- published: 17 Jan 2018
- views: 6491
KCNJ8
Potassium inwardly-rectifying channel, subfamily J, member 8, also known as KCNJ8, is a human gene encoding the Kir6.1 protein. A mutation in KCNJ8 has been associated with cardiac arrest in the early repolarization syndrome.
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. Kir6.1 is an integral membrane protein and inward-rectifier type potassium channel. Kir6.1, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins.
See also
References
Further reading
External links
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
This page contains text from Wikipedia, the Free Encyclopedia - https://wn.com/KCNJ8
Podcasts:
-
Frances Ashcroft (Oxford) 2: ATP-sensitive potassium channels & neonatal diabetes
https://www.ibiology.org/human-disease/neonatal-diabetes/#part-2 Frances Ashcroft and her colleagues have identified mutations in a potassium channel as the cause of neonatal diabetes. Their discovery vastly improved treatment for patients. Talk Overview: Diabetes is a devastating disease which takes an enormous toll on both human life and healthcare spending worldwide. Dr. Frances Ashcroft begins her talk by explaining that blood glucose must be controlled within narrow limits. In a healthy person, insulin is released from the pancreatic beta cells in response to a rise in blood sugar, which stimulates the uptake of glucose into muscle, liver and fat and so restores the blood glucose to its resting level. Diabetes occurs when the beta cells do not release enough insulin, resulting in ...
published: 17 Jan 2018 -
ذباحو الحياة .. الحلقة 3 - 2018/3/6
يمكنكم متابعتنا على الموقع الرسمي: http://www.alforatnews.com يمكنكم متابعتنا على مواقع التواصل الإجتماعي: Facebook: http://facebook.com/alforattv.net Telegram: http://telegram.me/alforat_tv Instagram: http://instagram.com/alforat_tv Twitter: http://twitter.com/alforat_news تردد الفرات HD: القمر: نايل سات - التردد: 11137 - الاستقطاب: افقي H - معدل الترميز: 27500 تردد الفرات SD: القمر: نايل سات - التردد: 11747 - الاستقطاب: عمودي V - معدل الترميز: 27500
published: 06 Mar 2018 -
danalvaro.WMV
akin to noh
published: 18 Jul 2010 -
ANTIDIABETICI parte 1
published: 22 Feb 2017 -
Kırmızı Oda | 6. Bölüm | "DUY SESİMİ"
Kırmızı Oda 6. Bölüm Kırmızı Oda’nın altıncı bölümünde; annesi bir düğün konvoyundaki kurşun ile vurulup ölmüş ve yetiştirme yurduna yerleştirilmiş Osman’ın hayatı Dr. Ayşe’yi derinden etkiler. Doktor Hanım, Alya’yı (Melisa Sözen) konuşturabilmek için geçmişini çağrıştıracak yeni hikayeler anlatır. Dr. Piraye, Ahmet’in (Emre Kınay) yaşadığı suçluluk duygusunun kaynağını bulmaya çalışır, yaşama inancını giderek kaybeden Meliha ise (Evrim Alasya) Doktor Hanım’la hayati bir konuşma yapar. Kırmızı Oda da başrol oyuncusu Binnur Kaya psikiyatri kliniğinin sahibi ve bir psikiyatristi canlandıracak. Psikiyatri kliniğinde doktorlarını ve onlara başvuran hastaların hayatlarını anlatacağı "Kırmızı Oda"da her hayat hikayesinin altında yatan acılar, sevinçler, mutluluk ve hüzünler izleyicinin de ruh...
published: 09 Oct 2020 -
Gs/Gq signaling switch in β cells underlies the potential of incretins in diabetes
In this episode, Susumu Seino and Okechi S. Oduori explain how persistent depolarization of β-cells leads to Gs to Gq signaling switch, explaining the differential effects of GLP-1 and GIP on insulin secretion in diabetes.
published: 16 Nov 2020 -
dkNET Webinar: Illuminating The Druggable Genome With Pharos 10/23/2020
Pharos is an integrated web-based informatics platform for the analysis of data aggregated by the Illuminating the Druggable Genome (IDG) Knowledge Management Center, an NIH Common Fund initiative. The current version of Pharos (as of October 2019) spans 20,244 proteins in the human proteome, 19,880 disease and phenotype associations, and 226,829 ChEMBL compounds. This resource not only collates and analyzes data from over 60 high-quality resources to generate these types, but also uses text indexing to find less apparent connections between targets, and has recently begun to collaborate with institutions that generate data and resources. Proteins are ranked according to a knowledge-based classification system, which can help researchers to identify less studied “dark” targets that could b...
published: 30 Oct 2020
developed with YouTube
29:28
Frances Ashcroft (Oxford) 2: ATP-sensitive potassium channels & neonatal diabetes
- Order: Reorder
- Duration: 29:28
- Uploaded Date: 17 Jan 2018
- views: 6491
https://www.ibiology.org/human-disease/neonatal-diabetes/#part-2
Frances Ashcroft and her colleagues have identified mutations in a potassium channel as the ca...
https://www.ibiology.org/human-disease/neonatal-diabetes/#part-2
Frances Ashcroft and her colleagues have identified mutations in a potassium channel as the cause of neonatal diabetes. Their discovery vastly improved treatment for patients.
Talk Overview:
Diabetes is a devastating disease which takes an enormous toll on both human life and healthcare spending worldwide. Dr. Frances Ashcroft begins her talk by explaining that blood glucose must be controlled within narrow limits. In a healthy person, insulin is released from the pancreatic beta cells in response to a rise in blood sugar, which stimulates the uptake of glucose into muscle, liver and fat and so restores the blood glucose to its resting level. Diabetes occurs when the beta cells do not release enough insulin, resulting in chronically high blood sugar levels. There are several types of diabetes: type 1 occurs because the beta cells are damaged by autoimmune attack; type 2, the most common form, is usually due to a combination of insulin resistance and decreased insulin secretion and is exacerbated by obesity and age; monogenic diabetes results from a mutation in a single gene. Neonatal diabetes is a rare monogenic form of diabetes that presents at, or shortly after, birth. Ashcroft explains that in 1984, she and her colleagues found that the function of an ATP-sensitive potassium channel (KATP channel) in the plasma membrane of pancreatic beta cells is critical for linking increased blood glucose levels to insulin secretion. They postulated that a mutation that caused the KATP channel to be permanently open would impair insulin release. Twenty years later, these mutations were identified and shown to be the cause of neonatal diabetes.
In her second lecture, Ashcroft expands on what is known about the KATP channel and its role in insulin secretion. It is an octomeric complex composed of 4 Kir6.2 subunits and 4 SUR1 subunits. ATP binds to both proteins, and changes in metabolically generated ATP couple metabolism to KATP channel activity. Functional studies showed that the KATP channel mutations found in neonatal diabetes impair the ability of ATP to close the channel and stimulate insulin release. This suggested that drugs that could directly close the KATP channel would stimulate insulin release and might be a good therapy for neonatal diabetes. Sulfonylurea drugs were already known to directly close the KATP channel and have been safely used to treat type 2 diabetes for many years. Based on this knowledge, many patients with neonatal diabetes have now switched from insulin injections to oral sulfonylurea drugs. This has resulted in much better glucose control. Ashcroft goes on to explain how insights from studying neonatal diabetes have also led to a better understanding of the impact of chronic hyperglycemia in type 2 diabetes.
Speaker Biography:
Professor Dame Frances Ashcroft is the GlaxoSmithKline Royal Society Research Professor in the Department of Physiology, Anatomy and Genetics, and a Fellow of Trinity College, at the University of Oxford.
Ashcroft received her BA and PhD degrees from Cambridge University and was a post-doctoral fellow at Leicester University and the University of California, Los Angeles. When she set up her own lab at Oxford, Ashcroft began to study how a rise in blood sugar levels leads to the release of insulin from the pancreatic beta cells, and what goes wrong with this process in diabetes. Ashcroft’s more recent research has focused on neonatal diabetes, a rare genetic form of the disease that typically develops soon after birth. Together with her colleagues, she has shown that mutations in an ATP-sensitive potassium channel in the plasma membrane are responsible for this disease. Understanding the mechanism of action of this potassium channel has allowed many patients to switch from insulin injections to oral drug therapy. In addition, insights gained from the study of neonatal diabetes have implications for the understanding and treatment of type 2 diabetes, a much more common disease.
Ashcroft was elected a Fellow of the Royal Society in 1999 and in 2012 she was the European Laureate for the L’Oréal-UNESCO Women in Science Award. Learn more about Ashcroft’s research here:
https://www.dpag.ox.ac.uk/team/frances-ashcroft
https://wn.com/Frances_Ashcroft_(Oxford)_2_Atp_Sensitive_Potassium_Channels_Neonatal_Diabetes
https://www.ibiology.org/human-disease/neonatal-diabetes/#part-2
Frances Ashcroft and her colleagues have identified mutations in a potassium channel as the cause of neonatal diabetes. Their discovery vastly improved treatment for patients.
Talk Overview:
Diabetes is a devastating disease which takes an enormous toll on both human life and healthcare spending worldwide. Dr. Frances Ashcroft begins her talk by explaining that blood glucose must be controlled within narrow limits. In a healthy person, insulin is released from the pancreatic beta cells in response to a rise in blood sugar, which stimulates the uptake of glucose into muscle, liver and fat and so restores the blood glucose to its resting level. Diabetes occurs when the beta cells do not release enough insulin, resulting in chronically high blood sugar levels. There are several types of diabetes: type 1 occurs because the beta cells are damaged by autoimmune attack; type 2, the most common form, is usually due to a combination of insulin resistance and decreased insulin secretion and is exacerbated by obesity and age; monogenic diabetes results from a mutation in a single gene. Neonatal diabetes is a rare monogenic form of diabetes that presents at, or shortly after, birth. Ashcroft explains that in 1984, she and her colleagues found that the function of an ATP-sensitive potassium channel (KATP channel) in the plasma membrane of pancreatic beta cells is critical for linking increased blood glucose levels to insulin secretion. They postulated that a mutation that caused the KATP channel to be permanently open would impair insulin release. Twenty years later, these mutations were identified and shown to be the cause of neonatal diabetes.
In her second lecture, Ashcroft expands on what is known about the KATP channel and its role in insulin secretion. It is an octomeric complex composed of 4 Kir6.2 subunits and 4 SUR1 subunits. ATP binds to both proteins, and changes in metabolically generated ATP couple metabolism to KATP channel activity. Functional studies showed that the KATP channel mutations found in neonatal diabetes impair the ability of ATP to close the channel and stimulate insulin release. This suggested that drugs that could directly close the KATP channel would stimulate insulin release and might be a good therapy for neonatal diabetes. Sulfonylurea drugs were already known to directly close the KATP channel and have been safely used to treat type 2 diabetes for many years. Based on this knowledge, many patients with neonatal diabetes have now switched from insulin injections to oral sulfonylurea drugs. This has resulted in much better glucose control. Ashcroft goes on to explain how insights from studying neonatal diabetes have also led to a better understanding of the impact of chronic hyperglycemia in type 2 diabetes.
Speaker Biography:
Professor Dame Frances Ashcroft is the GlaxoSmithKline Royal Society Research Professor in the Department of Physiology, Anatomy and Genetics, and a Fellow of Trinity College, at the University of Oxford.
Ashcroft received her BA and PhD degrees from Cambridge University and was a post-doctoral fellow at Leicester University and the University of California, Los Angeles. When she set up her own lab at Oxford, Ashcroft began to study how a rise in blood sugar levels leads to the release of insulin from the pancreatic beta cells, and what goes wrong with this process in diabetes. Ashcroft’s more recent research has focused on neonatal diabetes, a rare genetic form of the disease that typically develops soon after birth. Together with her colleagues, she has shown that mutations in an ATP-sensitive potassium channel in the plasma membrane are responsible for this disease. Understanding the mechanism of action of this potassium channel has allowed many patients to switch from insulin injections to oral drug therapy. In addition, insights gained from the study of neonatal diabetes have implications for the understanding and treatment of type 2 diabetes, a much more common disease.
Ashcroft was elected a Fellow of the Royal Society in 1999 and in 2012 she was the European Laureate for the L’Oréal-UNESCO Women in Science Award. Learn more about Ashcroft’s research here:
https://www.dpag.ox.ac.uk/team/frances-ashcroft
19:58
ذباحو الحياة .. الحلقة 3 - 2018/3/6
- Order: Reorder
- Duration: 19:58
- Uploaded Date: 06 Mar 2018
- views: 258632
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تردد الفرات HD: القمر: نايل سات - التردد: 11137 - الاستقطاب: افقي H - معدل الترميز: 27500
تردد الفرات SD: القمر: نايل سات - التردد: 11747 - الاستقطاب: عمودي V - معدل الترميز: 27500
https://wn.com/ذباحو_الحياة_.._الحلقة_3_2018_3_6
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تردد الفرات HD: القمر: نايل سات - التردد: 11137 - الاستقطاب: افقي H - معدل الترميز: 27500
تردد الفرات SD: القمر: نايل سات - التردد: 11747 - الاستقطاب: عمودي V - معدل الترميز: 27500
- published: 06 Mar 2018
- views: 258632
6:26
danalvaro.WMV
- Order: Reorder
- Duration: 6:26
- Uploaded Date: 18 Jul 2010
- views: 43
akin to noh
akin to noh
https://wn.com/Danalvaro.Wmv
akin to noh
- published: 18 Jul 2010
- views: 43
21:52
ANTIDIABETICI parte 1
- Order: Reorder
- Duration: 21:52
- Uploaded Date: 22 Feb 2017
- views: 2054
- published: 22 Feb 2017
- views: 2054
2:06:43
Kırmızı Oda | 6. Bölüm | "DUY SESİMİ"
- Order: Reorder
- Duration: 2:06:43
- Uploaded Date: 09 Oct 2020
- views: 6759855
Kırmızı Oda 6. Bölüm
Kırmızı Oda’nın altıncı bölümünde; annesi bir düğün konvoyundaki kurşun ile vurulup ölmüş ve yetiştirme yurduna yerleştirilmiş Osman’ın h...
Kırmızı Oda 6. Bölüm
Kırmızı Oda’nın altıncı bölümünde; annesi bir düğün konvoyundaki kurşun ile vurulup ölmüş ve yetiştirme yurduna yerleştirilmiş Osman’ın hayatı Dr. Ayşe’yi derinden etkiler. Doktor Hanım, Alya’yı (Melisa Sözen) konuşturabilmek için geçmişini çağrıştıracak yeni hikayeler anlatır. Dr. Piraye, Ahmet’in (Emre Kınay) yaşadığı suçluluk duygusunun kaynağını bulmaya çalışır, yaşama inancını giderek kaybeden Meliha ise (Evrim Alasya) Doktor Hanım’la hayati bir konuşma yapar.
Kırmızı Oda da başrol oyuncusu Binnur Kaya psikiyatri kliniğinin sahibi ve bir psikiyatristi canlandıracak. Psikiyatri kliniğinde doktorlarını ve onlara başvuran hastaların hayatlarını anlatacağı "Kırmızı Oda"da her hayat hikayesinin altında yatan acılar, sevinçler, mutluluk ve hüzünler izleyicinin de ruhunun kapalı kapılarını aralayacak. Hastalar o Güne kadar kimselere söyleyemedikleri sırları dile getirirken izleyiciler de kendi bugünleri, geçmişleri ve yarınlarına dair bir şeyler bulacak.
KIRMIZI ODA OYUNCULARI
Binnur Kaya
Tülin Özen
Burak Sevinç
Meriç Aral
Halit Özgür Sarı
Gülçin Kültür Şahin
Sezin Bozacı
Baran Can Eraslan
İnstagram : https://www.instagram.com/kirmizioda.dizi/
Facebook: https://bit.ly/33gNq65
#KırmızıOda #BinnurKaya #Tv8 #OGM
https://wn.com/Kırmızı_Oda_|_6._Bölüm_|_Duy_Sesimi
Kırmızı Oda 6. Bölüm
Kırmızı Oda’nın altıncı bölümünde; annesi bir düğün konvoyundaki kurşun ile vurulup ölmüş ve yetiştirme yurduna yerleştirilmiş Osman’ın hayatı Dr. Ayşe’yi derinden etkiler. Doktor Hanım, Alya’yı (Melisa Sözen) konuşturabilmek için geçmişini çağrıştıracak yeni hikayeler anlatır. Dr. Piraye, Ahmet’in (Emre Kınay) yaşadığı suçluluk duygusunun kaynağını bulmaya çalışır, yaşama inancını giderek kaybeden Meliha ise (Evrim Alasya) Doktor Hanım’la hayati bir konuşma yapar.
Kırmızı Oda da başrol oyuncusu Binnur Kaya psikiyatri kliniğinin sahibi ve bir psikiyatristi canlandıracak. Psikiyatri kliniğinde doktorlarını ve onlara başvuran hastaların hayatlarını anlatacağı "Kırmızı Oda"da her hayat hikayesinin altında yatan acılar, sevinçler, mutluluk ve hüzünler izleyicinin de ruhunun kapalı kapılarını aralayacak. Hastalar o Güne kadar kimselere söyleyemedikleri sırları dile getirirken izleyiciler de kendi bugünleri, geçmişleri ve yarınlarına dair bir şeyler bulacak.
KIRMIZI ODA OYUNCULARI
Binnur Kaya
Tülin Özen
Burak Sevinç
Meriç Aral
Halit Özgür Sarı
Gülçin Kültür Şahin
Sezin Bozacı
Baran Can Eraslan
İnstagram : https://www.instagram.com/kirmizioda.dizi/
Facebook: https://bit.ly/33gNq65
#KırmızıOda #BinnurKaya #Tv8 #OGM
- published: 09 Oct 2020
- views: 6759855
7:17
Gs/Gq signaling switch in β cells underlies the potential of incretins in diabetes
- Order: Reorder
- Duration: 7:17
- Uploaded Date: 16 Nov 2020
- views: 1764
In this episode, Susumu Seino and Okechi S. Oduori explain how persistent depolarization of β-cells leads to Gs to Gq signaling switch, explaining the different...
In this episode, Susumu Seino and Okechi S. Oduori explain how persistent depolarization of β-cells leads to Gs to Gq signaling switch, explaining the differential effects of GLP-1 and GIP on insulin secretion in diabetes.
https://wn.com/Gs_Gq_Signaling_Switch_In_Β_Cells_Underlies_The_Potential_Of_Incretins_In_Diabetes
In this episode, Susumu Seino and Okechi S. Oduori explain how persistent depolarization of β-cells leads to Gs to Gq signaling switch, explaining the differential effects of GLP-1 and GIP on insulin secretion in diabetes.
- published: 16 Nov 2020
- views: 1764
52:33
dkNET Webinar: Illuminating The Druggable Genome With Pharos 10/23/2020
- Order: Reorder
- Duration: 52:33
- Uploaded Date: 30 Oct 2020
- views: 185
Pharos is an integrated web-based informatics platform for the analysis of data aggregated by the Illuminating the Druggable Genome (IDG) Knowledge Management C...
Pharos is an integrated web-based informatics platform for the analysis of data aggregated by the Illuminating the Druggable Genome (IDG) Knowledge Management Center, an NIH Common Fund initiative. The current version of Pharos (as of October 2019) spans 20,244 proteins in the human proteome, 19,880 disease and phenotype associations, and 226,829 ChEMBL compounds. This resource not only collates and analyzes data from over 60 high-quality resources to generate these types, but also uses text indexing to find less apparent connections between targets, and has recently begun to collaborate with institutions that generate data and resources. Proteins are ranked according to a knowledge-based classification system, which can help researchers to identify less studied “dark” targets that could be potentially further illuminated. This is an important process for both drug discovery and target validation, as more knowledge can accelerate target identification, and previously understudied proteins can serve as novel targets in drug discovery. In this webinar, Dr. Tudor Oprea will introduce how to use Pharos to find targets of interest for drug discovery.
The top 3 key questions that Pharos can answer:
1. What are the novel drug targets that may play a role in a specific disease?
2. What are the diseases that are related directly or indirectly to a drug target?
3. Find researchers that are related directly or indirectly to a drug target.
Presenter: Tudor Oprea, MD, PhD, Professor of Medicine, Chief of Translational Informatics Division & Internal Medicine, University of New Mexico
Upcoming webinars schedule: https://dknet.org/about/webinar
https://wn.com/Dknet_Webinar_Illuminating_The_Druggable_Genome_With_Pharos_10_23_2020
Pharos is an integrated web-based informatics platform for the analysis of data aggregated by the Illuminating the Druggable Genome (IDG) Knowledge Management Center, an NIH Common Fund initiative. The current version of Pharos (as of October 2019) spans 20,244 proteins in the human proteome, 19,880 disease and phenotype associations, and 226,829 ChEMBL compounds. This resource not only collates and analyzes data from over 60 high-quality resources to generate these types, but also uses text indexing to find less apparent connections between targets, and has recently begun to collaborate with institutions that generate data and resources. Proteins are ranked according to a knowledge-based classification system, which can help researchers to identify less studied “dark” targets that could be potentially further illuminated. This is an important process for both drug discovery and target validation, as more knowledge can accelerate target identification, and previously understudied proteins can serve as novel targets in drug discovery. In this webinar, Dr. Tudor Oprea will introduce how to use Pharos to find targets of interest for drug discovery.
The top 3 key questions that Pharos can answer:
1. What are the novel drug targets that may play a role in a specific disease?
2. What are the diseases that are related directly or indirectly to a drug target?
3. Find researchers that are related directly or indirectly to a drug target.
Presenter: Tudor Oprea, MD, PhD, Professor of Medicine, Chief of Translational Informatics Division & Internal Medicine, University of New Mexico
Upcoming webinars schedule: https://dknet.org/about/webinar
- published: 30 Oct 2020
- views: 185
29:28
Frances Ashcroft (Oxford) 2: ATP-sensitive potassium channels & neonatal diabetes
https://www.ibiology.org/human-disease/neonatal-diabetes/#part-2
Frances Ashcroft and her...
published: 17 Jan 2018
Frances Ashcroft (Oxford) 2: ATP-sensitive potassium channels & neonatal diabetes
Frances Ashcroft (Oxford) 2: ATP-sensitive potassium channels & neonatal diabetes
- Report rights infringement
- published: 17 Jan 2018
- views: 6491
https://www.ibiology.org/human-disease/neonatal-diabetes/#part-2
Frances Ashcroft and her colleagues have identified mutations in a potassium channel as the cause of neonatal diabetes. Their discovery vastly improved treatment for patients.
Talk Overview:
Diabetes is a devastating disease which takes an enormous toll on both human life and healthcare spending worldwide. Dr. Frances Ashcroft begins her talk by explaining that blood glucose must be controlled within narrow limits. In a healthy person, insulin is released from the pancreatic beta cells in response to a rise in blood sugar, which stimulates the uptake of glucose into muscle, liver and fat and so restores the blood glucose to its resting level. Diabetes occurs when the beta cells do not release enough insulin, resulting in chronically high blood sugar levels. There are several types of diabetes: type 1 occurs because the beta cells are damaged by autoimmune attack; type 2, the most common form, is usually due to a combination of insulin resistance and decreased insulin secretion and is exacerbated by obesity and age; monogenic diabetes results from a mutation in a single gene. Neonatal diabetes is a rare monogenic form of diabetes that presents at, or shortly after, birth. Ashcroft explains that in 1984, she and her colleagues found that the function of an ATP-sensitive potassium channel (KATP channel) in the plasma membrane of pancreatic beta cells is critical for linking increased blood glucose levels to insulin secretion. They postulated that a mutation that caused the KATP channel to be permanently open would impair insulin release. Twenty years later, these mutations were identified and shown to be the cause of neonatal diabetes.
In her second lecture, Ashcroft expands on what is known about the KATP channel and its role in insulin secretion. It is an octomeric complex composed of 4 Kir6.2 subunits and 4 SUR1 subunits. ATP binds to both proteins, and changes in metabolically generated ATP couple metabolism to KATP channel activity. Functional studies showed that the KATP channel mutations found in neonatal diabetes impair the ability of ATP to close the channel and stimulate insulin release. This suggested that drugs that could directly close the KATP channel would stimulate insulin release and might be a good therapy for neonatal diabetes. Sulfonylurea drugs were already known to directly close the KATP channel and have been safely used to treat type 2 diabetes for many years. Based on this knowledge, many patients with neonatal diabetes have now switched from insulin injections to oral sulfonylurea drugs. This has resulted in much better glucose control. Ashcroft goes on to explain how insights from studying neonatal diabetes have also led to a better understanding of the impact of chronic hyperglycemia in type 2 diabetes.
Speaker Biography:
Professor Dame Frances Ashcroft is the GlaxoSmithKline Royal Society Research Professor in the Department of Physiology, Anatomy and Genetics, and a Fellow of Trinity College, at the University of Oxford.
Ashcroft received her BA and PhD degrees from Cambridge University and was a post-doctoral fellow at Leicester University and the University of California, Los Angeles. When she set up her own lab at Oxford, Ashcroft began to study how a rise in blood sugar levels leads to the release of insulin from the pancreatic beta cells, and what goes wrong with this process in diabetes. Ashcroft’s more recent research has focused on neonatal diabetes, a rare genetic form of the disease that typically develops soon after birth. Together with her colleagues, she has shown that mutations in an ATP-sensitive potassium channel in the plasma membrane are responsible for this disease. Understanding the mechanism of action of this potassium channel has allowed many patients to switch from insulin injections to oral drug therapy. In addition, insights gained from the study of neonatal diabetes have implications for the understanding and treatment of type 2 diabetes, a much more common disease.
Ashcroft was elected a Fellow of the Royal Society in 1999 and in 2012 she was the European Laureate for the L’Oréal-UNESCO Women in Science Award. Learn more about Ashcroft’s research here:
https://www.dpag.ox.ac.uk/team/frances-ashcroft
19:58
ذباحو الحياة .. الحلقة 3 - 2018/3/6
يمكنكم متابعتنا على الموقع الرسمي:
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يمكنكم متابعتنا على مواقع ال...
published: 06 Mar 2018
ذباحو الحياة .. الحلقة 3 - 2018/3/6
ذباحو الحياة .. الحلقة 3 - 2018/3/6
- Report rights infringement
- published: 06 Mar 2018
- views: 258632
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تردد الفرات HD: القمر: نايل سات - التردد: 11137 - الاستقطاب: افقي H - معدل الترميز: 27500
تردد الفرات SD: القمر: نايل سات - التردد: 11747 - الاستقطاب: عمودي V - معدل الترميز: 27500
2:06:43
Kırmızı Oda | 6. Bölüm | "DUY SESİMİ"
Kırmızı Oda 6. Bölüm
Kırmızı Oda’nın altıncı bölümünde; annesi bir düğün konvoyundaki ku...
published: 09 Oct 2020
Kırmızı Oda | 6. Bölüm | "DUY SESİMİ"
Kırmızı Oda | 6. Bölüm | "DUY SESİMİ"
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- published: 09 Oct 2020
- views: 6759855
Kırmızı Oda 6. Bölüm
Kırmızı Oda’nın altıncı bölümünde; annesi bir düğün konvoyundaki kurşun ile vurulup ölmüş ve yetiştirme yurduna yerleştirilmiş Osman’ın hayatı Dr. Ayşe’yi derinden etkiler. Doktor Hanım, Alya’yı (Melisa Sözen) konuşturabilmek için geçmişini çağrıştıracak yeni hikayeler anlatır. Dr. Piraye, Ahmet’in (Emre Kınay) yaşadığı suçluluk duygusunun kaynağını bulmaya çalışır, yaşama inancını giderek kaybeden Meliha ise (Evrim Alasya) Doktor Hanım’la hayati bir konuşma yapar.
Kırmızı Oda da başrol oyuncusu Binnur Kaya psikiyatri kliniğinin sahibi ve bir psikiyatristi canlandıracak. Psikiyatri kliniğinde doktorlarını ve onlara başvuran hastaların hayatlarını anlatacağı "Kırmızı Oda"da her hayat hikayesinin altında yatan acılar, sevinçler, mutluluk ve hüzünler izleyicinin de ruhunun kapalı kapılarını aralayacak. Hastalar o Güne kadar kimselere söyleyemedikleri sırları dile getirirken izleyiciler de kendi bugünleri, geçmişleri ve yarınlarına dair bir şeyler bulacak.
KIRMIZI ODA OYUNCULARI
Binnur Kaya
Tülin Özen
Burak Sevinç
Meriç Aral
Halit Özgür Sarı
Gülçin Kültür Şahin
Sezin Bozacı
Baran Can Eraslan
İnstagram : https://www.instagram.com/kirmizioda.dizi/
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#KırmızıOda #BinnurKaya #Tv8 #OGM
7:17
Gs/Gq signaling switch in β cells underlies the potential of incretins in diabetes
In this episode, Susumu Seino and Okechi S. Oduori explain how persistent depolarization o...
published: 16 Nov 2020
Gs/Gq signaling switch in β cells underlies the potential of incretins in diabetes
Gs/Gq signaling switch in β cells underlies the potential of incretins in diabetes
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- published: 16 Nov 2020
- views: 1764
In this episode, Susumu Seino and Okechi S. Oduori explain how persistent depolarization of β-cells leads to Gs to Gq signaling switch, explaining the differential effects of GLP-1 and GIP on insulin secretion in diabetes.
52:33
dkNET Webinar: Illuminating The Druggable Genome With Pharos 10/23/2020
Pharos is an integrated web-based informatics platform for the analysis of data aggregated...
published: 30 Oct 2020
dkNET Webinar: Illuminating The Druggable Genome With Pharos 10/23/2020
dkNET Webinar: Illuminating The Druggable Genome With Pharos 10/23/2020
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- published: 30 Oct 2020
- views: 185
Pharos is an integrated web-based informatics platform for the analysis of data aggregated by the Illuminating the Druggable Genome (IDG) Knowledge Management Center, an NIH Common Fund initiative. The current version of Pharos (as of October 2019) spans 20,244 proteins in the human proteome, 19,880 disease and phenotype associations, and 226,829 ChEMBL compounds. This resource not only collates and analyzes data from over 60 high-quality resources to generate these types, but also uses text indexing to find less apparent connections between targets, and has recently begun to collaborate with institutions that generate data and resources. Proteins are ranked according to a knowledge-based classification system, which can help researchers to identify less studied “dark” targets that could be potentially further illuminated. This is an important process for both drug discovery and target validation, as more knowledge can accelerate target identification, and previously understudied proteins can serve as novel targets in drug discovery. In this webinar, Dr. Tudor Oprea will introduce how to use Pharos to find targets of interest for drug discovery.
The top 3 key questions that Pharos can answer:
1. What are the novel drug targets that may play a role in a specific disease?
2. What are the diseases that are related directly or indirectly to a drug target?
3. Find researchers that are related directly or indirectly to a drug target.
Presenter: Tudor Oprea, MD, PhD, Professor of Medicine, Chief of Translational Informatics Division & Internal Medicine, University of New Mexico
Upcoming webinars schedule: https://dknet.org/about/webinar
KCNJ8
Potassium inwardly-rectifying channel, subfamily J, member 8, also known as KCNJ8, is a human gene encoding the Kir6.1 protein. A mutation in KCNJ8 has been associated with cardiac arrest in the early repolarization syndrome.
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. Kir6.1 is an integral membrane protein and inward-rectifier type potassium channel. Kir6.1, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins.
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References
Further reading
External links
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
This page contains text from Wikipedia, the Free Encyclopedia - https://wn.com/KCNJ8
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Car 54
by: Suburban LegendsSometimes when I'm alone I always get this way,
I just think about how everyone is lame.
Jealousy and greed run rampant every day,
I think I'll forget this stuff, I'll go and run away.
Gohan
Where are you?
Gohan
Where are you?
Just run away.
What really gets to me is this mass stupidity,
Oh well I forgot I live in the land of the free.
Just remember not to hate nor to turn to apathy,
Than maybe we can change this really messed up society.
Gohan
Where are you?
Gohan
Where are you?
Just run away.
Every night around eight thirty my parents yell at me,
They say I'm stupid 'cause I watch my MTV.
When I looked in the miror I swear I saw someone else,
So I cut my hair, got a job and joined a really cool band.
Gohan
Where are you?
Gohan
Where are you?
Just run away.