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Friday, 15 November 2024

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Polycythemia vera

Polycythemia (or Polycythaemia, see spelling differences) vera (PV, PCV) (also known as erythremia, primary polycythemia, Vaquez disease, Osler-Vaquez disease and polycythemia rubra vera) is a neoplasm in which the bone marrow makes too many red blood cells. It may also result in the overproduction of white blood cells and platelets.

Most of the health concerns associated with polycythemia vera are caused by the blood being thicker as a result of the increased red blood cells. It is more common in the elderly and may be symptomatic or asymptomatic. Common signs and symptoms include itching (pruritus), and severe burning pain in the hands or feet that is usually accompanied by a reddish or bluish coloration of the skin. Patients with polycythemia vera are more likely to have gouty arthritis. Treatment consists primarily of phlebotomy.

Signs and symptoms

Patients with polycythemia vera can be asymptomatic. A classic symptom of polycythemia vera is pruritus or itching, particularly after exposure to warm water (such as when taking a bath), which may be due to abnormal histamine release or prostaglandin production. Such itching is present in approximately 40% of patients with polycythemia vera.Gouty arthritis may be present in up to 20% of patients.Peptic ulcer disease is also common in patients with polycythemia vera; most likely due to increased histamine from mast cells, but may be related to an increased susceptibility to infection with the ulcer-causing bacterium H. pylori. Another possible mechanism for the development for peptic ulcer is increased histamine release and gastric hyperacidity related with polycythemia vera.

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Latest News for: polycythemia vera

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Protagonist Reports Third Quarter 2024 Financial Results and Provides Corporate Update

ACCESSWIRE 07 Nov 2024

Subcutaneous Injectable Hepcidin Mimetic for Polycythemia Vera (PV) The top line data for the Phase 3 VERIFY study 1 in polycythemia vera, which has a 32-week primary efficacy endpoint, is expected in Q1 2025.

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Rusfertide, a mimetic of the natural hormone hepcidin, is the Company's lead drug candidate currently in a global Phase 3 development program for polycythemia vera (PV) ... in polycythemia vera.

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Protagonist Reports Second Quarter 2024 Financial Results and Provides Corporate Update

ACCESSWIRE 06 Aug 2024

"We presented updated long-term data from the REVIVE Phase 2 trial at EHA that reaffirms rusfertide's durability of positive response in polycythemia vera, and we look forward to the Phase 3 VERIFY 32-week primary endpoint readout in Q1 2025.

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Preclinical and Clinical Pharmacokinetic, Pharmacodynamic, and Safety Data of Targeted Oral Peptide JNJ-2113 Published in ...

ACCESSWIRE 01 Aug 2024

Rusfertide, a mimetic of the natural hormone hepcidin, is the Company's lead drug candidate currently in a global Phase 3 development program for polycythemia vera (PV) ... in polycythemia vera.

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RETRANSMISSION: Preclinical and Clinical Pharmacokinetic, Pharmacodynamic, and Safety Data of Targeted Oral Peptide JNJ-2113 Published ...

ACCESSWIRE 01 Aug 2024

Rusfertide, a mimetic of the natural hormone hepcidin, is the Company's lead drug candidate currently in a global Phase 3 development program for polycythemia vera (PV) ... in polycythemia vera.

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Preclinical and Clinical Pharmacokinetic, Pharmacodynamic, and Safety Data of Targeted Oral Peptide JNJ-2113 Published in Scientific Reports

Pharmiweb 01 Aug 2024

Rusfertide, a mimetic of the natural hormone hepcidin, is the Company's lead drug candidate currently in a global Phase 3 development program for polycythemia vera (PV) ... in polycythemia vera.

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RETRANSMISSION: Preclinical and Clinical Pharmacokinetic, Pharmacodynamic, and Safety Data of Targeted Oral Peptide JNJ-2113 Published in Scientific Reports

Pharmiweb 01 Aug 2024

Rusfertide, a mimetic of the natural hormone hepcidin, is the Company's lead drug candidate currently in a global Phase 3 development program for polycythemia vera (PV) ... in polycythemia vera.

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Protagonist Announces Appointment of Newman Yeilding, M.D. as Chief Scientific Advisor

ACCESSWIRE 31 Jul 2024

Rusfertide, a mimetic of the natural hormone hepcidin, is the Company's lead drug candidate currently in a global Phase 3 development program for polycythemia vera (PV) ... in polycythemia vera.

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