RTL3

RTL3
Identifiers
Aliases	RTL3, Mar3, Mart3, ZHC5, ZCCHC5, zinc finger CCHC-type containing 5, SIRH9, retrotransposon Gag like 3
External IDs	MGI: 2685221; HomoloGene: 19397; GeneCards: RTL3; OMA:RTL3 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	78,659,328 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	105,884,250 bp
RNA expression pattern
	Top expressed in
	gastric mucosa; ; right coronary artery; ; ascending aorta; ; tibia; ; Achilles tendon; ; apex of heart; ; smooth muscle tissue; ; popliteal artery; ; tibial arteries; ; left coronary artery;
	Top expressed in
	efferent ductule; ; tongue muscle; ; dermis; ; human fetus; ; condyle; ; internal carotid artery; ; intrinsic muscle of tongue; ; external carotid artery; ; extrinsic muscle of tongue; ; atrioventricular valve;
	More reference expression data
	n/a
Orthologs
	203430
	213436
	ENSG00000179300
	ENSMUSG00000047686
	Q8N8U3
	Q6P1Y1
	NM_152694
	NM_199468
	NP_689907
	NP_955762
	Wikidata
View/Edit Human	View/Edit Mouse

Retrotransposon Gag like 3 is a protein that in humans is encoded by the RTL3 gene. ^[5]

Function

This gene is a member of a family of gag-related retrotransposon genes. These genes appear to have lost the ability to retrotranspose; however, their open reading frames have remained intact, which may indicate that these genes have acquired new functions in the cell. Retrotransposon gag-like-3 (RTL3/ZCCHC5/MART3) is one of eleven Sushi-like neogenes identified in the human genome7 RTL3 encodes a 53 kDa protein with a nucleic acid-binding domain (CX2CX4HX4C), gag-like region within the open reading frame and an ssDNA/RNA-binding homeobox-associated leucine zipper motif.^[6] It has been reported that RTL3 and SOX-9 co-regulate the expression of COL2A1 in chondrocytes.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000179300 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000047686 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Retrotransposon Gag like 3". Retrieved 2017-09-18.
^ ^a ^b Ball HC, Ansari MY, Ahmad N, Novak K, Haqqi TM (November 2021). "A retrotransposon gag-like-3 gene RTL3 and SOX-9 co-regulate the expression of COL2A1 in chondrocytes". Connective Tissue Research. 62 (6): 615–628. doi:10.1080/03008207.2020.1828380. PMC 8404968. PMID 33043724.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on the human X chromosome and/or its associated protein is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000179300 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000047686 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Retrotransposon Gag like 3". Retrieved 2017-09-18.

[Ball_2021-6] Ball HC, Ansari MY, Ahmad N, Novak K, Haqqi TM (November 2021). "A retrotransposon gag-like-3 gene RTL3 and SOX-9 co-regulate the expression of COL2A1 in chondrocytes". Connective Tissue Research. 62 (6): 615–628. doi:10.1080/03008207.2020.1828380. PMC 8404968. PMID 33043724.

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