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ABL (gene)

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ABL1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesABL1, ABL proto-oncogene 1, non-receptor tyrosine kinase, ABL, JTK7, bcr/abl, c-ABL, c-p150, v-abl, CHDSKM, BCR-ABL, Genes, abl
External IDsOMIM: 189980; MGI: 87859; HomoloGene: 3783; GeneCards: ABL1; OMA:ABL1 - orthologs
EC number2.7.10.2
Orthologs
SpeciesHumanMouse
Entrez

25

11350

Ensembl

ENSG00000097007

ENSMUSG00000026842

UniProt

P00519

P00520

RefSeq (mRNA)

NM_007313
NM_005157

NM_001112703
NM_009594
NM_001283045
NM_001283046
NM_001283047

RefSeq (protein)

NP_005148
NP_009297

NP_001106174
NP_001269974
NP_001269975
NP_001269976
NP_033724

Location (UCSC)Chr 9: 130.71 – 130.89 MbChr 2: 31.58 – 31.69 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Tyrosine-protein kinase ABL1 also known as ABL1 is a protein that, in humans, is encoded by the ABL1 gene (previous symbol ABL) located on chromosome 9.[5] c-Abl is sometimes used to refer to the version of the gene found within the mammalian genome, while v-Abl refers to the viral gene, which was initially isolated from the Abelson murine leukemia virus.[6]

Function

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The ABL1 proto-oncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response such as DNA repair.[7][8][9][10] Activity of ABL1 protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR and ABL1 genes, leading to a fusion gene present in many cases of chronic myelogenous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or a 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2–11.[11]

Clinical significance

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ABL1 kinase domain (blue) in complex with the second-generation Bcr-Abl tyrosine-kinase inhibitor nilotinib (red)

Mutations in the ABL1 gene are associated with chronic myelogenous leukemia (CML). In CML, the gene is activated by being translocated within the BCR (breakpoint cluster region) gene on chromosome 22. This new fusion gene, BCR-ABL, encodes an unregulated, cytoplasm-targeted tyrosine kinase that allows the cells to proliferate without being regulated by cytokines. This, in turn, allows the cell to become cancerous.

This gene is a partner in a fusion gene with the BCR gene in the Philadelphia chromosome, a characteristic abnormality in chronic myelogenous leukemia (CML) and rarely in some other leukemia forms. The BCR-ABL transcript encodes a tyrosine kinase, which activates mediators of the cell cycle regulation system, leading to a clonal myeloproliferative disorder. The BCR-ABL protein can be inhibited by various small molecules. One such inhibitor is imatinib mesylate, which occupies the tyrosine kinase domain and inhibits BCR-ABL's influence on the cell cycle. Second generation BCR-ABL tyrosine-kinase inhibitors are also under development to inhibit BCR-ABL mutants resistant to imatinib.[12]

Interactions

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ABL gene has been shown to interact with:

Regulation

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There is some evidence that the expression of Abl is regulated by the microRNA miR-203.[61]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000097007 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026842 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
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  6. ^ Abelson HT, Rabstein LS (August 1970). "Lymphosarcoma: virus-induced thymic-independent disease in mice". Cancer Research. 30 (8): 2213–22. PMID 4318922.
  7. ^ Takizawa Y, Kinebuchi T, Kagawa W, Yokoyama S, Shibata T, Kurumizaka H (September 2004). "Mutational analyses of the human Rad51-Tyr315 residue, a site for phosphorylation in leukaemia cells". Genes to Cells. 9 (9): 781–90. doi:10.1111/j.1365-2443.2004.00772.x. PMID 15330855. S2CID 22916981.
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  9. ^ Siddiqui A, Tumiati M, Joko A, Sandholm J, Roering P, Aakko S, et al. (2021). "Targeting DNA Homologous Repair Proficiency With Concomitant Topoisomerase II and c-Abl Inhibition". Frontiers in Oncology. 11: 3666. doi:10.3389/fonc.2021.733700. PMC 8488401. PMID 34616682.
  10. ^ "UniProtKB - P00519 (ABL1_HUMAN)". Uniprot. Retrieved 18 May 2020.
  11. ^ "Entrez Gene: ABL1 v-abl Abelson murine leukemia viral oncogene homolog 1".
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Further reading

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