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Pharmaceutical industry in Pakistan

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The pharmaceutical industry in Pakistan was estimated to be worth Rs. 748 billion (US$2.6 billion) in 2023, representing about 1% of the country's GDP.[1] The industry is largely import-dependent, with more than 90% of raw material being imported and only 12% of APIs locally produced.[1] Pakistani pharmaceutical companies are engaged in importing raw materials, compounding APIs with excipients, coating of pills, and fill-finish activities.[1][2] The industry is regulated by the Drug Regulatory Authority of Pakistan, which oversees drug approvals and pricing.[3]

Pakistan imports all specialized finished dosage forms, vaccines and biologicals. An ICAP report estimated that the Pakistani pharmaceutical industry has a 50-60% import reliance on India.[1] Pakistan exported pharmaceutical products worth about $235 million in 2023,[1] mostly to a few less-regulated markets in Africa and Southeast Asia.[2]

History

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At the time of the independence of Pakistan in 1947, there were few production units in the country. Currently Pakistan has more than 800 large volume pharmaceutical formulation units, including those operated by 25 multinationals present in the country. Almost all the raw materials used in making of medicine are sourced from abroad.[4] There are factors hindering growth such as the manufacturing of counterfeit drugs made from substandard active ingredients.

The Pakistan pharmaceutical industry meets around 90% of the country's demand of finished dosage forms and 4% of active ingredients. Specialized finished dosage forms such as soft gelatin capsules, parenteral fat emulsions and metered-dose inhalers continue to be imported. There are only a few bulk drug active ingredient producers and Pakistan mainly depends on imports of bulk drugs for its formulation needs resulting in frequent drug shortages.[5] Political disturbances and allegations of under-invoicing add to the uncertainty of imports[6] and clashes with the customs and tax authorities are common.

In 2017, the World Health Organization accredited the first Pakistani drug formulated by Getz Pharma.[7]

Exodus of multinational companies (2000–present)

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Over the past three decades, the presence of multinational pharmaceutical companies in Pakistan has significantly dwindled, decreasing to 22 from 48.[8] The decline is attributed to the challenging business environment, where supplying quality medicines at rates lower than production costs has become unsustainable.[8][3]

In April 2008, Merck Sharp & Dohme (Pakistan) Ltd, an American research-based company operating in Pakistan since 1960, divested its business, including its manufacturing unit and locally registered products to a Pakistani local company, Organon Bio Sciences.[9][10] Similarly, Bristol Myers Squibb, another American company which was operational in Pakistan since 1984 and was manufacturing antibiotics, blood pressure control and cancer drugs in a local factory, transferred its business and product registrations to GlaxoSmithKline Pakistan in 2008.[10][11]

From the UK, ICI also disinvested, selling its name and production licenses to a local entity, a move mirrored by Roche Pakistan in 2010.[10][12] Johnson and Johnson, which entered Pakistan in 1966 upon President Ayub Khan's invitation, sold its pharmaceutical and surgical sutures manufacturing unit to a domestic company.[10]

In November 2016, Merck Group divested its operations to a local company, Martin Dow.[13][14]

In November 2022, Eli Lilly Pakistan, known for producing Humalog medical insulin for diabetes treatment, announced the closure of its operations in Pakistan.[8] In April 2023, Sanofi exited Pakistan and sold its shareholding to the local investors.[15] In July 2023, Bayer completed the sale of its manufacturing unit and local pharmaceutical brands to OBS Group.[16]

In May 2024, Pfizer sold its manufacturing plant in Karachi and pharmaceutical products to Lucky Core Industries.[17]

List of pharmaceutical companies in Pakistan

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There are 759 pharmaceutical units[18] operated by around 650 companies.[19]

As of 2023, the 10 largest pharmaceutical companies accounted for 48 percent of the total market, while top 50 companies had a market share of 93 percent.[1]

Listed companies

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Unlisted notable companies

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See also

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Notes and references

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  1. ^ a b c d e f "Pharmaceutical Industry" (PDF). icap.org.pk. Retrieved 28 May 2024.
  2. ^ a b Niazi, Sarfaraz K. (27 November 2023). "Corporate window: The need for vision in pharma". Dawn. Retrieved 28 May 2024.
  3. ^ a b Attarwala, Fatima S. (25 July 2022). "The ongoing pharma MNC exodus". Dawn. Pakistan.
  4. ^ Junaidi, Ikram (17 July 2015). "No law to stop pharma companies from importing raw materials". Dawn. Pakistan.
  5. ^ "The Express Tribune, 1 October 2014: Shahram Haq". 30 September 2014.
  6. ^ "Pakistan Observer, 4 October 2014". Archived from the original on 19 October 2014.
  7. ^ "WHO accredits first-ever Pak drug". The News International. Pakistan.
  8. ^ a b c Junaidi, Ikram (11 November 2022). "Another pharma MNC calls it quits". Dawn. Pakistan.
  9. ^ Subohi, Afshan (17 April 2008). "MSD winds up Pakistan operations". Dawn. Pakistan.
  10. ^ a b c d Junaidi, Ikram (16 February 2015). "As govt and pharmaceutical giants fight over price, the sick suffer". Dawn. Pakistan.
  11. ^ Khan, Aamir Shafaat (21 October 2008). "Bristol-Myers Squibb leaving". Dawn. Pakistan.
  12. ^ https://www.pacra.com/summary_report/RR_2390_12010_01-Sep-23.pdf [bare URL PDF]
  13. ^ Reporter, The Newspaper's Staff (8 November 2016). "Merck divests its Pakistan stake to Martin Dow". Dawn. Pakistan.
  14. ^ "German pharma giant divests interests". The Express Tribune. 7 November 2016.
  15. ^ "Sanofi-Aventis: Packages-led consortium acquires full 52.87pc stake held by Sanofi Foreign". Business Recorder. 29 April 2023.
  16. ^ "OBS Pharma (Private) Limited" (PDF). VIS Credit Rating Company. Retrieved 28 May 2024.
  17. ^ "Lucky Core seals deal for Pfizer's Karachi plant, pharma products". Profit by Pakistan Today. 17 May 2024. Retrieved 28 May 2024.
  18. ^ [1][dead link‍]
  19. ^ https://www.icap.org.pk/paib/pdf/guidelines/PharmaIndustry.pdf [bare URL PDF]
  20. ^ "Abbott Laboratories Pakistan Limited". 31 January 2024.
  21. ^ "AGP Limited". 8 June 2023.
  22. ^ "Glaxo's Supplier Plans Pakistan's Largest Pharma IPO". Bloomberg News. 19 February 2021.
  23. ^ "Citi Pharma attracts Rs 2.3b in IPO". 17 June 2021.
  24. ^ "Ferozsons Laboratories Limited". 27 August 2021.
  25. ^ "GSK Consumer Healthcare gets listed at PSX". 22 March 2017.
  26. ^ "Highnoon Laboratories and the curious (Court) case of Related Party Transactions". 13 May 2024.
  27. ^ "Pharma company Sanofi-Aventis Pakistan changes name to Hoechst Pakistan Limited". 9 August 2023.
  28. ^ "Macter International Limited". 25 September 2023.
  29. ^ "Otsuka Pakistan Limited". 19 July 2023.
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