocum
Commissioner: Michelle An
#KendrickLamar #NotLikeUs
http://vevo.ly/NcHpoC
https://wn.com/Kendrick_Lamar_Not_Like_US
Kendrick Lamar “Not Like Us”
Directed by Dave Free & Kendrick Lamar
Production Company: pgLang / project3
Executive Producers: Kendrick Lamar, Dave Free
Producers: Sam Canter, Jack Begert, Jamie Rabineau,
Cornell Brown, Anthony Saleh, Jared Heinke
Associate Producer: Charm La’Donna
Director of Photography: Xiaolong Liu
1st AD Los Angeles: Michael Pierrard
1st AD Compton: Kenneth Taylor
Production Designer: Freyja Bardell
Choreographer: Charm La’Donna
Wardrobe Department Head: Karizza Sanchez
KL Stylist: Taylor McNeill
Talent Stylist: Jessica Willis
Talent Stylist: Telsha Anderson-Boone
Stunts: Craig Jensen
Talent Grooming: Emily Cheng
Talent Hairstylist: Flipper Moore
Barber: Chris Donato Smith
Cast HMU: Camille Ariane
Location Manager: Derek Tramont
Editor: Chaz Smedley, Eddy Street Post
Colorist: Mikey Rossiter
VFX: Karen Arakelian
Additional VFX: Sunset Edit, SUPERCONTINENT
Sound Design: Matt Yocum
Commissioner: Michelle An
#KendrickLamar #NotLikeUs
http://vevo.ly/NcHpoC
- published: 04 Jul 2024
- views: 193024833
1:18:17
OLD SCHOOL HIP HOP MIX 2024 ~ Best of 90's Hip Hop Mix Playlist 🎵2Pac, Dr. Dre, Snoop Dogg, 50 Cent
🎵OLD SCHOOL HIP HOP MIX 2024 ~ Best of 90's Hip Hop Mix Playlist 🎵Dr. Dre, Snoop Dogg, 50 Cent
🎵 Welcome to the ultimate destination for Hip Hop enthusiasts, w...
🎵OLD SCHOOL HIP HOP MIX 2024 ~ Best of 90's Hip Hop Mix Playlist 🎵Dr. Dre, Snoop Dogg, 50 Cent
🎵 Welcome to the ultimate destination for Hip Hop enthusiasts, where the beats are fresh, the rhymes are tight, and the vibes are unmistakably 90s and 2000s.
Step into a world where urban culture thrives, as we pay homage to the iconic sounds that shaped an entire generation. From the gritty streets of New York to the West Coast swagger of LA, our channel is a melting pot of lyrical prowess and innovative production. Join us as we take a trip down memory lane, revisiting the classics that continue to resonate with fans worldwide. From legendary artists like Tupac and Biggie to trailblazers like Jay-Z and Nas, our playlist is a testament to the enduring influence of Hip Hop's golden era.
So whether you're a seasoned aficionado or a newcomer to the scene, tune in and let the rhythm of the streets guide you through the timeless sounds of 90s and 2000s Hip Hop.
🎵 Thanks for Whatching !!
https://wn.com/Old_School_Hip_Hop_Mix_2024_~_Best_Of_90's_Hip_Hop_Mix_Playlist_🎵2Pac,_Dr._Dre,_Snoop_Dogg,_50_Cent
🎵OLD SCHOOL HIP HOP MIX 2024 ~ Best of 90's Hip Hop Mix Playlist 🎵Dr. Dre, Snoop Dogg, 50 Cent
🎵 Welcome to the ultimate destination for Hip Hop enthusiasts, where the beats are fresh, the rhymes are tight, and the vibes are unmistakably 90s and 2000s.
Step into a world where urban culture thrives, as we pay homage to the iconic sounds that shaped an entire generation. From the gritty streets of New York to the West Coast swagger of LA, our channel is a melting pot of lyrical prowess and innovative production. Join us as we take a trip down memory lane, revisiting the classics that continue to resonate with fans worldwide. From legendary artists like Tupac and Biggie to trailblazers like Jay-Z and Nas, our playlist is a testament to the enduring influence of Hip Hop's golden era.
So whether you're a seasoned aficionado or a newcomer to the scene, tune in and let the rhythm of the streets guide you through the timeless sounds of 90s and 2000s Hip Hop.
🎵 Thanks for Whatching !!
- published: 19 May 2024
- views: 3392166
2:27
Future - SKI (Official Music Video)
Future - SKI (Official Music Video)
"MIXTAPE PLUTO" available at: https://future.lnk.to/MIXTAPEPLUTO
Follow Future:
Facebook: https://Future.lnk.to/followFI
T...
Future - SKI (Official Music Video)
"MIXTAPE PLUTO" available at: https://future.lnk.to/MIXTAPEPLUTO
Follow Future:
Facebook: https://Future.lnk.to/followFI
Twitter: https://Future.lnk.to/followTI
Instagram: https://Future.lnk.to/followII
Website: https://Future.lnk.to/followWI
Spotify: https://Future.lnk.to/followSI
(C) 2024 Wilburn Holding Co. under exclusive license to Epic Records, a division of Sony Music Entertainment.
#Future #SKI #MIXTAPEPLUTO
https://wn.com/Future_Ski_(Official_Music_Video)
Future - SKI (Official Music Video)
"MIXTAPE PLUTO" available at: https://future.lnk.to/MIXTAPEPLUTO
Follow Future:
Facebook: https://Future.lnk.to/followFI
Twitter: https://Future.lnk.to/followTI
Instagram: https://Future.lnk.to/followII
Website: https://Future.lnk.to/followWI
Spotify: https://Future.lnk.to/followSI
(C) 2024 Wilburn Holding Co. under exclusive license to Epic Records, a division of Sony Music Entertainment.
#Future #SKI #MIXTAPEPLUTO
- published: 30 Sep 2024
- views: 1807909
3:47
Megan Thee Stallion - Mamushi (feat. Yuki Chiba) [Official Video]
The official video for Megan Thee Stallion's "Mamushi" featuring Yuki Chiba - OUT NOW!
Stream "Mamushi": https://mts.lnk.to/megan
Text Megan Thee Stallion:
(8...
The official video for Megan Thee Stallion's "Mamushi" featuring Yuki Chiba - OUT NOW!
Stream "Mamushi": https://mts.lnk.to/megan
Text Megan Thee Stallion:
(832) 210-1202
Follow Megan Thee Stallion:
https://www.instagram.com/theestallion
https://twitter.com/theestallion
https://www.facebook.com/theestallionn
https://soundcloud.com/megan-thee-stallion
--
#MeganTheeStallion #Mamushi #YukiChiba #OfficialVideo
https://wn.com/Megan_Thee_Stallion_Mamushi_(Feat._Yuki_Chiba)_Official_Video
The official video for Megan Thee Stallion's "Mamushi" featuring Yuki Chiba - OUT NOW!
Stream "Mamushi": https://mts.lnk.to/megan
Text Megan Thee Stallion:
(832) 210-1202
Follow Megan Thee Stallion:
https://www.instagram.com/theestallion
https://twitter.com/theestallion
https://www.facebook.com/theestallionn
https://soundcloud.com/megan-thee-stallion
--
#MeganTheeStallion #Mamushi #YukiChiba #OfficialVideo
- published: 09 Aug 2024
- views: 59483061
4:05
Lil Durk - All My Life ft. J. Cole
Music video by Lil Durk performing All My Life. (C) 2023 Alamo Records, LLC/Sony Music Entertainment
Music video by Lil Durk performing All My Life. (C) 2023 Alamo Records, LLC/Sony Music Entertainment
https://wn.com/Lil_Durk_All_My_Life_Ft._J._Cole
Music video by Lil Durk performing All My Life. (C) 2023 Alamo Records, LLC/Sony Music Entertainment
- published: 12 May 2023
- views: 241169079
4:08
50 Cent - In Da Club (Official Music Video)
CELEBRATING ONE BILLION VIEWS!!
REMASTERED IN HD! UP TO 4K!!
Get your 50 Cent & G-Unit Merch here: https://www.gunitbrands.com/
Best Of: https://50Cent.lnk.to/...
CELEBRATING ONE BILLION VIEWS!!
REMASTERED IN HD! UP TO 4K!!
Get your 50 Cent & G-Unit Merch here: https://www.gunitbrands.com/
Best Of: https://50Cent.lnk.to/YTBestOf
Subscribe: https://50Cent.lnk.to/YTSubscribe
Stream: https://stream.lnk.to/50Cent
Music video by 50 Cent performing In Da Club. (C) 2003 Shady Records/Aftermath Records/Interscope Records
#50Cent #InDaClub #Remastered #BransonCognac #LeCheminDuRoi #GUnit #PowerTV #ForLife #ThisIs50 #BillionViewsClub
https://wn.com/50_Cent_In_Da_Club_(Official_Music_Video)
CELEBRATING ONE BILLION VIEWS!!
REMASTERED IN HD! UP TO 4K!!
Get your 50 Cent & G-Unit Merch here: https://www.gunitbrands.com/
Best Of: https://50Cent.lnk.to/YTBestOf
Subscribe: https://50Cent.lnk.to/YTSubscribe
Stream: https://stream.lnk.to/50Cent
Music video by 50 Cent performing In Da Club. (C) 2003 Shady Records/Aftermath Records/Interscope Records
#50Cent #InDaClub #Remastered #BransonCognac #LeCheminDuRoi #GUnit #PowerTV #ForLife #ThisIs50 #BillionViewsClub
- published: 16 Jun 2009
- views: 2240850879
39:55
HIP HOP MIX (EMINEM, 2PAC, SNOOP DOGG, 50 CENT, USHER, COOLIO, BEP, HOUSE OF PAIN) DJ DOO
Volví a subir el mix Hip hop por algunos problemas de Copyright.
No olviden compartir para poder subir la parte 2 pronto! :)
Track List:
00:00 Coolio - Gang...
Volví a subir el mix Hip hop por algunos problemas de Copyright.
No olviden compartir para poder subir la parte 2 pronto! :)
Track List:
00:00 Coolio - Gangsta's Paradise
02:56 Wiz Khalifa - Black And Yellow
05:58 50 Cent – Pimp
08:34 Jay Z & Alicia Keys - Empire State Of Mind
12:09 50 Cent - In Da Club
13:49 2Pac - California Love
16:05 Dr. Dree Ft. Snoop Dog – Still
20:20 50 Cent - Candy Shop
23:05 Black Eyed Peas = Lets Get It Started
26:26 Eminem - The Real Slim Shady
28:24 Usher Feat Lil' Jon & Ludacris - Yeah!
32:01 Will Smith - Gettin Jiggy Wit it
34:04 Eminem - Without Me
37:23 House Of Pain - Jump Around
Colaboración al Yape 966691971, mil gracias :)
https://wn.com/Hip_Hop_Mix_(Eminem,_2Pac,_Snoop_Dogg,_50_Cent,_Usher,_Coolio,_Bep,_House_Of_Pain)_Dj_Doo
Volví a subir el mix Hip hop por algunos problemas de Copyright.
No olviden compartir para poder subir la parte 2 pronto! :)
Track List:
00:00 Coolio - Gangsta's Paradise
02:56 Wiz Khalifa - Black And Yellow
05:58 50 Cent – Pimp
08:34 Jay Z & Alicia Keys - Empire State Of Mind
12:09 50 Cent - In Da Club
13:49 2Pac - California Love
16:05 Dr. Dree Ft. Snoop Dog – Still
20:20 50 Cent - Candy Shop
23:05 Black Eyed Peas = Lets Get It Started
26:26 Eminem - The Real Slim Shady
28:24 Usher Feat Lil' Jon & Ludacris - Yeah!
32:01 Will Smith - Gettin Jiggy Wit it
34:04 Eminem - Without Me
37:23 House Of Pain - Jump Around
Colaboración al Yape 966691971, mil gracias :)
- published: 01 Aug 2024
- views: 5347920
-
RAS Protein - Small GTPases
Hey Friends,
todays talk will be around the RAS G-Protein. This monomeric GTPase is a famous oncogene and is involved in signaling pathways affecting the cell cycle. How RAS is activated and which pathways it can switch on, I explain in this video. Thank you for your support!
Cheers,
Henrik
published: 20 Apr 2020
-
Alfred Wittinghofer (MPI) Part 1: GTP-binding Proteins as Molecular Switches
https://www.ibiology.org/biochemistry/g-protein/
When a growth factor binds to the plasma membrane of a quiescent cell, an intracellular signaling pathway is activated telling the cell to begin growing. A key molecule in this signaling pathway is the GTP-binding protein, or G-protein, Ras. Ras can act as an on-off switch telling the cell to grow or not. In its inactive form, Ras is bound to GDP while in its active form it is bound to GTP. This exchange of nucleotides is catalysed by guanine nucleotide-exchange-factors (GEFs). The return to the inactive state occurs through the GTPase reaction, which is accelerated by GTPase-activating proteins (GAPs). In Part 1 of his talk, Dr. Wittinghofer explains how solving the three-dimensional structure of Ras, and other G-proteins, allowed him to u...
published: 19 Jun 2011
-
Medical vocabulary: What does rap GTP-Binding Proteins mean
What does rap GTP-Binding Proteins mean in English?
published: 20 Jan 2016
-
The Universe of GTP-binding proteins: un tema con variationi
Air date: Wednesday, March 25, 2009, 3:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Category: Wednesday Afternoon Lectures
Description: GTP binding (G) proteins of the Ras superfamily cycle between a GDP-bound inactive and a GTP-bound active state. The switch-ON reaction involves the exchange of tightly bound GDP against GTP, while the switch-OFF mechanism involves the enzymatic cleavage of GTP to GDP. The switch function is tightly regulated since those reactions are intrinsically very slow and are stimulated through factors acting in trans. The first reaction is catalysed by guanine nucleotide exchange factors, GEFs, while the second is activated by GTPase-activating proteins called GAPs. The inability of certain of these proteins to be down-regulated or their un...
published: 31 Aug 2012
-
Medical vocabulary: What does rap1 GTP-Binding Proteins mean
What does rap1 GTP-Binding Proteins mean in English?
published: 20 Jan 2016
-
Alfred Wittinghofer (MPI) Part 2: GTPase Reactions and Diseases
https://www.ibiology.org/biochemistry/g-protein/#part-2
In the second part of Dr. Wittinghofer's talk he explains the link between GTPases and disease. Ras is both a key molecule in regulating normal cell growth and an oncogene in unregulated cancer cell growth. Mutations in Ras that prevent the hydrolysis of GTP to GDP lock Ras into an active state rendering it independent of upstream growth factor signals. Biophysical studies from Wittinghofer's lab solved the multiple steps in the hydrolysis of GTP to GDP and explained why particular mutations in either Ras or Ras-GAPs cause unregulated activation of Ras and tumor formation. Examples of other G-proteins that are unable to hydrolyse GTP and result in different diseases such as Retinitis Pigmentosa, are also presented.
published: 19 Jun 2011
-
Bruno Goud - The RAB6 GTPase, a master regulator of post-Golgi trafficking pathways
The members of the RAB GTPase family (less than 60 proteins in man) are master regulators of intracellular transport and membrane trafficking in eukaryotic cells. RAB6 is one of the five ancestral RAB genes conserved from yeast to human. The RAB6 family comprises four proteins, named RAB6A, RAB6A’, RAB6B and RAB6C. The two ubiquitously expressed isoforms, RAB6A and A, are generated by alternative splicing of the same gene and localize to the Golgi complex. We and others have established that RAB6 regulates several transport pathways at the level of this organelle.
Our recent work has focused on several aspects of RAB6 function:
-The mechanisms involved in the fission of RAB6-positive transport carriers from Golgi/TGN (Trans-Golgi Network) membranes. We have previo...
published: 26 Mar 2018
-
Conformational Change from active (GTP bound) to inactive (GDP bound) state of H-Ras protein.
Watch in 480p for best quality.
Ras are a group of small GTPases which are activated by binding of GTP( Guanosine tri phosphate) a process which is facilated by GEF (Guanine nucleotide exchange factor) protein. The Ras which then activates its cellular target for conveying the signal downstream then hydrolyses the bound GTP ( process stimulated by another protein GAP (GTPase Activating Protein) to GDP which the dissociates and the protein returns to its inactive conformation.
published: 14 May 2013
-
Rab delivery to a membrane
In this video we have discussed about the delivery of Rab to a membrane
published: 10 Sep 2021
-
Conformational Change from active GTP bound to inactive GDP bound state of H Ras protein
published: 29 Oct 2015
-
Dramatic conformational changes in Rap proteins
Look at how huge conformational changes a protein can undergo. This is first example of regulation of protein function by a dramatic conformational change that involves expansion of repeat domain in the protein. This video shows Rap proteins in their unbound (apo), target protein bound, and regulatory peptide bound states. Rap proteins regulate bacterial development in response to cell-cell communication signals. For more information read my research article at http://www.plosbiology.org/article/info%3Adoi%2F10.1371%2Fjournal.pbio.1001512
published: 20 Mar 2013
-
Menacing Mutations: Examining the Role of the RAS Oncogene in Cancer Development
Winner of the Judge’s Award Second Place in the 2022 RCSB PDB Video Challenge for High School Students “Molecular Mechanisms of Cancer”
By Xinyi Zhang
South Brunswick High School, NJ
Team Advisor: Mrs. Dana Armstrong
published: 17 May 2022
-
Keynote Presentation: Interplay between LRRK2 protein kinase and Rab GTPases in Parkinson's disease
Presented By: Dario Alessi, FRS FMedSci FRSE
Speaker Biography: Dario's research focuses on unravelling the roles of poorly characterised components which regulate protein phosphorylation or ubiquitylation pathways that are linked to human disease. Dario, obtained a BSc (1988) and PhD (1991) from the University of Birmingham, United Kingdom.
Webinar: Keynote Presentation: Interplay between LRRK2 protein kinase and Rab GTPases in Parkinson's disease
Webinar Abstract: I will discuss the identification and characterization of a novel PPM family phosphatase member that counteracts LRRK2 signalling by dephosphorylating Rab proteins. I will present data that indicates that the LRRK2 parlog termed LRRK1 also functions as a Rab kinase. Finally, I will discuss what is known about how LRRK2 regu...
published: 24 Mar 2020
-
Raf part 1 - regulation and function
This videos introduces the Raf kinase, how it is regulated by RasGTP, and the effect of Raf on its substrate Mek.
published: 29 Sep 2020
3:45
RAS Protein - Small GTPases
Hey Friends,
todays talk will be around the RAS G-Protein. This monomeric GTPase is a famous oncogene and is involved in signaling pathways affecting the cell ...
Hey Friends,
todays talk will be around the RAS G-Protein. This monomeric GTPase is a famous oncogene and is involved in signaling pathways affecting the cell cycle. How RAS is activated and which pathways it can switch on, I explain in this video. Thank you for your support!
Cheers,
Henrik
https://wn.com/Ras_Protein_Small_Gtpases
Hey Friends,
todays talk will be around the RAS G-Protein. This monomeric GTPase is a famous oncogene and is involved in signaling pathways affecting the cell cycle. How RAS is activated and which pathways it can switch on, I explain in this video. Thank you for your support!
Cheers,
Henrik
- published: 20 Apr 2020
- views: 60579
42:02
Alfred Wittinghofer (MPI) Part 1: GTP-binding Proteins as Molecular Switches
https://www.ibiology.org/biochemistry/g-protein/
When a growth factor binds to the plasma membrane of a quiescent cell, an intracellular signaling pathway is a...
https://www.ibiology.org/biochemistry/g-protein/
When a growth factor binds to the plasma membrane of a quiescent cell, an intracellular signaling pathway is activated telling the cell to begin growing. A key molecule in this signaling pathway is the GTP-binding protein, or G-protein, Ras. Ras can act as an on-off switch telling the cell to grow or not. In its inactive form, Ras is bound to GDP while in its active form it is bound to GTP. This exchange of nucleotides is catalysed by guanine nucleotide-exchange-factors (GEFs). The return to the inactive state occurs through the GTPase reaction, which is accelerated by GTPase-activating proteins (GAPs). In Part 1 of his talk, Dr. Wittinghofer explains how solving the three-dimensional structure of Ras, and other G-proteins, allowed him to understand the conserved mechanism by which G-proteins can act as switches. The structure also identified domains unique to each G-protein that provide the specificity for downstream signals.
https://wn.com/Alfred_Wittinghofer_(Mpi)_Part_1_Gtp_Binding_Proteins_As_Molecular_Switches
https://www.ibiology.org/biochemistry/g-protein/
When a growth factor binds to the plasma membrane of a quiescent cell, an intracellular signaling pathway is activated telling the cell to begin growing. A key molecule in this signaling pathway is the GTP-binding protein, or G-protein, Ras. Ras can act as an on-off switch telling the cell to grow or not. In its inactive form, Ras is bound to GDP while in its active form it is bound to GTP. This exchange of nucleotides is catalysed by guanine nucleotide-exchange-factors (GEFs). The return to the inactive state occurs through the GTPase reaction, which is accelerated by GTPase-activating proteins (GAPs). In Part 1 of his talk, Dr. Wittinghofer explains how solving the three-dimensional structure of Ras, and other G-proteins, allowed him to understand the conserved mechanism by which G-proteins can act as switches. The structure also identified domains unique to each G-protein that provide the specificity for downstream signals.
- published: 19 Jun 2011
- views: 52547
58:33
The Universe of GTP-binding proteins: un tema con variationi
Air date: Wednesday, March 25, 2009, 3:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Category: Wednesday Afternoon Lectures
Description: ...
Air date: Wednesday, March 25, 2009, 3:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Category: Wednesday Afternoon Lectures
Description: GTP binding (G) proteins of the Ras superfamily cycle between a GDP-bound inactive and a GTP-bound active state. The switch-ON reaction involves the exchange of tightly bound GDP against GTP, while the switch-OFF mechanism involves the enzymatic cleavage of GTP to GDP. The switch function is tightly regulated since those reactions are intrinsically very slow and are stimulated through factors acting in trans. The first reaction is catalysed by guanine nucleotide exchange factors, GEFs, while the second is activated by GTPase-activating proteins called GAPs. The inability of certain of these proteins to be down-regulated or their unregulated activation leads to various forms of diseases including cancer.
A lot is known about the structural requirements for the switch function of Ras proteins, the GEF and the GAP reaction, their membrane recruitment and the interaction with effectors.
The basic features and mechanistic principles using Ras and G proteins, the structural basis of the molecular switch, how it is activated and how it interacts with downstream effectors, will be presented. Particular attention will be given to the GTPase reaction and its importance for disease formation such as cancer, Retinitis pigmentosa or Parkinson.
The NIH Director's Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.
Author: Alfred Wittenhofer
Runtime: 00:58:32
Permanent link: http://videocast.nih.gov/launch.asp?14996
https://wn.com/The_Universe_Of_Gtp_Binding_Proteins_Un_Tema_Con_Variationi
Air date: Wednesday, March 25, 2009, 3:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Category: Wednesday Afternoon Lectures
Description: GTP binding (G) proteins of the Ras superfamily cycle between a GDP-bound inactive and a GTP-bound active state. The switch-ON reaction involves the exchange of tightly bound GDP against GTP, while the switch-OFF mechanism involves the enzymatic cleavage of GTP to GDP. The switch function is tightly regulated since those reactions are intrinsically very slow and are stimulated through factors acting in trans. The first reaction is catalysed by guanine nucleotide exchange factors, GEFs, while the second is activated by GTPase-activating proteins called GAPs. The inability of certain of these proteins to be down-regulated or their unregulated activation leads to various forms of diseases including cancer.
A lot is known about the structural requirements for the switch function of Ras proteins, the GEF and the GAP reaction, their membrane recruitment and the interaction with effectors.
The basic features and mechanistic principles using Ras and G proteins, the structural basis of the molecular switch, how it is activated and how it interacts with downstream effectors, will be presented. Particular attention will be given to the GTPase reaction and its importance for disease formation such as cancer, Retinitis pigmentosa or Parkinson.
The NIH Director's Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.
Author: Alfred Wittenhofer
Runtime: 00:58:32
Permanent link: http://videocast.nih.gov/launch.asp?14996
- published: 31 Aug 2012
- views: 1476
55:02
Alfred Wittinghofer (MPI) Part 2: GTPase Reactions and Diseases
https://www.ibiology.org/biochemistry/g-protein/#part-2
In the second part of Dr. Wittinghofer's talk he explains the link between GTPases and disease. Ras is ...
https://www.ibiology.org/biochemistry/g-protein/#part-2
In the second part of Dr. Wittinghofer's talk he explains the link between GTPases and disease. Ras is both a key molecule in regulating normal cell growth and an oncogene in unregulated cancer cell growth. Mutations in Ras that prevent the hydrolysis of GTP to GDP lock Ras into an active state rendering it independent of upstream growth factor signals. Biophysical studies from Wittinghofer's lab solved the multiple steps in the hydrolysis of GTP to GDP and explained why particular mutations in either Ras or Ras-GAPs cause unregulated activation of Ras and tumor formation. Examples of other G-proteins that are unable to hydrolyse GTP and result in different diseases such as Retinitis Pigmentosa, are also presented.
https://wn.com/Alfred_Wittinghofer_(Mpi)_Part_2_Gtpase_Reactions_And_Diseases
https://www.ibiology.org/biochemistry/g-protein/#part-2
In the second part of Dr. Wittinghofer's talk he explains the link between GTPases and disease. Ras is both a key molecule in regulating normal cell growth and an oncogene in unregulated cancer cell growth. Mutations in Ras that prevent the hydrolysis of GTP to GDP lock Ras into an active state rendering it independent of upstream growth factor signals. Biophysical studies from Wittinghofer's lab solved the multiple steps in the hydrolysis of GTP to GDP and explained why particular mutations in either Ras or Ras-GAPs cause unregulated activation of Ras and tumor formation. Examples of other G-proteins that are unable to hydrolyse GTP and result in different diseases such as Retinitis Pigmentosa, are also presented.
- published: 19 Jun 2011
- views: 17223
1:03:38
Bruno Goud - The RAB6 GTPase, a master regulator of post-Golgi trafficking pathways
The members of the RAB GTPase family (less than 60 proteins in man) are master regulators of intracellular transport and membrane trafficking in eukaryotic cell...
The members of the RAB GTPase family (less than 60 proteins in man) are master regulators of intracellular transport and membrane trafficking in eukaryotic cells. RAB6 is one of the five ancestral RAB genes conserved from yeast to human. The RAB6 family comprises four proteins, named RAB6A, RAB6A’, RAB6B and RAB6C. The two ubiquitously expressed isoforms, RAB6A and A, are generated by alternative splicing of the same gene and localize to the Golgi complex. We and others have established that RAB6 regulates several transport pathways at the level of this organelle.
Our recent work has focused on several aspects of RAB6 function:
-The mechanisms involved in the fission of RAB6-positive transport carriers from Golgi/TGN (Trans-Golgi Network) membranes. We have previously shown that RAB6-Myosin IIA interaction is critical for this process [1].
Recently, we showed that the kinesin protein KIF20A is also involved in the fission process and serves to anchor RAB6 on Golgi/TGN membranes near microtubule (MT) nucleating sites. Our results suggest that the coupling between actin and MT cytoskeletons driven by Myosin II and KIF20A ensures the spatial coordination between the fission of RAB6-positive
vesicles from Golgi/TGN membranes and their exit along microtubules [2].
- The role of RAB6 in post-Golgi transport. Using the RUSH system
[3] and a variety of secretory cargos, including GPI-anchored proteins, TNF-alpha and Collagen-X, we found that RAB6 associates with post-Golgi vesicles containing all of these cargos. Depletion of RAB6 inhibits their arrival at the plasma membrane. These results suggest that RAB6 could be a general regulator of post-Golgi vesicles, possibly targeting secretory vesicles to defined exocytic sites on the cell surface [4].
-The role of RAB6 in cell lineages and tissues. We have generated mice with a conditional null allele of RAB6A [5]. The mice, which do not express RAB6A and RAB6A’, die at an early stage of
embryonic development (day 5.5), indicating that RAB6A is an essential gene. The phenotype of RAB6A-/- embryos is very similar tothat of beta-1 integrin null embryos. This result is consistent with the finding that a pool of inactive integrins follows the retrograde pathway regulated by RAB6 and that this pathway is critical for adhesion and persistent cell migration [6].
The RAB6 k/o mice were crossed with several mouse lines to deplete RAB6 in various tissues or cell lineages. We will present data illustrating that RAB6 fulfills different functions depending on the cell or tissue context.
References
1. Miserey-Lenkei et al. Nat. Cell Biol. 12, 645 (2010).
2. Miserey-Lenkei et al. Nat Commun. 8, 1254 (2017).
3. Boncompain et al. Nat. Methods 9, 493 (2012).
4. Miserey-Lenkei et al. submitted for publication.
5. Bardin et al. Biol. Cell 107, 427 (2015).
6. Shafaq-Zadah, Gomes-Santos, et al. Nat. Cell Biol. 18, 54 (2015).
https://wn.com/Bruno_Goud_The_Rab6_Gtpase,_A_Master_Regulator_Of_Post_Golgi_Trafficking_Pathways
The members of the RAB GTPase family (less than 60 proteins in man) are master regulators of intracellular transport and membrane trafficking in eukaryotic cells. RAB6 is one of the five ancestral RAB genes conserved from yeast to human. The RAB6 family comprises four proteins, named RAB6A, RAB6A’, RAB6B and RAB6C. The two ubiquitously expressed isoforms, RAB6A and A, are generated by alternative splicing of the same gene and localize to the Golgi complex. We and others have established that RAB6 regulates several transport pathways at the level of this organelle.
Our recent work has focused on several aspects of RAB6 function:
-The mechanisms involved in the fission of RAB6-positive transport carriers from Golgi/TGN (Trans-Golgi Network) membranes. We have previously shown that RAB6-Myosin IIA interaction is critical for this process [1].
Recently, we showed that the kinesin protein KIF20A is also involved in the fission process and serves to anchor RAB6 on Golgi/TGN membranes near microtubule (MT) nucleating sites. Our results suggest that the coupling between actin and MT cytoskeletons driven by Myosin II and KIF20A ensures the spatial coordination between the fission of RAB6-positive
vesicles from Golgi/TGN membranes and their exit along microtubules [2].
- The role of RAB6 in post-Golgi transport. Using the RUSH system
[3] and a variety of secretory cargos, including GPI-anchored proteins, TNF-alpha and Collagen-X, we found that RAB6 associates with post-Golgi vesicles containing all of these cargos. Depletion of RAB6 inhibits their arrival at the plasma membrane. These results suggest that RAB6 could be a general regulator of post-Golgi vesicles, possibly targeting secretory vesicles to defined exocytic sites on the cell surface [4].
-The role of RAB6 in cell lineages and tissues. We have generated mice with a conditional null allele of RAB6A [5]. The mice, which do not express RAB6A and RAB6A’, die at an early stage of
embryonic development (day 5.5), indicating that RAB6A is an essential gene. The phenotype of RAB6A-/- embryos is very similar tothat of beta-1 integrin null embryos. This result is consistent with the finding that a pool of inactive integrins follows the retrograde pathway regulated by RAB6 and that this pathway is critical for adhesion and persistent cell migration [6].
The RAB6 k/o mice were crossed with several mouse lines to deplete RAB6 in various tissues or cell lineages. We will present data illustrating that RAB6 fulfills different functions depending on the cell or tissue context.
References
1. Miserey-Lenkei et al. Nat. Cell Biol. 12, 645 (2010).
2. Miserey-Lenkei et al. Nat Commun. 8, 1254 (2017).
3. Boncompain et al. Nat. Methods 9, 493 (2012).
4. Miserey-Lenkei et al. submitted for publication.
5. Bardin et al. Biol. Cell 107, 427 (2015).
6. Shafaq-Zadah, Gomes-Santos, et al. Nat. Cell Biol. 18, 54 (2015).
- published: 26 Mar 2018
- views: 444
0:10
Conformational Change from active (GTP bound) to inactive (GDP bound) state of H-Ras protein.
Watch in 480p for best quality.
Ras are a group of small GTPases which are activated by binding of GTP( Guanosine tri phosphate) a process which is facilated by...
Watch in 480p for best quality.
Ras are a group of small GTPases which are activated by binding of GTP( Guanosine tri phosphate) a process which is facilated by GEF (Guanine nucleotide exchange factor) protein. The Ras which then activates its cellular target for conveying the signal downstream then hydrolyses the bound GTP ( process stimulated by another protein GAP (GTPase Activating Protein) to GDP which the dissociates and the protein returns to its inactive conformation.
https://wn.com/Conformational_Change_From_Active_(Gtp_Bound)_To_Inactive_(Gdp_Bound)_State_Of_H_Ras_Protein.
Watch in 480p for best quality.
Ras are a group of small GTPases which are activated by binding of GTP( Guanosine tri phosphate) a process which is facilated by GEF (Guanine nucleotide exchange factor) protein. The Ras which then activates its cellular target for conveying the signal downstream then hydrolyses the bound GTP ( process stimulated by another protein GAP (GTPase Activating Protein) to GDP which the dissociates and the protein returns to its inactive conformation.
- published: 14 May 2013
- views: 6649
4:00
Rab delivery to a membrane
In this video we have discussed about the delivery of Rab to a membrane
In this video we have discussed about the delivery of Rab to a membrane
https://wn.com/Rab_Delivery_To_A_Membrane
In this video we have discussed about the delivery of Rab to a membrane
- published: 10 Sep 2021
- views: 362
0:09
Dramatic conformational changes in Rap proteins
Look at how huge conformational changes a protein can undergo. This is first example of regulation of protein function by a dramatic conformational change that...
Look at how huge conformational changes a protein can undergo. This is first example of regulation of protein function by a dramatic conformational change that involves expansion of repeat domain in the protein. This video shows Rap proteins in their unbound (apo), target protein bound, and regulatory peptide bound states. Rap proteins regulate bacterial development in response to cell-cell communication signals. For more information read my research article at http://www.plosbiology.org/article/info%3Adoi%2F10.1371%2Fjournal.pbio.1001512
https://wn.com/Dramatic_Conformational_Changes_In_Rap_Proteins
Look at how huge conformational changes a protein can undergo. This is first example of regulation of protein function by a dramatic conformational change that involves expansion of repeat domain in the protein. This video shows Rap proteins in their unbound (apo), target protein bound, and regulatory peptide bound states. Rap proteins regulate bacterial development in response to cell-cell communication signals. For more information read my research article at http://www.plosbiology.org/article/info%3Adoi%2F10.1371%2Fjournal.pbio.1001512
- published: 20 Mar 2013
- views: 1942
2:05
Menacing Mutations: Examining the Role of the RAS Oncogene in Cancer Development
Winner of the Judge’s Award Second Place in the 2022 RCSB PDB Video Challenge for High School Students “Molecular Mechanisms of Cancer”
By Xinyi Zhang
South Br...
Winner of the Judge’s Award Second Place in the 2022 RCSB PDB Video Challenge for High School Students “Molecular Mechanisms of Cancer”
By Xinyi Zhang
South Brunswick High School, NJ
Team Advisor: Mrs. Dana Armstrong
https://wn.com/Menacing_Mutations_Examining_The_Role_Of_The_Ras_Oncogene_In_Cancer_Development
Winner of the Judge’s Award Second Place in the 2022 RCSB PDB Video Challenge for High School Students “Molecular Mechanisms of Cancer”
By Xinyi Zhang
South Brunswick High School, NJ
Team Advisor: Mrs. Dana Armstrong
- published: 17 May 2022
- views: 4974
1:02:26
Keynote Presentation: Interplay between LRRK2 protein kinase and Rab GTPases in Parkinson's disease
Presented By: Dario Alessi, FRS FMedSci FRSE
Speaker Biography: Dario's research focuses on unravelling the roles of poorly characterised components which regu...
Presented By: Dario Alessi, FRS FMedSci FRSE
Speaker Biography: Dario's research focuses on unravelling the roles of poorly characterised components which regulate protein phosphorylation or ubiquitylation pathways that are linked to human disease. Dario, obtained a BSc (1988) and PhD (1991) from the University of Birmingham, United Kingdom.
Webinar: Keynote Presentation: Interplay between LRRK2 protein kinase and Rab GTPases in Parkinson's disease
Webinar Abstract: I will discuss the identification and characterization of a novel PPM family phosphatase member that counteracts LRRK2 signalling by dephosphorylating Rab proteins. I will present data that indicates that the LRRK2 parlog termed LRRK1 also functions as a Rab kinase. Finally, I will discuss what is known about how LRRK2 regulates ciliogenesis, the endosomal-lysosome system, and immune responses and how this might be linked to Parkinson’s disease.
Earn PACE Credits:
1. Make sure you’re a registered member of LabRoots (www.labroots.com)
2. Watch the webinar on YouTube or on the LabRoots Website (https://www.labroots.com/virtual-event/neuroscience-2020/agenda)
3. Click Here to get your PACE credits (Expiration date –3/11/2022): https://www.labroots.com/credit/pace-credits/3758/cert
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https://wn.com/Keynote_Presentation_Interplay_Between_Lrrk2_Protein_Kinase_And_Rab_Gtpases_In_Parkinson's_Disease
Presented By: Dario Alessi, FRS FMedSci FRSE
Speaker Biography: Dario's research focuses on unravelling the roles of poorly characterised components which regulate protein phosphorylation or ubiquitylation pathways that are linked to human disease. Dario, obtained a BSc (1988) and PhD (1991) from the University of Birmingham, United Kingdom.
Webinar: Keynote Presentation: Interplay between LRRK2 protein kinase and Rab GTPases in Parkinson's disease
Webinar Abstract: I will discuss the identification and characterization of a novel PPM family phosphatase member that counteracts LRRK2 signalling by dephosphorylating Rab proteins. I will present data that indicates that the LRRK2 parlog termed LRRK1 also functions as a Rab kinase. Finally, I will discuss what is known about how LRRK2 regulates ciliogenesis, the endosomal-lysosome system, and immune responses and how this might be linked to Parkinson’s disease.
Earn PACE Credits:
1. Make sure you’re a registered member of LabRoots (www.labroots.com)
2. Watch the webinar on YouTube or on the LabRoots Website (https://www.labroots.com/virtual-event/neuroscience-2020/agenda)
3. Click Here to get your PACE credits (Expiration date –3/11/2022): https://www.labroots.com/credit/pace-credits/3758/cert
LabRoots on Social:
Facebook: https://www.facebook.com/LabRootsInc
Twitter: https://twitter.com/LabRoots
LinkedIn: https://www.linkedin.com/company/labroots
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SnapChat: labroots_inc
- published: 24 Mar 2020
- views: 2078
10:26
Raf part 1 - regulation and function
This videos introduces the Raf kinase, how it is regulated by RasGTP, and the effect of Raf on its substrate Mek.
This videos introduces the Raf kinase, how it is regulated by RasGTP, and the effect of Raf on its substrate Mek.
https://wn.com/Raf_Part_1_Regulation_And_Function
This videos introduces the Raf kinase, how it is regulated by RasGTP, and the effect of Raf on its substrate Mek.
- published: 29 Sep 2020
- views: 600