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2-Minute Neuroscience: Huntington's disease
Huntington's disease is an incurable and fatal neurodegenerative disorder characterized by movement problems and a variety of other symptoms. It is a rare example of a neurological disorder that can be traced back to a mutation in a single gene. In this video, I discuss the symptoms and pathology of Huntington's disease.
For an article (on my website) that discusses Huntington's disease more in-depth, click this link: https://neuroscientificallychallenged.com/posts/know-your-brain-huntingtons-disease
TRANSCRIPT:
Welcome to 2 minute neuroscience, where I explain neuroscience topics in 2 minutes or less. In this installment I will discuss Huntington’s disease.
The symptoms of Huntington’s disease typically emerge during middle age and at first often involve subtle changes in personality,...
published: 06 Jul 2018
-
What is Huntington's disease?
Huntington’s disease is a genetic, neurodegenerative disease with a devastating impact on individuals and entire families. Despite knowing the exact cause of Huntington’s disease since 1993, there still remains much unknown about this complex brain disease.
In this animation, Lauren Byrne, a Research Fellow at the UCL Huntington's Disease Centre shares her personal experience with Huntington's. She takes us inside the brain to explore the mechanism of this disease leading to the cognitive, behavioural and motor symptoms in Huntington's.
This is a Roche video developed in collaboration with Ed Wild, also from UCL Huntington's Disease Centre, George Yohrling from the Huntington's Disease Society of America, and Roger and Brenda Wylie, a family living with Huntington's disease.
Subscribe t...
published: 06 May 2019
-
What is Huntington's Disease?
For more information and resources, please visit www.HDSA.org.
The Huntington’s Disease Society of America is the premier nonprofit organization dedicated to improving the lives of everyone affected by Huntington’s disease. From community services and education to advocacy and research, HDSA is the world’s leader in providing help for today, hope for tomorrow for people with Huntington’s disease and their families. In the battle against Huntington’s disease no one fights alone. At HDSA, family is everything.
#HuntingtonsDisease #LetsTalkAboutHD #HDSAFamily #HDSA #Huntingtons #Disease #Brain #HD
published: 22 Apr 2020
-
Living with Huntington’s disease
ABC News’ Linsey Davis follows two families grappling with the rare genetic disorder Huntington’s disease, compared to ALS, Parkinson’s disease and Alzheimer's disease all in one.
ABC News Live Prime, Weekdays at 7EST & 9EST
WATCH the ABC News Live Stream Here: https://www.youtube.com/watch?v=w_Ma8oQLmSM
SUBSCRIBE to ABC NEWS: https://bit.ly/2vZb6yP
Watch More on http://abcnews.go.com/
LIKE ABC News on FACEBOOK https://www.facebook.com/abcnews
FOLLOW ABC News on TWITTER: https://twitter.com/abc
published: 04 Jul 2020
-
Understanding Huntington's disease: One family's experience
Huntington's disease affects a patient's physical and mental abilities, and one woman is working to spread awareness.
published: 22 Jun 2022
-
Living with Huntington's disease
Tammy Stewart's family has a history of Huntington's disease. Her father and sister both died from it, and now she is caring for her sick brother. But a clinical trial for a new drug is offering hope.
published: 04 Dec 2019
-
Huntington's Disease | Pathology of Huntington's Chorea | Diagnosis of Huntington's disease
In this video, we will talk about Huntington's Disease, pathology of Huntington's Chorea and diagnosis of Huntington's disease.
Also follow me on other social media -
Facebook: https://www.facebook.com/arpan.parich...
Instagram: https://www.instagram.com/arpanparichha/
Linked in: https://in.linkedin.com/in/arpan-pari...
Twitter : https://twitter.com/arpan_parichha?la...
Instagram page : https://www.instagram.com/animatedbiologywitharpan/
Facebook page : https://www.facebook.com/Animated-biology-with-Arpan-109894017509038/?ref=pages_you_manage
Link to my other channel - Lets crack bio exams https://www.youtube.com/channel/UC4IpyopsGWSjaPACNTZLuqg
For Physics part of bio exams - Physics for IIT JAM biotechnology
https://www.youtube.com/channel/UCJvSHjOoL2FDN85hQbu7vfw
#huntingtonsdisease...
published: 10 Jun 2022
-
Neurology - Topic 17 Huntingtons disease - patient
Neurology - Topic 17 Huntingtons disease - patient
published: 10 Jan 2013
-
Huntington Disease
Huntington disease is caused by a mutation in the HTT gene. Understanding how the mutation causes neurodegeneration might help researchers develop treatments that protect brain function. This animation describes the genetic defect that underlies Huntington disease. Created by the editors at Nature Reviews Disease Primers.
Learn more about Huntington disease with the Primer http://dx.doi.org/10.1038/nrdp.2015.5 and PrimeView http://go.nature.com/hPMENh
published: 23 Apr 2015
-
Huntington's Disease: Stages and Therapies
Huntington's disease is a rare genetic disorder that causes programmed degeneration of brain cells, called neurons, in certain areas of the brain. This talk explores the diagnosis, stages of the disease, and its treatment. The Stanford Huntington's Disease and Ataxia Clinic has been named a Center of Excellence by the Huntington's Disease Society of America. This talk reflects the treatment standards offered at Stanford.
Speaker: Veronica Santini, MD Clinical Instructor, Neurology and Neurological Sciences, Stanford University Medical Center
published: 11 Nov 2015
1:59
2-Minute Neuroscience: Huntington's disease
Huntington's disease is an incurable and fatal neurodegenerative disorder characterized by movement problems and a variety of other symptoms. It is a rare examp...
Huntington's disease is an incurable and fatal neurodegenerative disorder characterized by movement problems and a variety of other symptoms. It is a rare example of a neurological disorder that can be traced back to a mutation in a single gene. In this video, I discuss the symptoms and pathology of Huntington's disease.
For an article (on my website) that discusses Huntington's disease more in-depth, click this link: https://neuroscientificallychallenged.com/posts/know-your-brain-huntingtons-disease
TRANSCRIPT:
Welcome to 2 minute neuroscience, where I explain neuroscience topics in 2 minutes or less. In this installment I will discuss Huntington’s disease.
The symptoms of Huntington’s disease typically emerge during middle age and at first often involve subtle changes in personality, cognition, and movement. Eventually, the symptoms progress into substantial movement problems like chorea, which involves uncontrolled, spasmodic movements; impaired coordination and balance; muscle rigidity; and difficulty speaking and/or swallowing. Cognitive and psychiatric symptoms like dementia and depression occur as well. The disease is incurable and fatal.
These symptoms are associated with neurodegeneration, or the deterioration and death of neurons. A group of structures called the basal ganglia are strongly affected, but other regions of the brain experience neurodegeneration as well.
The pathology of Huntington’s disease can be traced back to a mutation in a single gene called huntingtin. The mutation that causes Huntington’s disease is a dominant mutation. Thus, if one parent has the disease, their child has a 50% chance of developing it, too. The huntingtin gene contains a DNA sequence that consists of three nucleotides (cytosine, adenine, and guanine) in repetition---a pattern known as a trinucleotide repeat. When the gene is mutated, an excess number of repeats can occur, and a mutated form of huntingtin protein is created. The higher the number of repeats, the greater the risk of disease, and all people with 40 or more repeats in the huntingtin gene will develop Huntington’s disease. Mutated huntingtin proteins have a tendency to group together, forming clusters within neurons that are not easily removed by brain enzymes. It has been hypothesized these clusters may play a role in the neurodegeneration seen in Huntington’s disease, for their accumulation in the brain is associated with increased neurodegeneration.
Reference:
Walker FO. Huntington's disease. Lancet. 2007 Jan 20;369(9557):218-28.
https://wn.com/2_Minute_Neuroscience_Huntington's_Disease
Huntington's disease is an incurable and fatal neurodegenerative disorder characterized by movement problems and a variety of other symptoms. It is a rare example of a neurological disorder that can be traced back to a mutation in a single gene. In this video, I discuss the symptoms and pathology of Huntington's disease.
For an article (on my website) that discusses Huntington's disease more in-depth, click this link: https://neuroscientificallychallenged.com/posts/know-your-brain-huntingtons-disease
TRANSCRIPT:
Welcome to 2 minute neuroscience, where I explain neuroscience topics in 2 minutes or less. In this installment I will discuss Huntington’s disease.
The symptoms of Huntington’s disease typically emerge during middle age and at first often involve subtle changes in personality, cognition, and movement. Eventually, the symptoms progress into substantial movement problems like chorea, which involves uncontrolled, spasmodic movements; impaired coordination and balance; muscle rigidity; and difficulty speaking and/or swallowing. Cognitive and psychiatric symptoms like dementia and depression occur as well. The disease is incurable and fatal.
These symptoms are associated with neurodegeneration, or the deterioration and death of neurons. A group of structures called the basal ganglia are strongly affected, but other regions of the brain experience neurodegeneration as well.
The pathology of Huntington’s disease can be traced back to a mutation in a single gene called huntingtin. The mutation that causes Huntington’s disease is a dominant mutation. Thus, if one parent has the disease, their child has a 50% chance of developing it, too. The huntingtin gene contains a DNA sequence that consists of three nucleotides (cytosine, adenine, and guanine) in repetition---a pattern known as a trinucleotide repeat. When the gene is mutated, an excess number of repeats can occur, and a mutated form of huntingtin protein is created. The higher the number of repeats, the greater the risk of disease, and all people with 40 or more repeats in the huntingtin gene will develop Huntington’s disease. Mutated huntingtin proteins have a tendency to group together, forming clusters within neurons that are not easily removed by brain enzymes. It has been hypothesized these clusters may play a role in the neurodegeneration seen in Huntington’s disease, for their accumulation in the brain is associated with increased neurodegeneration.
Reference:
Walker FO. Huntington's disease. Lancet. 2007 Jan 20;369(9557):218-28.
- published: 06 Jul 2018
- views: 300570
5:30
What is Huntington's disease?
Huntington’s disease is a genetic, neurodegenerative disease with a devastating impact on individuals and entire families. Despite knowing the exact cause of Hu...
Huntington’s disease is a genetic, neurodegenerative disease with a devastating impact on individuals and entire families. Despite knowing the exact cause of Huntington’s disease since 1993, there still remains much unknown about this complex brain disease.
In this animation, Lauren Byrne, a Research Fellow at the UCL Huntington's Disease Centre shares her personal experience with Huntington's. She takes us inside the brain to explore the mechanism of this disease leading to the cognitive, behavioural and motor symptoms in Huntington's.
This is a Roche video developed in collaboration with Ed Wild, also from UCL Huntington's Disease Centre, George Yohrling from the Huntington's Disease Society of America, and Roger and Brenda Wylie, a family living with Huntington's disease.
Subscribe to our YouTube channel now: https://www.youtube.com/user/roche?sub_confirmation=1
Get in touch with us:
https://www.roche.com/
https://www.facebook.com/RocheCareers
https://www.linkedin.com/company/roche
https://twitter.com/roche
Roche has been committed to improving lives since the company was founded in 1896 in Basel, Switzerland. Today, Roche creates innovative medicines and diagnostic tests that help millions of patients globally.
Roche is a leader in research-focused healthcare with combined strengths in pharmaceuticals and diagnostics. Roche is the world’s largest biotech company, with truly differentiated medicines in oncology, immunology, infectious diseases, ophthalmology and neuroscience.
For more information and insights visit: https://www.roche.com/
https://wn.com/What_Is_Huntington's_Disease
Huntington’s disease is a genetic, neurodegenerative disease with a devastating impact on individuals and entire families. Despite knowing the exact cause of Huntington’s disease since 1993, there still remains much unknown about this complex brain disease.
In this animation, Lauren Byrne, a Research Fellow at the UCL Huntington's Disease Centre shares her personal experience with Huntington's. She takes us inside the brain to explore the mechanism of this disease leading to the cognitive, behavioural and motor symptoms in Huntington's.
This is a Roche video developed in collaboration with Ed Wild, also from UCL Huntington's Disease Centre, George Yohrling from the Huntington's Disease Society of America, and Roger and Brenda Wylie, a family living with Huntington's disease.
Subscribe to our YouTube channel now: https://www.youtube.com/user/roche?sub_confirmation=1
Get in touch with us:
https://www.roche.com/
https://www.facebook.com/RocheCareers
https://www.linkedin.com/company/roche
https://twitter.com/roche
Roche has been committed to improving lives since the company was founded in 1896 in Basel, Switzerland. Today, Roche creates innovative medicines and diagnostic tests that help millions of patients globally.
Roche is a leader in research-focused healthcare with combined strengths in pharmaceuticals and diagnostics. Roche is the world’s largest biotech company, with truly differentiated medicines in oncology, immunology, infectious diseases, ophthalmology and neuroscience.
For more information and insights visit: https://www.roche.com/
- published: 06 May 2019
- views: 258694
4:00
What is Huntington's Disease?
For more information and resources, please visit www.HDSA.org.
The Huntington’s Disease Society of America is the premier nonprofit organization dedicated to ...
For more information and resources, please visit www.HDSA.org.
The Huntington’s Disease Society of America is the premier nonprofit organization dedicated to improving the lives of everyone affected by Huntington’s disease. From community services and education to advocacy and research, HDSA is the world’s leader in providing help for today, hope for tomorrow for people with Huntington’s disease and their families. In the battle against Huntington’s disease no one fights alone. At HDSA, family is everything.
#HuntingtonsDisease #LetsTalkAboutHD #HDSAFamily #HDSA #Huntingtons #Disease #Brain #HD
https://wn.com/What_Is_Huntington's_Disease
For more information and resources, please visit www.HDSA.org.
The Huntington’s Disease Society of America is the premier nonprofit organization dedicated to improving the lives of everyone affected by Huntington’s disease. From community services and education to advocacy and research, HDSA is the world’s leader in providing help for today, hope for tomorrow for people with Huntington’s disease and their families. In the battle against Huntington’s disease no one fights alone. At HDSA, family is everything.
#HuntingtonsDisease #LetsTalkAboutHD #HDSAFamily #HDSA #Huntingtons #Disease #Brain #HD
- published: 22 Apr 2020
- views: 60630
15:55
Living with Huntington’s disease
ABC News’ Linsey Davis follows two families grappling with the rare genetic disorder Huntington’s disease, compared to ALS, Parkinson’s disease and Alzheimer's ...
ABC News’ Linsey Davis follows two families grappling with the rare genetic disorder Huntington’s disease, compared to ALS, Parkinson’s disease and Alzheimer's disease all in one.
ABC News Live Prime, Weekdays at 7EST & 9EST
WATCH the ABC News Live Stream Here: https://www.youtube.com/watch?v=w_Ma8oQLmSM
SUBSCRIBE to ABC NEWS: https://bit.ly/2vZb6yP
Watch More on http://abcnews.go.com/
LIKE ABC News on FACEBOOK https://www.facebook.com/abcnews
FOLLOW ABC News on TWITTER: https://twitter.com/abc
https://wn.com/Living_With_Huntington’S_Disease
ABC News’ Linsey Davis follows two families grappling with the rare genetic disorder Huntington’s disease, compared to ALS, Parkinson’s disease and Alzheimer's disease all in one.
ABC News Live Prime, Weekdays at 7EST & 9EST
WATCH the ABC News Live Stream Here: https://www.youtube.com/watch?v=w_Ma8oQLmSM
SUBSCRIBE to ABC NEWS: https://bit.ly/2vZb6yP
Watch More on http://abcnews.go.com/
LIKE ABC News on FACEBOOK https://www.facebook.com/abcnews
FOLLOW ABC News on TWITTER: https://twitter.com/abc
- published: 04 Jul 2020
- views: 62098
1:21
Understanding Huntington's disease: One family's experience
Huntington's disease affects a patient's physical and mental abilities, and one woman is working to spread awareness.
Huntington's disease affects a patient's physical and mental abilities, and one woman is working to spread awareness.
https://wn.com/Understanding_Huntington's_Disease_One_Family's_Experience
Huntington's disease affects a patient's physical and mental abilities, and one woman is working to spread awareness.
- published: 22 Jun 2022
- views: 22704
4:42
Living with Huntington's disease
Tammy Stewart's family has a history of Huntington's disease. Her father and sister both died from it, and now she is caring for her sick brother. But a clinica...
Tammy Stewart's family has a history of Huntington's disease. Her father and sister both died from it, and now she is caring for her sick brother. But a clinical trial for a new drug is offering hope.
https://wn.com/Living_With_Huntington's_Disease
Tammy Stewart's family has a history of Huntington's disease. Her father and sister both died from it, and now she is caring for her sick brother. But a clinical trial for a new drug is offering hope.
- published: 04 Dec 2019
- views: 292061
8:39
Huntington's Disease | Pathology of Huntington's Chorea | Diagnosis of Huntington's disease
In this video, we will talk about Huntington's Disease, pathology of Huntington's Chorea and diagnosis of Huntington's disease.
Also follow me on other social ...
In this video, we will talk about Huntington's Disease, pathology of Huntington's Chorea and diagnosis of Huntington's disease.
Also follow me on other social media -
Facebook: https://www.facebook.com/arpan.parich...
Instagram: https://www.instagram.com/arpanparichha/
Linked in: https://in.linkedin.com/in/arpan-pari...
Twitter : https://twitter.com/arpan_parichha?la...
Instagram page : https://www.instagram.com/animatedbiologywitharpan/
Facebook page : https://www.facebook.com/Animated-biology-with-Arpan-109894017509038/?ref=pages_you_manage
Link to my other channel - Lets crack bio exams https://www.youtube.com/channel/UC4IpyopsGWSjaPACNTZLuqg
For Physics part of bio exams - Physics for IIT JAM biotechnology
https://www.youtube.com/channel/UCJvSHjOoL2FDN85hQbu7vfw
#huntingtonsdisease #Huntington #HuntingtonsChorea #pathology #diagnosis #huntington #Huntington'sDisease #PathologyofHuntington'sChorea #DiagnosisofHuntington'sdisease #biology #animated_biology #animated_biology_with_arpan #biology #bio_facts #CSIR_NET #IIT_JAM #IIT_JAM_BT #biotechnology #bioscience #biological_sciences #microbiology #genetics #zoology #molecular_biology #cell_biology #botany #immunology #ecology
0:00 Introduction
0:41 Highlights
1:26 Movement disorders In Huntington's disease
2:07 Impaired gait, posture, and balance in Huntington's disease
2:41 Progression of Huntington's disease
3:24 Initially, damage to the brain is regionally specific with the dorsal striatum in the subcortical basal ganglia being primarily affected.
5:33 Geographic distribution of Huntington's disease
6:01 Genetic basis of Huntington's disease
6:39 Diagnosis of
6:49 Genetic counseling for
7:11 Life expectancy for Huntington's disease
7:29 Treatment for Huntington's disease
8:18 Revising is easy with dynamic flashcards
https://wn.com/Huntington's_Disease_|_Pathology_Of_Huntington's_Chorea_|_Diagnosis_Of_Huntington's_Disease
In this video, we will talk about Huntington's Disease, pathology of Huntington's Chorea and diagnosis of Huntington's disease.
Also follow me on other social media -
Facebook: https://www.facebook.com/arpan.parich...
Instagram: https://www.instagram.com/arpanparichha/
Linked in: https://in.linkedin.com/in/arpan-pari...
Twitter : https://twitter.com/arpan_parichha?la...
Instagram page : https://www.instagram.com/animatedbiologywitharpan/
Facebook page : https://www.facebook.com/Animated-biology-with-Arpan-109894017509038/?ref=pages_you_manage
Link to my other channel - Lets crack bio exams https://www.youtube.com/channel/UC4IpyopsGWSjaPACNTZLuqg
For Physics part of bio exams - Physics for IIT JAM biotechnology
https://www.youtube.com/channel/UCJvSHjOoL2FDN85hQbu7vfw
#huntingtonsdisease #Huntington #HuntingtonsChorea #pathology #diagnosis #huntington #Huntington'sDisease #PathologyofHuntington'sChorea #DiagnosisofHuntington'sdisease #biology #animated_biology #animated_biology_with_arpan #biology #bio_facts #CSIR_NET #IIT_JAM #IIT_JAM_BT #biotechnology #bioscience #biological_sciences #microbiology #genetics #zoology #molecular_biology #cell_biology #botany #immunology #ecology
0:00 Introduction
0:41 Highlights
1:26 Movement disorders In Huntington's disease
2:07 Impaired gait, posture, and balance in Huntington's disease
2:41 Progression of Huntington's disease
3:24 Initially, damage to the brain is regionally specific with the dorsal striatum in the subcortical basal ganglia being primarily affected.
5:33 Geographic distribution of Huntington's disease
6:01 Genetic basis of Huntington's disease
6:39 Diagnosis of
6:49 Genetic counseling for
7:11 Life expectancy for Huntington's disease
7:29 Treatment for Huntington's disease
8:18 Revising is easy with dynamic flashcards
- published: 10 Jun 2022
- views: 45732
2:11
Huntington Disease
Huntington disease is caused by a mutation in the HTT gene. Understanding how the mutation causes neurodegeneration might help researchers develop treatments th...
Huntington disease is caused by a mutation in the HTT gene. Understanding how the mutation causes neurodegeneration might help researchers develop treatments that protect brain function. This animation describes the genetic defect that underlies Huntington disease. Created by the editors at Nature Reviews Disease Primers.
Learn more about Huntington disease with the Primer http://dx.doi.org/10.1038/nrdp.2015.5 and PrimeView http://go.nature.com/hPMENh
https://wn.com/Huntington_Disease
Huntington disease is caused by a mutation in the HTT gene. Understanding how the mutation causes neurodegeneration might help researchers develop treatments that protect brain function. This animation describes the genetic defect that underlies Huntington disease. Created by the editors at Nature Reviews Disease Primers.
Learn more about Huntington disease with the Primer http://dx.doi.org/10.1038/nrdp.2015.5 and PrimeView http://go.nature.com/hPMENh
- published: 23 Apr 2015
- views: 133201
1:02:22
Huntington's Disease: Stages and Therapies
Huntington's disease is a rare genetic disorder that causes programmed degeneration of brain cells, called neurons, in certain areas of the brain. This talk exp...
Huntington's disease is a rare genetic disorder that causes programmed degeneration of brain cells, called neurons, in certain areas of the brain. This talk explores the diagnosis, stages of the disease, and its treatment. The Stanford Huntington's Disease and Ataxia Clinic has been named a Center of Excellence by the Huntington's Disease Society of America. This talk reflects the treatment standards offered at Stanford.
Speaker: Veronica Santini, MD Clinical Instructor, Neurology and Neurological Sciences, Stanford University Medical Center
https://wn.com/Huntington's_Disease_Stages_And_Therapies
Huntington's disease is a rare genetic disorder that causes programmed degeneration of brain cells, called neurons, in certain areas of the brain. This talk explores the diagnosis, stages of the disease, and its treatment. The Stanford Huntington's Disease and Ataxia Clinic has been named a Center of Excellence by the Huntington's Disease Society of America. This talk reflects the treatment standards offered at Stanford.
Speaker: Veronica Santini, MD Clinical Instructor, Neurology and Neurological Sciences, Stanford University Medical Center
- published: 11 Nov 2015
- views: 75885