EF-Tu (elongation factor thermo unstable) is one of the prokaryotic elongation factors. Elongation factors are part of the mechanism that synthesizes new proteins by translation at the ribosome. Individual amino acid links are added to the protein chain by transfer RNA (t-RNA). Messenger RNA (mRNA) carries a codon that codes for each amino acid. t-RNA carries the amino acid and an anticodon for that amino acid. The ribosome creates a protein chain by following the mRNA code and selecting the next t-RNA and its amino acid.
The prokaryotic factor EF-Tu helps the aminoacyl-tRNA move onto a free site on the ribosome. In the cytoplasm, EF-Tu binds an aminoacylated, or charged, tRNA molecule. This complex enters the ribosome.
There are 3 tRNA attachment sites on the ribosome: aminoacyl (A), peptidyl (P) and exit (E). The tRNA complex first binds to the A site, then moves to the P site, and is released at the E site.
The tRNA anticodon domain associates with the mRNA codon domain in the ribosomal A site. If the codon-anticodon pairing is correct, EF-Tu hydrolyzes guanosine triphosphate (GTP) into guanosine diphosphate (GDP) and inorganic phosphate. This creates a conformational change in EF-Tu that causes EF-Tu to dissociate from the tRNA of the ternary complex (and therefore leave the ribosome). The aminoacyl-tRNA then fully enters the A site, where its amino acid is brought near the P site's polypeptide and the ribosome catalyzes the covalent transfer of the polypeptide onto the amino acid . The tRNA on the P site (without peptide) moves to the E site and is then released.
Translation Animation 2 - translation elongation in prokaryotes
Translation Animation 2 - translation elongation in prokaryotes - This video lecture explains about the elongation of protein synthesis in prokaryotes. Once translation initiation is complete elongation begins the elongation phase consists of three steps binding of a tRNA to the ribosome formation of a peptide bond between adjacent amino acids and movement of the ribosome to the next codon elongation continues one: a time and the start codon is reached as initiation concluded that tRNA was hydrogen bonded to AUG in the piece side of the ribosome next codon is in the a site in this case the codon's UCC which encodes serine is bearing tRNA in the cytoplasm is a complex with the elongation factor TU and GTP this serial tRNA EF TU GTP complex enters the inside with a tRNA anti-codon was hydrog...
published: 15 Apr 2016
Figure 18.13 EF-T (Tu + Ts) and EFG in Phe-tRNA binding and poly-Phe synthesis
This video describes early experiments aimed at understanding the role of EFTu and EFG (with GTP) in ribosome function. At the time, they didn't thought EFTu and EFTs were one factor, called EFT. Regardless, these data are nice examples of how the model for the steps in translation were determined. This is figure 18.13 from Molecular Biology 5th edition by Robert Weaver. It was made for MCDB 427, a molecular biology course at the University of Michigan
published: 24 Apr 2018
Bacterial elongation factor EF-Tu
Translation the basics
aspects of Translation
also see
tRNA structure
http://www.youtube.com/watch?v=4MRCH_J7Fhk&feature=plcp&context=C23642UDOEgsToPDskI0ZadVpj71emFP3i8YGVtg
Polyribsomes
http://www.youtube.com/watch?v=bJmml5KLJO8&feature=plcp&context=C209baUDOEgsToPDskKoec1mf5JFxp-sr_dlbBon
Protein translocation into the ER
http://www.youtube.com/watch?v=PUy_Em5dXmc&feature=plcp&context=C28da7UDOEgsToPDskLJNwTHgLu9Oa1yGqkY5mYj
published: 04 Feb 2012
Ef-tu factor
EF-Tu (elongation factor thermo unstable) is a prokaryotic elongation factor responsible for catalyzing the binding of an aminoacyl-tRNA (aa-tRNA) to the ribosome. It is a G-protein, and facilitates the selection and binding of an aa-tRNA to the A-site of the ribosome. As a reflection of its crucial role in translation, EF-Tu is one of the most abundant and highly conserved proteins in prokaryotes.
published: 10 Aug 2017
EFTU-EFHK 7.8.2018
published: 28 Oct 2018
Prokaryotic Translation ELONGATION - How do EF-Tu and EF-G move the ribosome? - Deep-dive Video
References/Resources: https://www.patreon.com/the_Crux
What is the process of translation elongation in prokaryotes? How does a 70S ribosome translocate? What are the elongation factors involved in the elongation process and how do they work? What are EF-Tu and EF-G and why are they important? How does the Peptidyl transferase reaction occur? How does 23S rRNA catalyze this reaction? How does the ribosome translocate? Find out answers to all these questions in this deep-dive video:
Jump to your favorite section:
00:00 Outline
00:27 70S initiation complex
02:11 EF-Tu
05:29 23S rRNA
06:33 Peptide bond formation
11:03 EF-G and translocation
14:37 Energy consumption
Recommended videos to watch before watching this video:
Prokaryotic Translation INITIATION: https://youtu.be/q8BPMK10IrY
tRNA...
published: 14 Nov 2021
benim best ikilim sarılmışmı..😂💗 #eftubff #Eftu #çağtudiziailesi
published: 14 Jan 2022
abi tuananın tarzı efenin karizması bittim ben bu ikiliye #eftu #bff #bestfriends #bestie #edit
Translation Animation 2 - translation elongation in prokaryotes - This video lecture explains about the elongation of protein synthesis in prokaryotes. Once tra...
Translation Animation 2 - translation elongation in prokaryotes - This video lecture explains about the elongation of protein synthesis in prokaryotes. Once translation initiation is complete elongation begins the elongation phase consists of three steps binding of a tRNA to the ribosome formation of a peptide bond between adjacent amino acids and movement of the ribosome to the next codon elongation continues one: a time and the start codon is reached as initiation concluded that tRNA was hydrogen bonded to AUG in the piece side of the ribosome next codon is in the a site in this case the codon's UCC which encodes serine is bearing tRNA in the cytoplasm is a complex with the elongation factor TU and GTP this serial tRNA EF TU GTP complex enters the inside with a tRNA anti-codon was hydrogen bonds with the UCC codon upon binding the GTP is hydrolysed and DEF TU is released and recycled with a tRNA in both the P and a cites a peptide bond can form between adjacent amino acids this reaction is catalysed by peptidase transferase residing in the wild ribosomal subunit first step involves breaking the bond between Matt and its tRNA in the piece site next a peptide bond is between the now freed as Matt on the serine which is attached to its tRNA in the a site peptide bond formation is a condensation reaction that results in the release of water at one time it was thought that peptidase transferase was an enzymatic protein however more recently it was discovered that peptidase transferase is a catabolic RNA molecule and RNA capable of catalysing a reaction is called ribozyme is the peptide bond has formed the remains and an charged tRNA in the piece site and a tRNA with the growing polypeptide chain in the site the ribosome now moves one codon along the mRNA with the help of EFG and another GTP EFG GTP complex binds to the ribosome hydrolysis of GTP occurs and translocation began is an charged tRNA moves from the insight into the east side blocking the next amino ACL tRNA from attaching to the a side until translocation is complete tRNA in the a side still bound to it: now moves into the piece site once this tRNA is bound correctly in the piece side of the charged tRNA is rejected from the ease site site is now open for the next amino ACL tRNA to enter allowing the elongation process to continue an average polypeptide consists of about 300 amino acids let's watch the elongation process once again.
Thank You for watching our videos from Biology Animation Videos channel. This channel is created to compile animated biology lectures and videos from different animation sources. None of these videos are created by us. we just organize them and place them in YouTube for your understanding so If you want to know details about these animation please see the credit section for knowing the original content developer and please convey privilege and gratitude to them. Thank You.
Title-
Translation initiation Animation - translation initiation in prokaryotes
Our website-
https://www.biologyanimationvideos.weebly.com
Translation Animation 2 - translation elongation in prokaryotes - This video lecture explains about the elongation of protein synthesis in prokaryotes. Once translation initiation is complete elongation begins the elongation phase consists of three steps binding of a tRNA to the ribosome formation of a peptide bond between adjacent amino acids and movement of the ribosome to the next codon elongation continues one: a time and the start codon is reached as initiation concluded that tRNA was hydrogen bonded to AUG in the piece side of the ribosome next codon is in the a site in this case the codon's UCC which encodes serine is bearing tRNA in the cytoplasm is a complex with the elongation factor TU and GTP this serial tRNA EF TU GTP complex enters the inside with a tRNA anti-codon was hydrogen bonds with the UCC codon upon binding the GTP is hydrolysed and DEF TU is released and recycled with a tRNA in both the P and a cites a peptide bond can form between adjacent amino acids this reaction is catalysed by peptidase transferase residing in the wild ribosomal subunit first step involves breaking the bond between Matt and its tRNA in the piece site next a peptide bond is between the now freed as Matt on the serine which is attached to its tRNA in the a site peptide bond formation is a condensation reaction that results in the release of water at one time it was thought that peptidase transferase was an enzymatic protein however more recently it was discovered that peptidase transferase is a catabolic RNA molecule and RNA capable of catalysing a reaction is called ribozyme is the peptide bond has formed the remains and an charged tRNA in the piece site and a tRNA with the growing polypeptide chain in the site the ribosome now moves one codon along the mRNA with the help of EFG and another GTP EFG GTP complex binds to the ribosome hydrolysis of GTP occurs and translocation began is an charged tRNA moves from the insight into the east side blocking the next amino ACL tRNA from attaching to the a side until translocation is complete tRNA in the a side still bound to it: now moves into the piece site once this tRNA is bound correctly in the piece side of the charged tRNA is rejected from the ease site site is now open for the next amino ACL tRNA to enter allowing the elongation process to continue an average polypeptide consists of about 300 amino acids let's watch the elongation process once again.
Thank You for watching our videos from Biology Animation Videos channel. This channel is created to compile animated biology lectures and videos from different animation sources. None of these videos are created by us. we just organize them and place them in YouTube for your understanding so If you want to know details about these animation please see the credit section for knowing the original content developer and please convey privilege and gratitude to them. Thank You.
Title-
Translation initiation Animation - translation initiation in prokaryotes
Our website-
https://www.biologyanimationvideos.weebly.com
This video describes early experiments aimed at understanding the role of EFTu and EFG (with GTP) in ribosome function. At the time, they didn't thought EFTu an...
This video describes early experiments aimed at understanding the role of EFTu and EFG (with GTP) in ribosome function. At the time, they didn't thought EFTu and EFTs were one factor, called EFT. Regardless, these data are nice examples of how the model for the steps in translation were determined. This is figure 18.13 from Molecular Biology 5th edition by Robert Weaver. It was made for MCDB 427, a molecular biology course at the University of Michigan
This video describes early experiments aimed at understanding the role of EFTu and EFG (with GTP) in ribosome function. At the time, they didn't thought EFTu and EFTs were one factor, called EFT. Regardless, these data are nice examples of how the model for the steps in translation were determined. This is figure 18.13 from Molecular Biology 5th edition by Robert Weaver. It was made for MCDB 427, a molecular biology course at the University of Michigan
Translation the basics
aspects of Translation
also see
tRNA structure
http://www.youtube.com/watch?v=4MRCH_J7Fhk&feature=plcp&context=C23642UDOEgsToPDskI0Za...
Translation the basics
aspects of Translation
also see
tRNA structure
http://www.youtube.com/watch?v=4MRCH_J7Fhk&feature=plcp&context=C23642UDOEgsToPDskI0ZadVpj71emFP3i8YGVtg
Polyribsomes
http://www.youtube.com/watch?v=bJmml5KLJO8&feature=plcp&context=C209baUDOEgsToPDskKoec1mf5JFxp-sr_dlbBon
Protein translocation into the ER
http://www.youtube.com/watch?v=PUy_Em5dXmc&feature=plcp&context=C28da7UDOEgsToPDskLJNwTHgLu9Oa1yGqkY5mYj
Translation the basics
aspects of Translation
also see
tRNA structure
http://www.youtube.com/watch?v=4MRCH_J7Fhk&feature=plcp&context=C23642UDOEgsToPDskI0ZadVpj71emFP3i8YGVtg
Polyribsomes
http://www.youtube.com/watch?v=bJmml5KLJO8&feature=plcp&context=C209baUDOEgsToPDskKoec1mf5JFxp-sr_dlbBon
Protein translocation into the ER
http://www.youtube.com/watch?v=PUy_Em5dXmc&feature=plcp&context=C28da7UDOEgsToPDskLJNwTHgLu9Oa1yGqkY5mYj
EF-Tu (elongation factor thermo unstable) is a prokaryotic elongation factor responsible for catalyzing the binding of an aminoacyl-tRNA (aa-tRNA) to the riboso...
EF-Tu (elongation factor thermo unstable) is a prokaryotic elongation factor responsible for catalyzing the binding of an aminoacyl-tRNA (aa-tRNA) to the ribosome. It is a G-protein, and facilitates the selection and binding of an aa-tRNA to the A-site of the ribosome. As a reflection of its crucial role in translation, EF-Tu is one of the most abundant and highly conserved proteins in prokaryotes.
EF-Tu (elongation factor thermo unstable) is a prokaryotic elongation factor responsible for catalyzing the binding of an aminoacyl-tRNA (aa-tRNA) to the ribosome. It is a G-protein, and facilitates the selection and binding of an aa-tRNA to the A-site of the ribosome. As a reflection of its crucial role in translation, EF-Tu is one of the most abundant and highly conserved proteins in prokaryotes.
References/Resources: https://www.patreon.com/the_Crux
What is the process of translation elongation in prokaryotes? How does a 70S ribosome translocate? What ...
References/Resources: https://www.patreon.com/the_Crux
What is the process of translation elongation in prokaryotes? How does a 70S ribosome translocate? What are the elongation factors involved in the elongation process and how do they work? What are EF-Tu and EF-G and why are they important? How does the Peptidyl transferase reaction occur? How does 23S rRNA catalyze this reaction? How does the ribosome translocate? Find out answers to all these questions in this deep-dive video:
Jump to your favorite section:
00:00 Outline
00:27 70S initiation complex
02:11 EF-Tu
05:29 23S rRNA
06:33 Peptide bond formation
11:03 EF-G and translocation
14:37 Energy consumption
Recommended videos to watch before watching this video:
Prokaryotic Translation INITIATION: https://youtu.be/q8BPMK10IrY
tRNA Charging: https://youtu.be/rEQDWIARmVY
Translation Introduction: https://youtu.be/xpOpPl1V1sQ
***Complete Transcription Playlist*** https://www.youtube.com/playlist?list=PL0Ymnd-zt4Ij2VcAOHNUweftSElVsc-MX
*Other playlists you must explore*
Advanced concepts in Genetics: https://www.youtube.com/playlist?list=PL0Ymnd-zt4IgEBW8xWPZhHSN4O8HXqQ6j
Journal Club: https://www.youtube.com/playlist?list=PL0Ymnd-zt4IiRbmmqRbJdTskp4e5AhgrQ
I hope these videos are helpful. If so, do leave a like or a comment. If you have any questions/suggestions/thoughts, you can COMMENT them as well :) Consider subscribing, and click on the bell icon, so you don't miss out on any new videos :)
References/Resources: https://www.patreon.com/the_Crux
What is the process of translation elongation in prokaryotes? How does a 70S ribosome translocate? What are the elongation factors involved in the elongation process and how do they work? What are EF-Tu and EF-G and why are they important? How does the Peptidyl transferase reaction occur? How does 23S rRNA catalyze this reaction? How does the ribosome translocate? Find out answers to all these questions in this deep-dive video:
Jump to your favorite section:
00:00 Outline
00:27 70S initiation complex
02:11 EF-Tu
05:29 23S rRNA
06:33 Peptide bond formation
11:03 EF-G and translocation
14:37 Energy consumption
Recommended videos to watch before watching this video:
Prokaryotic Translation INITIATION: https://youtu.be/q8BPMK10IrY
tRNA Charging: https://youtu.be/rEQDWIARmVY
Translation Introduction: https://youtu.be/xpOpPl1V1sQ
***Complete Transcription Playlist*** https://www.youtube.com/playlist?list=PL0Ymnd-zt4Ij2VcAOHNUweftSElVsc-MX
*Other playlists you must explore*
Advanced concepts in Genetics: https://www.youtube.com/playlist?list=PL0Ymnd-zt4IgEBW8xWPZhHSN4O8HXqQ6j
Journal Club: https://www.youtube.com/playlist?list=PL0Ymnd-zt4IiRbmmqRbJdTskp4e5AhgrQ
I hope these videos are helpful. If so, do leave a like or a comment. If you have any questions/suggestions/thoughts, you can COMMENT them as well :) Consider subscribing, and click on the bell icon, so you don't miss out on any new videos :)
Translation Animation 2 - translation elongation in prokaryotes - This video lecture explains about the elongation of protein synthesis in prokaryotes. Once translation initiation is complete elongation begins the elongation phase consists of three steps binding of a tRNA to the ribosome formation of a peptide bond between adjacent amino acids and movement of the ribosome to the next codon elongation continues one: a time and the start codon is reached as initiation concluded that tRNA was hydrogen bonded to AUG in the piece side of the ribosome next codon is in the a site in this case the codon's UCC which encodes serine is bearing tRNA in the cytoplasm is a complex with the elongation factor TU and GTP this serial tRNA EF TU GTP complex enters the inside with a tRNA anti-codon was hydrogen bonds with the UCC codon upon binding the GTP is hydrolysed and DEF TU is released and recycled with a tRNA in both the P and a cites a peptide bond can form between adjacent amino acids this reaction is catalysed by peptidase transferase residing in the wild ribosomal subunit first step involves breaking the bond between Matt and its tRNA in the piece site next a peptide bond is between the now freed as Matt on the serine which is attached to its tRNA in the a site peptide bond formation is a condensation reaction that results in the release of water at one time it was thought that peptidase transferase was an enzymatic protein however more recently it was discovered that peptidase transferase is a catabolic RNA molecule and RNA capable of catalysing a reaction is called ribozyme is the peptide bond has formed the remains and an charged tRNA in the piece site and a tRNA with the growing polypeptide chain in the site the ribosome now moves one codon along the mRNA with the help of EFG and another GTP EFG GTP complex binds to the ribosome hydrolysis of GTP occurs and translocation began is an charged tRNA moves from the insight into the east side blocking the next amino ACL tRNA from attaching to the a side until translocation is complete tRNA in the a side still bound to it: now moves into the piece site once this tRNA is bound correctly in the piece side of the charged tRNA is rejected from the ease site site is now open for the next amino ACL tRNA to enter allowing the elongation process to continue an average polypeptide consists of about 300 amino acids let's watch the elongation process once again.
Thank You for watching our videos from Biology Animation Videos channel. This channel is created to compile animated biology lectures and videos from different animation sources. None of these videos are created by us. we just organize them and place them in YouTube for your understanding so If you want to know details about these animation please see the credit section for knowing the original content developer and please convey privilege and gratitude to them. Thank You.
Title-
Translation initiation Animation - translation initiation in prokaryotes
Our website-
https://www.biologyanimationvideos.weebly.com
This video describes early experiments aimed at understanding the role of EFTu and EFG (with GTP) in ribosome function. At the time, they didn't thought EFTu and EFTs were one factor, called EFT. Regardless, these data are nice examples of how the model for the steps in translation were determined. This is figure 18.13 from Molecular Biology 5th edition by Robert Weaver. It was made for MCDB 427, a molecular biology course at the University of Michigan
Translation the basics
aspects of Translation
also see
tRNA structure
http://www.youtube.com/watch?v=4MRCH_J7Fhk&feature=plcp&context=C23642UDOEgsToPDskI0ZadVpj71emFP3i8YGVtg
Polyribsomes
http://www.youtube.com/watch?v=bJmml5KLJO8&feature=plcp&context=C209baUDOEgsToPDskKoec1mf5JFxp-sr_dlbBon
Protein translocation into the ER
http://www.youtube.com/watch?v=PUy_Em5dXmc&feature=plcp&context=C28da7UDOEgsToPDskLJNwTHgLu9Oa1yGqkY5mYj
EF-Tu (elongation factor thermo unstable) is a prokaryotic elongation factor responsible for catalyzing the binding of an aminoacyl-tRNA (aa-tRNA) to the ribosome. It is a G-protein, and facilitates the selection and binding of an aa-tRNA to the A-site of the ribosome. As a reflection of its crucial role in translation, EF-Tu is one of the most abundant and highly conserved proteins in prokaryotes.
References/Resources: https://www.patreon.com/the_Crux
What is the process of translation elongation in prokaryotes? How does a 70S ribosome translocate? What are the elongation factors involved in the elongation process and how do they work? What are EF-Tu and EF-G and why are they important? How does the Peptidyl transferase reaction occur? How does 23S rRNA catalyze this reaction? How does the ribosome translocate? Find out answers to all these questions in this deep-dive video:
Jump to your favorite section:
00:00 Outline
00:27 70S initiation complex
02:11 EF-Tu
05:29 23S rRNA
06:33 Peptide bond formation
11:03 EF-G and translocation
14:37 Energy consumption
Recommended videos to watch before watching this video:
Prokaryotic Translation INITIATION: https://youtu.be/q8BPMK10IrY
tRNA Charging: https://youtu.be/rEQDWIARmVY
Translation Introduction: https://youtu.be/xpOpPl1V1sQ
***Complete Transcription Playlist*** https://www.youtube.com/playlist?list=PL0Ymnd-zt4Ij2VcAOHNUweftSElVsc-MX
*Other playlists you must explore*
Advanced concepts in Genetics: https://www.youtube.com/playlist?list=PL0Ymnd-zt4IgEBW8xWPZhHSN4O8HXqQ6j
Journal Club: https://www.youtube.com/playlist?list=PL0Ymnd-zt4IiRbmmqRbJdTskp4e5AhgrQ
I hope these videos are helpful. If so, do leave a like or a comment. If you have any questions/suggestions/thoughts, you can COMMENT them as well :) Consider subscribing, and click on the bell icon, so you don't miss out on any new videos :)
EF-Tu (elongation factor thermo unstable) is one of the prokaryotic elongation factors. Elongation factors are part of the mechanism that synthesizes new proteins by translation at the ribosome. Individual amino acid links are added to the protein chain by transfer RNA (t-RNA). Messenger RNA (mRNA) carries a codon that codes for each amino acid. t-RNA carries the amino acid and an anticodon for that amino acid. The ribosome creates a protein chain by following the mRNA code and selecting the next t-RNA and its amino acid.
The prokaryotic factor EF-Tu helps the aminoacyl-tRNA move onto a free site on the ribosome. In the cytoplasm, EF-Tu binds an aminoacylated, or charged, tRNA molecule. This complex enters the ribosome.
There are 3 tRNA attachment sites on the ribosome: aminoacyl (A), peptidyl (P) and exit (E). The tRNA complex first binds to the A site, then moves to the P site, and is released at the E site.
The tRNA anticodon domain associates with the mRNA codon domain in the ribosomal A site. If the codon-anticodon pairing is correct, EF-Tu hydrolyzes guanosine triphosphate (GTP) into guanosine diphosphate (GDP) and inorganic phosphate. This creates a conformational change in EF-Tu that causes EF-Tu to dissociate from the tRNA of the ternary complex (and therefore leave the ribosome). The aminoacyl-tRNA then fully enters the A site, where its amino acid is brought near the P site's polypeptide and the ribosome catalyzes the covalent transfer of the polypeptide onto the amino acid . The tRNA on the P site (without peptide) moves to the E site and is then released.
Life.. by Marshall Mathers What is life? Life is like a big obstacle put in front of your optical to slow you down And everytime you think you gotten past it it's gonna come back around and tackle you to the damn ground What are friends? Friends are people that you think are your friends But they really your enemies, with secret indentities and disguises, to hide they true colors So just when you think you close enough to be brothers they wanna come back and cut your throat when you ain't lookin What is money? Money is what makes a man act funny Money is the root of all evil Money'll make them same friends come back around swearing that they was always down What is life? I'm tired of life I'm tired of backstabbing ass snakes with friendly grins I'm tired of committing so many sins Tired of always giving in when this bottle of Henny wins Tired of never having any ends Tired of having skinny friends hooked on crack and mini-thins I'm tired of this DJ playing YOUR shit when he spins Tired of not having a deal Tired of having to deal with the bullshit without grabbing the steel Tired of drowning in my sorrow Tired of having to borrow a dollar for gas to start my Monte Carlo I'm tired of motherfuckers spraying shit and dartin off I'm tired of jobs startin off at five fifty an hour then this boss wanders why I'm smartin off I'm tired of being fired everytime I fart and cough Tired of having to work as a gas station clerk for this jerk breathing down my neck driving me bezerk I'm tired of using plastic silverware Tired of working in Building Square Tired of not being a millionaire But if I had a million dollars I'd buy a damn brewery, and turn the planet into alcoholics If I had a magic wand, I'd make the world suck my dick without a condom on, while I'm on the john If I had a million bucks it wouldn't be enough, because I'd still be out robbing armored trucks If I had one wish I would ask for a big enough ass for the whole world to kiss I'm tired of being white trash, broke and always poor Tired of taking pop bottles back to the party store I'm tired of not having a phone Tired of not having a home to have one in if I did have it on Tired of not driving a BM Tired of not working at GM, tired of wanting to be him Tired of not sleeping without a Tylenol PM Tired of not performing in a packed coliseum Tired of not being on tour Tired of fucking the same blonde whore after work in the back of a Contour I'm tired of faking knots with a stack of ones Having a lack of funds and resorting back to guns Tired of being stared at I'm tired of wearing the same damn Nike Air hat Tired of stepping in clubs wearing the same pair of Lugz Tired of people saying they're tired of hearing me rap about drugs Tired of other rappers who ain't bringin half the skill as me saying they wasn't feeling me on "Nobody's As Ill As Me" I'm tired of radio stations telling fibs Tired of J-L-B saying "Where Hip-Hop Lives" But if I had a million dollars I'd buy a damn brewery, and turn the planet into alcoholics If I had a magic wand, I'd make the world suck my dick without a condom on, while I'm on the john If I had a million bucks it wouldn't be enough, because I'd still be out robbing armored trucks If I had one wish I would ask for a big enough ass for the whole world to kiss You know what I'm saying? I'm tired of all of this bullshit Telling me to be positive How'm I 'sposed to be positive when I don't see shit positive? Know what I'm sayin? I rap about shit around me, shit I see Know what I'm sayin? Right now I'm tired of everything Tired of all this player hating that's going on in my own city Can't get no airplay, you know what I'm sayin? But ey, it's cool though, you know what I'm sayin? Just fed up
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