NPDC1

NPDC1
Identifiers
Aliases	NPDC1, CAB, CAB-, CAB-1, CAB1, NPDC-1, neural proliferation, differentiation and control, 1, neural proliferation, differentiation and control 1
External IDs	OMIM: 605798; MGI: 1099802; HomoloGene: 32050; GeneCards: NPDC1; OMA:NPDC1 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	137,046,179 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	25,299,506 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; pituitary gland; ; anterior pituitary; ; right frontal lobe; ; prostate; ; Brodmann area 9; ; cerebellar vermis; ; primary visual cortex; ; hypothalamus; ; right uterine tube;
	Top expressed in
	dentate gyrus of hippocampal formation granule cell; ; primary visual cortex; ; superior frontal gyrus; ; cerebellar cortex; ; perirhinal cortex; ; entorhinal cortex; ; CA3 field; ; superior colliculus; ; ventromedial nucleus; ; primary motor cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	membrane; integral component of membrane; plasma membrane;
Biological process	regulation of immune response;
	Sources:Amigo / QuickGO
Orthologs
	56654
	18146
	ENSG00000107281
	ENSMUSG00000015094
	Q9NQX5
	Q64322
	NM_015392
	NM_008721
	NP_056207
	NP_032747
	Wikidata
View/Edit Human	View/Edit Mouse

Neural proliferation differentiation and control protein 1 is a protein that in humans is encoded by the NPDC1 gene.^[5]^[6]

Interactions

NPDC1 has been shown to interact with E2F1.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000107281 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000015094 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Qu X, Zhang C, Zhai Y, Xing G, Wei H, Yu Y, Wu S, He F (March 2001). "Characterization and tissue expression of a novel human gene npdc1". Gene. 264 (1): 37–44. doi:10.1016/S0378-1119(01)00324-9. PMID 11245976.
^ "Entrez Gene: NPDC1 neural proliferation, differentiation and control, 1".
^ Sansal I, Dupont E, Toru D, Evrard C, Rouget P (October 2000). "NPDC-1, a regulator of neural cell proliferation and differentiation, interacts with E2F-1, reduces its binding to DNA and modulates its transcriptional activity". Oncogene. 19 (43): 5000–9. doi:10.1038/sj.onc.1203843. PMID 11042687.

Dupont E, Sansal I, Toru D, Evrard C, Rouget P (1997). "[Identification of NPDC-1, gene involved in the control of proliferation and differentiation of neural and glial precursors]". C. R. Séances Soc. Biol. Fil. 191 (1): 95–104. PMID 9181131.
Galiana E, Vernier P, Dupont E, Evrard C, Rouget P (1995). "Identification of a neural-specific cDNA, NPDC-1, able to down-regulate cell proliferation and to suppress transformation". Proc. Natl. Acad. Sci. U.S.A. 92 (5): 1560–4. Bibcode:1995PNAS...92.1560G. doi:10.1073/pnas.92.5.1560. PMC 42559. PMID 7878019.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Iwasaki K, Toyonaga R (2000). "The Rab3 GDP/GTP exchange factor homolog AEX-3 has a dual function in synaptic transmission". EMBO J. 19 (17): 4806–16. doi:10.1093/emboj/19.17.4806. PMC 302062. PMID 10970871.
Sansal I, Dupont E, Toru D, Evrard C, Rouget P (2000). "NPDC-1, a regulator of neural cell proliferation and differentiation, interacts with E2F-1, reduces its binding to DNA and modulates its transcriptional activity". Oncogene. 19 (43): 5000–9. doi:10.1038/sj.onc.1203843. PMID 11042687.
Spencer ML, Theodosiou M, Noonan DJ (2004). "NPDC-1, a novel regulator of neuronal proliferation, is degraded by the ubiquitin/proteasome system through a PEST degradation motif". J. Biol. Chem. 279 (35): 37069–78. doi:10.1074/jbc.M402507200. PMID 15229225.
Evrard C, Caron S, Rouget P (2004). "Functional analysis of the NPDC-1 gene". Gene. 343 (1): 153–63. doi:10.1016/j.gene.2004.08.020. PMID 15563841.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

This article on a gene on human chromosome 9 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000107281 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000015094 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11245976-5] Qu X, Zhang C, Zhai Y, Xing G, Wei H, Yu Y, Wu S, He F (March 2001). "Characterization and tissue expression of a novel human gene npdc1". Gene. 264 (1): 37–44. doi:10.1016/S0378-1119(01)00324-9. PMID 11245976.

[entrez-6] "Entrez Gene: NPDC1 neural proliferation, differentiation and control, 1".

[pmid11042687-7] Sansal I, Dupont E, Toru D, Evrard C, Rouget P (October 2000). "NPDC-1, a regulator of neural cell proliferation and differentiation, interacts with E2F-1, reduces its binding to DNA and modulates its transcriptional activity". Oncogene. 19 (43): 5000–9. doi:10.1038/sj.onc.1203843. PMID 11042687.

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Interactions

References

Further reading