Deprotonation is the removal of a proton (a hydrogen cation, H+) from a molecule, forming the conjugate base. The proton removal decreases positive charge in the molecule and increases negative charge. Deprotonation usually occurs from the donation of electrons or acceptance of the proton using a base, which forms its conjugate acid.
The relative ability of a molecule to give up a proton is measured by its pKa value. A low pKa value indicates that the compound is acidic and will easily give up its proton to a base. The pKa of a compound is determined by many things, but the most significant is the stability of the conjugate base. This is primarily determined by the ability (or inability) of the conjugated base to stabilize negative charge. One of the most important ways of assessing a conjugate base's ability to distribute negative charge is using resonance. Electron withdrawing groups (which can stabilize the molecule by increasing charge distribution) or electron donating groups (which destabilize by decreasing charge distribution) present on a molecule also determine its pKa. The solvent used can also assist in the stabilization of the negative charge on a conjugated base.
Mechanism of the Deprotonation of a Carboxylic Acid 001
Lecture: Show the mechanism of the deprotonation of benzoic acid with sodium hydroxide (NaOH).
————————————
INTERVIEW
1) Revell, K. (November 16, 2016) “An Interview with Heath Giesbrecht, Part I” The Macmillan Community https://community.macmillan.com/groups/flipped-chemistry/blog/2016/11/17/an-interview-with-heath-giesbrecht-part-1
2) Revell, K. (November 16, 2016) “An Interview with Heath Giesbrecht, Part II” The Macmillan Community https://community.macmillan.com/groups/flipped-chemistry/blog/2016/11/17/an-interview-with-heath-giesbrecht-part-2
————————————
INTERDISCIPLINARY ART LECTURE:
1) Giesbrecht, H., Peet, K. (January 20, 2016) “Translating Failure” WEDGE_SPACE https://vimeo.com/152432030
————————————
FACEBOOK: https://www.facebook.com/profheath/
TWITTER: https://twitter.com/...
published: 30 Mar 2012
Chemistry Vignettes: Protonation and deprotonation
This screencast lecture discusses protonation and deprotonation.
For more please go to the Royal Society of Chemistry; Learn Chemistry site
http://www.rsc.org/learn-chemistry/resource/listing?searchtext=chemistry+%2B+vignettes
published: 02 Jan 2014
Practice Problem: Site of Protonation on a Weak Base
For this one we will need to understand the basics about Bronsted-Lowry acid-base reactions, and we also should be able to gauge the stability of various potential conjugate bases.
Try all of the organic chemistry practice problems: http://bit.ly/ProfDaveOCPP
Organic Chemistry Tutorials: http://bit.ly/ProfDaveOrgChem
EMAIL► [email protected]
PATREON► http://patreon.com/ProfessorDaveExplains
Check out "Is This Wi-Fi Organic?", my book on disarming pseudoscience!
Amazon: https://amzn.to/2HtNpVH
Bookshop: https://bit.ly/39cKADM
Barnes and Noble: https://bit.ly/3pUjmrn
Book Depository: http://bit.ly/3aOVDlT
published: 25 Apr 2016
Proton Transfer and Rearrangement Mechanisms in Organic Chemistry
http://leah4sci.com/mechanism presents: Orgo Proton Transfer and Rearrangement Step by Step Mechanisms
Need help with Orgo? Download my free guide ’10 Secrets to Acing Organic Chemistry’ HERE: http://leah4sci.com/orgo-ebook/
Video two in this Mechanism Series gives you an in-depth look at 2 common mechanism types: Proton Transfer and Rearrangement which includes Hydride or Alkyl Shifts such as a methyl shift. Including conditions, and comparisons of stability to explain exactly WHY these are occurring.
Links & Resources Mentioned In This Video:
Formal charge formula shortcut: http://leah4sci.com/formal-charge-formula-and-shortcut/
Carbocation Rearrangement hydride and alkyl shift Tutorial: http://leah4sci.com/carbocation-stability-and-ranking/
Catch the entire Mechanism Video list in...
published: 24 Sep 2017
Amino acid affect on pH - BIOCHEMISTRY - MADE EASY- protonation and deprotonation
I'm New to YouTube , Please Like and Subscribe
Amino acid , protein , pH , protonation , deprotonation , zwitterion , isoelectric point , monomers , peptide bond , amino group , carboxylic group , alpha carbon , acidic pH , basic pH , charge , H ion ,
published: 29 Jan 2017
Chemistry - percentage deprotonation
Problem 65 of chapter 11 in Chemical Principles: The Quest for Insight 5th ed.
published: 13 Dec 2014
Amino acid charge at different pH and amino acid titration calculation problems
Amino acid charge at different pH and amino acid titration calculation problems - This lecture explains about the amino acid titration curve and this will teach you the process of calculating amino acid charge at different pH along with pka values and it will also help you to know the net charge of polypeptide chain from the pka values of amino acids.
For more information, log on to-
http://www.shomusbiology.com/
Get Shomu's Biology DVD set here-
http://www.shomusbiology.com/dvd-store/
Download the study materials here-
http://shomusbiology.com/bio-materials.html
Remember Shomu’s Biology is created to spread the knowledge of life science and biology by sharing all this free biology lectures video and animation presented by Suman Bhattacharjee in YouTube. All these tutorials are brought to ...
published: 21 Oct 2017
Zwitterion and Amino Acid Charge Given pH and pKa
http://leah4sci.com/aminoacids presents: Zwitterion and Amino Acid Charge given specific pH and pKa Values
Is your MCAT just around the corner? Grab a free copy of my ebook "MCAT Exam Strategy - A 6 Week Guide To Crushing The MCAT" at http://mcatexamstrategy.com/ebook
This is video 5 in the MCAT amino acids tutorial video series. Learn how to easily determine the charge of any amino acid carboxy, amine, and side chain by comparing the pH to the pKa
Referenced in this video:
Acid/Base series: http://leah4sci.com/mcatacidbase
Henderson Hasselbalch Trick: https://youtu.be/hb8bEeUlBV4
Catch this entire video series along with my amino acid cheat sheet, tutorials and practice quiz on my website:
http://leah4sci.com/aminoacids
Need more help? I offer private online MCAT tutoring. Details ht...
Lecture: Show the mechanism of the deprotonation of benzoic acid with sodium hydroxide (NaOH).
————————————
INTERVIEW
1) Revell, K. (November 16, 2016) “An Inte...
Lecture: Show the mechanism of the deprotonation of benzoic acid with sodium hydroxide (NaOH).
————————————
INTERVIEW
1) Revell, K. (November 16, 2016) “An Interview with Heath Giesbrecht, Part I” The Macmillan Community https://community.macmillan.com/groups/flipped-chemistry/blog/2016/11/17/an-interview-with-heath-giesbrecht-part-1
2) Revell, K. (November 16, 2016) “An Interview with Heath Giesbrecht, Part II” The Macmillan Community https://community.macmillan.com/groups/flipped-chemistry/blog/2016/11/17/an-interview-with-heath-giesbrecht-part-2
————————————
INTERDISCIPLINARY ART LECTURE:
1) Giesbrecht, H., Peet, K. (January 20, 2016) “Translating Failure” WEDGE_SPACE https://vimeo.com/152432030
————————————
FACEBOOK: https://www.facebook.com/profheath/
TWITTER: https://twitter.com/prof_heath
Lecture: Show the mechanism of the deprotonation of benzoic acid with sodium hydroxide (NaOH).
————————————
INTERVIEW
1) Revell, K. (November 16, 2016) “An Interview with Heath Giesbrecht, Part I” The Macmillan Community https://community.macmillan.com/groups/flipped-chemistry/blog/2016/11/17/an-interview-with-heath-giesbrecht-part-1
2) Revell, K. (November 16, 2016) “An Interview with Heath Giesbrecht, Part II” The Macmillan Community https://community.macmillan.com/groups/flipped-chemistry/blog/2016/11/17/an-interview-with-heath-giesbrecht-part-2
————————————
INTERDISCIPLINARY ART LECTURE:
1) Giesbrecht, H., Peet, K. (January 20, 2016) “Translating Failure” WEDGE_SPACE https://vimeo.com/152432030
————————————
FACEBOOK: https://www.facebook.com/profheath/
TWITTER: https://twitter.com/prof_heath
This screencast lecture discusses protonation and deprotonation.
For more please go to the Royal Society of Chemistry; Learn Chemistry site
http://www.rsc.org/...
This screencast lecture discusses protonation and deprotonation.
For more please go to the Royal Society of Chemistry; Learn Chemistry site
http://www.rsc.org/learn-chemistry/resource/listing?searchtext=chemistry+%2B+vignettes
This screencast lecture discusses protonation and deprotonation.
For more please go to the Royal Society of Chemistry; Learn Chemistry site
http://www.rsc.org/learn-chemistry/resource/listing?searchtext=chemistry+%2B+vignettes
For this one we will need to understand the basics about Bronsted-Lowry acid-base reactions, and we also should be able to gauge the stability of various potent...
For this one we will need to understand the basics about Bronsted-Lowry acid-base reactions, and we also should be able to gauge the stability of various potential conjugate bases.
Try all of the organic chemistry practice problems: http://bit.ly/ProfDaveOCPP
Organic Chemistry Tutorials: http://bit.ly/ProfDaveOrgChem
EMAIL► [email protected]
PATREON► http://patreon.com/ProfessorDaveExplains
Check out "Is This Wi-Fi Organic?", my book on disarming pseudoscience!
Amazon: https://amzn.to/2HtNpVH
Bookshop: https://bit.ly/39cKADM
Barnes and Noble: https://bit.ly/3pUjmrn
Book Depository: http://bit.ly/3aOVDlT
For this one we will need to understand the basics about Bronsted-Lowry acid-base reactions, and we also should be able to gauge the stability of various potential conjugate bases.
Try all of the organic chemistry practice problems: http://bit.ly/ProfDaveOCPP
Organic Chemistry Tutorials: http://bit.ly/ProfDaveOrgChem
EMAIL► [email protected]
PATREON► http://patreon.com/ProfessorDaveExplains
Check out "Is This Wi-Fi Organic?", my book on disarming pseudoscience!
Amazon: https://amzn.to/2HtNpVH
Bookshop: https://bit.ly/39cKADM
Barnes and Noble: https://bit.ly/3pUjmrn
Book Depository: http://bit.ly/3aOVDlT
http://leah4sci.com/mechanism presents: Orgo Proton Transfer and Rearrangement Step by Step Mechanisms
Need help with Orgo? Download my free guide ’10 Secrets ...
http://leah4sci.com/mechanism presents: Orgo Proton Transfer and Rearrangement Step by Step Mechanisms
Need help with Orgo? Download my free guide ’10 Secrets to Acing Organic Chemistry’ HERE: http://leah4sci.com/orgo-ebook/
Video two in this Mechanism Series gives you an in-depth look at 2 common mechanism types: Proton Transfer and Rearrangement which includes Hydride or Alkyl Shifts such as a methyl shift. Including conditions, and comparisons of stability to explain exactly WHY these are occurring.
Links & Resources Mentioned In This Video:
Formal charge formula shortcut: http://leah4sci.com/formal-charge-formula-and-shortcut/
Carbocation Rearrangement hydride and alkyl shift Tutorial: http://leah4sci.com/carbocation-stability-and-ranking/
Catch the entire Mechanism Video list in Organic Chemistry Series, on my website at http://leah4sci.com/mechanism
For more in-depth review including practice problems and explanations, check out my online membership site: http://leah4sci.com/join
For private online tutoring visit my website: http://leah4sci.com/organic-chemistry-tutor/
For questions and comments, find me on social media here:
Facebook: https://www.facebook.com/Leah4Sci
Twitter: https://twitter.com/Leah4Sci
Instagram: https://www.instagram.com/leah4sci/
Pinterest: http://www.pinterest.com/leah4sci/
http://leah4sci.com/mechanism presents: Orgo Proton Transfer and Rearrangement Step by Step Mechanisms
Need help with Orgo? Download my free guide ’10 Secrets to Acing Organic Chemistry’ HERE: http://leah4sci.com/orgo-ebook/
Video two in this Mechanism Series gives you an in-depth look at 2 common mechanism types: Proton Transfer and Rearrangement which includes Hydride or Alkyl Shifts such as a methyl shift. Including conditions, and comparisons of stability to explain exactly WHY these are occurring.
Links & Resources Mentioned In This Video:
Formal charge formula shortcut: http://leah4sci.com/formal-charge-formula-and-shortcut/
Carbocation Rearrangement hydride and alkyl shift Tutorial: http://leah4sci.com/carbocation-stability-and-ranking/
Catch the entire Mechanism Video list in Organic Chemistry Series, on my website at http://leah4sci.com/mechanism
For more in-depth review including practice problems and explanations, check out my online membership site: http://leah4sci.com/join
For private online tutoring visit my website: http://leah4sci.com/organic-chemistry-tutor/
For questions and comments, find me on social media here:
Facebook: https://www.facebook.com/Leah4Sci
Twitter: https://twitter.com/Leah4Sci
Instagram: https://www.instagram.com/leah4sci/
Pinterest: http://www.pinterest.com/leah4sci/
I'm New to YouTube , Please Like and Subscribe
Amino acid , protein , pH , protonation , deprotonation , zwitterion , isoelectric point , monomers , peptide bo...
I'm New to YouTube , Please Like and Subscribe
Amino acid , protein , pH , protonation , deprotonation , zwitterion , isoelectric point , monomers , peptide bond , amino group , carboxylic group , alpha carbon , acidic pH , basic pH , charge , H ion ,
I'm New to YouTube , Please Like and Subscribe
Amino acid , protein , pH , protonation , deprotonation , zwitterion , isoelectric point , monomers , peptide bond , amino group , carboxylic group , alpha carbon , acidic pH , basic pH , charge , H ion ,
Amino acid charge at different pH and amino acid titration calculation problems - This lecture explains about the amino acid titration curve and this will teach...
Amino acid charge at different pH and amino acid titration calculation problems - This lecture explains about the amino acid titration curve and this will teach you the process of calculating amino acid charge at different pH along with pka values and it will also help you to know the net charge of polypeptide chain from the pka values of amino acids.
For more information, log on to-
http://www.shomusbiology.com/
Get Shomu's Biology DVD set here-
http://www.shomusbiology.com/dvd-store/
Download the study materials here-
http://shomusbiology.com/bio-materials.html
Remember Shomu’s Biology is created to spread the knowledge of life science and biology by sharing all this free biology lectures video and animation presented by Suman Bhattacharjee in YouTube. All these tutorials are brought to you for free. Please subscribe to our channel so that we can grow together. You can check for any of the following services from Shomu’s Biology-
Buy Shomu’s Biology lecture DVD set- www.shomusbiology.com/dvd-store
Shomu’s Biology assignment services – www.shomusbiology.com/assignment -help
Join Online coaching for CSIR NET exam – www.shomusbiology.com/net-coaching
We are social. Find us on different sites here-
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LinkedIn - https://www.linkedin.com/in/suman-bhattacharjee-2a051661
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Thank you for watching the video lecture on amino acid titration curve and net charge problems.
This will also teach you about the amino acid charge pH and Pka values and the way to calculate net charge of amino acid.
Amino acid charge at different pH and amino acid titration calculation problems - This lecture explains about the amino acid titration curve and this will teach you the process of calculating amino acid charge at different pH along with pka values and it will also help you to know the net charge of polypeptide chain from the pka values of amino acids.
For more information, log on to-
http://www.shomusbiology.com/
Get Shomu's Biology DVD set here-
http://www.shomusbiology.com/dvd-store/
Download the study materials here-
http://shomusbiology.com/bio-materials.html
Remember Shomu’s Biology is created to spread the knowledge of life science and biology by sharing all this free biology lectures video and animation presented by Suman Bhattacharjee in YouTube. All these tutorials are brought to you for free. Please subscribe to our channel so that we can grow together. You can check for any of the following services from Shomu’s Biology-
Buy Shomu’s Biology lecture DVD set- www.shomusbiology.com/dvd-store
Shomu’s Biology assignment services – www.shomusbiology.com/assignment -help
Join Online coaching for CSIR NET exam – www.shomusbiology.com/net-coaching
We are social. Find us on different sites here-
Our Website – www.shomusbiology.com
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LinkedIn - https://www.linkedin.com/in/suman-bhattacharjee-2a051661
Youtube- https://www.youtube.com/user/TheFunsuman
Thank you for watching the video lecture on amino acid titration curve and net charge problems.
This will also teach you about the amino acid charge pH and Pka values and the way to calculate net charge of amino acid.
http://leah4sci.com/aminoacids presents: Zwitterion and Amino Acid Charge given specific pH and pKa Values
Is your MCAT just around the corner? Grab a free cop...
http://leah4sci.com/aminoacids presents: Zwitterion and Amino Acid Charge given specific pH and pKa Values
Is your MCAT just around the corner? Grab a free copy of my ebook "MCAT Exam Strategy - A 6 Week Guide To Crushing The MCAT" at http://mcatexamstrategy.com/ebook
This is video 5 in the MCAT amino acids tutorial video series. Learn how to easily determine the charge of any amino acid carboxy, amine, and side chain by comparing the pH to the pKa
Referenced in this video:
Acid/Base series: http://leah4sci.com/mcatacidbase
Henderson Hasselbalch Trick: https://youtu.be/hb8bEeUlBV4
Catch this entire video series along with my amino acid cheat sheet, tutorials and practice quiz on my website:
http://leah4sci.com/aminoacids
Need more help? I offer private online MCAT tutoring. Details http://leah4sci.com/mcat-tutoring/
Have questions? Leave a comment below this video or hit me up on social media:
Twitter: http://twitter.com/leah4sci
Facebook: https://www.facebook.com/mcatexamstrategy
Google+: https://plus.google.com/+LeahFisch/
http://leah4sci.com/aminoacids presents: Zwitterion and Amino Acid Charge given specific pH and pKa Values
Is your MCAT just around the corner? Grab a free copy of my ebook "MCAT Exam Strategy - A 6 Week Guide To Crushing The MCAT" at http://mcatexamstrategy.com/ebook
This is video 5 in the MCAT amino acids tutorial video series. Learn how to easily determine the charge of any amino acid carboxy, amine, and side chain by comparing the pH to the pKa
Referenced in this video:
Acid/Base series: http://leah4sci.com/mcatacidbase
Henderson Hasselbalch Trick: https://youtu.be/hb8bEeUlBV4
Catch this entire video series along with my amino acid cheat sheet, tutorials and practice quiz on my website:
http://leah4sci.com/aminoacids
Need more help? I offer private online MCAT tutoring. Details http://leah4sci.com/mcat-tutoring/
Have questions? Leave a comment below this video or hit me up on social media:
Twitter: http://twitter.com/leah4sci
Facebook: https://www.facebook.com/mcatexamstrategy
Google+: https://plus.google.com/+LeahFisch/
Lecture: Show the mechanism of the deprotonation of benzoic acid with sodium hydroxide (NaOH).
————————————
INTERVIEW
1) Revell, K. (November 16, 2016) “An Interview with Heath Giesbrecht, Part I” The Macmillan Community https://community.macmillan.com/groups/flipped-chemistry/blog/2016/11/17/an-interview-with-heath-giesbrecht-part-1
2) Revell, K. (November 16, 2016) “An Interview with Heath Giesbrecht, Part II” The Macmillan Community https://community.macmillan.com/groups/flipped-chemistry/blog/2016/11/17/an-interview-with-heath-giesbrecht-part-2
————————————
INTERDISCIPLINARY ART LECTURE:
1) Giesbrecht, H., Peet, K. (January 20, 2016) “Translating Failure” WEDGE_SPACE https://vimeo.com/152432030
————————————
FACEBOOK: https://www.facebook.com/profheath/
TWITTER: https://twitter.com/prof_heath
This screencast lecture discusses protonation and deprotonation.
For more please go to the Royal Society of Chemistry; Learn Chemistry site
http://www.rsc.org/learn-chemistry/resource/listing?searchtext=chemistry+%2B+vignettes
For this one we will need to understand the basics about Bronsted-Lowry acid-base reactions, and we also should be able to gauge the stability of various potential conjugate bases.
Try all of the organic chemistry practice problems: http://bit.ly/ProfDaveOCPP
Organic Chemistry Tutorials: http://bit.ly/ProfDaveOrgChem
EMAIL► [email protected]
PATREON► http://patreon.com/ProfessorDaveExplains
Check out "Is This Wi-Fi Organic?", my book on disarming pseudoscience!
Amazon: https://amzn.to/2HtNpVH
Bookshop: https://bit.ly/39cKADM
Barnes and Noble: https://bit.ly/3pUjmrn
Book Depository: http://bit.ly/3aOVDlT
http://leah4sci.com/mechanism presents: Orgo Proton Transfer and Rearrangement Step by Step Mechanisms
Need help with Orgo? Download my free guide ’10 Secrets to Acing Organic Chemistry’ HERE: http://leah4sci.com/orgo-ebook/
Video two in this Mechanism Series gives you an in-depth look at 2 common mechanism types: Proton Transfer and Rearrangement which includes Hydride or Alkyl Shifts such as a methyl shift. Including conditions, and comparisons of stability to explain exactly WHY these are occurring.
Links & Resources Mentioned In This Video:
Formal charge formula shortcut: http://leah4sci.com/formal-charge-formula-and-shortcut/
Carbocation Rearrangement hydride and alkyl shift Tutorial: http://leah4sci.com/carbocation-stability-and-ranking/
Catch the entire Mechanism Video list in Organic Chemistry Series, on my website at http://leah4sci.com/mechanism
For more in-depth review including practice problems and explanations, check out my online membership site: http://leah4sci.com/join
For private online tutoring visit my website: http://leah4sci.com/organic-chemistry-tutor/
For questions and comments, find me on social media here:
Facebook: https://www.facebook.com/Leah4Sci
Twitter: https://twitter.com/Leah4Sci
Instagram: https://www.instagram.com/leah4sci/
Pinterest: http://www.pinterest.com/leah4sci/
I'm New to YouTube , Please Like and Subscribe
Amino acid , protein , pH , protonation , deprotonation , zwitterion , isoelectric point , monomers , peptide bond , amino group , carboxylic group , alpha carbon , acidic pH , basic pH , charge , H ion ,
Amino acid charge at different pH and amino acid titration calculation problems - This lecture explains about the amino acid titration curve and this will teach you the process of calculating amino acid charge at different pH along with pka values and it will also help you to know the net charge of polypeptide chain from the pka values of amino acids.
For more information, log on to-
http://www.shomusbiology.com/
Get Shomu's Biology DVD set here-
http://www.shomusbiology.com/dvd-store/
Download the study materials here-
http://shomusbiology.com/bio-materials.html
Remember Shomu’s Biology is created to spread the knowledge of life science and biology by sharing all this free biology lectures video and animation presented by Suman Bhattacharjee in YouTube. All these tutorials are brought to you for free. Please subscribe to our channel so that we can grow together. You can check for any of the following services from Shomu’s Biology-
Buy Shomu’s Biology lecture DVD set- www.shomusbiology.com/dvd-store
Shomu’s Biology assignment services – www.shomusbiology.com/assignment -help
Join Online coaching for CSIR NET exam – www.shomusbiology.com/net-coaching
We are social. Find us on different sites here-
Our Website – www.shomusbiology.com
Facebook page- https://www.facebook.com/ShomusBiology/
Twitter - https://twitter.com/shomusbiology
SlideShare- www.slideshare.net/shomusbiology
Google plus- https://plus.google.com/113648584982732129198
LinkedIn - https://www.linkedin.com/in/suman-bhattacharjee-2a051661
Youtube- https://www.youtube.com/user/TheFunsuman
Thank you for watching the video lecture on amino acid titration curve and net charge problems.
This will also teach you about the amino acid charge pH and Pka values and the way to calculate net charge of amino acid.
http://leah4sci.com/aminoacids presents: Zwitterion and Amino Acid Charge given specific pH and pKa Values
Is your MCAT just around the corner? Grab a free copy of my ebook "MCAT Exam Strategy - A 6 Week Guide To Crushing The MCAT" at http://mcatexamstrategy.com/ebook
This is video 5 in the MCAT amino acids tutorial video series. Learn how to easily determine the charge of any amino acid carboxy, amine, and side chain by comparing the pH to the pKa
Referenced in this video:
Acid/Base series: http://leah4sci.com/mcatacidbase
Henderson Hasselbalch Trick: https://youtu.be/hb8bEeUlBV4
Catch this entire video series along with my amino acid cheat sheet, tutorials and practice quiz on my website:
http://leah4sci.com/aminoacids
Need more help? I offer private online MCAT tutoring. Details http://leah4sci.com/mcat-tutoring/
Have questions? Leave a comment below this video or hit me up on social media:
Twitter: http://twitter.com/leah4sci
Facebook: https://www.facebook.com/mcatexamstrategy
Google+: https://plus.google.com/+LeahFisch/
Deprotonation is the removal of a proton (a hydrogen cation, H+) from a molecule, forming the conjugate base. The proton removal decreases positive charge in the molecule and increases negative charge. Deprotonation usually occurs from the donation of electrons or acceptance of the proton using a base, which forms its conjugate acid.
The relative ability of a molecule to give up a proton is measured by its pKa value. A low pKa value indicates that the compound is acidic and will easily give up its proton to a base. The pKa of a compound is determined by many things, but the most significant is the stability of the conjugate base. This is primarily determined by the ability (or inability) of the conjugated base to stabilize negative charge. One of the most important ways of assessing a conjugate base's ability to distribute negative charge is using resonance. Electron withdrawing groups (which can stabilize the molecule by increasing charge distribution) or electron donating groups (which destabilize by decreasing charge distribution) present on a molecule also determine its pKa. The solvent used can also assist in the stabilization of the negative charge on a conjugated base.