In mammals, B cells mature in the bone marrow, which is at the core of most bones. In birds, B cells mature in the bursa of Fabricius, a lymphoid organ. (the "B" from B cells comes from the name of this organ), where it was first discovered by Chang and Glick, and not from bone marrow as commonly believed.
B cells develop from hematopoietic stem cells (HSCs) that originate from bone marrow. HSCs first differentiate into multipotent progenitor (MPP) cells, then common lymphoid progenitor (CLP) cells. From here, their development into B cells occurs in several stages (shown in image to the right), each marked by various gene expression patterns and immunoglobulinH chain and L chaingene loci arrangements, the latter due to B cells undergoing V(D)J recombination as they develop.
B1 cells are first produced in the fetus and most B1 cells undergo self-renewal in the periphery, unlike conventional B cells (B2 cells) that are produced after birth and replaced in the bone marrow.
Types
In January 2011, human B1 cells were found to have marker profile of CD20+CD27+CD43+CD70- and could either be CD5+ or CD5-, which has been debated since. CD5-CD72 is thought to mediate B cell-B cell interaction. B-1 B cells, in the mouse, can be further subdivided into B-1a (CD5+) and B-1b (CD5−) subtypes. Unlike B1a B cells, the B-1b subtype can be generated from precursors in the adult bone marrow. The B1a and B1b precursors have been reported to differ in the expression levels of CD138.
The Humoral Response - B Cell Activation, Antibody Production & Memory Cells
In this video, we demystify B cell activation, antibody production, and memory cell formation in this informative video. Learn how your immune system battles pathogens like the West Nile virus, how B and T cells work together, and the essential roles of plasma and memory B cells. We'll also touch on isotype switching and affinity maturation, processes that refine our immune response. Stay tuned for our next video on the cell-mediated response! Subscribe for more insights into the fascinating world of biology.
published: 12 May 2023
B cell activation
This video gives a quick overview of the B cell activation process.
published: 14 Sep 2019
Immunology - Adaptive Immunity (B cell Activation, Hypermutation and Class Switching Overview)
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published: 18 May 2017
B-Cell Activation and Class Switching | Immunology | Physiology Series
B-Cell (B-lymphocyte) Activation and Class Switching | Immunology | Physiology Lecture Series (Medicosis Physiology Playlist).
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published: 13 Jan 2022
B cell Activation and Differentiation (PART 1): T Independent Activation (FL-Immuno/48)
In this video lecture we will study..
Types of B cell Activation
Td and Ti antigens
T independent B cell Activation
published: 10 Nov 2017
B Cell Development
published: 06 Aug 2018
B lymphocytes (B cells) | Immune system physiology | NCLEX-RN | Khan Academy
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Overview of B cells (B lymphocytes) and how they are activated and produce antibodies. Created by Sal Khan.
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NCLEX-RN on Khan Academy: A collection...
1:29 Basics of peripheral B cell neoplasms
8:01 Chronic Lymphocytic Leukemia (CLL)- Detailed
Dive into the essentials of Chronic Lymphocytic Leukemia (CLL) and Basics of peripheral B cell neoplasms with Dr. Bala's latest educational video.
This detailed guide offers you everything you need to understand the basics and complex aspects of CLL. Designed specifically for MBBS and NEET PG aspirants, this video delivers high-quality, easy-to-follow notes aimed at helping you achieve top marks. No lengthy lectures, just straight-to-the-point facts and a dedicated MCQ section to test your knowledge. Don't forget to like, share, and subscribe to Dr. Bala's channel for more exceptional hematology content and expert exam preparation tips. Your success in medical exams starts here!
#ChronicLymphoc...
published: 16 Jun 2024
B cell development
This video describes the process of B cell development and also describes the signaling pathways that help in this process in details.
In this video, we demystify B cell activation, antibody production, and memory cell formation in this informative video. Learn how your immune system battles pa...
In this video, we demystify B cell activation, antibody production, and memory cell formation in this informative video. Learn how your immune system battles pathogens like the West Nile virus, how B and T cells work together, and the essential roles of plasma and memory B cells. We'll also touch on isotype switching and affinity maturation, processes that refine our immune response. Stay tuned for our next video on the cell-mediated response! Subscribe for more insights into the fascinating world of biology.
In this video, we demystify B cell activation, antibody production, and memory cell formation in this informative video. Learn how your immune system battles pathogens like the West Nile virus, how B and T cells work together, and the essential roles of plasma and memory B cells. We'll also touch on isotype switching and affinity maturation, processes that refine our immune response. Stay tuned for our next video on the cell-mediated response! Subscribe for more insights into the fascinating world of biology.
Mack The Molecule Breaks it Down
Learn more: http://lupusresearch.org/lupus/glossary
Follow Us:
http://Twitter.com/LupusResearch
http://Facebook.com/LupusRese...
Mack The Molecule Breaks it Down
Learn more: http://lupusresearch.org/lupus/glossary
Follow Us:
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http://Facebook.com/LupusResearchAlliance
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Mack The Molecule Breaks it Down
Learn more: http://lupusresearch.org/lupus/glossary
Follow Us:
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B-Cell (B-lymphocyte) Activation and Class Switching | Immunology | Physiology Lecture Series (Medicosis Physiology Playlist).
🍱 Endocrine Pharmacology Course:...
B-Cell (B-lymphocyte) Activation and Class Switching | Immunology | Physiology Lecture Series (Medicosis Physiology Playlist).
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Courses on Khan Academy are always 100% free. Start practicing—and saving your progress—now: https://www.khanacademy.org/science/biology/human-biology/immunolog...
Courses on Khan Academy are always 100% free. Start practicing—and saving your progress—now: https://www.khanacademy.org/science/biology/human-biology/immunology/v/b-lymphocytes-b-cells
Overview of B cells (B lymphocytes) and how they are activated and produce antibodies. Created by Sal Khan.
Watch the next lesson: https://www.khanacademy.org/test-prep/nclex-rn/rn-immune-system/rn-the-immune-system/v/professional-antigen-presenting-cells-apc-and-mhc-ii-complexes?utm_source=YT&utm_medium=Desc&utm_campaign=Nclex-rn
Missed the previous lesson? https://www.khanacademy.org/test-prep/nclex-rn/rn-immune-system/rn-the-immune-system/v/types-of-immune-responses-innate-and-adaptive-humoral-vs-cell-mediated?utm_source=YT&utm_medium=Desc&utm_campaign=Nclex-rn
NCLEX-RN on Khan Academy: A collection of questions from content covered on the NCLEX-RN. These questions are available under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 United States License (available at http://creativecommons.org/licenses/by-nc-sa/3.0/us/).
About Khan Academy: Khan Academy offers practice exercises, instructional videos, and a personalized learning dashboard that empower learners to study at their own pace in and outside of the classroom. We tackle math, science, computer programming, history, art history, economics, and more. Our math missions guide learners from kindergarten to calculus using state-of-the-art, adaptive technology that identifies strengths and learning gaps. We've also partnered with institutions like NASA, The Museum of Modern Art, The California Academy of Sciences, and MIT to offer specialized content.
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Courses on Khan Academy are always 100% free. Start practicing—and saving your progress—now: https://www.khanacademy.org/science/biology/human-biology/immunology/v/b-lymphocytes-b-cells
Overview of B cells (B lymphocytes) and how they are activated and produce antibodies. Created by Sal Khan.
Watch the next lesson: https://www.khanacademy.org/test-prep/nclex-rn/rn-immune-system/rn-the-immune-system/v/professional-antigen-presenting-cells-apc-and-mhc-ii-complexes?utm_source=YT&utm_medium=Desc&utm_campaign=Nclex-rn
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NCLEX-RN on Khan Academy: A collection of questions from content covered on the NCLEX-RN. These questions are available under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 United States License (available at http://creativecommons.org/licenses/by-nc-sa/3.0/us/).
About Khan Academy: Khan Academy offers practice exercises, instructional videos, and a personalized learning dashboard that empower learners to study at their own pace in and outside of the classroom. We tackle math, science, computer programming, history, art history, economics, and more. Our math missions guide learners from kindergarten to calculus using state-of-the-art, adaptive technology that identifies strengths and learning gaps. We've also partnered with institutions like NASA, The Museum of Modern Art, The California Academy of Sciences, and MIT to offer specialized content.
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1:29 Basics of peripheral B cell neoplasms
8:01 Chronic Lymphocytic Leukemia (CLL)- Detailed
Dive into the essentials of Chronic Lymphocytic Leukemia (CLL) an...
1:29 Basics of peripheral B cell neoplasms
8:01 Chronic Lymphocytic Leukemia (CLL)- Detailed
Dive into the essentials of Chronic Lymphocytic Leukemia (CLL) and Basics of peripheral B cell neoplasms with Dr. Bala's latest educational video.
This detailed guide offers you everything you need to understand the basics and complex aspects of CLL. Designed specifically for MBBS and NEET PG aspirants, this video delivers high-quality, easy-to-follow notes aimed at helping you achieve top marks. No lengthy lectures, just straight-to-the-point facts and a dedicated MCQ section to test your knowledge. Don't forget to like, share, and subscribe to Dr. Bala's channel for more exceptional hematology content and expert exam preparation tips. Your success in medical exams starts here!
#ChronicLymphocyticLeukemia #CLL #BcellNeoplasms #Hematology #MedicalEducation #MBBS #NEETPG #INICET #DrBala #MedicalStudents #FutureDoctors #MedEd #MCQs #ExamPrep #StudyNotes #HealthEducation #MedicalChannel #YouTubeMedEd #LearnMedicine #MedicalKnowledge #Pathology #Oncology #CancerResearch #LeukemiaAwareness #MedSchool #MedicalExams #DoctorInTraining #MedStudentLife #ClinicalMedicine #MedicalScience #NeetPreparation #MedicalNotes #NoLecture #StudyTips #Medicine #HealthcareEducation #MedicalProfessional #Medico #MBBSNotes #MedPrep #MedicalJourney #MedEdOnline #ClinicalKnowledge #MedicalLearning #MedStudent #MedicalGuidance #MedExams #TestPrep #AcademicMedicine #MedicalContent #SubscribeForMore
Hello, my dear students and viewers, Dr. Bala here. Welcome to my YouTube channel, Dr.Bala239, where I create and share specialized medical notes tailored for MBBS students. These notes are meticulously crafted from several authoritative medical textbooks and integrate seamlessly with my professional duties in fetal imaging. Please note that all content on this channel, including notes and publications, is copyrighted. However, you are encouraged to take down notes from my videos for your personal study and review. This means that no part of this material can be reproduced, stored, or transmitted in any form without explicit written permission from the publishers or editors. Thank you for joining me, and like, share and subscribe.
Medical knowledge continuously evolves, and while every effort is made to ensure the accuracy and relevance of the information provided, I encourage all viewers and medical professionals to consult additional sources and stay updated with the latest medical standards, especially when it concerns new treatments or drugs. Always verify the information regarding drug dosages and contraindications directly from the product's information sheet or manufacturer before application. Thank you for tuning in, and please remember to use these resources responsibly and ethically as part of your ongoing medical education."
1:29 Basics of peripheral B cell neoplasms
8:01 Chronic Lymphocytic Leukemia (CLL)- Detailed
Dive into the essentials of Chronic Lymphocytic Leukemia (CLL) and Basics of peripheral B cell neoplasms with Dr. Bala's latest educational video.
This detailed guide offers you everything you need to understand the basics and complex aspects of CLL. Designed specifically for MBBS and NEET PG aspirants, this video delivers high-quality, easy-to-follow notes aimed at helping you achieve top marks. No lengthy lectures, just straight-to-the-point facts and a dedicated MCQ section to test your knowledge. Don't forget to like, share, and subscribe to Dr. Bala's channel for more exceptional hematology content and expert exam preparation tips. Your success in medical exams starts here!
#ChronicLymphocyticLeukemia #CLL #BcellNeoplasms #Hematology #MedicalEducation #MBBS #NEETPG #INICET #DrBala #MedicalStudents #FutureDoctors #MedEd #MCQs #ExamPrep #StudyNotes #HealthEducation #MedicalChannel #YouTubeMedEd #LearnMedicine #MedicalKnowledge #Pathology #Oncology #CancerResearch #LeukemiaAwareness #MedSchool #MedicalExams #DoctorInTraining #MedStudentLife #ClinicalMedicine #MedicalScience #NeetPreparation #MedicalNotes #NoLecture #StudyTips #Medicine #HealthcareEducation #MedicalProfessional #Medico #MBBSNotes #MedPrep #MedicalJourney #MedEdOnline #ClinicalKnowledge #MedicalLearning #MedStudent #MedicalGuidance #MedExams #TestPrep #AcademicMedicine #MedicalContent #SubscribeForMore
Hello, my dear students and viewers, Dr. Bala here. Welcome to my YouTube channel, Dr.Bala239, where I create and share specialized medical notes tailored for MBBS students. These notes are meticulously crafted from several authoritative medical textbooks and integrate seamlessly with my professional duties in fetal imaging. Please note that all content on this channel, including notes and publications, is copyrighted. However, you are encouraged to take down notes from my videos for your personal study and review. This means that no part of this material can be reproduced, stored, or transmitted in any form without explicit written permission from the publishers or editors. Thank you for joining me, and like, share and subscribe.
Medical knowledge continuously evolves, and while every effort is made to ensure the accuracy and relevance of the information provided, I encourage all viewers and medical professionals to consult additional sources and stay updated with the latest medical standards, especially when it concerns new treatments or drugs. Always verify the information regarding drug dosages and contraindications directly from the product's information sheet or manufacturer before application. Thank you for tuning in, and please remember to use these resources responsibly and ethically as part of your ongoing medical education."
In this video, we demystify B cell activation, antibody production, and memory cell formation in this informative video. Learn how your immune system battles pathogens like the West Nile virus, how B and T cells work together, and the essential roles of plasma and memory B cells. We'll also touch on isotype switching and affinity maturation, processes that refine our immune response. Stay tuned for our next video on the cell-mediated response! Subscribe for more insights into the fascinating world of biology.
Mack The Molecule Breaks it Down
Learn more: http://lupusresearch.org/lupus/glossary
Follow Us:
http://Twitter.com/LupusResearch
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B-Cell (B-lymphocyte) Activation and Class Switching | Immunology | Physiology Lecture Series (Medicosis Physiology Playlist).
🍱 Endocrine Pharmacology Course: https://www.medicosisperfectionalis.com/products/
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Overview of B cells (B lymphocytes) and how they are activated and produce antibodies. Created by Sal Khan.
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1:29 Basics of peripheral B cell neoplasms
8:01 Chronic Lymphocytic Leukemia (CLL)- Detailed
Dive into the essentials of Chronic Lymphocytic Leukemia (CLL) and Basics of peripheral B cell neoplasms with Dr. Bala's latest educational video.
This detailed guide offers you everything you need to understand the basics and complex aspects of CLL. Designed specifically for MBBS and NEET PG aspirants, this video delivers high-quality, easy-to-follow notes aimed at helping you achieve top marks. No lengthy lectures, just straight-to-the-point facts and a dedicated MCQ section to test your knowledge. Don't forget to like, share, and subscribe to Dr. Bala's channel for more exceptional hematology content and expert exam preparation tips. Your success in medical exams starts here!
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Hello, my dear students and viewers, Dr. Bala here. Welcome to my YouTube channel, Dr.Bala239, where I create and share specialized medical notes tailored for MBBS students. These notes are meticulously crafted from several authoritative medical textbooks and integrate seamlessly with my professional duties in fetal imaging. Please note that all content on this channel, including notes and publications, is copyrighted. However, you are encouraged to take down notes from my videos for your personal study and review. This means that no part of this material can be reproduced, stored, or transmitted in any form without explicit written permission from the publishers or editors. Thank you for joining me, and like, share and subscribe.
Medical knowledge continuously evolves, and while every effort is made to ensure the accuracy and relevance of the information provided, I encourage all viewers and medical professionals to consult additional sources and stay updated with the latest medical standards, especially when it concerns new treatments or drugs. Always verify the information regarding drug dosages and contraindications directly from the product's information sheet or manufacturer before application. Thank you for tuning in, and please remember to use these resources responsibly and ethically as part of your ongoing medical education."
In mammals, B cells mature in the bone marrow, which is at the core of most bones. In birds, B cells mature in the bursa of Fabricius, a lymphoid organ. (the "B" from B cells comes from the name of this organ), where it was first discovered by Chang and Glick, and not from bone marrow as commonly believed.
B cells develop from hematopoietic stem cells (HSCs) that originate from bone marrow. HSCs first differentiate into multipotent progenitor (MPP) cells, then common lymphoid progenitor (CLP) cells. From here, their development into B cells occurs in several stages (shown in image to the right), each marked by various gene expression patterns and immunoglobulinH chain and L chaingene loci arrangements, the latter due to B cells undergoing V(D)J recombination as they develop.
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